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Protein

Myoblast growth factor receptor egl-15

Gene

egl-15

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor tyrosine kinase required for larval development (PubMed:7585964). May phosphorylate adapter protein soc-1 which in turn may result in the recruitment and/or activation of phosphatase ptp-2 (PubMed:11689700). May activate the Ras/MAPK kinase signaling pathway which includes sem-5, sos-1, let-60/Ras, lin-45/Raf, mek-2 and mpk-1 (PubMed:11689700). Acts in the hypodermis to regulate axon growth and fluid homeostasis (PubMed:12835392, PubMed:7585964). Activates protein degradation in muscles (PubMed:14517244). Probably following interaction with ligand let-756, regulates negatively membrane protrusion from body wall muscles during larval development (PubMed:16495308). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAChR subunit lev-1 in the nerve cord (PubMed:15990870).6 Publications
Isoform b: Affects the maintenance of axon position without affecting axon growth. Interaction with egl-17 is required for the guidance of sex myoblast migration during gonad development.1 Publication
Isoform a: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Isoform c: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Isoform d: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Isoform e: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Mg2+Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei672ATPPROSITE-ProRule annotation1
Active sitei797Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi646 – 654ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.1 1045
ReactomeiR-CEL-1257604 PIP3 activates AKT signaling
R-CEL-190322 FGFR4 ligand binding and activation
R-CEL-190370 FGFR1b ligand binding and activation
R-CEL-190371 FGFR3b ligand binding and activation
R-CEL-190372 FGFR3c ligand binding and activation
R-CEL-190373 FGFR1c ligand binding and activation
R-CEL-190375 FGFR2c ligand binding and activation
R-CEL-190377 FGFR2b ligand binding and activation
R-CEL-445144 Signal transduction by L1
R-CEL-5654219 Phospholipase C-mediated cascade: FGFR1
R-CEL-5654221 Phospholipase C-mediated cascade, FGFR2
R-CEL-5654227 Phospholipase C-mediated cascade, FGFR3
R-CEL-5654228 Phospholipase C-mediated cascade, FGFR4
R-CEL-5654688 SHC-mediated cascade:FGFR1
R-CEL-5654693 FRS-mediated FGFR1 signaling
R-CEL-5654695 PI-3K cascade:FGFR2
R-CEL-5654699 SHC-mediated cascade:FGFR2
R-CEL-5654700 FRS-mediated FGFR2 signaling
R-CEL-5654704 SHC-mediated cascade:FGFR3
R-CEL-5654706 FRS-mediated FGFR3 signaling
R-CEL-5654710 PI-3K cascade:FGFR3
R-CEL-5654712 FRS-mediated FGFR4 signaling
R-CEL-5654719 SHC-mediated cascade:FGFR4
R-CEL-5654726 Negative regulation of FGFR1 signaling
R-CEL-5654727 Negative regulation of FGFR2 signaling
R-CEL-5654732 Negative regulation of FGFR3 signaling
R-CEL-5654733 Negative regulation of FGFR4 signaling
R-CEL-5673001 RAF/MAP kinase cascade
R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiQ10656

Names & Taxonomyi

Protein namesi
Recommended name:
Myoblast growth factor receptor egl-15 (EC:2.7.10.1)
Alternative name(s):
Egg-laying defective protein 15
Gene namesi
Name:egl-15
ORF Names:F58A3.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF58A3.2a ; CE28238 ; WBGene00001184 ; egl-15
F58A3.2b ; CE35726 ; WBGene00001184 ; egl-15
F58A3.2c ; CE50149 ; WBGene00001184 ; egl-15
F58A3.2d ; CE50303 ; WBGene00001184 ; egl-15
F58A3.2e ; CE50247 ; WBGene00001184 ; egl-15

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 525ExtracellularSequence analysisAdd BLAST506
Transmembranei526 – 549HelicalSequence analysisAdd BLAST24
Topological domaini550 – 1040CytoplasmicSequence analysisAdd BLAST491

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Early arrest in larval development. Impaired guided migration of sex myoblasts (PubMed:7585964). RNAi-mediated knockdown causes ectopic membrane extension from body wall muscles (PubMed:16495308).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi680E → K in n1775; loss of activity. 1 Publication1
Mutagenesisi714P → L in n1783; loss of activity. Ectopic membrane extension in body wall muscles. 2 Publications1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001679620 – 1040Myoblast growth factor receptor egl-15Add BLAST1021

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 109PROSITE-ProRule annotation
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi280N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi314 ↔ 367PROSITE-ProRule annotation
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi407N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi414 ↔ 485PROSITE-ProRule annotation
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi449N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi474N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei828Phosphotyrosine; by autocatalysisBy similarity1

