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Protein

RNA-binding protein rnp-1

Gene

rnp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

RNA-binding protein that is required for the germ line to transition from spermatogenesis to oogenesis and allow for normal oocyte development.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 97CCHC-typeAdd BLAST14

GO - Molecular functioni

GO - Biological processi

  • oocyte fate commitment Source: UniProtKB
  • positive regulation of oocyte development Source: UniProtKB
  • spermatogenesis Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding protein rnp-1
Gene namesi
Name:rnp-1Imported
ORF Names:ZK863.7Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiZK863.7a ; CE15447 ; WBGene00004384 ; rnp-1

Pathology & Biotechi

Disruption phenotypei

Hermaphrodites are sterile and produce no oocytes due to the failure of the germ line to transition from spermatogenesis to oogenesis during oocyte development.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818091 – 305RNA-binding protein rnp-1Add BLAST305

Proteomic databases

EPDiQ10667
PaxDbiQ10667
PeptideAtlasiQ10667
PRIDEiQ10667

Expressioni

Tissue specificityi

Expressed throughout the germline.1 Publication

Gene expression databases

BgeeiWBGene00004384 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

BioGridi44695, 2 interactors
DIPiDIP-24668N
IntActiQ10667, 5 interactors
STRINGi6239.ZK863.7a

Structurei

3D structure databases

ProteinModelPortaliQ10667
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 72RRMPROSITE-ProRule annotationAdd BLAST70

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri84 – 97CCHC-typeAdd BLAST14

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0109 Eukaryota
ENOG41105PP LUCA
GeneTreeiENSGT00390000020883
HOGENOMiHOG000022464
InParanoidiQ10667
KOiK13187
OMAiFCKVTEC
OrthoDBiEOG091G15DU

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q10667-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSKLFVGNL PDNVDSNKLK QVFQPFCKVT ECDIVKNYAF VHIEEDDVDP
60 70 80 90 100
IITRLTGYTI DGKVVNIKKS TSKLRPTPGM PNRCFRCQSD EHRTPQCPQD
110 120 130 140 150
PTNNQKTENG VQTLKFDLTS GAGVKRSAGD PIIDSAKRIA YGAQSVVEPE
160 170 180 190 200
IPQPMDPDLQ ALYQEYQLSR QRYVYYRDRL LKEMEAKQHG STAGFALSSS
210 220 230 240 250
STVPVPVASA PPGATQLSAA PVSYQPNAPP VIASINAPYA VASNLRAPYA
260 270 280 290 300
LQSAPYASAA SAPYGSVTPA GAPSNVMTTQ QYLQQIQHQQ ATGSPAPVPA

PPRLY
Length:305
Mass (Da):33,049
Last modified:November 1, 1996 - v1
Checksum:i20C19544E58FBA2F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D9N141D9N141_CAEEL
RNA-binding protein rnp-1
rnp-1 CELE_ZK863.7, ZK863.7
29Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21302 Genomic DNA Translation: AAA92287.1
Z78019 Genomic DNA Translation: CAB01455.1
PIRiT28063
RefSeqiNP_001256408.1, NM_001269479.1
UniGeneiCel.9134

Genome annotation databases

EnsemblMetazoaiZK863.7a; ZK863.7a; WBGene00004384
GeneIDi179672
KEGGicel:CELE_ZK863.7
UCSCiZK863.7 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21302 Genomic DNA Translation: AAA92287.1
Z78019 Genomic DNA Translation: CAB01455.1
PIRiT28063
RefSeqiNP_001256408.1, NM_001269479.1
UniGeneiCel.9134

3D structure databases

ProteinModelPortaliQ10667
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi44695, 2 interactors
DIPiDIP-24668N
IntActiQ10667, 5 interactors
STRINGi6239.ZK863.7a

Proteomic databases

EPDiQ10667
PaxDbiQ10667
PeptideAtlasiQ10667
PRIDEiQ10667

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK863.7a; ZK863.7a; WBGene00004384
GeneIDi179672
KEGGicel:CELE_ZK863.7
UCSCiZK863.7 c. elegans

Organism-specific databases

CTDi179672
WormBaseiZK863.7a ; CE15447 ; WBGene00004384 ; rnp-1

Phylogenomic databases

eggNOGiKOG0109 Eukaryota
ENOG41105PP LUCA
GeneTreeiENSGT00390000020883
HOGENOMiHOG000022464
InParanoidiQ10667
KOiK13187
OMAiFCKVTEC
OrthoDBiEOG091G15DU

Miscellaneous databases

PROiPR:Q10667

Gene expression databases

BgeeiWBGene00004384 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRNP1_CAEEL
AccessioniPrimary (citable) accession number: Q10667
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1996
Last modified: October 10, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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