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Entry version 160 (10 Feb 2021)
Sequence version 2 (20 Jun 2003)
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Protein

Bifunctional glyoxylate cycle protein

Gene

icl-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glyoxylate cycle

This protein is involved in step 1 and 2 of the subpathway that synthesizes (S)-malate from isocitrate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Bifunctional glyoxylate cycle protein (icl-1)
  2. Bifunctional glyoxylate cycle protein (icl-1)
This subpathway is part of the pathway glyoxylate cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-malate from isocitrate, the pathway glyoxylate cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei601Proton acceptorPROSITE-ProRule annotation1
Active sitei881Proton donorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Multifunctional enzyme, Transferase
Biological processGlyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00703;UER00719
UPA00703;UER00720

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Bifunctional glyoxylate cycle protein
Alternative name(s):
Gex-3-interacting protein 7
Including the following 2 domains:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Malate synthase (EC:2.3.3.9)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:icl-1
Synonyms:gei-7
ORF Names:C05E4.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
C05E4.9a ; CE23521 ; WBGene00001564 ; icl-1
C05E4.9b ; CE32565 ; WBGene00001564 ; icl-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001668741 – 968Bifunctional glyoxylate cycle proteinAdd BLAST968

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q10663

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10663

PeptideAtlas

More...
PeptideAtlasi
Q10663

PRoteomics IDEntifications database

More...
PRIDEi
Q10663

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q10663

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Intestinal and body wall muscle cells.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

First detected early in the generation of the clonal E cell lineage that is committed to intestinal development and then increases to maximal levels in actively differentiating intestinal and body wall muscle cells. Highest activity in embryos and falls dramatically during L1 larval development (PubMed:7781887). Expression is highest in L3 larval stage with low levels at other stages (PubMed:21884719).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00001564, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
43657, 13 interactors

Database of interacting proteins

More...
DIPi
DIP-25113N

STRING: functional protein association networks

More...
STRINGi
6239.C05E4.9a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q10663

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 443Isocitrate lyaseAdd BLAST443
Regioni444 – 968Malate synthaseAdd BLAST525

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.Curated
In the C-terminal section; belongs to the malate synthase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1260, Eukaryota
KOG1261, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000174673

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012853_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10663

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWMETSH

Database of Orthologous Groups

More...
OrthoDBi
358540at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q10663

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00377, ICL_PEPM, 1 hit
cd00727, malate_synt_A, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039556, ICL/PEPM
IPR006254, Isocitrate_lyase
IPR018523, Isocitrate_lyase_ph_CS
IPR011076, Malate_synth-like_sf
IPR006252, Malate_synthA
IPR001465, Malate_synthase
IPR019830, Malate_synthase_CS
IPR015813, Pyrv/PenolPyrv_Kinase-like_dom
IPR040442, Pyrv_Kinase-like_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR21631, PTHR21631, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00463, ICL, 1 hit
PF01274, Malate_synthase, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51621, SSF51621, 1 hit
SSF51645, SSF51645, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01346, isocit_lyase, 1 hit
TIGR01344, malate_syn_A, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00161, ISOCITRATE_LYASE, 1 hit
PS00510, MALATE_SYNTHASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q10663-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSAAKNFYQ VVKSAPKGRF KGIKRDYTVE DVLKLRGSID IDYTLATRGA
60 70 80 90 100
NKLWQLLHTE PFVPALGAQT GNQAVQMVRA GLKAIYLSGW QVAADANSAG
110 120 130 140 150
DMYPDQSLYP ANSGPELAKR INRSLRRADQ IEACEAEDYL AQRDWYAPIV
160 170 180 190 200
ADAEAGFGGA LNCFELMKAY IEAGAAGVHY EDQLGSEKKC GHMGGKVLIP
210 220 230 240 250
TAQHIRHLNA SRLAADVCGV PTIIVARTDA ESSRLLTSDI DPRDHPYIDY
260 270 280 290 300
EAGRTIEGFY RLKDSTAIQY CIDRAIQYAP YTDLIWMETS HPTIADAREF
310 320 330 340 350
AEGVHKQYPD KMFAYNCSPS FNWKKHLSPS QMEKFQKELG AMGFKYQFIT
360 370 380 390 400
LAGYHANSYS MFDLARNYKE KGMLAYSGLQ EGEFAAEKHG YTAVKHQREV
410 420 430 440 450
GTGYFDAVSR AVTGGLSSTT ALSGSTEEAQ FQTAVASQDE EILSLTAQNV
460 470 480 490 500
AGDEKILTPD ALRFLHDLNT EFNPRRLRLL SKRNQVQADI NNSLWFPDFN
510 520 530 540 550
KETEVLRSDQ GWKGAEIPRD LQDRRVEITG PTDRKMVINA MNSGANVFMA
560 570 580 590 600
DFEDSNSPTW RNQLEGQINL YDAVRNNISY THPTTKKEYT LNEKHAVLKV
610 620 630 640 650
RPRGWHLPEK HVLIHNQPTS GSLFDFGLFV FHNAKALIAQ GSGPYFYLPK
660 670 680 690 700
LQSAEEAQLW ADVFKYTEDK LGLARGTIKC TVLIEHLLAS FQLHEIIHAL
710 720 730 740 750
KDNIVGLNCG RWDYIFSYIK TFQNHRKFLL PDRFQIGMTA PFMRNYSLEV
760 770 780 790 800
IKACHLRGIH AMGGMAAQIP IKHDQVANDK AFALVRADKE REATDGHDGT
810 820 830 840 850
WVAHPGLVPL AKRVFDQMMP KPNQISKNLT RANCTKEDLT VIPEGTRTEA
860 870 880 890 900
GFRHNISVTL GYLDSWLRGT GCVPLYNLME DAATAEISRA QLWQWLHHDA
910 920 930 940 950
KLEDGRTIDA GLVKQTIAAE TERRLIRAGS VVNRIPEAAD LLEKFVTEEK
960
MSDFLTTDAY DRLVSEGY
Length:968
Mass (Da):108,629
Last modified:June 20, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7BAAF979C1F6D31F
GO
Isoform b (identifier: Q10663-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     862-863: YL → EP
     864-968: Missing.