Post-translational modificationi

Activity is regulated by the phosphatase clr-1, however it is not known whether clr-1 acts directly on egl-15.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ10656
PeptideAtlasiQ10656

PTM databases

iPTMnetiQ10656

Expressioni

Gene expression databases

BgeeiWBGene00001184 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

BioGridi46202, 148 interactors
IntActiQ10656, 1 interactor
STRINGi6239.F58A3.2c

Structurei

3D structure databases

ProteinModelPortaliQ10656
SMRiQ10656
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 125Ig-like C2-type 1Add BLAST93
Domaini287 – 383Ig-like C2-type 2Add BLAST97
Domaini391 – 501Ig-like C2-type 3Add BLAST111
Domaini640 – 931Protein kinasePROSITE-ProRule annotationAdd BLAST292

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
InParanoidiQ10656
OrthoDBiEOG091G0CQZ
PhylomeDBiQ10656

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show allAlign All

Isoform a (identifier: Q10656-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE
60 70 80 90 100
IKFDCQTAAS KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID
110 120 130 140 150
VSDQGLWSCR VHNAYGQISR NFTVEVIDFC DYFLFPDIHH LNIPMECVCL
160 170 180 190 200
WKYNKEAKRS DVNYAAVTGE VCSKYASRMI NRARKPLPMI PCFGDHCKEF
210 220 230 240 250
DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES PSESRTEFIN
260 270 280 290 300
ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE
310 320 330 340 350
THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW
360 370 380 390 400
SLEVEDAVVA DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA
410 420 430 440 450
NQSVNINDTA TFHCKVVSDL LPHIIWVRIN KINGSYSYYN NSAEEYMFNY
460 470 480 490 500
TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ GIYACLSGNS LGMSMANATL
510 520 530 540 550
TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT LFGILFMVCK
560 570 580 590 600
QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET
610 620 630 640 650
PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA
660 670 680 690 700
FGEVWKATYK ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE
710 720 730 740 750
NVLRLIGCCT GAGPLYVVVE LCKHGNLRDF LRAHRPKEEK AKKSSQELTD
760 770 780 790 800
YLEPRKASDK DDIELIPNLT QRHLVQFAWQ VAQGMNFLAS KKIIHRDLAA
810 820 830 840 850
RNVLVGDGHV LKISDFGLSR DVHCNDYYRK RGNGRLPIKW MALEALDSNV
860 870 880 890 900
YTVESDVWSY GVLLWEIMTL GGTPYPTIAM PELYANLKEG YRMEPPHLCP
910 920 930 940 950
QEVYHLMCSC WREKLEERPS FKTIVDYLDW MLTMTNETIE GSQEFNDQFF
960 970 980 990 1000
SERSTASGPV SPMESFQKKR KHRPLSAPVN LPSEPQHTIC DDYESNFSVE
1010 1020 1030 1040
PPNDPNHLYC NDNMLKNHII TPETSQRIPS NNNSMSKPEF
Length:1,040
Mass (Da):118,956
Last modified:November 1, 1997 - v1
Checksum:i8CA227195DDBCD69
GO
Isoform b (identifier: Q10656-2) [UniParc]FASTAAdd to basket
Also known as: EGL-15(5A)

The sequence of this isoform differs from the canonical sequence as follows:
     129-245: FCDYFLFPDI...DSEESPSESR → PLKLFDWLTE...RLRQINHALG

Show »
Length:988
Mass (Da):113,327
Checksum:iA7365D218C082E49
GO
Isoform c (identifier: Q10656-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEP...NPLPTKETIV

Show »
Length:1,158
Mass (Da):132,425
Checksum:i2159D2E7C6564685
GO
Isoform d (identifier: Q10656-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEP...DDEKHHYYYS

Show »
Length:1,096
Mass (Da):125,172
Checksum:iC76B0B8A20852F80
GO
Isoform e (identifier: Q10656-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEPIGNGSNSPVL

Show »
Length:1,051
Mass (Da):120,070
Checksum:iA9616D4CAEA14AEE
GO

Computationally mapped potential isoform sequencesi

There are 11 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0K3AYK2A0A0K3AYK2_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,091Annotation score:
A0A0K3ASR7A0A0K3ASR7_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,044Annotation score:
A0A0K3AYL0A0A0K3AYL0_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,101Annotation score:
A0A0K3AVM0A0A0K3AVM0_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,153Annotation score:
A0A0K3AWC6A0A0K3AWC6_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,105Annotation score:
A0A0K3AVM4A0A0K3AVM4_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
998Annotation score:
A0A0K3ASS4A0A0K3ASS4_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
994Annotation score:
A0A0K3ATB0A0A0K3ATB0_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,046Annotation score:
A0A0K3AWC2A0A0K3AWC2_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
992Annotation score:
A0A0K3AYK6A0A0K3AYK6_CAEEL
Myoblast growth factor receptor egl...
egl-15 CELE_F58A3.2, F58A3.2
1,043Annotation score:
There is more potential isoformShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti551Q → G in AAP44084 (PubMed:12835392).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019861129 – 245FCDYF…PSESR → PLKLFDWLTEHRVFDISHLL PKLLPPAEMRRVKSQLGGWE KMNNEQKIVRARHILRLRQI NHALG in isoform b. 1 PublicationAdd BLAST117
Alternative sequenceiVSP_002991829R → RL in isoform c, isoform d and isoform e. 1 Publication1
Alternative sequenceiVSP_002992984E → EVDQN in isoform c, isoform d and isoform e. 1 Publication1
Alternative sequenceiVSP_0029941027 – 1040RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDQTHQ YYNTTSKIQYLHFTFDDPDC MTRSRDSAIFEESYHPNYIQ SHPLYSKIIIKKNMTPRNPL PTKETIV in isoform c. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0198621027 – 1040RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDDEKH HYYYS in isoform d. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_0198631027 – 1040RIPSN…SKPEF → LYIHKVLNEPIGNGSNSPVL in isoform e. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39761 mRNA Translation: AAC46934.1
AY268435 mRNA Translation: AAP31029.1
AY268436 mRNA Translation: AAP31030.1
AY288941 mRNA Translation: AAP44084.1
AY288942 mRNA Translation: AAP44085.1
AY292532 mRNA Translation: AAP74805.1
Z81017 Genomic DNA Translation: CAB02673.2
Z81017 Genomic DNA Translation: CAC70094.2
Z81017 Genomic DNA Translation: CAC70095.2
Z81017 Genomic DNA Translation: CAD44136.1
Z81017 Genomic DNA Translation: CAE47468.1
PIRiA57638
T22889
RefSeqiNP_001024723.1, NM_001029552.2 [Q10656-2]
NP_001024724.3, NM_001029553.5
NP_001024725.2, NM_001029554.4
NP_001024726.2, NM_001029555.4
NP_509842.2, NM_077441.6 [Q10656-1]
UniGeneiCel.17140

Genome annotation databases

EnsemblMetazoaiF58A3.2a.1; F58A3.2a.1; WBGene00001184 [Q10656-1]
F58A3.2a.2; F58A3.2a.2; WBGene00001184 [Q10656-1]
F58A3.2a.3; F58A3.2a.3; WBGene00001184 [Q10656-1]
F58A3.2a.4; F58A3.2a.4; WBGene00001184 [Q10656-1]
F58A3.2a.5; F58A3.2a.5; WBGene00001184 [Q10656-1]
F58A3.2a.6; F58A3.2a.6; WBGene00001184 [Q10656-1]
F58A3.2b.1; F58A3.2b.1; WBGene00001184 [Q10656-2]
F58A3.2b.2; F58A3.2b.2; WBGene00001184 [Q10656-2]
F58A3.2b.3; F58A3.2b.3; WBGene00001184 [Q10656-2]
F58A3.2b.4; F58A3.2b.4; WBGene00001184 [Q10656-2]
F58A3.2b.5; F58A3.2b.5; WBGene00001184 [Q10656-2]
F58A3.2b.6; F58A3.2b.6; WBGene00001184 [Q10656-2]
GeneIDi181291
KEGGicel:CELE_F58A3.2
UCSCiF58A3.2e c. elegans [Q10656-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39761 mRNA Translation: AAC46934.1
AY268435 mRNA Translation: AAP31029.1
AY268436 mRNA Translation: AAP31030.1
AY288941 mRNA Translation: AAP44084.1
AY288942 mRNA Translation: AAP44085.1
AY292532 mRNA Translation: AAP74805.1
Z81017 Genomic DNA Translation: CAB02673.2
Z81017 Genomic DNA Translation: CAC70094.2
Z81017 Genomic DNA Translation: CAC70095.2
Z81017 Genomic DNA Translation: CAD44136.1
Z81017 Genomic DNA Translation: CAE47468.1
PIRiA57638
T22889
RefSeqiNP_001024723.1, NM_001029552.2 [Q10656-2]
NP_001024724.3, NM_001029553.5
NP_001024725.2, NM_001029554.4
NP_001024726.2, NM_001029555.4
NP_509842.2, NM_077441.6 [Q10656-1]
UniGeneiCel.17140

