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Entry version 155 (18 Sep 2019)
Sequence version 3 (14 Dec 2011)
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Protein

Protein pop-1

Gene

pop-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the Wnt signaling pathway essential for the specification of the mesodermal cell fate in early embryos (PubMed:11742996, PubMed:11807036, PubMed:19427847). Required for asymmetrical division of somatic gonadal precursor descendants which initiate axis formation required to control organ shape (PubMed:11807036). Represses expression of target genes via its interaction with hda-1 histone deacetylase (PubMed:11742996). Required for specification of the M lineage-derived coelomocyte and sex myoblast fate (PubMed:19427847). Regulates coelomocyte fate by positively regulating proliferation and ceh-34 and possibly eya-1 expression in M.dlpa and M.drpa precursors (PubMed:19427847).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi192 – 262HMG boxPROSITE-ProRule annotationAdd BLAST71

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation, Wnt signaling pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-201722 Formation of the beta-catenin:TCF transactivating complex
R-CEL-3769402 Deactivation of the beta-catenin transactivating complex
R-CEL-4086398 Ca2+ pathway
R-CEL-4641265 Repression of WNT target genes
R-CEL-8951430 RUNX3 regulates WNT signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q10666

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein pop-1
Alternative name(s):
Posterior pharynx defect protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pop-1
ORF Names:W10C8.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
W10C8.2 ; CE46967 ; WBGene00004077 ; pop-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown in L1 larvae causes a severe loss of M lineage-derived coelomocytes and sex myoblasts. The loss of sex myoblasts is due to a fate transformation of M.v(l/r)pa cell to the fate of its posterior sister M.v(l/r)pp cell. The loss of coelomocytes is due to a combination of reduced proliferation of the dorsal M lineage and fate transformation of M.d(l/r)pa cell to the fate of its posterior sister M.d(l/r)pp cell. Loss of ceh-34 expression in the M lineage.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi9D → E in q645; abnormal gonad development and hermaphrodites are sterile. Formation of ectopic M lineage-derived coelomocytes on the dorsal side and ectopic sex myoblast on the ventral side. Simultaneous RNAi-mediated knockdown of ceh-34 causes a loss of all M lineage-derived coelomocytes. 2 Publications1
Mutagenesisi107S → A: Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-109; A-118; T-120 and A-127. 1 Publication1
Mutagenesisi109S → A: Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-107; A-118; T-120 and A-127. 1 Publication1
Mutagenesisi118S → A: Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-107; A-109; T-120 and A-127. 1 Publication1
Mutagenesisi120T → A: Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-107; A-109; A-118 and A-127. 1 Publication1
Mutagenesisi127S → A: Abolishes nuclear asymmetry, defective in nuclear export and loss of par-5 interaction; when associated with A-107; A-109; A-118 and A-120. 1 Publication1
Mutagenesisi225N → I in q624; low penetrance defects including abnormal gonad development, L1 viability and T-cell defects. Severe loss of M lineage-derived coelomocytes and sex myoblasts. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000486031 – 438Protein pop-1Add BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei118Phosphoserine; by LIT11 Publication1
Modified residuei127Phosphoserine; by LIT11 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by lit-1. Lit-1 forms a complex with wrm-1 which activates lit-1 kinase activity and triggers phosphorylation of pop-1.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q10666

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10666

PeptideAtlas

More...
PeptideAtlasi
Q10666

PRoteomics IDEntifications database

More...
PRIDEi
Q10666

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q10666

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed maternally and zygotically (PubMed:10380924). Expressed in the first 32 daughter cells of the MS blastomere cell, and in the 8-cell stage ABar blastomere and subsequently, asymmetrically in its descendants (PubMed:12810601). Expression is higher in the anterior daughters of dividing cells, but lower in the posterior daughters (PubMed:12810601). Expressed asymmetrically in vulva precursor cells P5.p, P6.p and P7.p at L2 larval stage and in their descendants (PubMed:15649465). Expressed asymmetrically in somatic gonadal precursor cells Z1.p, Z4.a, Z1.a and Z4.p (PubMed:25569233). During M-lineage cell fate specification, expressed evenly from 1-M to 4-M stages followed by asymmetric expression in anterior cells at the 8-M, 16-M and 18-M stages (PubMed:19427847).5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004077 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with hda-1 and bar-1.

Interacts (phosphorylated on 'Ser-118' and 'Ser-127') with lit-1/wrm-1 complex.

