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Entry version 62 (23 Feb 2022)
Sequence version 2 (17 Jun 2020)
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Protein

Hemocyanin 2

Gene

KLH2

Organism
Megathura crenulata (Giant keyhole limpet)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi62Copper 1; via tele nitrogenBy similarity1
Metal bindingi81Copper 1; via tele nitrogenBy similarity1
Metal bindingi90Copper 1; via tele nitrogenBy similarity1
Metal bindingi200Copper 2; via tele nitrogenBy similarity1
Metal bindingi204Copper 2; via tele nitrogenBy similarity1
Metal bindingi231Copper 2; via tele nitrogenBy similarity1
Metal bindingi483Copper 3; via tele nitrogenBy similarity1
Metal bindingi503Copper 3; via tele nitrogenBy similarity1
Metal bindingi512Copper 3; via tele nitrogenBy similarity1
Metal bindingi622Copper 4; via tele nitrogenBy similarity1
Metal bindingi626Copper 4; via tele nitrogenBy similarity1
Metal bindingi653Copper 4; via tele nitrogenBy similarity1
Metal bindingi894Copper 5; via tele nitrogenBy similarity1
Metal bindingi914Copper 5; via tele nitrogenBy similarity1
Metal bindingi923Copper 5; via tele nitrogenBy similarity1
Metal bindingi1033Copper 6; via tele nitrogenBy similarity1
Metal bindingi1037Copper 6; via tele nitrogenBy similarity1
Metal bindingi1063Copper 6; via tele nitrogenBy similarityCurated1
Metal bindingi1313Copper 7; via tele nitrogenBy similarity1
Metal bindingi1331Copper 7; via tele nitrogenBy similarity1
Metal bindingi1340Copper 7; via tele nitrogenBy similarity1
Metal bindingi1444Copper 8; via tele nitrogenBy similarity1
Metal bindingi1448Copper 8; via tele nitrogenBy similarity1
Metal bindingi1475Copper 8; via tele nitrogenBy similarity1
Metal bindingi1726Copper 9; via tele nitrogenBy similarity1
Metal bindingi1746Copper 9; via tele nitrogenBy similarity1
Metal bindingi1755Copper 9; via tele nitrogenBy similarity1
Metal bindingi1868Copper 10; via tele nitrogenBy similarity1
Metal bindingi1872Copper 10; via tele nitrogenBy similarity1
Metal bindingi1899Copper 10; via tele nitrogenBy similarity1
Metal bindingi2143Copper 11; via tele nitrogenBy similarity1
Metal bindingi2162Copper 11; via tele nitrogenBy similarity1
Metal bindingi2171Copper 11; via tele nitrogenBy similarity1
Metal bindingi2281Copper 12; via tele nitrogenBy similarity1
Metal bindingi2285Copper 12; via tele nitrogenBy similarity1
Metal bindingi2312Copper 12; via tele nitrogenBy similarity1
Metal bindingi2563Copper 13; via tele nitrogenBy similarity1
Metal bindingi2582Copper 13; via tele nitrogenBy similarity1
Metal bindingi2591Copper 13; via tele nitrogenBy similarity1
Metal bindingi2691Copper 14; via tele nitrogenBy similarity1
Metal bindingi2695Copper 14; via tele nitrogenBy similarity1
Metal bindingi2722Copper 14; via tele nitrogenBy similarity1
Metal bindingi2970Copper 15; via tele nitrogenBy similarity1
Metal bindingi2989Copper 15; via tele nitrogenBy similarity1
Metal bindingi2998Copper 15; via tele nitrogenBy similarity1
Metal bindingi3099Copper 16; via tele nitrogenBy similarity1
Metal bindingi3103Copper 16; via tele nitrogenBy similarity1
Metal bindingi3130Copper 16; via tele nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOxygen transport, Transport
LigandCopper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemocyanin 2Imported
Alternative name(s):
Keyhole limpet hemocyanin B1 Publication
Short name:
KLH-B1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLH21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMegathura crenulata (Giant keyhole limpet)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri55429 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaGastropodaVetigastropodaLepetellidaFissurelloideaFissurellidaeMegathura