Show »
Length:863
Mass (Da):96,743
Checksum:i5392FF3F102D0903
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA85857 differs from that shown. Chimeric cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152D → H in AAA85857 (PubMed:7781887).Curated1
Sequence conflicti436A → R in AAA85857 (PubMed:7781887).Curated1
Sequence conflicti463R → A in AAA85857 (PubMed:7781887).Curated1
Sequence conflicti957 – 968TDAYD…VSEGY → DRRLRQACL in AAA85857 (PubMed:7781887).CuratedAdd BLAST12

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056035862 – 863YL → EP in isoform b. Curated2
Alternative sequenceiVSP_056036864 – 968Missing in isoform b. CuratedAdd BLAST105

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U23159 mRNA Translation: AAA85857.1 Sequence problems.
FO080368 Genomic DNA Translation: CCD63238.1
FO080368 Genomic DNA Translation: CCD63239.1

Protein sequence database of the Protein Information Resource

More...
PIRi
E88940

NCBI Reference Sequences

More...
RefSeqi
NP_001021367.1, NM_001026196.4 [Q10663-2]
NP_503306.1, NM_070905.5 [Q10663-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C05E4.9a.1; C05E4.9a.1; WBGene00001564 [Q10663-1]
C05E4.9a.2; C05E4.9a.2; WBGene00001564 [Q10663-1]
C05E4.9b.1; C05E4.9b.1; WBGene00001564 [Q10663-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
178583

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C05E4.9

UCSC genome browser

More...
UCSCi
C05E4.9a, c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23159 mRNA Translation: AAA85857.1 Sequence problems.
FO080368 Genomic DNA Translation: CCD63238.1
FO080368 Genomic DNA Translation: CCD63239.1
PIRiE88940
RefSeqiNP_001021367.1, NM_001026196.4 [Q10663-2]
NP_503306.1, NM_070905.5 [Q10663-1]

3D structure databases

SMRiQ10663
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi43657, 13 interactors
DIPiDIP-25113N
STRINGi6239.C05E4.9a

PTM databases

iPTMnetiQ10663

Proteomic databases

EPDiQ10663
PaxDbiQ10663
PeptideAtlasiQ10663
PRIDEiQ10663

Genome annotation databases

EnsemblMetazoaiC05E4.9a.1; C05E4.9a.1; WBGene00001564 [Q10663-1]
C05E4.9a.2; C05E4.9a.2; WBGene00001564 [Q10663-1]
C05E4.9b.1; C05E4.9b.1; WBGene00001564 [Q10663-2]
GeneIDi178583
KEGGicel:CELE_C05E4.9
UCSCiC05E4.9a, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178583
WormBaseiC05E4.9a ; CE23521 ; WBGene00001564 ; icl-1
C05E4.9b ; CE32565 ; WBGene00001564 ; icl-1

Phylogenomic databases

eggNOGiKOG1260, Eukaryota
KOG1261, Eukaryota
GeneTreeiENSGT00940000174673
HOGENOMiCLU_012853_0_0_1
InParanoidiQ10663
OMAiIWMETSH
OrthoDBi358540at2759
PhylomeDBiQ10663

Enzyme and pathway databases

UniPathwayiUPA00703;UER00719
UPA00703;UER00720

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10663

Gene expression databases

BgeeiWBGene00001564, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

CDDicd00377, ICL_PEPM, 1 hit
cd00727, malate_synt_A, 1 hit
Gene3Di3.20.20.60, 1 hit
InterProiView protein in InterPro
IPR039556, ICL/PEPM
IPR006254, Isocitrate_lyase
IPR018523, Isocitrate_lyase_ph_CS
IPR011076, Malate_synth-like_sf
IPR006252, Malate_synthA
IPR001465, Malate_synthase
IPR019830, Malate_synthase_CS
IPR015813, Pyrv/PenolPyrv_Kinase-like_dom
IPR040442, Pyrv_Kinase-like_dom_sf
PANTHERiPTHR21631, PTHR21631, 1 hit
PfamiView protein in Pfam
PF00463, ICL, 1 hit
PF01274, Malate_synthase, 1 hit
SUPFAMiSSF51621, SSF51621, 1 hit
SSF51645, SSF51645, 1 hit
TIGRFAMsiTIGR01346, isocit_lyase, 1 hit
TIGR01344, malate_syn_A, 1 hit
PROSITEiView protein in PROSITE
PS00161, ISOCITRATE_LYASE, 1 hit
PS00510, MALATE_SYNTHASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCP_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10663
Secondary accession number(s): O17353, Q8IA71
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: June 20, 2003
Last modified: February 10, 2021
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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