Interacts with par-5; interaction is dependent on lit-1 phosphorylation and is required for nuclear asymmetry.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
37329, 25 interactors

Database of interacting proteins

More...
DIPi
DIP-25683N

Protein interaction database and analysis system

More...
IntActi
Q10666, 50 interactors

STRING: functional protein association networks

More...
STRINGi
6239.W10C8.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q10666

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q10666

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni88 – 130Involved in nuclear asymmetryAdd BLAST43

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi55 – 173Pro-richAdd BLAST119
Compositional biasi132 – 139Poly-Ala8
Compositional biasi340 – 347Poly-Ser8
Compositional biasi359 – 362Poly-Gln4
Compositional biasi411 – 416Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TCF/LEF family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3248 Eukaryota
ENOG41109RU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168653

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000184838

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10666

KEGG Orthology (KO)

More...
KOi
K04491

Identification of Orthologs from Complete Genome Data

More...
OMAi
RCLWYRE

Database of Orthologous Groups

More...
OrthoDBi
807716at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.30.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF

The PANTHER Classification System

More...
PANTHERi
PTHR10373 PTHR10373, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00505 HMG_box, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00398 HMG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47095 SSF47095, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q10666-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMADEELGDE VKVFRRDEDA DDDPMISGET SEQQLADDKK EAVMEAELDG
60 70 80 90 100
AGRNPSIDVL KSAFPKVEPM SPSFPGLMSH FSPGYSAAAL PMFMPLFMNP
110 120 130 140 150
YAAALRSPSL MFPMGAMSPT FPMFPPSPVY GAAIAAAAAK QHFENMAPLN
160 170 180 190 200
MRAGHPMNQM GMPPYMHPSS MAPQNVDRRA QGGGKAKKDD HVKKPLNAFM
210 220 230 240 250
WFMKENRKAL LEEIGNNEKQ SAELNKELGK RWHDLSKEEQ AKYFEMAKKD
260 270 280 290 300
KETHKERYPE WSARENYAVN KKKTKKRRDK SIPSENNDQK KCRARFGVNN
310 320 330 340 350
TEMWCKFCKR KKKCEYATDR SGGSDITDSQ DGRGTSGAYS SSSESPSPKA
360 370 380 390 400
NAGIALTTQQ QQAAMMHTML MQMRLGSTTG ASTHVPSPLA SSSAGRSPLD
410 420 430
ANASDSESDV EEEEDEQIDP TVMQQTHDML MQESMCTI
Length:438
Mass (Da):48,627
Last modified:December 14, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i494078BE40B40E2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti200M → V in AAC05308 (PubMed:7585963).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U37532 mRNA Translation: AAC05308.1
FO081765 Genomic DNA Translation: CCD73394.2

Protein sequence database of the Protein Information Resource

More...
PIRi
A57667
C87732
T32931

NCBI Reference Sequences

More...
RefSeqi
NP_491053.4, NM_058652.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W10C8.2.1; W10C8.2.1; WBGene00004077

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
171849

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W10C8.2

UCSC genome browser

More...
UCSCi
W10C8.2 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U37532 mRNA Translation: AAC05308.1
FO081765 Genomic DNA Translation: CCD73394.2
PIRiA57667
C87732
T32931
RefSeqiNP_491053.4, NM_058652.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C2GX-ray2.50C/D8-15[»]
SMRiQ10666
ModBaseiSearch...

Protein-protein interaction databases

BioGridi37329, 25 interactors
DIPiDIP-25683N
IntActiQ10666, 50 interactors
STRINGi6239.W10C8.2

PTM databases

iPTMnetiQ10666

Proteomic databases

EPDiQ10666
PaxDbiQ10666
PeptideAtlasiQ10666
PRIDEiQ10666

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW10C8.2.1; W10C8.2.1; WBGene00004077
GeneIDi171849
KEGGicel:CELE_W10C8.2
UCSCiW10C8.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
171849
WormBaseiW10C8.2 ; CE46967 ; WBGene00004077 ; pop-1

Phylogenomic databases

eggNOGiKOG3248 Eukaryota
ENOG41109RU LUCA
GeneTreeiENSGT00940000168653
HOGENOMiHOG000184838
InParanoidiQ10666
KOiK04491
OMAiRCLWYRE
OrthoDBi807716at2759

Enzyme and pathway databases

ReactomeiR-CEL-201722 Formation of the beta-catenin:TCF transactivating complex
R-CEL-3769402 Deactivation of the beta-catenin transactivating complex
R-CEL-4086398 Ca2+ pathway
R-CEL-4641265 Repression of WNT target genes
R-CEL-8951430 RUNX3 regulates WNT signaling
SignaLinkiQ10666

Miscellaneous databases

EvolutionaryTraceiQ10666

Protein Ontology

More...
PROi
PR:Q10666

Gene expression databases

BgeeiWBGene00004077 Expressed in 4 organ(s), highest expression level in pharyngeal muscle cell (C elegans)

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR024940 TCF/LEF
PANTHERiPTHR10373 PTHR10373, 1 hit
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOP1_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10666
Secondary accession number(s): O45007
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 14, 2011
Last modified: September 18, 2019
This is version 155 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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