UniProtKB - Q10587 (TEF_HUMAN)
Protein
Thyrotroph embryonic factor
Gene
TEF
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor that binds to and transactivates the TSHB promoter. Binds to a minimal DNA-binding sequence 5'-[TC][AG][AG]TTA[TC][AG]-3'.
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of transcription by RNA polymerase II Source: ProtInc
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q10587 |
SignaLinki | Q10587 |
SIGNORi | Q10587 |
Names & Taxonomyi
Protein namesi | Recommended name: Thyrotroph embryonic factor |
Gene namesi | Name:TEF Synonyms:KIAA1655 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11722, TEF |
MIMi | 188595, gene |
neXtProti | NX_Q10587 |
VEuPathDBi | HostDB:ENSG00000167074.14 |
Subcellular locationi
Nucleus
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 7008 |
OpenTargetsi | ENSG00000167074 |
PharmGKBi | PA36439 |
Miscellaneous databases
Pharosi | Q10587, Tbio |
Genetic variation databases
BioMutai | TEF |
DMDMi | 51338730 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076512 | 1 – 303 | Thyrotroph embryonic factorAdd BLAST | 303 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 32 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q10587 |
jPOSTi | Q10587 |
MassIVEi | Q10587 |
PaxDbi | Q10587 |
PeptideAtlasi | Q10587 |
PRIDEi | Q10587 |
ProteomicsDBi | 58863 [Q10587-1] 58864 [Q10587-2] |
PTM databases
iPTMneti | Q10587 |
PhosphoSitePlusi | Q10587 |
Expressioni
Inductioni
Accumulates according to a robust circadian rhythm.By similarity
Gene expression databases
Bgeei | ENSG00000167074, Expressed in cerebellar hemisphere and 224 other tissues |
ExpressionAtlasi | Q10587, baseline and differential |
Genevisiblei | Q10587, HS |
Organism-specific databases
HPAi | ENSG00000167074, Low tissue specificity |
Interactioni
Subunit structurei
Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with DBP.
Binary interactionsi
Hide detailsQ10587
With | #Exp. | IntAct |
---|---|---|
DNM2 - isoform 2 [P50570-2] | 3 | EBI-2796967,EBI-10968534 |
MRPL28 [Q13084] | 3 | EBI-2796967,EBI-723426 |
NFE2L2 [Q16236] | 5 | EBI-2796967,EBI-2007911 |
Protein-protein interaction databases
BioGRIDi | 112867, 2 interactors |
IntActi | Q10587, 33 interactors |
STRINGi | 9606.ENSP00000266304 |
Miscellaneous databases
RNActi | Q10587, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q10587 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 233 – 296 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 235 – 255 | Basic motifPROSITE-ProRule annotationAdd BLAST | 21 | |
Regioni | 256 – 263 | Leucine-zipperPROSITE-ProRule annotation | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 166 – 217 | Pro-rich (proline/acidic region (PAR))Add BLAST | 52 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000156578 |
HOGENOMi | CLU_051922_2_0_1 |
InParanoidi | Q10587 |
OMAi | GAERNTP |
OrthoDBi | 1023460at2759 |
PhylomeDBi | Q10587 |
TreeFami | TF315869 |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR040223, PAR_bZIP IPR029832, TEF/VBP |
PANTHERi | PTHR11988, PTHR11988, 1 hit PTHR11988:SF24, PTHR11988:SF24, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q10587-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSDAGGGKKP PVDPQAGPGP GPGRAAGERG LSGSFPLVLK KLMENPPREA
60 70 80 90 100
RLDKEKGKEK LEEDEAAAAS TMAVSASLMP PIWDKTIPYD GESFHLEYMD
110 120 130 140 150
LDEFLLENGI PASPTHLAHN LLLPVAELEG KESASSSTAS PPSSSTAIFQ
160 170 180 190 200
PSETVSSTES SLEKERETPS PIDPNCVEVD VNFNPDPADL VLSSVPGGEL
210 220 230 240 250
FNPRKHKFAE EDLKPQPMIK KAKKVFVPDE QKDEKYWTRR KKNNVAAKRS
260 270 280 290 300
RDARRLKENQ ITIRAAFLEK ENTALRTEVA ELRKEVGKCK TIVSKYETKY
GPL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y797 | H0Y797_HUMAN | Thyrotroph embryonic factor | TEF | 184 | Annotation score: |
Sequence cautioni
