egl-15

Functionⁱ

Receptor tyrosine kinase required for larval development (PubMed:7585964). May phosphorylate adapter protein soc-1 which in turn may result in the recruitment and/or activation of phosphatase ptp-2 (PubMed:11689700). May activate the Ras/MAPK kinase signaling pathway which includes sem-5, sos-1, let-60/Ras, lin-45/Raf, mek-2 and mpk-1 (PubMed:11689700). Acts in the hypodermis to regulate axon growth and fluid homeostasis (PubMed:12835392, PubMed:7585964). Activates protein degradation in muscles (PubMed:14517244). Probably following interaction with ligand let-756, regulates negatively membrane protrusion from body wall muscles during larval development (PubMed:16495308). Plays a role in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine (PubMed:15990870). Regulates synaptic levels of nAChR subunit lev-1 in the nerve cord (PubMed:15990870).6 Publications

Isoform b: Affects the maintenance of axon position without affecting axon growth. Interaction with egl-17 is required for the guidance of sex myoblast migration during gonad development.1 Publication

Isoform a: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication

Isoform c: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication

Isoform d: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication

Isoform e: Interaction with let-756 appears to play a role in maintaining body morphology at higher temperatures.1 Publication

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactorⁱ

Mg²⁺Curated

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	672	ATPPROSITE-ProRule annotation		1
Active siteⁱ	797	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	646 – 654	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
protein kinase activity
Source: WormBase
Inferred from direct assayⁱ
- 20004187
transmembrane receptor protein tyrosine kinase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration
Source: WormBase
Inferred from mutant phenotypeⁱ
- 7585964
digestive tract morphogenesis
Source: WormBase
Inferred from mutant phenotypeⁱ
- 20004187
fibroblast growth factor receptor signaling pathway
Source: WormBase
Inferred from mutant phenotypeⁱ
- 7585964
muscle cell cellular homeostasis
Source: UniProtKB
Inferred from genetic interactionⁱ
- 24285704
muscle organ development
Source: WormBase
Inferred from mutant phenotypeⁱ
- 16495308
nematode larval development
Source: WormBase
Inferred from mutant phenotypeⁱ
- 11689700
oviposition
Source: WormBase
Inferred from mutant phenotypeⁱ
- 11689700
protein phosphorylation
Source: WormBase
Inferred from direct assayⁱ
- 20004187
regulation of cell projection organization
Source: WormBase
Inferred from mutant phenotypeⁱ
- 16495308
regulation of protein stability
Source: UniProtKB
Inferred from genetic interactionⁱ
- 24285704

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 1045
Reactomeⁱ	R-CEL-1257604 PIP3 activates AKT signaling R-CEL-190322 FGFR4 ligand binding and activation R-CEL-190370 FGFR1b ligand binding and activation R-CEL-190371 FGFR3b ligand binding and activation R-CEL-190372 FGFR3c ligand binding and activation R-CEL-190373 FGFR1c ligand binding and activation R-CEL-190375 FGFR2c ligand binding and activation R-CEL-190377 FGFR2b ligand binding and activation R-CEL-445144 Signal transduction by L1 R-CEL-5654219 Phospholipase C-mediated cascade: FGFR1 R-CEL-5654221 Phospholipase C-mediated cascade, FGFR2 R-CEL-5654227 Phospholipase C-mediated cascade, FGFR3 R-CEL-5654228 Phospholipase C-mediated cascade, FGFR4 R-CEL-5654688 SHC-mediated cascade:FGFR1 R-CEL-5654693 FRS-mediated FGFR1 signaling R-CEL-5654695 PI-3K cascade:FGFR2 R-CEL-5654699 SHC-mediated cascade:FGFR2 R-CEL-5654700 FRS-mediated FGFR2 signaling R-CEL-5654704 SHC-mediated cascade:FGFR3 R-CEL-5654706 FRS-mediated FGFR3 signaling R-CEL-5654710 PI-3K cascade:FGFR3 R-CEL-5654712 FRS-mediated FGFR4 signaling R-CEL-5654719 SHC-mediated cascade:FGFR4 R-CEL-5654726 Negative regulation of FGFR1 signaling R-CEL-5654727 Negative regulation of FGFR2 signaling R-CEL-5654732 Negative regulation of FGFR3 signaling R-CEL-5654733 Negative regulation of FGFR4 signaling R-CEL-5673001 RAF/MAP kinase cascade R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkⁱ	Q10656