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Potent immunogen used classically as a carrier protein for haptens and more recently in human vaccines and for immunotherapy of bladder cancer.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000020430520 – 3421Hemocyanin 2Add BLAST3402

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi68 ↔ 78By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki79 ↔ 812'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi190 ↔ 257By similarity
Disulfide bondi344 ↔ 356By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi408N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi489 ↔ 500By similarity
Cross-linki501 ↔ 5032'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi612 ↔ 678By similarity
Disulfide bondi900 ↔ 911By similarity
Cross-linki912 ↔ 9142'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi1023 ↔ 1090By similarity
Disulfide bondi1180 ↔ 1187By similarity
Glycosylationi1183N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1319 ↔ 1328By similarity
Cross-linki1329 ↔ 13312'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi1434 ↔ 1501By similarity
Disulfide bondi1590 ↔ 1599By similarity
Glycosylationi1653N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1732 ↔ 1743By similarity
Cross-linki1744 ↔ 17462'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi1858 ↔ 1925By similarity
Disulfide bondi2014 ↔ 2020By similarity
Disulfide bondi2149 ↔ 2159By similarity
Cross-linki2160 ↔ 21622'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi2271 ↔ 2338By similarity
Disulfide bondi2425 ↔ 2431By similarity
Disulfide bondi2569 ↔ 2579By similarity
Cross-linki2580 ↔ 25822'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi2681 ↔ 2748By similarity
Disulfide bondi2835 ↔ 2841By similarity
Disulfide bondi2976 ↔ 2986By similarity
Cross-linki2987 ↔ 29892'-(S-cysteinyl)-histidine (Cys-His)By similarity
Disulfide bondi3089 ↔ 3156By similarity
Disulfide bondi3374 ↔ 3407By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably N-glycosylated. Asn-2489 is buried deeply in the protein which make it inaccessible for sugar attachment.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Thioether bond

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
211, 15 N-Linked glycans

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Hemolymph.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homo-didecamer and homo-multidecamer.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati632 – 673WD 1Sequence analysisAdd BLAST42
Repeati1043 – 1084WD 2Sequence analysisAdd BLAST42
Repeati1387 – 1425WD 3Sequence analysisAdd BLAST39
Repeati1454 – 1495WD 4Sequence analysisAdd BLAST42
Repeati1878 – 1919WD 5Sequence analysisAdd BLAST42
Repeati2168 – 2204WD 6Sequence analysisAdd BLAST37
Repeati2700 – 2742WD 7Sequence analysisAdd BLAST43
Repeati3109 – 3150WD 8Sequence analysisAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni20 – 442Functional unit a (wall)By similarityAdd BLAST423
Regioni443 – 853Functional unit b (wall)By similarityAdd BLAST411
Regioni854 – 1275Functional unit c (wall)By similarityAdd BLAST422
Regioni969 – 988DisorderedSequence analysisAdd BLAST20
Regioni1276 – 1685Functional unit d (wall)By similarityAdd BLAST410
Regioni1686 – 2102Functional unit e (wall)By similarityAdd BLAST417
Regioni2103 – 2522Functional unit f (wall)By similarityAdd BLAST420
Regioni2523 – 2929Functional unit g (internal arc)By similarityAdd BLAST407
Regioni2896 – 2928DisorderedSequence analysisAdd BLAST33
Regioni2930 – 3421Functional unit h (internal slab)By similarityAdd BLAST492

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi972 – 988Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi2902 – 2928Basic and acidic residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein is composed of 8 globular functional units (a->h), forming a 'pearl chain'. Each unit is separated from the next by a linker. Since the lengths but not the exact positions are known, lengths are indicated here in free text. Linker lengths in amino acids are: 20 (a->b), 13 (b->c), 19 (c->d), 16 (d->e), 14 (e->f), 17 (f->g), and 17 (g->h).By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tyrosinase family. Hemocyanin subfamily.Curated

Keywords - Domaini

Repeat, Signal, WD repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1280.10, 8 hits
2.60.310.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028999, Haemocyanin_beta-sandwich
IPR036848, Haemocyanin_C_sf
IPR002227, Tyrosinase_Cu-bd
IPR008922, Unchr_di-copper_centre

