UniProtKB - Q10656 (EGL15_CAEEL)
Protein
Myoblast growth factor receptor egl-15
Gene
egl-15
Organism
Caenorhabditis elegans
Status
Functioni
Receptor tyrosine kinase required for larval development (PubMed:7585964). May phosphorylate adapter protein soc-1 which in turn may result in the recruitment and/or activation of phosphatase ptp-2 (PubMed:11689700). May activate the Ras/MAPK kinase signaling pathway which includes sem-5, sos-1, let-60/Ras, lin-45/Raf, mek-2 and mpk-1 (PubMed:11689700). Acts in the hypodermis to regulate axon growth and fluid homeostasis (PubMed:12835392, PubMed:7585964). Activates protein degradation in muscles (PubMed:14517244). Probably following interaction with ligand let-756, regulates negatively membrane protrusion from body wall muscles during larval development (PubMed:16495308). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAChR subunit lev-1 in the nerve cord (PubMed:15990870).6 Publications
Affects the maintenance of axon position without affecting axon growth. Interaction with egl-17 is required for the guidance of sex myoblast migration during gonad development.1 Publication
Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication
Catalytic activityi
- EC:2.7.10.1PROSITE-ProRule annotation
Cofactori
Mg2+Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 672 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 797 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 646 – 654 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- protein kinase activity Source: WormBase
- transmembrane receptor protein tyrosine kinase activity Source: GO_Central
GO - Biological processi
- cell migration Source: WormBase
- digestive tract morphogenesis Source: WormBase
- fibroblast growth factor receptor signaling pathway Source: WormBase
- multicellular organism development Source: GO_Central
- muscle cell cellular homeostasis Source: UniProtKB
- muscle organ development Source: WormBase
- nematode larval development Source: WormBase
- oviposition Source: WormBase
- positive regulation of kinase activity Source: GO_Central
- protein phosphorylation Source: WormBase
- regulation of cell projection organization Source: WormBase
- regulation of protein stability Source: UniProtKB
- transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central
Keywordsi
Molecular function | Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 1045 |
Reactomei | R-CEL-109704, PI3K Cascade R-CEL-1257604, PIP3 activates AKT signaling R-CEL-1307965, betaKlotho-mediated ligand binding R-CEL-190322, FGFR4 ligand binding and activation R-CEL-190370, FGFR1b ligand binding and activation R-CEL-190371, FGFR3b ligand binding and activation R-CEL-190372, FGFR3c ligand binding and activation R-CEL-190373, FGFR1c ligand binding and activation R-CEL-190374, FGFR1c and Klotho ligand binding and activation R-CEL-190375, FGFR2c ligand binding and activation R-CEL-190377, FGFR2b ligand binding and activation R-CEL-445144, Signal transduction by L1 R-CEL-5654219, Phospholipase C-mediated cascade: FGFR1 R-CEL-5654221, Phospholipase C-mediated cascade, FGFR2 R-CEL-5654227, Phospholipase C-mediated cascade, FGFR3 R-CEL-5654228, Phospholipase C-mediated cascade, FGFR4 R-CEL-5654688, SHC-mediated cascade:FGFR1 R-CEL-5654689, PI-3K cascade:FGFR1 R-CEL-5654693, FRS-mediated FGFR1 signaling R-CEL-5654695, PI-3K cascade:FGFR2 R-CEL-5654699, SHC-mediated cascade:FGFR2 R-CEL-5654704, SHC-mediated cascade:FGFR3 R-CEL-5654710, PI-3K cascade:FGFR3 R-CEL-5654712, FRS-mediated FGFR4 signaling R-CEL-5654719, SHC-mediated cascade:FGFR4 R-CEL-5654720, PI-3K cascade:FGFR4 R-CEL-5654726, Negative regulation of FGFR1 signaling R-CEL-5654733, Negative regulation of FGFR4 signaling R-CEL-5673001, RAF/MAP kinase cascade R-CEL-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SignaLinki | Q10656 |