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Myoblast growth factor receptor egl-15 (EC:2.7.10.1) Alternative name(s): Egg-laying defective protein 15
Gene namesⁱ	Name:egl-15 ORF Names:F58A3.2
Organismⁱ	Caenorhabditis elegans
Taxonomic identifierⁱ	6239 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
Proteomesⁱ	UP000001940 Componentⁱ: Chromosome X

Organism-specific databases

WormBase More...WormBaseⁱ	F58A3.2a ; CE28238 ; WBGene00001184 ; egl-15 F58A3.2b ; CE35726 ; WBGene00001184 ; egl-15 F58A3.2c ; CE50149 ; WBGene00001184 ; egl-15 F58A3.2d ; CE50303 ; WBGene00001184 ; egl-15 F58A3.2e ; CE50247 ; WBGene00001184 ; egl-15

WormBaseⁱ

F58A3.2a ; CE28238 ; WBGene00001184 ; egl-15
F58A3.2b ; CE35726 ; WBGene00001184 ; egl-15
F58A3.2c ; CE50149 ; WBGene00001184 ; egl-15
F58A3.2d ; CE50303 ; WBGene00001184 ; egl-15
F58A3.2e ; CE50247 ; WBGene00001184 ; egl-15

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 525	ExtracellularSequence analysisAdd BLAST	506
Transmembraneⁱ	526 – 549	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	550 – 1040	CytoplasmicSequence analysisAdd BLAST	491

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Early arrest in larval development. Impaired guided migration of sex myoblasts (PubMed:7585964). RNAi-mediated knockdown causes ectopic membrane extension from body wall muscles (PubMed:16495308).2 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	680	E → K in n1775; loss of activity. 1 Publication		1
Mutagenesisⁱ	714	P → L in n1783; loss of activity. Ectopic membrane extension in body wall muscles. 2 Publications		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000016796	20 – 1040	Myoblast growth factor receptor egl-15Add BLAST		1021

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	55 ↔ 109	PROSITE-ProRule annotation
Glycosylationⁱ	121	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	280	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	299	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	314 ↔ 367	PROSITE-ProRule annotation
Glycosylationⁱ	401	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	407	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	414 ↔ 485	PROSITE-ProRule annotation
Glycosylationⁱ	433	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	440	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	449	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	474	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	497	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	828	Phosphotyrosine; by autocatalysisBy similarity	1

Post-translational modificationⁱ

Activity is regulated by the phosphatase clr-1, however it is not known whether clr-1 acts directly on egl-15.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q10656
PeptideAtlas More...PeptideAtlasⁱ	Q10656

PTM databases

iPTMnetⁱ	Q10656

iPTMnetⁱ

Q10656

Expressionⁱ

Gene expression databases

Bgeeⁱ	WBGene00001184 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Bgeeⁱ

WBGene00001184 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	46202, 148 interactors
IntActⁱ	Q10656, 1 interactor
STRINGⁱ	6239.F58A3.2c

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q10656
SMRⁱ	Q10656
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	33 – 125	Ig-like C2-type 1Add BLAST	93
Domainⁱ	287 – 383	Ig-like C2-type 2Add BLAST	97
Domainⁱ	391 – 501	Ig-like C2-type 3Add BLAST	111
Domainⁱ	640 – 931	Protein kinasePROSITE-ProRule annotationAdd BLAST	292

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG0200 Eukaryota COG0515 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118923
InParanoidⁱ	Q10656
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0CQZ
PhylomeDBⁱ	Q10656

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07679 I-set, 3 hits PF07714 Pkinase_Tyr, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00409 IG, 3 hits SM00408 IGc2, 3 hits SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 11 potential isoforms that are computationally mapped.Show all Align All

