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Protein

Thyrotroph embryonic factor

Gene

TEF

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

SignaLinkiQ10587
SIGNORiQ10587

Names & Taxonomyi

Protein namesi
Recommended name:
Thyrotroph embryonic factor
Gene namesi
Name:TEF
Synonyms:KIAA1655
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000167074.14
HGNCiHGNC:11722 TEF
MIMi188595 gene
neXtProtiNX_Q10587

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7008
OpenTargetsiENSG00000167074
PharmGKBiPA36439

Polymorphism and mutation databases

BioMutaiTEF
DMDMi51338730

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765121 – 303Thyrotroph embryonic factorAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ10587
PaxDbiQ10587
PeptideAtlasiQ10587
PRIDEiQ10587
ProteomicsDBi58863
58864 [Q10587-2]

PTM databases

iPTMnetiQ10587
PhosphoSitePlusiQ10587

Expressioni

Inductioni

Accumulates according to a robust circadian rhythm.By similarity

Gene expression databases

BgeeiENSG00000167074 Expressed in 210 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_TEF
ExpressionAtlasiQ10587 baseline and differential
GenevisibleiQ10587 HS

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.

Binary interactionsi

WithEntry#Exp.IntActNotes
MRPL28Q130843EBI-2796967,EBI-723426

Protein-protein interaction databases

BioGridi112867, 1 interactor
IntActiQ10587, 31 interactors
STRINGi9606.ENSP00000266304

Structurei

3D structure databases

ProteinModelPortaliQ10587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini233 – 296bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 255Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni256 – 263Leucine-zipperPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi166 – 217Pro-rich (proline/acidic region (PAR))Add BLAST52

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated

Phylogenomic databases

eggNOGiKOG3119 Eukaryota
ENOG410YJ8G LUCA
GeneTreeiENSGT00440000039070
HOVERGENiHBG004983
InParanoidiQ10587
KOiK09058
OMAiSKYETRY
OrthoDBiEOG091G0EO0
PhylomeDBiQ10587
TreeFamiTF315869

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029832 TEF/VBP
PANTHERiPTHR11988:SF24 PTHR11988:SF24, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q10587-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDAGGGKKP PVDPQAGPGP GPGRAAGERG LSGSFPLVLK KLMENPPREA
60 70 80 90 100
RLDKEKGKEK LEEDEAAAAS TMAVSASLMP PIWDKTIPYD GESFHLEYMD
110 120 130 140 150
LDEFLLENGI PASPTHLAHN LLLPVAELEG KESASSSTAS PPSSSTAIFQ
160 170 180 190 200
PSETVSSTES SLEKERETPS PIDPNCVEVD VNFNPDPADL VLSSVPGGEL
210 220 230 240 250
FNPRKHKFAE EDLKPQPMIK KAKKVFVPDE QKDEKYWTRR KKNNVAAKRS
260 270 280 290 300
RDARRLKENQ ITIRAAFLEK ENTALRTEVA ELRKEVGKCK TIVSKYETKY

GPL
Length:303
Mass (Da):33,248
Last modified:August 16, 2004 - v3
Checksum:i4A87B7BFA7248C6F
GO
Isoform 2 (identifier: Q10587-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: MSDAGGGKKPPVDPQAGPGPGPGRAAGERGLSGSFPLVLKKLMENPPREARL → MDMPEVLKSLLEHSLPWPEKRT

Note: No experimental confirmation available.
Show »
Length:273
Mass (Da):30,635
Checksum:iB1A956839CBC4AC4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y797H0Y797_HUMAN
Thyrotroph embryonic factor
TEF
184Annotation score:

Sequence cautioni

The sequence AAA81373 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54K → E in AAA81373 (PubMed:7835883).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413761 – 52MSDAG…REARL → MDMPEVLKSLLEHSLPWPEK RT in isoform 2. 1 PublicationAdd BLAST52