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14830, Haemocyan_bet_s, 8 hits
PF00264, Tyrosinase, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00092, TYROSINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48056, SSF48056, 8 hits
SSF81277, SSF81277, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00497, TYROSINASE_1, 7 hits
PS00498, TYROSINASE_2, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q10584-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWTILALLTA TLLFEGAFSV DTVVRKNVDS LSSDEVLALE KALDDLQQDD
60 70 80 90 100
SNQGYQAIAG YHGVPTMCVD KHEKNVACCL HGMPSFPLWH RLYVVQLERA
110 120 130 140 150
LIRKKATISI PYWDWTSELT HLPELVSHPL FVGTEGGKAH DNSWYRADIT
160 170 180 190 200
FLNKKTSRAV DDRLFEKVQP GHHTRLMEGI LDALEQDEFC KFEIQFELAH
210 220 230 240 250
NAIHYLVGGR HTYSMSHLEY TSYDPLFFLH HSNTDRIFAI WQRLQQLRGK
260 270 280 290 300
DPNSADCAHN LIHTPMEPFD RDTNPLDLTR EHAKPADSFD YGRLGYQYDD
310 320 330 340 350
LSLNGMSPEE LNVYLGERAA KERTFASFIL SGFGGSANVV VYVCRPAHDE
360 370 380 390 400
ISDDQCIKAG DFFLLGGPTE MKWGFYRAYH FDVTDSVASI DDDGHGHYYV
410 420 430 440 450
KSELFSVNGS ALSNDILRQP TLVHRPAKGH FDKPPVPVAQ ANLAVRKNIN
460 470 480 490 500
DLTAEETYSL RKAMERFQND KSVDGYQATV EFHALPARCP RPDAKDRFAC
510 520 530 540 550
CVHGMATFPH WHRLFVTQVE DALLRRGSTI GLPNWDWTMP MDHLPELATS
560 570 580 590 600
ETYLDPVTGE TKNNPFHHAQ VAFENGVTSR NPDAKLFMKP TYGDHTYLFD
610 620 630 640 650
SMIYAFEQED FCDFEVQYEL THNAIHAWVG GSEKYSMSSL HYTAFDPIFY
660 670 680 690 700
LHHSNVDRLW AIWQALQIRR GKSYKAHCAS SQEREPLKPF AFSSPLNNNE
710 720 730 740 750
KTYHNSVPTN VYDYVGVLHY RYDDLQFGGM TMSELEEYIH KQTQHDRTFA
760 770 780 790 800
GFFLSYIGTS ASVDIFINRE GHDKYKVGSF VVLGGSKEMK WGFDRMYKYE
810 820 830 840 850
ITEALKTLNV AVDDGFSITV EITDVDGSPP SADLIPPPAI IFERADAKDF
860 870 880 890 900
GHSRKIRKAV DSLTVEEQTS LRRAMADLQD DKTSGGFQQI AAFHGEPKWC
910 920 930 940 950
PSPEAEKKFA CCVHGMAVFP HWHRLLTVQG ENALRKHGFT GGLPYWDWTR
960 970 980 990 1000
SMSALPHFVA DPTYNDAISS QEEDNPWHHG HIDSVGHDTT RDVRDDLYQS
1010 1020 1030 1040 1050
PGFGHYTDIA KQVLLAFEQD DFCDFEVQFE IAHNFIHALV GGNEPYSMSS
1060 1070 1080 1090 1100
LRYTTYDPIF FLHRSNTDRL WAIWQALQKY RGKPYNTANC AIASMRKPLQ
1110 1120 1130 1140 1150
PFGLDSVINP DDETREHSVP FRVFDYKNNF DYEYESLAFN GLSIAQLDRE
1160 1170 1180 1190 1200
LQRRKSHDRV FAGFLLHEIG QSALVKFYVC KHNVSDCDHY AGEFYILGDE
1210 1220 1230 1240 1250
AEMPWRYDRV YKYEITQQLH DLDLHVGDNF FLKYEAFDLN GGSLGGSIFS
1260 1270 1280 1290 1300