Isoform a (identifier: Q10656-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE 
        60         70         80         90        100
IKFDCQTAAS KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID 
       110        120        130        140        150
VSDQGLWSCR VHNAYGQISR NFTVEVIDFC DYFLFPDIHH LNIPMECVCL 
       160        170        180        190        200
WKYNKEAKRS DVNYAAVTGE VCSKYASRMI NRARKPLPMI PCFGDHCKEF 
       210        220        230        240        250
DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES PSESRTEFIN 
       260        270        280        290        300
ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE 
       310        320        330        340        350
THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW 
       360        370        380        390        400
SLEVEDAVVA DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA 
       410        420        430        440        450
NQSVNINDTA TFHCKVVSDL LPHIIWVRIN KINGSYSYYN NSAEEYMFNY 
       460        470        480        490        500
TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ GIYACLSGNS LGMSMANATL 
       510        520        530        540        550
TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT LFGILFMVCK 
       560        570        580        590        600
QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET 
       610        620        630        640        650
PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA 
       660        670        680        690        700
FGEVWKATYK ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE 
       710        720        730        740        750
NVLRLIGCCT GAGPLYVVVE LCKHGNLRDF LRAHRPKEEK AKKSSQELTD 
       760        770        780        790        800
YLEPRKASDK DDIELIPNLT QRHLVQFAWQ VAQGMNFLAS KKIIHRDLAA 
       810        820        830        840        850
RNVLVGDGHV LKISDFGLSR DVHCNDYYRK RGNGRLPIKW MALEALDSNV 
       860        870        880        890        900
YTVESDVWSY GVLLWEIMTL GGTPYPTIAM PELYANLKEG YRMEPPHLCP 
       910        920        930        940        950
QEVYHLMCSC WREKLEERPS FKTIVDYLDW MLTMTNETIE GSQEFNDQFF 
       960        970        980        990       1000
SERSTASGPV SPMESFQKKR KHRPLSAPVN LPSEPQHTIC DDYESNFSVE 
      1010       1020       1030       1040
PPNDPNHLYC NDNMLKNHII TPETSQRIPS NNNSMSKPEF

Length:1,040

Mass (Da):118,956

Last modified:November 1, 1997 - v1

Checksum:ⁱ8CA227195DDBCD69

GO

Isoform b (identifier: Q10656-2) [UniParc]FASTA Add to basket

Also known as: EGL-15(5A)

The sequence of this isoform differs from the canonical sequence as follows:
129-245: FCDYFLFPDI...DSEESPSESR → PLKLFDWLTE...RLRQINHALG

« Hide

        10         20         30         40         50
MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE 
        60         70         80         90        100
IKFDCQTAAS KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID 
       110        120        130        140        150
VSDQGLWSCR VHNAYGQISR NFTVEVIDPL KLFDWLTEHR VFDISHLLPK 
       160        170        180        190        200
LLPPAEMRRV KSQLGGWEKM NNEQKIVRAR HILRLRQINH ALGTEFINAD 
       210        220        230        240        250
EKENKEDEEE DYSVSQPVAP DAGLTELNIT AEEPPYFKSN DNIVLFNETH 
       260        270        280        290        300
ALPAGRTLKL NCRAKGYPEP QIIWYKNGKM LKKSSARSGG YEFKFNRWSL 
       310        320        330        340        350
EVEDAVVADS GEFHCEALNK VGSAKKYFHV IIVNRMRRPP IIVPNILANQ 
       360        370        380        390        400
SVNINDTATF HCKVVSDLLP HIIWVRINKI NGSYSYYNNS AEEYMFNYTE 
       410        420        430        440        450
MDTFDKAHVH HVGDESTLTI FNVSLDDQGI YACLSGNSLG MSMANATLTV 
       460        470        480        490        500
NEFMAIHLLT GDEPKIDRWT TSDYIFTTIL LFLLLAATLF GILFMVCKQT 
       510        520        530        540        550
LHKKGFMDDT VGLVARKKRV VVSKRPMNED NENSDDEPSP YQIQIIETPI 
       560        570        580        590        600
TKKEAARKQR KRMNSENTVL SEYEVDSDPV WEVERSKLSL VHMLGEGAFG 
       610        620        630        640        650
EVWKATYKET ENNEIAVAVK KLKMSAHEKE LIDLVSEMET FKVIGEHENV 
       660        670        680        690        700
LRLIGCCTGA GPLYVVVELC KHGNLRDFLR AHRPKEEKAK KSSQELTDYL 
       710        720        730        740        750
EPRKASDKDD IELIPNLTQR HLVQFAWQVA QGMNFLASKK IIHRDLAARN 
       760        770        780        790        800
VLVGDGHVLK ISDFGLSRDV HCNDYYRKRG NGRLPIKWMA LEALDSNVYT 
       810        820        830        840        850
VESDVWSYGV LLWEIMTLGG TPYPTIAMPE LYANLKEGYR MEPPHLCPQE 
       860        870        880        890        900
VYHLMCSCWR EKLEERPSFK TIVDYLDWML TMTNETIEGS QEFNDQFFSE 
       910        920        930        940        950
RSTASGPVSP MESFQKKRKH RPLSAPVNLP SEPQHTICDD YESNFSVEPP 
       960        970        980 
NDPNHLYCND NMLKNHIITP ETSQRIPSNN NSMSKPEF