3D structure databases

ProteinModelPortaliQ10656
SMRiQ10656
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi46202, 148 interactors
IntActiQ10656, 1 interactor
STRINGi6239.F58A3.2c

PTM databases

iPTMnetiQ10656

Proteomic databases

PaxDbiQ10656
PeptideAtlasiQ10656

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF58A3.2a.1; F58A3.2a.1; WBGene00001184 [Q10656-1]
F58A3.2a.2; F58A3.2a.2; WBGene00001184 [Q10656-1]
F58A3.2a.3; F58A3.2a.3; WBGene00001184 [Q10656-1]
F58A3.2a.4; F58A3.2a.4; WBGene00001184 [Q10656-1]
F58A3.2a.5; F58A3.2a.5; WBGene00001184 [Q10656-1]
F58A3.2a.6; F58A3.2a.6; WBGene00001184 [Q10656-1]
F58A3.2b.1; F58A3.2b.1; WBGene00001184 [Q10656-2]
F58A3.2b.2; F58A3.2b.2; WBGene00001184 [Q10656-2]
F58A3.2b.3; F58A3.2b.3; WBGene00001184 [Q10656-2]
F58A3.2b.4; F58A3.2b.4; WBGene00001184 [Q10656-2]
F58A3.2b.5; F58A3.2b.5; WBGene00001184 [Q10656-2]
F58A3.2b.6; F58A3.2b.6; WBGene00001184 [Q10656-2]
GeneIDi181291
KEGGicel:CELE_F58A3.2
UCSCiF58A3.2e c. elegans [Q10656-1]

Organism-specific databases

CTDi181291
WormBaseiF58A3.2a ; CE28238 ; WBGene00001184 ; egl-15
F58A3.2b ; CE35726 ; WBGene00001184 ; egl-15
F58A3.2c ; CE50149 ; WBGene00001184 ; egl-15
F58A3.2d ; CE50303 ; WBGene00001184 ; egl-15
F58A3.2e ; CE50247 ; WBGene00001184 ; egl-15

Phylogenomic databases

eggNOGiKOG0200 Eukaryota
COG0515 LUCA
GeneTreeiENSGT00760000118923
InParanoidiQ10656
OrthoDBiEOG091G0CQZ
PhylomeDBiQ10656

Enzyme and pathway databases

BRENDAi2.7.10.1 1045
ReactomeiR-CEL-1257604 PIP3 activates AKT signaling
R-CEL-190322 FGFR4 ligand binding and activation
R-CEL-190370 FGFR1b ligand binding and activation
R-CEL-190371 FGFR3b ligand binding and activation
R-CEL-190372 FGFR3c ligand binding and activation
R-CEL-190373 FGFR1c ligand binding and activation
R-CEL-190375 FGFR2c ligand binding and activation
R-CEL-190377 FGFR2b ligand binding and activation
R-CEL-445144 Signal transduction by L1
R-CEL-5654219 Phospholipase C-mediated cascade: FGFR1
R-CEL-5654221 Phospholipase C-mediated cascade, FGFR2
R-CEL-5654227 Phospholipase C-mediated cascade, FGFR3
R-CEL-5654228 Phospholipase C-mediated cascade, FGFR4
R-CEL-5654688 SHC-mediated cascade:FGFR1
R-CEL-5654693 FRS-mediated FGFR1 signaling
R-CEL-5654695 PI-3K cascade:FGFR2
R-CEL-5654699 SHC-mediated cascade:FGFR2
R-CEL-5654700 FRS-mediated FGFR2 signaling
R-CEL-5654704 SHC-mediated cascade:FGFR3
R-CEL-5654706 FRS-mediated FGFR3 signaling
R-CEL-5654710 PI-3K cascade:FGFR3
R-CEL-5654712 FRS-mediated FGFR4 signaling
R-CEL-5654719 SHC-mediated cascade:FGFR4
R-CEL-5654726 Negative regulation of FGFR1 signaling
R-CEL-5654727 Negative regulation of FGFR2 signaling
R-CEL-5654732 Negative regulation of FGFR3 signaling
R-CEL-5654733 Negative regulation of FGFR4 signaling
R-CEL-5673001 RAF/MAP kinase cascade
R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkiQ10656

Miscellaneous databases

PROiPR:Q10656

Gene expression databases

BgeeiWBGene00001184 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07679 I-set, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00219 TyrKc, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEGL15_CAEEL
AccessioniPrimary (citable) accession number: Q10656
Secondary accession number(s): Q7JL68
, Q7YZM7, Q7YZM8, Q7YZN0, Q7YZN1, Q7Z025, Q8MQ14, Q93804, Q95QE0, Q95QE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 10, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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