QPSVIFEPAA GSHQADEYRE AVTSASHIRK NIRDLSEGEI ESIRSAFLQI
1310 1320 1330 1340 1350
QKEGIYENIA KFHGKPGLCE HDGHPVACCV HGMPTFPHWH RLYVLQVENA
1360 1370 1380 1390 1400
LLERGSAVAV PYWDWTEKAD SLPSLINDAT YFNSRSQTFD PNPFFRGHIA
1410 1420 1430 1440 1450
FENAVTSRDP QPELWDNKDF YENVMLALEQ DNFCDFEIQL ELIHNALHSR
1460 1470 1480 1490 1500
LGGRAKYSLS SLDYTAFDPV FFLHHANVDR IWAIWQDLQR YRKKPYNEAD
1510 1520 1530 1540 1550
CAVNEMRKPL QPFNNPELNS DSMTLKHNLP QDSFDYQNRF RYQYDNLQFN
1560 1570 1580 1590 1600
HFSIQKLDQT IQARKQHDRV FAGFILHNIG TSAVVDIYIC VEQGGEQNCK
1610 1620 1630 1640 1650
TKAGSFTILG GETEMPFHFD RLYKFDITSA LHKLGVPLDG HGFDIKVDVR
1660 1670 1680 1690 1700
AVNGSHLDQH ILNEPSLLFV PGERKNIYYD GLSQHNLVRK EVSSLTTLEK
1710 1720 1730 1740 1750
HFLRKALKNM QADDSPDGYQ AIASFHALPP LCPSPSAAHR HACCLHGMAT
1760 1770 1780 1790 1800
FPQWHRLYTV QFEDSLKRHG SIVGLPYWDW LKPQSALPDL VTQETYEHLF
1810 1820 1830 1840 1850
SHKTFPNPFL KANIEFEGEG VTTERDVDAE HLFAKGNLVY NNWFCNQALY
1860 1870 1880 1890 1900
ALEQENYCDF EIQFEILHNG IHSWVGGSKT HSIGHLHYAS YDPLFYIHHS
1910 1920 1930 1940 1950
QTDRIWAIWQ ALQEHRGLSG KEAHCALEQM KDPLKPFSFG SPYNLNKRTQ
1960 1970 1980 1990 2000
EFSKPEDTFD YHRFGYEYDS LEFVGMSVSS LHNYIKQQQE ADRVFAGFLL
2010 2020 2030 2040 2050
KGFGQSASVS FDICRPDQSC QEAGYFSVLG GSSEMPWQFD RLYKYDITKT
2060 2070 2080 2090 2100
LKDMKLRYDD TFTIKVHIKD IAGAELDSDL IPTPSVLLEE GKHGINVRHV
2110 2120 2130 2140 2150
GRNRIRMELS ELTERDLASL KSAMRSLQAD DGVNGYQAIA SFHGLPASCH
2160 2170 2180 2190 2200
DDEGHEIACC IHGMPVFPHW HRLYTLQMDM ALLSHGSAVA IPYWDWTKPI
2210 2220 2230 2240 2250
SKLPDLFTSP EYYDPWRDAV VNNPFAKGYI KSEDAYTVRD PQDILYHLQD
2260 2270 2280 2290 2300
ETGTSVLLDQ TLLALEQTDF CDFEVQFEVV HNAIHYLVGG RQVYALSSQH
2310 2320 2330 2340 2350
YASYDPAFFI HHSFVDKIWA VWQALQKKRK RPYHKADCAL NMMTKPMRPF
2360 2370 2380 2390 2400
AHDFNHNGFT KMHAVPNTLF DFQDLFYTYD NLEIAGMNVN QLEAEINRRK
2410 2420 2430 2440 2450
SQTRVFAGFL LHGIGRSADV RFWICKTADD CHASGMIFIL GGSKEMHWAY
2460 2470 2480 2490 2500
DRNFKYDITQ ALKAQSIHPE DVFDTDAPFF IKVEVHGVNK TALPSSAIPA
2510 2520 2530 2540 2550
PTIIYSAGEG HTDDHGSDHI AGSGVRKDVT SLTASEIENL RHALQSVMDD
2560 2570 2580 2590 2600
DGPNGFQAIA AYHGSPPMCH MXDGRDVACC THGMASFPHW HRLFVKQMED
2610 2620 2630 2640 2650
ALAAHGAHIG IPYWDWTSAF SHLPALVTDH EHNPFHHGHI AHRNVDTSRS
2660 2670 2680 2690 2700
PRDMLFNDPE HGSESFFYRQ VLLALEQTDF CQFEVQFEIT HNAIHSWTGG
2710 2720 2730 2740 2750
HTPYGMSSLE YTAYDPLFYL HHSNTDRIWA IWQALQKYRG FQYNAAHCDI
