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Entry version 172 (13 Feb 2019)
Sequence version 3 (11 Sep 2007)
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Protein

Angiotensin-converting enzyme

Gene

Ance

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in the specific maturation or degradation of a number of bioactive peptides. May play a role in the contractions of the heart, gut and testes, and in spermatid differentiation.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+Note: Binds 1 zinc ion per subunit.

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by captopril and, to a lesser extent, by lisinopril, trandolaprilat, fosinoprilat and enalaprilat.2 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=33.5 µM for angiotensin I3 Publications
  2. KM=53.4 µM for N-acetyl-Ser-Asp-Lys-Pro3 Publications
  3. KM=2.59 mM for Hip-His-Leu3 Publications
  4. KM=10.26 mM for Hip-His-Leu-NH23 Publications
  5. KM=372 µM for (Leu5)enkephalin3 Publications
  6. KM=1.88 mM for (Leu5)enkephalinamide3 Publications

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi367Zinc; catalytic1
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei3681
    Metal bindingi371Zinc; catalytic1
    Metal bindingi395Zinc; catalytic1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • carboxypeptidase activity Source: UniProtKB-KW
    • dipeptidyl-peptidase activity Source: GO_Central
    • exopeptidase activity Source: GO_Central
    • metal ion binding Source: UniProtKB-KW
    • metallopeptidase activity Source: GO_Central
    • peptidyl-dipeptidase activity Source: FlyBase

    GO - Biological processi

    • metamorphosis Source: FlyBase
    • proteolysis Source: FlyBase
    • response to symbiotic bacterium Source: FlyBase
    • spermatid nucleus differentiation Source: FlyBase
    • sperm individualization Source: FlyBase

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionCarboxypeptidase, Hydrolase, Metalloprotease, Protease
    LigandMetal-binding, Zinc

    Enzyme and pathway databases

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    3.4.15.1 1994

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-DME-2022377 Metabolism of Angiotensinogen to Angiotensins

    SABIO-RK: Biochemical Reaction Kinetics Database

    More...
    SABIO-RKi
    Q10714

    Protein family/group databases

    MEROPS protease database

    More...
    MEROPSi
    M02.003

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Angiotensin-converting enzyme (EC:3.4.15.1)
    Alternative name(s):
    Dipeptidyl carboxypeptidase I
    Kininase II
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Ance
    Synonyms:Race
    ORF Names:CG8827
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2L

    Organism-specific databases

    Drosophila genome database

    More...
    FlyBasei
    FBgn0012037 Ance

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

    Male flies are sterile.1 Publication

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 17Add BLAST17
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002856318 – 615Angiotensin-converting enzymeAdd BLAST598

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi53N-linked (GlcNAc...) asparagine1 Publication1
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi133 ↔ 141
    Glycosylationi196N-linked (GlcNAc...) asparagine1 Publication1
    Glycosylationi311N-linked (GlcNAc...) asparagine1 Publication1
    Disulfide bondi336 ↔ 354
    Disulfide bondi467 ↔ 612
    Disulfide bondi522 ↔ 540

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Glycosylated.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q10714

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q10714

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q10714

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in vesicular structures in spermatocytes and early spermatids (at protein level).1 Publication

    <p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Expressed in the amnioserosa during germ band elongation, shortening and heart morphogenesis. Expressed in midgut throughout embryogenesis.

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    FBgn0012037 Expressed in 66 organ(s), highest expression level in eye disc (Drosophila)

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q10714 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q10714 DM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    60835, 2 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q10714, 7 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q10714

    STRING: functional protein association networks

    More...
    STRINGi
    7227.FBpp0080129

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1615
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1J36X-ray2.40A/B14-615[»]
    1J37X-ray2.40A/B14-615[»]
    1J38X-ray2.60A/B14-615[»]
    2X8YX-ray1.90A17-614[»]
    2X8ZX-ray1.98A17-614[»]
    2X90X-ray1.98A17-614[»]
    2X91X-ray1.98A17-614[»]
    2X92X-ray2.11A17-615[»]
    2X93X-ray1.98A17-615[»]
    2X94X-ray1.88A17-615[»]
    2X95X-ray1.96A17-615[»]
    2X96X-ray1.85A17-614[»]
    2X97X-ray1.85A17-614[»]
    2XHMX-ray1.96A17-614[»]
    3ZQZX-ray2.35A17-614[»]
    4AA1X-ray1.99A17-614[»]
    4AA2X-ray1.99A17-614[»]
    4ASQX-ray1.99A17-614[»]
    4ASRX-ray1.90A17-614[»]
    4CA7X-ray1.82A17-614[»]
    4CA8X-ray1.99A17-614[»]
    5A2RX-ray1.85A18-615[»]