Names & Taxonomyi
Protein namesi | Recommended name: Myoblast growth factor receptor egl-15 (EC:2.7.10.1)Alternative name(s): Egg-laying defective protein 15 |
Gene namesi | Name:egl-15 ORF Names:F58A3.2 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F58A3.2a ; CE28238 ; WBGene00001184 ; egl-15 F58A3.2b ; CE35726 ; WBGene00001184 ; egl-15 F58A3.2c ; CE50149 ; WBGene00001184 ; egl-15 F58A3.2d ; CE50303 ; WBGene00001184 ; egl-15 F58A3.2e ; CE50247 ; WBGene00001184 ; egl-15 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- receptor complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 20 – 525 | ExtracellularSequence analysisAdd BLAST | 506 | |
Transmembranei | 526 – 549 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 550 – 1040 | CytoplasmicSequence analysisAdd BLAST | 491 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Disruption phenotypei
Early arrest in larval development. Impaired guided migration of sex myoblasts (PubMed:7585964). RNAi-mediated knockdown causes ectopic membrane extension from body wall muscles (PubMed:16495308).2 Publications
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 680 | E → K in n1775; loss of activity. 1 Publication | 1 | |
Mutagenesisi | 714 | P → L in n1783; loss of activity. Ectopic membrane extension in body wall muscles. 2 Publications | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | Sequence analysisAdd BLAST | 19 | |
ChainiPRO_0000016796 | 20 – 1040 | Myoblast growth factor receptor egl-15Add BLAST | 1021 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 55 ↔ 109 | PROSITE-ProRule annotation | ||
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 280 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 299 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 314 ↔ 367 | PROSITE-ProRule annotation | ||
Glycosylationi | 401 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 407 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 414 ↔ 485 | PROSITE-ProRule annotation | ||
Glycosylationi | 433 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 440 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 449 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 474 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 497 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 828 | Phosphotyrosine; by autocatalysisBy similarity | 1 |
Post-translational modificationi
Activity is regulated by the phosphatase clr-1, however it is not known whether clr-1 acts directly on egl-15.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q10656 |
PeptideAtlasi | Q10656 |
PRIDEi | Q10656 |
PTM databases
iPTMneti | Q10656 |
Expressioni
Gene expression databases
Bgeei | WBGene00001184, Expressed in multi-cellular organism and 4 other tissues |
ExpressionAtlasi | Q10656, baseline and differential |
Interactioni
Protein-protein interaction databases
BioGRIDi | 46202, 148 interactors |
IntActi | Q10656, 1 interactor |