2760 2770 2780 2790 2800
QVLKQPLKPF SESRNPNPVT RANSRAVDSF DYERLNYQYD TLTFHGHSIS
2810 2820 2830 2840 2850
ELDAMLQERK KEERTFAAFL LHGFGASADV SFDVCTPDGH CAFAGTFAVL
2860 2870 2880 2890 2900
GGELEMPWSF ERLFRYDITK VLKQMNLHYD SEFHFELKIV GTDGTELPSD
2910 2920 2930 2940 2950
RIKSPTIEHH GGDHHGGDTS GHDHSERHDG FFRKEVGSLS LDEANDLKNA
2960 2970 2980 2990 3000
LYKLQNDQGP NGYESIAGYH GYPFLCPEHG EDQYACCVHG MPVFPHWHRL
3010 3020 3030 3040 3050
HTIQFERALK EHGSHLGIPY WDWTKSMIAL PAFFADSSNS NPFYKYHIMK
3060 3070 3080 3090 3100
AGHDTARSPS DLLFNQPQLH GYDYLYYLAL STLEEDNYCD FEVHYEILHN
3110 3120 3130 3140 3150
AVHLWLGGTE TYSMSSLAFS AYDPVFMILH SGLDRLWIIW QELQKLRKKP
3160 3170 3180 3190 3200
YNAAKCAGHM MDEPLHPFNY ESANHDSFTR ANAKPSTVFD SHKFNYHYDN
3210 3220 3230 3240 3250
PDVRGNSIQE ISAIIHDLRN QPRVFAGFVL SGIYTSANVK IYLVREGHDD
3260 3270 3280 3290 3300
ENVGSFVVLG GPKEMPWAYE RIFKYDITEV ANRLNMHHDD TFNFRLEVQS
3310 3320 3330 3340 3350
YTGEMVTHHL PEPLIIYRPA KQEYDVLVIP LGSGHKLPPK VIVKRGTRIM
3360 3370 3380 3390 3400
FHPVDDTVNR PVVDLGSHTA LYNCVVPPFT YNGYELDHAY SLRDGHYYIA
3410 3420
GPTKDLCTSG NVRIHIHIED E
Length:3,421
Mass (Da):391,513
Last modified:June 17, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i94915A26F0870962
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ698342 Genomic DNA Translation: CAG28310.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ698342 Genomic DNA Translation: CAG28310.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

PTM databases

GlyConnecti211, 15 N-Linked glycans

Family and domain databases

Gene3Di1.10.1280.10, 8 hits
2.60.310.10, 8 hits
InterProiView protein in InterPro
IPR028999, Haemocyanin_beta-sandwich
IPR036848, Haemocyanin_C_sf
IPR002227, Tyrosinase_Cu-bd
IPR008922, Unchr_di-copper_centre
PfamiView protein in Pfam
PF14830, Haemocyan_bet_s, 8 hits
PF00264, Tyrosinase, 9 hits
PRINTSiPR00092, TYROSINASE
SUPFAMiSSF48056, SSF48056, 8 hits
SSF81277, SSF81277, 8 hits
PROSITEiView protein in PROSITE
PS00497, TYROSINASE_1, 7 hits
PS00498, TYROSINASE_2, 7 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCY2_MEGCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10584
Secondary accession number(s): Q1MVA1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 17, 2020
Last modified: February 23, 2022
This is version 62 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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