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q10714

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q10714

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q10714

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the peptidase M2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3690 Eukaryota
    ENOG410XPJ3 LUCA

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q10714

    KEGG Orthology (KO)

    More...
    KOi
    K01283

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    GWTTSNK

    Database of Orthologous Groups

    More...
    OrthoDBi
    422699at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q10714

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd06461 M2_ACE, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001548 Peptidase_M2

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR10514 PTHR10514, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF01401 Peptidase_M2, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00791 PEPDIPTASEA

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00142 ZINC_PROTEASE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

    Q10714-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MRLFLLALLA TLAVTQALVK EEIQAKEYLE NLNKELAKRT NVETEAAWAY
    60 70 80 90 100
    GSNITDENEK KKNEISAELA KFMKEVASDT TKFQWRSYQS EDLKRQFKAL
    110 120 130 140 150
    TKLGYAALPE DDYAELLDTL SAMESNFAKV KVCDYKDSTK CDLALDPEIE
    160 170 180 190 200
    EVISKSRDHE ELAYYWREFY DKAGTAVRSQ FERYVELNTK AAKLNNFTSG
    210 220 230 240 250
    AEAWLDEYED DTFEQQLEDI FADIRPLYQQ IHGYVRFRLR KHYGDAVVSE
    260 270 280 290 300
    TGPIPMHLLG NMWAQQWSEI ADIVSPFPEK PLVDVSAEME KQGYTPLKMF
    310 320 330 340 350
    QMGDDFFTSM NLTKLPQDFW DKSIIEKPTD GRDLVCHASA WDFYLTDDVR
    360 370 380 390 400
    IKQCTRVTQD QLFTVHHELG HIQYFLQYQH QPFVYRTGAN PGFHEAVGDV
    410 420 430 440 450
    LSLSVSTPKH LEKIGLLKDY VRDDEARINQ LFLTALDKIV FLPFAFTMDK
    460 470 480 490 500
    YRWSLFRGEV DKANWNCAFW KLRDEYSGIE PPVVRSEKDF DAPAKYHISA
    510 520 530 540 550
    DVEYLRYLVS FIIQFQFYKS ACIKAGQYDP DNVELPLDNC DIYGSAAAGA
    560 570 580 590 600
    AFHNMLSMGA SKPWPDALEA FNGERIMSGK AIAEYFEPLR VWLEAENIKN
    610
    NVHIGWTTSN KCVSS
    Length:615
    Mass (Da):70,914
    Last modified:September 11, 2007 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9E3691BCC51D6C48
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    X2J8C3X2J8C3_DROME
    Angiotensin-converting enzyme
    Ance ACE, ANCE, AnCE, ance, anon-EST:fe3D10
    615Annotation score:

    Annotation score:4 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48 – 51WAYG → GPMR in AAC46902 (PubMed:7547464).Curated4
    Sequence conflicti141C → S in AAC46902 (PubMed:7547464).Curated1
    Sequence conflicti293G → A in AAB02171 (PubMed:7775412).Curated1
    Sequence conflicti346T → I (PubMed:8224398).Curated1
    Sequence conflicti346T → I in AAB02171 (PubMed:7775412).Curated1
    Sequence conflicti346T → I in AAC46902 (PubMed:7547464).Curated1
    Sequence conflicti346T → I (PubMed:10471707).Curated1
    Sequence conflicti365V → E (PubMed:8224398).Curated1
    Sequence conflicti402S → A (PubMed:8224398).Curated1
    Sequence conflicti414I → T (PubMed:8224398).Curated1
    Sequence conflicti486S → T in AAC46902 (PubMed:7547464).Curated1
    Sequence conflicti533V → M in AAC46902 (PubMed:7547464).Curated1
    Sequence conflicti547A → R in AAB02171 (PubMed:7775412).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U25344 mRNA Translation: AAB02171.1
    U34599 mRNA Translation: AAC46902.1
    AE014134 Genomic DNA Translation: AAF53353.2
    AE014134 Genomic DNA Translation: AAN10856.1
    AY061129 mRNA Translation: AAL28677.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001285915.1, NM_001298986.1
    NP_477046.1, NM_057698.5
    NP_723852.1, NM_165070.3

