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Protein

D site-binding protein

Gene

DBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
SignaLinkiQ10586
SIGNORiQ10586

Names & Taxonomyi

Protein namesi
Recommended name:
D site-binding protein
Alternative name(s):
Albumin D box-binding protein
Albumin D-element-binding protein
Tax-responsive enhancer element-binding protein 302
Short name:
TaxREB302
Gene namesi
Name:DBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105516.10
HGNCiHGNC:2697 DBP
MIMi124097 gene
neXtProtiNX_Q10586

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi1628
OpenTargetsiENSG00000105516
PharmGKBiPA27165

Polymorphism and mutation databases

BioMutaiDBP
DMDMi1706312

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765071 – 325D site-binding proteinAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei86PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ10586
PaxDbiQ10586
PeptideAtlasiQ10586
PRIDEiQ10586
ProteomicsDBi58862

PTM databases

iPTMnetiQ10586
PhosphoSitePlusiQ10586

Expressioni

Tissue specificityi

Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.

Gene expression databases

BgeeiENSG00000105516 Expressed in 206 organ(s), highest expression level in left adrenal gland
CleanExiHS_DBP
ExpressionAtlasiQ10586 baseline and differential
GenevisibleiQ10586 HS

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

Protein-protein interaction databases

BioGridi107996, 11 interactors
IntActiQ10586, 3 interactors
STRINGi9606.ENSP00000222122

Structurei

3D structure databases

ProteinModelPortaliQ10586
SMRiQ10586
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 318bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni257 – 279Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni283 – 297Leucine-zipperPROSITE-ProRule annotationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 135Poly-Pro7
Compositional biasi188 – 239Pro-rich (proline/acidic region (PAR))Add BLAST52

Sequence similaritiesi

Belongs to the bZIP family. PAR subfamily.Curated

Phylogenomic databases

eggNOGiKOG3119 Eukaryota
ENOG410YJ8G LUCA
GeneTreeiENSGT00440000039070
HOGENOMiHOG000234383
HOVERGENiHBG004983
InParanoidiQ10586
KOiK09056
OMAiDSCESPS
OrthoDBiEOG091G0EO0
PhylomeDBiQ10586
TreeFamiTF315869

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029830 DBP
PANTHERiPTHR11988:SF7 PTHR11988:SF7, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q10586-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARPVSDRTP APLLLGGPAG TPPGGGALLG LRSLLQGTSK PKEPASCLLK
60 70 80 90 100
EKERKAALPA ATTPGPGLET AGPADAPAGA VVGGGSPRGR PGPVPAPGLL
110 120 130 140 150
APLLWERTLP FGDVEYVDLD AFLLEHGLPP SPPPPGGPSP EPSPARTPAP
160 170 180 190 200
SPGPGSCGSA SPRSSPGHAP ARAALGTASG HRAGLTSRDT PSPVDPDTVE
210 220 230 240 250
VLMTFEPDPA DLALSSIPGH ETFDPRRHRF SEEELKPQPI MKKARKIQVP
260 270 280 290 300
EEQKDEKYWS RRYKNNEAAK RSRDARRLKE NQISVRAAFL EKENALLRQE
310 320
VVAVRQELSH YRAVLSRYQA QHGAL
Length:325
Mass (Da):34,349
Last modified:October 1, 1996 - v1
Checksum:iA6933CE21399ECF3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QXW3M0QXW3_HUMAN
D site-binding protein
DBP
123Annotation score:
M0QXP1M0QXP1_HUMAN
D site-binding protein
DBP
262Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti179S → T in AAA81374 (PubMed:7835883).Curated1
Sequence conflicti245R → K in BAA05833 (PubMed:8482542).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06936 mRNA Translation: AAA81374.1
U48213, U48212 Genomic DNA Translation: AAB18668.1
EF015902 Genomic DNA Translation: ABM64213.1
U79283 mRNA Translation: AAB50219.1
BT006836 mRNA Translation: AAP35482.1
CH471177 Genomic DNA Translation: EAW52374.1
BC011965 mRNA Translation: AAH11965.1
D28468 mRNA Translation: BAA05833.1
CCDSiCCDS12728.1
PIRiA55558
RefSeqiNP_001343.2, NM_001352.4
UniGeneiHs.414480
Hs.528006

Genome annotation databases

EnsembliENST00000222122; ENSP00000222122; ENSG00000105516
GeneIDi1628
KEGGihsa:1628
UCSCiuc002pjx.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06936 mRNA Translation: AAA81374.1
U48213, U48212 Genomic DNA Translation: AAB18668.1
EF015902 Genomic DNA Translation: ABM64213.1
U79283 mRNA Translation: AAB50219.1
BT006836 mRNA Translation: AAP35482.1
CH471177 Genomic DNA Translation: EAW52374.1
BC011965 mRNA Translation: AAH11965.1
D28468 mRNA Translation: BAA05833.1
CCDSiCCDS12728.1
PIRiA55558
RefSeqiNP_001343.2, NM_001352.4
UniGeneiHs.414480
Hs.528006

3D structure databases

ProteinModelPortaliQ10586
SMRiQ10586
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107996, 11 interactors
IntActiQ10586, 3 interactors
STRINGi9606.ENSP00000222122

PTM databases

iPTMnetiQ10586
PhosphoSitePlusiQ10586

Polymorphism and mutation databases

BioMutaiDBP
DMDMi1706312

Proteomic databases

EPDiQ10586
PaxDbiQ10586
PeptideAtlasiQ10586
PRIDEiQ10586
ProteomicsDBi58862

Protocols and materials databases

DNASUi1628
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222122; ENSP00000222122; ENSG00000105516
GeneIDi1628
KEGGihsa:1628
UCSCiuc002pjx.5 human

Organism-specific databases

CTDi1628
DisGeNETi1628
EuPathDBiHostDB:ENSG00000105516.10
GeneCardsiDBP
HGNCiHGNC:2697 DBP
MIMi124097 gene
neXtProtiNX_Q10586
OpenTargetsiENSG00000105516
PharmGKBiPA27165
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3119 Eukaryota
ENOG410YJ8G LUCA
GeneTreeiENSGT00440000039070
HOGENOMiHOG000234383
HOVERGENiHBG004983
InParanoidiQ10586
KOiK09056
OMAiDSCESPS
OrthoDBiEOG091G0EO0
PhylomeDBiQ10586
TreeFamiTF315869

Enzyme and pathway databases

ReactomeiR-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression
SignaLinkiQ10586
SIGNORiQ10586

Miscellaneous databases

ChiTaRSiDBP human
GeneWikiiDBP_(gene)
GenomeRNAii1628
PROiPR:Q10586
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105516 Expressed in 206 organ(s), highest expression level in left adrenal gland
CleanExiHS_DBP
ExpressionAtlasiQ10586 baseline and differential
GenevisibleiQ10586 HS

Family and domain databases

InterProiView protein in InterPro
IPR004827 bZIP
IPR029830 DBP
PANTHERiPTHR11988:SF7 PTHR11988:SF7, 1 hit
PfamiView protein in Pfam
PF07716 bZIP_2, 1 hit
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDBP_HUMAN
AccessioniPrimary (citable) accession number: Q10586
Secondary accession number(s): A2I2P4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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