The sequence AAA81373 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 54 | K → E in AAA81373 (PubMed:7835883).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041376 | 1 – 52 | MSDAG…REARL → MDMPEVLKSLLEHSLPWPEK RT in isoform 2. 1 PublicationAdd BLAST | 52 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06935 mRNA Translation: AAA81373.1 Different initiation. U44059 mRNA Translation: AAB06497.1 CR456592 mRNA Translation: CAG30478.1 CR541827 mRNA Translation: CAG46626.1 AK091916 mRNA Translation: BAG52441.1 AK314906 mRNA Translation: BAG37419.1 AL035659 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60430.1 CH471095 Genomic DNA Translation: EAW60431.1 BC039258 mRNA Translation: AAH39258.1 BC042476 mRNA Translation: AAH42476.1 BX537848 mRNA Translation: CAD97856.1 |
CCDSi | CCDS14014.1 [Q10587-1] CCDS46716.1 [Q10587-2] |
PIRi | G02360 |
RefSeqi | NP_001138870.1, NM_001145398.2 [Q10587-2] NP_003207.1, NM_003216.3 [Q10587-1] |
Genome annotation databases
Ensembli | ENST00000266304; ENSP00000266304; ENSG00000167074 [Q10587-1] ENST00000406644; ENSP00000385256; ENSG00000167074 [Q10587-2] |
GeneIDi | 7008 |
KEGGi | hsa:7008 |
UCSCi | uc003azx.5, human [Q10587-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06935 mRNA Translation: AAA81373.1 Different initiation. U44059 mRNA Translation: AAB06497.1 CR456592 mRNA Translation: CAG30478.1 CR541827 mRNA Translation: CAG46626.1 AK091916 mRNA Translation: BAG52441.1 AK314906 mRNA Translation: BAG37419.1 AL035659 Genomic DNA No translation available. CH471095 Genomic DNA Translation: EAW60430.1 CH471095 Genomic DNA Translation: EAW60431.1 BC039258 mRNA Translation: AAH39258.1 BC042476 mRNA Translation: AAH42476.1 BX537848 mRNA Translation: CAD97856.1 |
CCDSi | CCDS14014.1 [Q10587-1] CCDS46716.1 [Q10587-2] |
PIRi | G02360 |
RefSeqi | NP_001138870.1, NM_001145398.2 [Q10587-2] NP_003207.1, NM_003216.3 [Q10587-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4U5T | X-ray | 3.30 | A/B | 257-295 | [»] | |
SMRi | Q10587 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112867, 2 interactors |
IntActi | Q10587, 33 interactors |
STRINGi | 9606.ENSP00000266304 |
PTM databases
iPTMneti | Q10587 |
PhosphoSitePlusi | Q10587 |
Genetic variation databases
BioMutai | TEF |
DMDMi | 51338730 |
Proteomic databases
EPDi | Q10587 |
jPOSTi | Q10587 |
MassIVEi | Q10587 |
PaxDbi | Q10587 |
PeptideAtlasi | Q10587 |
PRIDEi | Q10587 |
ProteomicsDBi | 58863 [Q10587-1] 58864 [Q10587-2] |
Protocols and materials databases
Antibodypediai | 26917, 164 antibodies |
DNASUi | 7008 |
Genome annotation databases
Ensembli | ENST00000266304; ENSP00000266304; ENSG00000167074 [Q10587-1] ENST00000406644; ENSP00000385256; ENSG00000167074 [Q10587-2] |
GeneIDi | 7008 |
KEGGi | hsa:7008 |
UCSCi | uc003azx.5, human [Q10587-1] |
Organism-specific databases
CTDi | 7008 |
DisGeNETi | 7008 |
GeneCardsi | TEF |
HGNCi | HGNC:11722, TEF |
HPAi | ENSG00000167074, Low tissue specificity |
MIMi | 188595, gene |
neXtProti | NX_Q10587 |
OpenTargetsi | ENSG00000167074 |
PharmGKBi | PA36439 |
VEuPathDBi | HostDB:ENSG00000167074.14 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3119, Eukaryota |
GeneTreei | ENSGT00940000156578 |
HOGENOMi | CLU_051922_2_0_1 |
InParanoidi | Q10587 |
OMAi | GAERNTP |
OrthoDBi | 1023460at2759 |
PhylomeDBi | Q10587 |
TreeFami | TF315869 |
Enzyme and pathway databases
PathwayCommonsi | Q10587 |
SignaLinki | Q10587 |
SIGNORi | Q10587 |
Miscellaneous databases
BioGRID-ORCSi | 7008, 24 hits in 897 CRISPR screens |
ChiTaRSi | TEF, human |
GeneWikii | TEF_(gene) |
GenomeRNAii | 7008 |
Pharosi | Q10587, Tbio |
PROi | PR:Q10587 |
RNActi | Q10587, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167074, Expressed in cerebellar hemisphere and 224 other tissues |
ExpressionAtlasi | Q10587, baseline and differential |
Genevisiblei | Q10587, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004827, bZIP IPR040223, PAR_bZIP IPR029832, TEF/VBP |
PANTHERi | PTHR11988, PTHR11988, 1 hit PTHR11988:SF24, PTHR11988:SF24, 1 hit |
Pfami | View protein in Pfam PF07716, bZIP_2, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TEF_HUMAN | |
Accessioni | Q10587Primary (citable) accession number: Q10587 Secondary accession number(s): B0QYS8 Q96TG4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | August 16, 2004 | |
Last modified: | February 10, 2021 | |
This is version 179 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 22
Human chromosome 22: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families