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06935 mRNA Translation: AAA81373.1 Different initiation.
U44059 mRNA Translation: AAB06497.1
CR456592 mRNA Translation: CAG30478.1
CR541827 mRNA Translation: CAG46626.1
AK091916 mRNA Translation: BAG52441.1
AK314906 mRNA Translation: BAG37419.1
AL035659 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60430.1
CH471095 Genomic DNA Translation: EAW60431.1
BC039258 mRNA Translation: AAH39258.1
BC042476 mRNA Translation: AAH42476.1
BX537848 mRNA Translation: CAD97856.1
CCDSiCCDS14014.1 [Q10587-1]
CCDS46716.1 [Q10587-2]
PIRiG02360
RefSeqiNP_001138870.1, NM_001145398.2 [Q10587-2]
NP_003207.1, NM_003216.3 [Q10587-1]
UniGeneiHs.181159

Genome annotation databases

EnsembliENST00000266304; ENSP00000266304; ENSG00000167074 [Q10587-1]
ENST00000406644; ENSP00000385256; ENSG00000167074 [Q10587-2]
GeneIDi7008
KEGGihsa:7008
UCSCiuc003azx.5 human [Q10587-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06935 mRNA Translation: AAA81373.1 Different initiation.
U44059 mRNA Translation: AAB06497.1
CR456592 mRNA Translation: CAG30478.1
CR541827 mRNA Translation: CAG46626.1
AK091916 mRNA Translation: BAG52441.1
AK314906 mRNA Translation: BAG37419.1
AL035659 Genomic DNA No translation available.
CH471095 Genomic DNA Translation: EAW60430.1
CH471095 Genomic DNA Translation: EAW60431.1
BC039258 mRNA Translation: AAH39258.1
BC042476 mRNA Translation: AAH42476.1
BX537848 mRNA Translation: CAD97856.1
CCDSiCCDS14014.1 [Q10587-1]
CCDS46716.1 [Q10587-2]
PIRiG02360
RefSeqiNP_001138870.1, NM_001145398.2 [Q10587-2]
NP_003207.1, NM_003216.3 [Q10587-1]
UniGeneiHs.181159

3D structure databases

ProteinModelPortaliQ10587
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112867, 1 interactor
IntActiQ10587, 31 interactors
STRINGi9606.ENSP00000266304

PTM databases

iPTMnetiQ10587
PhosphoSitePlusiQ10587

Polymorphism and mutation databases

BioMutaiTEF
DMDMi51338730

Proteomic databases

EPDiQ10587
PaxDbiQ10587
PeptideAtlasiQ10587
PRIDEiQ10587
ProteomicsDBi58863
58864 [Q10587-2]

Protocols and materials databases

DNASUi7008
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266304; ENSP00000266304; ENSG00000167074 [Q10587-1]
ENST00000406644; ENSP00000385256; ENSG00000167074 [Q10587-2]
GeneIDi7008
KEGGihsa:7008
UCSCiuc003azx.5 human [Q10587-1]

Organism-specific databases

CTDi7008
DisGeNETi7008
EuPathDBiHostDB:ENSG00000167074.14
GeneCardsiTEF
HGNCiHGNC:11722 TEF
MIMi188595 gene
neXtProtiNX_Q10587
OpenTargetsiENSG00000167074
PharmGKBiPA36439
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3119 Eukaryota
ENOG410YJ8G LUCA
GeneTreeiENSGT00440000039070
HOVERGENiHBG004983
InParanoidiQ10587
KOiK09058
OMAiSKYETRY
OrthoDBiEOG091G0EO0
PhylomeDBiQ10587
TreeFamiTF315869

Enzyme and pathway databases

SignaLinkiQ10587
SIGNORiQ10587

Miscellaneous databases

ChiTaRSiTEF human
GeneWikiiTEF_(gene)
GenomeRNAii7008
PROiPR:Q10587
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167074 Expressed in 210 organ(s), highest expression level in cerebellar hemisphere
CleanExiHS_TEF
ExpressionAtlasiQ10587 baseline and differential
GenevisibleiQ10587 HS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029832 TEF/VBP
PANTHERiPTHR11988:SF24 PTHR11988:SF24, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTEF_HUMAN
AccessioniPrimary (citable) accession number: Q10587
Secondary accession number(s): B0QYS8
, B2RC22, Q15729, Q7Z3J7, Q8IU94, Q96TG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 16, 2004
Last modified: September 12, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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