Show »

Length:988

Mass (Da):113,327

Checksum:ⁱA7365D218C082E49

GO

Isoform c (identifier: Q10656-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEP...NPLPTKETIV

« Hide

        10         20         30         40         50
MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE 
        60         70         80         90        100
IKFDCQTAAS KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID 
       110        120        130        140        150
VSDQGLWSCR VHNAYGQISR NFTVEVIDFC DYFLFPDIHH LNIPMECVCL 
       160        170        180        190        200
WKYNKEAKRS DVNYAAVTGE VCSKYASRMI NRARKPLPMI PCFGDHCKEF 
       210        220        230        240        250
DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES PSESRTEFIN 
       260        270        280        290        300
ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE 
       310        320        330        340        350
THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW 
       360        370        380        390        400
SLEVEDAVVA DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA 
       410        420        430        440        450
NQSVNINDTA TFHCKVVSDL LPHIIWVRIN KINGSYSYYN NSAEEYMFNY 
       460        470        480        490        500
TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ GIYACLSGNS LGMSMANATL 
       510        520        530        540        550
TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT LFGILFMVCK 
       560        570        580        590        600
QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET 
       610        620        630        640        650
PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA 
       660        670        680        690        700
FGEVWKATYK ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE 
       710        720        730        740        750
NVLRLIGCCT GAGPLYVVVE LCKHGNLRDF LRAHRPKEEK AKKSSQELTD 
       760        770        780        790        800
YLEPRKASDK DDIELIPNLT QRHLVQFAWQ VAQGMNFLAS KKIIHRDLAA 
       810        820        830        840        850
RNVLVGDGHV LKISDFGLSR DVHCNDYYRL KRGNGRLPIK WMALEALDSN 
       860        870        880        890        900
VYTVESDVWS YGVLLWEIMT LGGTPYPTIA MPELYANLKE GYRMEPPHLC 
       910        920        930        940        950
PQEVYHLMCS CWREKLEERP SFKTIVDYLD WMLTMTNETI EGSQEFNDQF 
       960        970        980        990       1000
FSERSTASGP VSPMESFQKK RKHRPLSAPV NLPSEVDQNP QHTICDDYES 
      1010       1020       1030       1040       1050
NFSVEPPNDP NHLYCNDNML KNHIITPETS QLYIHKVLNE PIGNGYVRQD 
      1060       1070       1080       1090       1100
KLARAVSGVA NQSLDSALGS PAWPSYDRPS NKASCLDQTH QYYNTTSKIQ 
      1110       1120       1130       1140       1150
YLHFTFDDPD CMTRSRDSAI FEESYHPNYI QSHPLYSKII IKKNMTPRNP 

LPTKETIV

Show »

Length:1,158

Mass (Da):132,425

Checksum:ⁱ2159D2E7C6564685

GO

Isoform d (identifier: Q10656-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEP...DDEKHHYYYS