STRINGi | 6239.F58A3.2c |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 125 | Ig-like C2-type 1Add BLAST | 93 | |
Domaini | 287 – 383 | Ig-like C2-type 2Add BLAST | 97 | |
Domaini | 391 – 501 | Ig-like C2-type 3Add BLAST | 111 | |
Domaini | 640 – 931 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 292 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000167157 |
InParanoidi | Q10656 |
OrthoDBi | 220433at2759 |
PhylomeDBi | Q10656 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07679, I-set, 3 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform a (identifier: Q10656-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE
60 70 80 90 100
IKFDCQTAAS KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID
110 120 130 140 150
VSDQGLWSCR VHNAYGQISR NFTVEVIDFC DYFLFPDIHH LNIPMECVCL
160 170 180 190 200
WKYNKEAKRS DVNYAAVTGE VCSKYASRMI NRARKPLPMI PCFGDHCKEF
210 220 230 240 250
DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES PSESRTEFIN
260 270 280 290 300
ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE
310 320 330 340 350
THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW
360 370 380 390 400
SLEVEDAVVA DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA
410 420 430 440 450
NQSVNINDTA TFHCKVVSDL LPHIIWVRIN KINGSYSYYN NSAEEYMFNY
460 470 480 490 500
TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ GIYACLSGNS LGMSMANATL
510 520 530 540 550
TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT LFGILFMVCK
560 570 580 590 600
QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET
610 620 630 640 650
PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA
660 670 680 690 700
FGEVWKATYK ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE
710 720 730 740 750
NVLRLIGCCT GAGPLYVVVE LCKHGNLRDF LRAHRPKEEK AKKSSQELTD
760 770 780 790 800
YLEPRKASDK DDIELIPNLT QRHLVQFAWQ VAQGMNFLAS KKIIHRDLAA
810 820 830 840 850
RNVLVGDGHV LKISDFGLSR DVHCNDYYRK RGNGRLPIKW MALEALDSNV
860 870 880 890 900
YTVESDVWSY GVLLWEIMTL GGTPYPTIAM PELYANLKEG YRMEPPHLCP
910 920 930 940 950
QEVYHLMCSC WREKLEERPS FKTIVDYLDW MLTMTNETIE GSQEFNDQFF
960 970 980 990 1000
SERSTASGPV SPMESFQKKR KHRPLSAPVN LPSEPQHTIC DDYESNFSVE
1010 1020 1030 1040
PPNDPNHLYC NDNMLKNHII TPETSQRIPS NNNSMSKPEF
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0K3AVM0 | A0A0K3AVM0_CAEEL | Receptor protein-tyrosine kinase | egl-15 CELE_F58A3.2, F58A3.2 | 1,153 | Annotation score: | ||
A0A0K3ATB0 | A0A0K3ATB0_CAEEL | Receptor protein-tyrosine kinase | egl-15 CELE_F58A3.2, F58A3.2 | 1,046 | Annotation score: | ||
A0A0K3AYK2 | A0A0K3AYK2_CAEEL | Receptor protein-tyrosine kinase | egl-15 CELE_F58A3.2, F58A3.2 | 1,091 | Annotation score: | ||
A0A0K3AYL0 | A0A0K3AYL0_CAEEL | Receptor protein-tyrosine kinase | egl-15 CELE_F58A3.2, F58A3.2 | 1,101 | Annotation score: | ||
A0A0K3ASS4 | A0A0K3ASS4_CAEEL | Receptor protein-tyrosine kinase | egl-15 CELE_F58A3.2, F58A3.2 | 994 | Annotation score: | ||
A0A0K3ATB5 | A0A0K3ATB5_CAEEL | Receptor protein-tyrosine kinase | egl-15 CELE_F58A3.2, F58A3.2 | 1,039 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 551 | Q → G in AAP44084 (PubMed:12835392).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019861 | 129 – 245 | FCDYF…PSESR → PLKLFDWLTEHRVFDISHLL PKLLPPAEMRRVKSQLGGWE KMNNEQKIVRARHILRLRQI NHALG in isoform b. 1 PublicationAdd BLAST | 117 | |
Alternative sequenceiVSP_002991 | 829 | R → RL in isoform c, isoform d and isoform e. 1 Publication | 1 | |