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Dm.2157

    Genome annotation databases

    Ensembl metazoan genome annotation project

    More...
    EnsemblMetazoai
    FBtr0080552; FBpp0080129; FBgn0012037
    FBtr0080553; FBpp0080130; FBgn0012037
    FBtr0343667; FBpp0310259; FBgn0012037

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    34805

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    dme:Dmel_CG8827

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U25344 mRNA Translation: AAB02171.1
    U34599 mRNA Translation: AAC46902.1
    AE014134 Genomic DNA Translation: AAF53353.2
    AE014134 Genomic DNA Translation: AAN10856.1
    AY061129 mRNA Translation: AAL28677.1
    RefSeqiNP_001285915.1, NM_001298986.1
    NP_477046.1, NM_057698.5
    NP_723852.1, NM_165070.3
    UniGeneiDm.2157

    3D structure databases

    Select the link destinations:
    PDBei
    RCSB PDBi
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    1J36X-ray2.40A/B14-615[»]
    1J37X-ray2.40A/B14-615[»]
    1J38X-ray2.60A/B14-615[»]
    2X8YX-ray1.90A17-614[»]
    2X8ZX-ray1.98A17-614[»]
    2X90X-ray1.98A17-614[»]
    2X91X-ray1.98A17-614[»]
    2X92X-ray2.11A17-615[»]
    2X93X-ray1.98A17-615[»]
    2X94X-ray1.88A17-615[»]
    2X95X-ray1.96A17-615[»]
    2X96X-ray1.85A17-614[»]
    2X97X-ray1.85A17-614[»]
    2XHMX-ray1.96A17-614[»]
    3ZQZX-ray2.35A17-614[»]
    4AA1X-ray1.99A17-614[»]
    4AA2X-ray1.99A17-614[»]
    4ASQX-ray1.99A17-614[»]
    4ASRX-ray1.90A17-614[»]
    4CA7X-ray1.82A17-614[»]
    4CA8X-ray1.99A17-614[»]
    5A2RX-ray1.85A18-615[»]
    ProteinModelPortaliQ10714
    SMRiQ10714
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi60835, 2 interactors
    IntActiQ10714, 7 interactors
    MINTiQ10714
    STRINGi7227.FBpp0080129

    Protein family/group databases

    MEROPSiM02.003

    PTM databases

    iPTMnetiQ10714

    Proteomic databases

    PaxDbiQ10714
    PRIDEiQ10714

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblMetazoaiFBtr0080552; FBpp0080129; FBgn0012037
    FBtr0080553; FBpp0080130; FBgn0012037
    FBtr0343667; FBpp0310259; FBgn0012037
    GeneIDi34805
    KEGGidme:Dmel_CG8827

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    34805
    FlyBaseiFBgn0012037 Ance

    Phylogenomic databases

    eggNOGiKOG3690 Eukaryota
    ENOG410XPJ3 LUCA
    InParanoidiQ10714
    KOiK01283
    OMAiGWTTSNK
    OrthoDBi422699at2759
    PhylomeDBiQ10714

    Enzyme and pathway databases

    BRENDAi3.4.15.1 1994
    ReactomeiR-DME-2022377 Metabolism of Angiotensinogen to Angiotensins
    SABIO-RKiQ10714

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    Ance fly
    EvolutionaryTraceiQ10714

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    34805

    Protein Ontology

    More...
    PROi
    PR:Q10714

    Gene expression databases

    BgeeiFBgn0012037 Expressed in 66 organ(s), highest expression level in eye disc (Drosophila)
    ExpressionAtlasiQ10714 baseline and differential
    GenevisibleiQ10714 DM

    Family and domain databases

    CDDicd06461 M2_ACE, 1 hit
    InterProiView protein in InterPro
    IPR001548 Peptidase_M2
    PANTHERiPTHR10514 PTHR10514, 1 hit
    PfamiView protein in Pfam
    PF01401 Peptidase_M2, 1 hit
    PRINTSiPR00791 PEPDIPTASEA
    PROSITEiView protein in PROSITE
    PS00142 ZINC_PROTEASE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACE_DROME
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10714
    Secondary accession number(s): A4V0P3
    , Q27572, Q9NKE4, Q9TX66, Q9VJV3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 11, 2007
    Last modified: February 13, 2019
    This is version 172 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
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