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Protein

Probable 26S proteasome non-ATPase regulatory subunit 9

Gene

psmd-9

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC).By similarity

GO - Biological processi

Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S proteasome non-ATPase regulatory subunit 9
Gene namesi
Name:psmd-9
ORF Names:C44B7.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiC44B7.1 ; CE25810 ; WBGene00016623 ; psmd-9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001738551 – 197Probable 26S proteasome non-ATPase regulatory subunit 9Add BLAST197

Proteomic databases

EPDiQ10920
PaxDbiQ10920
PeptideAtlasiQ10920
PRIDEiQ10920

Expressioni

Gene expression databases

BgeeiWBGene00016623

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
rpt-5O763713EBI-317193,EBI-317201

Protein-protein interaction databases

IntActiQ10920, 6 interactors
STRINGi6239.C44B7.1.1

Structurei

3D structure databases

ProteinModelPortaliQ10920
SMRiQ10920
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 166PDZAdd BLAST92

Sequence similaritiesi

Belongs to the proteasome subunit p27 family.Curated

Phylogenomic databases

eggNOGiKOG3129 Eukaryota
COG0265 LUCA
GeneTreeiENSGT00390000004147
HOGENOMiHOG000216665
InParanoidiQ10920
KOiK06693
OMAiLGCNIVP
OrthoDBiEOG091G0N53
PhylomeDBiQ10920

Family and domain databases

InterProiView protein in InterPro
IPR036034 PDZ_sf
IPR035269 PSMD9
PANTHERiPTHR12651 PTHR12651, 1 hit
SUPFAMiSSF50156 SSF50156, 1 hit

Sequencei

Sequence statusi: Complete.

Q10920-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHHSKAKEL LQQRDELDGK IKELMLVLET NNSTMDSPLL DAEGYPLNTI
60 70 80 90 100
DVYAVRHARH DLICLRNDRA ALTEKIVVEM ENENKEVSGQ TATSEEKPVH
110 120 130 140 150
RTSNEPFVKI SSVVELSPAD IGGFRKDDLI IQYGNLHHGN FNDMQEVAQI
160 170 180 190
TKQSEDKIIR VTVIRENRPV RLEICPKKWS GPGLLGCNIV PISGANV
Length:197
Mass (Da):22,133
Last modified:July 19, 2003 - v2
Checksum:iE6693CE5141FE0E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080139 Genomic DNA Translation: CCD61554.1
PIRiT15289
RefSeqiNP_001293499.1, NM_001306570.1

Genome annotation databases

EnsemblMetazoaiC44B7.1; C44B7.1; WBGene00016623
GeneIDi24104302
KEGGicel:CELE_C44B7.1
UCSCiC44B7.1.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPSMD9_CAEEL
AccessioniPrimary (citable) accession number: Q10920
Secondary accession number(s): G8JXY6, Q95QR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: July 19, 2003
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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