Alternative sequenceiVSP_002992 | 984 | E → EVDQN in isoform c, isoform d and isoform e. 1 Publication | 1 | |
Alternative sequenceiVSP_002994 | 1027 – 1040 | RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDQTHQ YYNTTSKIQYLHFTFDDPDC MTRSRDSAIFEESYHPNYIQ SHPLYSKIIIKKNMTPRNPL PTKETIV in isoform c. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_019862 | 1027 – 1040 | RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDDEKH HYYYS in isoform d. 1 PublicationAdd BLAST | 14 | |
Alternative sequenceiVSP_019863 | 1027 – 1040 | RIPSN…SKPEF → LYIHKVLNEPIGNGSNSPVL in isoform e. 1 PublicationAdd BLAST | 14 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39761 mRNA Translation: AAC46934.1 AY268435 mRNA Translation: AAP31029.1 AY268436 mRNA Translation: AAP31030.1 AY288941 mRNA Translation: AAP44084.1 AY288942 mRNA Translation: AAP44085.1 AY292532 mRNA Translation: AAP74805.1 Z81017 Genomic DNA Translation: CAB02673.2 Z81017 Genomic DNA Translation: CAC70094.2 Z81017 Genomic DNA Translation: CAC70095.2 Z81017 Genomic DNA Translation: CAD44136.1 Z81017 Genomic DNA Translation: CAE47468.1 |
PIRi | A57638 T22889 |
RefSeqi | NP_001024723.1, NM_001029552.2 NP_001024724.3, NM_001029553.5 NP_001024725.2, NM_001029554.4 NP_001024726.2, NM_001029555.4 NP_509842.2, NM_077441.6 |
Genome annotation databases
EnsemblMetazoai | F58A3.2a.1; F58A3.2a.1; WBGene00001184 [Q10656-1] F58A3.2a.2; F58A3.2a.2; WBGene00001184 [Q10656-1] F58A3.2a.3; F58A3.2a.3; WBGene00001184 [Q10656-1] F58A3.2a.4; F58A3.2a.4; WBGene00001184 [Q10656-1] F58A3.2a.5; F58A3.2a.5; WBGene00001184 [Q10656-1] F58A3.2a.6; F58A3.2a.6; WBGene00001184 [Q10656-1] F58A3.2b.1; F58A3.2b.1; WBGene00001184 [Q10656-2] F58A3.2b.2; F58A3.2b.2; WBGene00001184 [Q10656-2] F58A3.2b.3; F58A3.2b.3; WBGene00001184 [Q10656-2] F58A3.2b.4; F58A3.2b.4; WBGene00001184 [Q10656-2] F58A3.2b.5; F58A3.2b.5; WBGene00001184 [Q10656-2] F58A3.2b.6; F58A3.2b.6; WBGene00001184 [Q10656-2] F58A3.2c.1; F58A3.2c.1; WBGene00001184 F58A3.2d.1; F58A3.2d.1; WBGene00001184 F58A3.2e.1; F58A3.2e.1; WBGene00001184 |
UCSCi | F58A3.2e, c. elegans [Q10656-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U39761 mRNA Translation: AAC46934.1 AY268435 mRNA Translation: AAP31029.1 AY268436 mRNA Translation: AAP31030.1 AY288941 mRNA Translation: AAP44084.1 AY288942 mRNA Translation: AAP44085.1 AY292532 mRNA Translation: AAP74805.1 Z81017 Genomic DNA Translation: CAB02673.2 Z81017 Genomic DNA Translation: CAC70094.2 Z81017 Genomic DNA Translation: CAC70095.2 Z81017 Genomic DNA Translation: CAD44136.1 Z81017 Genomic DNA Translation: CAE47468.1 |
PIRi | A57638 T22889 |
RefSeqi | NP_001024723.1, NM_001029552.2 NP_001024724.3, NM_001029553.5 NP_001024725.2, NM_001029554.4 NP_001024726.2, NM_001029555.4 NP_509842.2, NM_077441.6 |
3D structure databases
SMRi | Q10656 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 46202, 148 interactors |
IntActi | Q10656, 1 interactor |
STRINGi | 6239.F58A3.2c |
PTM databases
iPTMneti | Q10656 |
Proteomic databases
PaxDbi | Q10656 |
PeptideAtlasi | Q10656 |
PRIDEi | Q10656 |
Genome annotation databases