« Hide

        10         20         30         40         50
MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE 
        60         70         80         90        100
IKFDCQTAAS KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID 
       110        120        130        140        150
VSDQGLWSCR VHNAYGQISR NFTVEVIDFC DYFLFPDIHH LNIPMECVCL 
       160        170        180        190        200
WKYNKEAKRS DVNYAAVTGE VCSKYASRMI NRARKPLPMI PCFGDHCKEF 
       210        220        230        240        250
DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES PSESRTEFIN 
       260        270        280        290        300
ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE 
       310        320        330        340        350
THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW 
       360        370        380        390        400
SLEVEDAVVA DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA 
       410        420        430        440        450
NQSVNINDTA TFHCKVVSDL LPHIIWVRIN KINGSYSYYN NSAEEYMFNY 
       460        470        480        490        500
TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ GIYACLSGNS LGMSMANATL 
       510        520        530        540        550
TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT LFGILFMVCK 
       560        570        580        590        600
QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET 
       610        620        630        640        650
PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA 
       660        670        680        690        700
FGEVWKATYK ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE 
       710        720        730        740        750
NVLRLIGCCT GAGPLYVVVE LCKHGNLRDF LRAHRPKEEK AKKSSQELTD 
       760        770        780        790        800
YLEPRKASDK DDIELIPNLT QRHLVQFAWQ VAQGMNFLAS KKIIHRDLAA 
       810        820        830        840        850
RNVLVGDGHV LKISDFGLSR DVHCNDYYRL KRGNGRLPIK WMALEALDSN 
       860        870        880        890        900
VYTVESDVWS YGVLLWEIMT LGGTPYPTIA MPELYANLKE GYRMEPPHLC 
       910        920        930        940        950
PQEVYHLMCS CWREKLEERP SFKTIVDYLD WMLTMTNETI EGSQEFNDQF 
       960        970        980        990       1000
FSERSTASGP VSPMESFQKK RKHRPLSAPV NLPSEVDQNP QHTICDDYES 
      1010       1020       1030       1040       1050
NFSVEPPNDP NHLYCNDNML KNHIITPETS QLYIHKVLNE PIGNGYVRQD 
      1060       1070       1080       1090 
KLARAVSGVA NQSLDSALGS PAWPSYDRPS NKASCLDDEK HHYYYS

Show »

Length:1,096

Mass (Da):125,172

Checksum:ⁱC76B0B8A20852F80

GO

Isoform e (identifier: Q10656-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     829-829: R → RL
     984-984: E → EVDQN
     1027-1040: RIPSNNNSMSKPEF → LYIHKVLNEPIGNGSNSPVL

« Hide

        10         20         30         40         50
MSYFLASCLG VGLLSTVSCS LQGLTSHYRE NIPRFKHVAN ERYEVFLGDE 
        60         70         80         90        100
IKFDCQTAAS KISAFVEWYR NDKLLKNDQI DKDKIRKDNN RMMLHLKNID 
       110        120        130        140        150
VSDQGLWSCR VHNAYGQISR NFTVEVIDFC DYFLFPDIHH LNIPMECVCL 
       160        170        180        190        200
WKYNKEAKRS DVNYAAVTGE VCSKYASRMI NRARKPLPMI PCFGDHCKEF 
       210        220        230        240        250
DTTPVSDFGL PGKPEDDPLV KRVVLKKDDV IVPVHDSEES PSESRTEFIN 
       260        270        280        290        300
ADEKENKEDE EEDYSVSQPV APDAGLTELN ITAEEPPYFK SNDNIVLFNE 
       310        320        330        340        350
THALPAGRTL KLNCRAKGYP EPQIIWYKNG KMLKKSSARS GGYEFKFNRW 
       360        370        380        390        400
SLEVEDAVVA DSGEFHCEAL NKVGSAKKYF HVIIVNRMRR PPIIVPNILA 
       410        420        430        440        450
NQSVNINDTA TFHCKVVSDL LPHIIWVRIN KINGSYSYYN NSAEEYMFNY 
       460        470        480        490        500
TEMDTFDKAH VHHVGDESTL TIFNVSLDDQ GIYACLSGNS LGMSMANATL 
       510        520        530        540        550
TVNEFMAIHL LTGDEPKIDR WTTSDYIFTT ILLFLLLAAT LFGILFMVCK 
       560        570        580        590        600
QTLHKKGFMD DTVGLVARKK RVVVSKRPMN EDNENSDDEP SPYQIQIIET 
       610        620        630        640        650
PITKKEAARK QRKRMNSENT VLSEYEVDSD PVWEVERSKL SLVHMLGEGA 
       660        670        680        690        700
FGEVWKATYK ETENNEIAVA VKKLKMSAHE KELIDLVSEM ETFKVIGEHE 
       710        720        730        740        750
NVLRLIGCCT GAGPLYVVVE LCKHGNLRDF LRAHRPKEEK AKKSSQELTD 
       760        770        780        790        800
YLEPRKASDK DDIELIPNLT QRHLVQFAWQ VAQGMNFLAS KKIIHRDLAA 
       810        820        830        840        850
RNVLVGDGHV LKISDFGLSR DVHCNDYYRL KRGNGRLPIK WMALEALDSN 
       860        870        880        890        900
VYTVESDVWS YGVLLWEIMT LGGTPYPTIA MPELYANLKE GYRMEPPHLC 
       910        920        930        940        950
PQEVYHLMCS CWREKLEERP SFKTIVDYLD WMLTMTNETI EGSQEFNDQF 
       960        970        980        990       1000
FSERSTASGP VSPMESFQKK RKHRPLSAPV NLPSEVDQNP QHTICDDYES 
      1010       1020       1030       1040       1050
NFSVEPPNDP NHLYCNDNML KNHIITPETS QLYIHKVLNE PIGNGSNSPV 

