UniProtKB - Q10751 (ACE_CHICK)
Protein
Angiotensin-converting enzyme
Gene
ACE
Organism
Gallus gallus (Chicken)
Status
Functioni
Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin.
Catalytic activityi
- Release of a C-terminal dipeptide, oligopeptide-|-Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II. EC:3.4.15.1
Cofactori
Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 288 | Zinc 1; catalyticBy similarity | 1 | |
Active sitei | 289 | 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 292 | Zinc 1; catalyticBy similarity | 1 | |
Metal bindingi | 886 | Zinc 2; catalyticBy similarity | 1 | |
Active sitei | 887 | 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 890 | Zinc 2; catalyticBy similarity | 1 |
GO - Molecular functioni
- carboxypeptidase activity Source: UniProtKB-KW
- metallopeptidase activity Source: GO_Central
- peptidyl-dipeptidase activity Source: GO_Central
- zinc ion binding Source: AgBase
GO - Biological processi
- cell population proliferation Source: AgBase
- positive regulation of systemic arterial blood pressure Source: GO_Central
- primitive erythrocyte differentiation Source: AgBase
- regulation of systemic arterial blood pressure by renin-angiotensin Source: GO_Central
Keywordsi
Molecular function | Carboxypeptidase, Hydrolase, Metalloprotease, Protease |
Ligand | Metal-binding, Zinc |
Protein family/group databases
MEROPSi | M02.001 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:ACE Synonyms:DCP1 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Other locations
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: AgBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | ‹1 – 1156 | ExtracellularSequence analysisAdd BLAST | ›1156 | |
Transmembranei | 1157 – 1173 | HelicalSequence analysisAdd BLAST | 17 | |
Topological domaini | 1174 – 1193 | CytoplasmicSequence analysisAdd BLAST | 20 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000078152 | ‹1 – 1193 | Angiotensin-converting enzymeAdd BLAST | ›1193 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 216 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 407 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 447 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 485 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 513 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 555 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 575 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 658 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1089 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q10751 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 125 – 481 | Add BLAST | 357 | |
Repeati | 723 – 1079 | Add BLAST | 357 |
Sequence similaritiesi
Belongs to the peptidase M2 family.Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3690, Eukaryota |
InParanoidi | Q10751 |
PhylomeDBi | Q10751 |
Family and domain databases
CDDi | cd06461, M2_ACE, 2 hits |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 2 hits |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 2 hits |
PRINTSi | PR00791, PEPDIPTASEA |
PROSITEi | View protein in PROSITE PS00142, ZINC_PROTEASE, 2 hits |
i Sequence
Sequence statusi: Fragment.
Q10751-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
AKELYGNIWS NFSDPQLKKI IGSIQTLGPS NLPLDKRQQY NTILSDMDKI
60 70 80 90 100
YSTAKVCLDN GTCWDLEPDI SDIMATSRSY KKLLYAWEGW HNAAGNPLRA
110 120 130 140 150
KYQEFVTLSN EAYQMDGFED TGSYWRSWYD STTFEDDLEH LYNQLEPLYL
160 170 180 190 200
NLHAFVRRKL YDRYGPKYIN LKGPIPAHLL GNMWAQQWNN IYDLMVPYPD
210 220 230 240 250
KPNLDVTNTM VNQGWNATHM FRVSEEFFTS LGLLEMPPEF WEKSMLEKPA
260 270 280 290 300
DGREVVCHAS AWDFYNRKDF RIKQCTTVTM EQLFTVHHEM GHVQYYLQYK
310 320 330 340 350
DQPVSFRGGA NPGFHEAIGD VLSLSVSTPS HLQKIGLLSS AVEDEESNIN
360 370 380 390 400
YLLKMALEKI AFLPFGYLID QWRWNVFSGR TPPSRYNYDW WYLRTKYQGI
410 420 430 440 450
CAPVSRNESN FDPGAKYHIP GNTPYIRYFV SFILQFQFHK ALCQAANHTG
460 470 480 490 500
PLHTCDIYMS KEAGAKLREV LKAGSSKSWQ EILFNLTGTD KMDAGALLEY
510 520 530 540 550
FSPVTTWLQE QNNKTNEVLG WPEFDWRSPI PEGYPEGIDK IVDEAQAKEF
560 570 580 590 600
LSEYNSTAEV VWNAYTEASW EYNTNITDHN KEVMLEKNLA MSKHTIEYGM
610 620 630 640 650
RARQFDPSDF QDETVTRILN KLSVLERAAL PEDELKEYNT LLSDMETTYS
660 670 680 690 700
VAKVCRENNT FHPLDPDLTD ILATSRDYNE LLFAWKGWWD ASGAKIKDKY
710 720 730 740 750
KRYVELSNKA AVLNGYTDNG AYWRSLYETP TFEEDLERLY LQLQPLYLNL
760 770 780 790 800
HAYVRRALYN KYGAEHISLK GPIPAHLLGN MWAQSWSNIF DLVMPFPDAT
810 820 830 840 850
KVDATPAMKQ QGWTPKMMFE ESDRFFTSLG LIPMPQEFWD KSMIEKPADG
860 870 880 890 900
REVVCHASAW DFYNRKDFRI KQCTVVNMDD LITVHHEMGH VQYFLQYMDQ
910 920 930 940 950
PISFRDGANP GFHEAIGDVM ALSVSTPKHL HSINLLDQVT ENEESDINYL
960 970 980 990 1000
MSIALDKIAF LPFGYLMDQW RWKVFDGRIK EDEYNQQWWN LRLKYQGLCP
1010 1020 1030 1040 1050
PVPRSEDDFD PGAKFHIPAN VPYIRYFVSF VIQFQFHQAL CKAAGHTGPL
1060 1070 1080 1090 1100
HTCDIYQSKE AGKLLGDAMK LGFSKPWPEA MQLITGQPNM SAEALMSYFE
1110 1120 1130 1140 1150
PLMTWLVKKN TENGEVLGWP EYSWTPYAVT EFHAATDTAD FLGMSVGTKQ
1160 1170 1180 1190
ATAGAWVLLA LALVFLITSI FLGVKLFSSR RKAFKSSSEM ELK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L40175 mRNA Translation: AAA75554.1 |
PIRi | JC2489 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L40175 mRNA Translation: AAA75554.1 |
PIRi | JC2489 |
3D structure databases
SMRi | Q10751 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000039731 |
Protein family/group databases
MEROPSi | M02.001 |
Proteomic databases
PaxDbi | Q10751 |
Phylogenomic databases
eggNOGi | KOG3690, Eukaryota |
InParanoidi | Q10751 |
PhylomeDBi | Q10751 |
Family and domain databases
CDDi | cd06461, M2_ACE, 2 hits |
InterProi | View protein in InterPro IPR001548, Peptidase_M2 |
PANTHERi | PTHR10514, PTHR10514, 2 hits |
Pfami | View protein in Pfam PF01401, Peptidase_M2, 2 hits |
PRINTSi | PR00791, PEPDIPTASEA |
PROSITEi | View protein in PROSITE PS00142, ZINC_PROTEASE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACE_CHICK | |
Accessioni | Q10751Primary (citable) accession number: Q10751 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - Peptidase families
Classification of peptidase families and list of entries - SIMILARITY comments
Index of protein domains and families