EnsemblMetazoai | F58A3.2a.1; F58A3.2a.1; WBGene00001184 [Q10656-1] F58A3.2a.2; F58A3.2a.2; WBGene00001184 [Q10656-1] F58A3.2a.3; F58A3.2a.3; WBGene00001184 [Q10656-1] F58A3.2a.4; F58A3.2a.4; WBGene00001184 [Q10656-1] F58A3.2a.5; F58A3.2a.5; WBGene00001184 [Q10656-1] F58A3.2a.6; F58A3.2a.6; WBGene00001184 [Q10656-1] F58A3.2b.1; F58A3.2b.1; WBGene00001184 [Q10656-2] F58A3.2b.2; F58A3.2b.2; WBGene00001184 [Q10656-2] F58A3.2b.3; F58A3.2b.3; WBGene00001184 [Q10656-2] F58A3.2b.4; F58A3.2b.4; WBGene00001184 [Q10656-2] F58A3.2b.5; F58A3.2b.5; WBGene00001184 [Q10656-2] F58A3.2b.6; F58A3.2b.6; WBGene00001184 [Q10656-2] F58A3.2c.1; F58A3.2c.1; WBGene00001184 F58A3.2d.1; F58A3.2d.1; WBGene00001184 F58A3.2e.1; F58A3.2e.1; WBGene00001184 |
UCSCi | F58A3.2e, c. elegans [Q10656-1] |
Organism-specific databases
CTDi | 181291 |
WormBasei | F58A3.2a ; CE28238 ; WBGene00001184 ; egl-15 F58A3.2b ; CE35726 ; WBGene00001184 ; egl-15 F58A3.2c ; CE50149 ; WBGene00001184 ; egl-15 F58A3.2d ; CE50303 ; WBGene00001184 ; egl-15 F58A3.2e ; CE50247 ; WBGene00001184 ; egl-15 |
Phylogenomic databases
eggNOGi | KOG0200, Eukaryota |
GeneTreei | ENSGT00940000167157 |
InParanoidi | Q10656 |
OrthoDBi | 220433at2759 |
PhylomeDBi | Q10656 |
Enzyme and pathway databases
BRENDAi | 2.7.10.1, 1045 |
Reactomei | R-CEL-109704, PI3K Cascade R-CEL-1257604, PIP3 activates AKT signaling R-CEL-1307965, betaKlotho-mediated ligand binding R-CEL-190322, FGFR4 ligand binding and activation R-CEL-190370, FGFR1b ligand binding and activation R-CEL-190371, FGFR3b ligand binding and activation R-CEL-190372, FGFR3c ligand binding and activation R-CEL-190373, FGFR1c ligand binding and activation R-CEL-190374, FGFR1c and Klotho ligand binding and activation R-CEL-190375, FGFR2c ligand binding and activation R-CEL-190377, FGFR2b ligand binding and activation R-CEL-445144, Signal transduction by L1 R-CEL-5654219, Phospholipase C-mediated cascade: FGFR1 R-CEL-5654221, Phospholipase C-mediated cascade, FGFR2 R-CEL-5654227, Phospholipase C-mediated cascade, FGFR3 R-CEL-5654228, Phospholipase C-mediated cascade, FGFR4 R-CEL-5654688, SHC-mediated cascade:FGFR1 R-CEL-5654689, PI-3K cascade:FGFR1 R-CEL-5654693, FRS-mediated FGFR1 signaling R-CEL-5654695, PI-3K cascade:FGFR2 R-CEL-5654699, SHC-mediated cascade:FGFR2 R-CEL-5654704, SHC-mediated cascade:FGFR3 R-CEL-5654710, PI-3K cascade:FGFR3 R-CEL-5654712, FRS-mediated FGFR4 signaling R-CEL-5654719, SHC-mediated cascade:FGFR4 R-CEL-5654720, PI-3K cascade:FGFR4 R-CEL-5654726, Negative regulation of FGFR1 signaling R-CEL-5654733, Negative regulation of FGFR4 signaling R-CEL-5673001, RAF/MAP kinase cascade R-CEL-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
SignaLinki | Q10656 |
Miscellaneous databases
PROi | PR:Q10656 |
Gene expression databases
Bgeei | WBGene00001184, Expressed in multi-cellular organism and 4 other tissues |
ExpressionAtlasi | Q10656, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013098, Ig_I-set IPR003599, Ig_sub IPR003598, Ig_sub2 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008266, Tyr_kinase_AS IPR020635, Tyr_kinase_cat_dom |
Pfami | View protein in Pfam PF07679, I-set, 3 hits PF07714, PK_Tyr_Ser-Thr, 1 hit |
PRINTSi | PR00109, TYRKINASE |
SMARTi | View protein in SMART SM00409, IG, 3 hits SM00408, IGc2, 3 hits SM00219, TyrKc, 1 hit |
SUPFAMi | SSF48726, SSF48726, 3 hits SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00109, PROTEIN_KINASE_TYR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EGL15_CAEEL | |
Accessioni | Q10656Primary (citable) accession number: Q10656 Secondary accession number(s): Q7JL68 Q95QE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 182 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families