L

Show »

Length:1,051

Mass (Da):120,070

Checksum:ⁱA9616D4CAEA14AEE

GO

Computationally mapped potential isoform sequencesⁱ

There are 11 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A0K3AYK2	A0A0K3AYK2_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	1,091	Annotation score:
	A0A0K3ASR7	A0A0K3ASR7_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	1,044	Annotation score:
	A0A0K3AYL0	A0A0K3AYL0_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	1,101	Annotation score:
	A0A0K3AVM0	A0A0K3AVM0_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	1,153	Annotation score:
	A0A0K3AWC6	A0A0K3AWC6_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	1,105	Annotation score:
	A0A0K3AVM4	A0A0K3AVM4_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	998	Annotation score:
	A0A0K3ASS4	A0A0K3ASS4_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	994	Annotation score:
	A0A0K3ATB0	A0A0K3ATB0_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	1,046	Annotation score:
	A0A0K3AWC2	A0A0K3AWC2_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	992	Annotation score:
	A0A0K3AYK6	A0A0K3AYK6_CAEEL	Myoblast growth factor receptor egl... Myoblast growth factor receptor egl-15	egl-15 CELE_F58A3.2, F58A3.2	1,043	Annotation score:
There is more potential isoformShow all

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	551	Q → G in AAP44084 (PubMed:12835392).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_019861	129 – 245	FCDYF…PSESR → PLKLFDWLTEHRVFDISHLL PKLLPPAEMRRVKSQLGGWE KMNNEQKIVRARHILRLRQI NHALG in isoform b. 1 PublicationAdd BLAST	117
Alternative sequenceⁱVSP_002991	829	R → RL in isoform c, isoform d and isoform e. 1 Publication	1
Alternative sequenceⁱVSP_002992	984	E → EVDQN in isoform c, isoform d and isoform e. 1 Publication	1
Alternative sequenceⁱVSP_002994	1027 – 1040	RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDQTHQ YYNTTSKIQYLHFTFDDPDC MTRSRDSAIFEESYHPNYIQ SHPLYSKIIIKKNMTPRNPL PTKETIV in isoform c. 1 PublicationAdd BLAST	14
Alternative sequenceⁱVSP_019862	1027 – 1040	RIPSN…SKPEF → LYIHKVLNEPIGNGYVRQDK LARAVSGVANQSLDSALGSP AWPSYDRPSNKASCLDDEKH HYYYS in isoform d. 1 PublicationAdd BLAST	14
Alternative sequenceⁱVSP_019863	1027 – 1040	RIPSN…SKPEF → LYIHKVLNEPIGNGSNSPVL in isoform e. 1 PublicationAdd BLAST	14

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39761 mRNA Translation: AAC46934.1 AY268435 mRNA Translation: AAP31029.1 AY268436 mRNA Translation: AAP31030.1 AY288941 mRNA Translation: AAP44084.1 AY288942 mRNA Translation: AAP44085.1 AY292532 mRNA Translation: AAP74805.1 Z81017 Genomic DNA Translation: CAB02673.2 Z81017 Genomic DNA Translation: CAC70094.2 Z81017 Genomic DNA Translation: CAC70095.2 Z81017 Genomic DNA Translation: CAD44136.1 Z81017 Genomic DNA Translation: CAE47468.1
PIRⁱ	A57638 T22889
NCBI Reference Sequences More...RefSeqⁱ	NP_001024723.1, NM_001029552.2 [Q10656-2] NP_001024724.3, NM_001029553.5 NP_001024725.2, NM_001029554.4 NP_001024726.2, NM_001029555.4 NP_509842.2, NM_077441.6 [Q10656-1]
UniGeneⁱ	Cel.17140

