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Entry version 139 (12 Aug 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Cell fusion protein fus1

Gene

fus1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for cell fusion. It associates with the pre-zygotic projection tips in conjugating cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processStress response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell fusion protein fus1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fus1
ORF Names:SPAC20G4.02c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC20G4.02c

Schizosaccharomyces pombe database

More...
PomBasei
SPAC20G4.02c, fus1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949021 – 1372Cell fusion protein fus1Add BLAST1372

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10719

PRoteomics IDEntifications database

More...
PRIDEi
Q10719

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By nitrogen starvation and by a pheromone signal in both P and M cell types. Essentially unexpressed in vegetative cells.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with actin at the FH2 domain.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278235, 42 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC20G4.02c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini104 – 522GBD/FH3PROSITE-ProRule annotationAdd BLAST419
Domaini868 – 1278FH2PROSITE-ProRule annotationAdd BLAST411

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi802 – 817SH3-bindingAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the formin homology family. BNI1 subfamily.Curated

Keywords - Domaini

SH3-binding

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1922, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001313_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10719

KEGG Orthology (KO)

More...
KOi
K17971

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAKENIE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q10719

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.58.2220, 1 hit
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q10719-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTASFKGIR ISKPIVKEIS SFGSLTNIDL HTDPYEKVEA KALSRSRLKN
60 70 80 90 100
QSVKKTDLRI TNDYSSLFVS IENKKNTIPD IHCNNLSKRP VGFTDSYVPG
110 120 130 140 150
EALLCPDDPN LVNELFDDVL KRLREEKSDS GEQFHWDANV TLSQENKWSF
160 170 180 190 200
ITGYLSRNDK FLKISSNDSE LNVKASVISY IEKLSCTPLK LKYVESLAVA
210 220 230 240 250
LRTESVTWVR YFLLMGGHIV LAKILQAIHE KKHLKSPDIT LEIAILKSMR
260 270 280 290 300
CIIGQKIGTD FYLSNKYPID SVVHCLLSTK LLVRKLAAEL LTFLCYSEKP
310 320 330 340 350
NGINAIMKCM KNFANLKVES MNVFDLWLSQ WKRTLLEKVV TEEKKVLEEA
360 370 380 390 400
ALHDKITIEY IISQMLLINA FLENIPSKTA LLQFKESLRI GNFKSILLIL
410 420 430 440 450
KKINDEGVLK QLEKCVKLVS LDTANEKHFL KHTPNSAAHQ SLLNTNMFND
460 470 480 490 500
ANFEFMVKEH IKNFLKLLKE HNNPVRIIKL LDCLVLTLQA DKGNGNSNND
510 520 530 540 550
IDCFYKELKI GNEQGNNAPG YSSVTSGYGT TNSKKVVASY DNTDDNEYSV
560 570 580 590 600
SKSELYATGD TNNTTNQGYE NSERKYVESS KYETDLKNIF DCLCLLFPSE
610 620 630 640 650
FDPQSSFSAE KIFSKLKHLL TRTRDSYISE DTKILRLLNR SSSKLQDRDQ
660 670 680 690 700
EYLISKNNVN GNGNRDWVQP VNTTSSVSAF ASPRIKPKLL FQPNQDEKLK
710 720 730 740 750
LCKLDLAKAN SITLKSEPSS AVSTHSFEVH LSMPGTQIKS ANLAEKMETS
760 770 780 790 800
KHKVFNPKRI DVVSDLPLDY RKSYYGRFSI TDTKRFSKIE NMRIKEVIDG
810 820 830 840 850
NPFKAPPPAP LPPPAPPLPT AMSSLQKFEK NDSQIFRKTI IIPENISIDD
860 870 880 890 900
IFKFCSGSES EVYASKIPGE LCNPSKRLKQ LHWKRLEVPF EKTLWNIVVA
910 920 930 940 950
DPYLLTLKLT AEGIFKQLED CYPLREVTVS NKKVKEYTGF MPVDLQQMVS
960 970 980 990 1000
IRLHRFNSLT PIEIAKKFFH CDHDIMELVD FFNDRKFFRQ EGLKKQLKPY
1010 1020 1030 1040 1050
MSSRNEEVME VSEKLLELSR FDQIYTLIVV DIDTYYEKRM AALKIKSFLA
1060 1070 1080 1090 1100
NNFRDFRRQI RKLHCASLEL KSSLHFKYFL NLVLHIGNFM NDAPRRAKGY
1110 1120 1130 1140 1150
RLESLLRASM IKNDKTGLTL LHTIEKIVRT HFPQLEAFLV DLKAIPEISR
1160 1170 1180 1190 1200
FNLEQLEQDC NDICERMKNV EKDFSNEGIF SNHKALHPDD HICEVMVPWI
1210 1220 1230 1240 1250
PSGKSMVDEL NSDITELKTT LKTTLLMYGE NPDEPTSSAR FFNNLNEIIL
1260 1270 1280 1290 1300
EYKKASTVNQ KMEKEEELAF LRLQALKASV KSNNAENSGS SKNEEVSATM
1310 1320 1330 1340 1350
ENLISQLQKG LCDDSLSNKT DCTESSKQTI ETLMNYENDK QTLEGSNKKR
1360 1370
QTVVLKAECM LKQLENNNEL KR
Length:1,372
Mass (Da):157,074
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52349B4E1B9D6B98
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L37838 Genomic DNA Translation: AAA99003.1
CU329670 Genomic DNA Translation: CAB11252.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T43296

NCBI Reference Sequences

More...
RefSeqi
NP_594737.1, NM_001020165.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC20G4.02c.1; SPAC20G4.02c.1:pep; SPAC20G4.02c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541741

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC20G4.02c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L37838 Genomic DNA Translation: AAA99003.1
CU329670 Genomic DNA Translation: CAB11252.1
PIRiT43296
RefSeqiNP_594737.1, NM_001020165.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi278235, 42 interactors
STRINGi4896.SPAC20G4.02c.1

Proteomic databases

PaxDbiQ10719
PRIDEiQ10719

Genome annotation databases

EnsemblFungiiSPAC20G4.02c.1; SPAC20G4.02c.1:pep; SPAC20G4.02c
GeneIDi2541741
KEGGispo:SPAC20G4.02c

Organism-specific databases

EuPathDBiFungiDB:SPAC20G4.02c
PomBaseiSPAC20G4.02c, fus1

Phylogenomic databases

eggNOGiKOG1922, Eukaryota
HOGENOMiCLU_001313_1_0_1
InParanoidiQ10719
KOiK17971
OMAiCAKENIE
PhylomeDBiQ10719

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10719

Family and domain databases

Gene3Di1.20.58.2220, 1 hit
1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR015425, FH2_Formin
IPR042201, FH2_Formin_sf
IPR014768, GBD/FH3_dom
IPR010473, GTPase-bd
PfamiView protein in Pfam
PF06371, Drf_GBD, 1 hit
PF02181, FH2, 1 hit
SMARTiView protein in SMART
SM01140, Drf_GBD, 1 hit
SM00498, FH2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS51444, FH2, 1 hit
PS51232, GBD_FH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUS1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10719
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 12, 2020
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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