Genome annotation databases

EnsemblMetazoaⁱ	F58A3.2a.1; F58A3.2a.1; WBGene00001184 [Q10656-1] F58A3.2a.2; F58A3.2a.2; WBGene00001184 [Q10656-1] F58A3.2a.3; F58A3.2a.3; WBGene00001184 [Q10656-1] F58A3.2a.4; F58A3.2a.4; WBGene00001184 [Q10656-1] F58A3.2a.5; F58A3.2a.5; WBGene00001184 [Q10656-1] F58A3.2a.6; F58A3.2a.6; WBGene00001184 [Q10656-1] F58A3.2b.1; F58A3.2b.1; WBGene00001184 [Q10656-2] F58A3.2b.2; F58A3.2b.2; WBGene00001184 [Q10656-2] F58A3.2b.3; F58A3.2b.3; WBGene00001184 [Q10656-2] F58A3.2b.4; F58A3.2b.4; WBGene00001184 [Q10656-2] F58A3.2b.5; F58A3.2b.5; WBGene00001184 [Q10656-2] F58A3.2b.6; F58A3.2b.6; WBGene00001184 [Q10656-2]
GeneIDⁱ	181291
KEGGⁱ	cel:CELE_F58A3.2
UCSC genome browser More...UCSCⁱ	F58A3.2e c. elegans [Q10656-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q10656	Isoform c of Myoblast growth factor receptor egl-15		CAEEL		1158	UniRef90_Q10656
Myoblast growth factor receptor egl-15		CAEEL		1153
Isoform d of Myoblast growth factor receptor egl-15		CAEEL		1096
Myoblast growth factor receptor egl-15		CAEEL		1091
Isoform e of Myoblast growth factor receptor egl-15		CAEEL		1051
+5
Q10656-2	Myoblast growth factor receptor egl-15		CAEEL		1105	UniRef90_Q10656-2
Myoblast growth factor receptor egl-15		CAEEL		1101
Myoblast growth factor receptor egl-15		CAEEL		1043
Myoblast growth factor receptor egl-15		CAEEL		1039
Myoblast growth factor receptor egl-15		CAEEL		998
+2

Protein	Similar proteins		Species	Score	Length	Source
Q10656	Isoform c of Myoblast growth factor receptor egl-15		CAEEL		1158	UniRef50_Q10656
Receptor protein-tyrosine kinase (Fragment)		Caenorhabditis latens		1152
CRE-EGL-15 protein		CAERE		1166
Protein CBR-EGL-15		CAEBR		1192
Uncharacterized protein		CAEBE		1094
+16
Q10656-2	Myoblast growth factor receptor egl-15		CAEEL		1105	UniRef50_Q10656-2
Uncharacterized protein		CAEJA		1110
Uncharacterized protein		Caenorhabditis tropicalis		1103
Myoblast growth factor receptor egl-15		CAEEL		1101
Myoblast growth factor receptor egl-15		CAEEL		1043
+5

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U39761 mRNA Translation: AAC46934.1 AY268435 mRNA Translation: AAP31029.1 AY268436 mRNA Translation: AAP31030.1 AY288941 mRNA Translation: AAP44084.1 AY288942 mRNA Translation: AAP44085.1 AY292532 mRNA Translation: AAP74805.1 Z81017 Genomic DNA Translation: CAB02673.2 Z81017 Genomic DNA Translation: CAC70094.2 Z81017 Genomic DNA Translation: CAC70095.2 Z81017 Genomic DNA Translation: CAD44136.1 Z81017 Genomic DNA Translation: CAE47468.1
PIRⁱ	A57638 T22889
RefSeqⁱ	NP_001024723.1, NM_001029552.2 [Q10656-2] NP_001024724.3, NM_001029553.5 NP_001024725.2, NM_001029554.4 NP_001024726.2, NM_001029555.4 NP_509842.2, NM_077441.6 [Q10656-1]
UniGeneⁱ	Cel.17140

3D structure databases

ProteinModelPortalⁱ	Q10656
SMRⁱ	Q10656
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	46202, 148 interactors
IntActⁱ	Q10656, 1 interactor
STRINGⁱ	6239.F58A3.2c

PTM databases

iPTMnetⁱ	Q10656

iPTMnetⁱ

Q10656

Proteomic databases

PaxDbⁱ	Q10656
PeptideAtlasⁱ	Q10656

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	F58A3.2a.1; F58A3.2a.1; WBGene00001184 [Q10656-1] F58A3.2a.2; F58A3.2a.2; WBGene00001184 [Q10656-1] F58A3.2a.3; F58A3.2a.3; WBGene00001184 [Q10656-1] F58A3.2a.4; F58A3.2a.4; WBGene00001184 [Q10656-1] F58A3.2a.5; F58A3.2a.5; WBGene00001184 [Q10656-1] F58A3.2a.6; F58A3.2a.6; WBGene00001184 [Q10656-1] F58A3.2b.1; F58A3.2b.1; WBGene00001184 [Q10656-2] F58A3.2b.2; F58A3.2b.2; WBGene00001184 [Q10656-2] F58A3.2b.3; F58A3.2b.3; WBGene00001184 [Q10656-2] F58A3.2b.4; F58A3.2b.4; WBGene00001184 [Q10656-2] F58A3.2b.5; F58A3.2b.5; WBGene00001184 [Q10656-2] F58A3.2b.6; F58A3.2b.6; WBGene00001184 [Q10656-2]
GeneIDⁱ	181291
KEGGⁱ	cel:CELE_F58A3.2
UCSCⁱ	F58A3.2e c. elegans [Q10656-1]

Organism-specific databases

CTDⁱ	181291
WormBaseⁱ	F58A3.2a ; CE28238 ; WBGene00001184 ; egl-15 F58A3.2b ; CE35726 ; WBGene00001184 ; egl-15 F58A3.2c ; CE50149 ; WBGene00001184 ; egl-15 F58A3.2d ; CE50303 ; WBGene00001184 ; egl-15 F58A3.2e ; CE50247 ; WBGene00001184 ; egl-15

Phylogenomic databases

eggNOGⁱ	KOG0200 Eukaryota COG0515 LUCA
GeneTreeⁱ	ENSGT00760000118923
InParanoidⁱ	Q10656
OrthoDBⁱ	EOG091G0CQZ
PhylomeDBⁱ	Q10656

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 1045
Reactomeⁱ	R-CEL-1257604 PIP3 activates AKT signaling R-CEL-190322 FGFR4 ligand binding and activation R-CEL-190370 FGFR1b ligand binding and activation R-CEL-190371 FGFR3b ligand binding and activation R-CEL-190372 FGFR3c ligand binding and activation R-CEL-190373 FGFR1c ligand binding and activation R-CEL-190375 FGFR2c ligand binding and activation R-CEL-190377 FGFR2b ligand binding and activation R-CEL-445144 Signal transduction by L1 R-CEL-5654219 Phospholipase C-mediated cascade: FGFR1 R-CEL-5654221 Phospholipase C-mediated cascade, FGFR2 R-CEL-5654227 Phospholipase C-mediated cascade, FGFR3 R-CEL-5654228 Phospholipase C-mediated cascade, FGFR4 R-CEL-5654688 SHC-mediated cascade:FGFR1 R-CEL-5654693 FRS-mediated FGFR1 signaling R-CEL-5654695 PI-3K cascade:FGFR2 R-CEL-5654699 SHC-mediated cascade:FGFR2 R-CEL-5654700 FRS-mediated FGFR2 signaling R-CEL-5654704 SHC-mediated cascade:FGFR3 R-CEL-5654706 FRS-mediated FGFR3 signaling R-CEL-5654710 PI-3K cascade:FGFR3 R-CEL-5654712 FRS-mediated FGFR4 signaling R-CEL-5654719 SHC-mediated cascade:FGFR4 R-CEL-5654726 Negative regulation of FGFR1 signaling R-CEL-5654727 Negative regulation of FGFR2 signaling R-CEL-5654732 Negative regulation of FGFR3 signaling R-CEL-5654733 Negative regulation of FGFR4 signaling R-CEL-5673001 RAF/MAP kinase cascade R-CEL-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
SignaLinkⁱ	Q10656

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q10656

PROⁱ

PR:Q10656

Gene expression databases

Bgeeⁱ	WBGene00001184 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Bgeeⁱ

WBGene00001184 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom
Pfamⁱ	View protein in Pfam PF07679 I-set, 3 hits PF07714 Pkinase_Tyr, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00409 IG, 3 hits SM00408 IGc2, 3 hits SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 3 hits SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EGL15_CAEEL
Accessionⁱ	Q10656Primary (citable) accession number: Q10656 Secondary accession number(s): Q7JL68 Q95QE1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	October 10, 2018
	This is version 168 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Caenorhabditis annotation project

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase

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UniProtKB - Q10656 (EGL15_CAEEL)

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Myoblast growth factor receptor egl-15

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

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3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

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Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

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PTM databases

Proteomic databases

Protocols and materials databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