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UniProtKB - Q10583 (HCY1_MEGCR)

Entry version 60 (23 Feb 2022)
Sequence version 2 (17 Jun 2020)
Previous versions | rss
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Protein

Hemocyanin 1

Gene

KLH1

Organism
Megathura crenulata (Giant keyhole limpet)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi17Divalent metal cation; structural1 Publication1
Metal bindingi58Copper 1; via tele nitrogenCombined sources1
Metal bindingi76Copper 1; via tele nitrogenCombined sources1
Metal bindingi85Copper 1; via tele nitrogenCombined sources1
Metal bindingi195Copper 2; via tele nitrogenCombined sources1
Metal bindingi199Copper 2; via tele nitrogenCombined sources1
Metal bindingi226Copper 2; via tele nitrogenCombined sources1
Metal bindingi478Copper 3; via tele nitrogenCombined sources1
Metal bindingi498Copper 3; via tele nitrogenCombined sources1
Metal bindingi507Copper 3; via tele nitrogenCombined sources1
Metal bindingi618Copper 4; via tele nitrogenCombined sources1
Metal bindingi622Copper 4; via tele nitrogenCombined sources1
Metal bindingi649Copper 4; via tele nitrogenCombined sources1
Metal bindingi737Divalent metal cation; structural1 Publication1
Metal bindingi892Copper 5; via tele nitrogenCombined sources1
Metal bindingi912Copper 5; via tele nitrogenCombined sources1
Metal bindingi921Copper 5; via tele nitrogenCombined sources1
Metal bindingi1031Copper 6; via tele nitrogenCombined sources1
Metal bindingi1035Copper 6; via tele nitrogenCombined sources1
Metal bindingi1062Copper 6; via tele nitrogenCombined sources1
Metal bindingi1309Copper 7; via tele nitrogenCombined sources1
Metal bindingi1327Copper 7; via tele nitrogenCombined sources1
Metal bindingi1336Copper 7; via tele nitrogenCombined sources1
Metal bindingi1440Copper 8; via tele nitrogenCombined sources1
Metal bindingi1444Copper 8; via tele nitrogenCombined sources1
Metal bindingi1471Copper 8; via tele nitrogenCombined sources1
Metal bindingi1721Copper 9; via tele nitrogenCombined sources1
Metal bindingi1741Copper 9; via tele nitrogenCombined sources1
Metal bindingi1750Copper 9; via tele nitrogenCombined sources1
Metal bindingi1863Copper 10; via tele nitrogenCombined sources1
Metal bindingi1867Copper 10; via tele nitrogenCombined sources1
Metal bindingi1894Copper 10; via tele nitrogenCombined sources1
Metal bindingi2138Copper 11; via tele nitrogenCombined sources1
Metal bindingi2157Copper 11; via tele nitrogenCombined sources1
Metal bindingi2166Copper 11; via tele nitrogenCombined sources1
Metal bindingi2276Copper 12; via tele nitrogenCombined sources1
Metal bindingi2280Copper 12; via tele nitrogenCombined sources1
Metal bindingi2307Copper 12; via tele nitrogenCombined sources1
Metal bindingi2424Divalent metal cation; structural1 Publication1
Metal bindingi2558Copper 13; via tele nitrogenCombined sources1
Metal bindingi2577Copper 13; via tele nitrogenCombined sources1
Metal bindingi2586Copper 13; via tele nitrogenCombined sources1
Metal bindingi2686Copper 14; via tele nitrogenCombined sources1
Metal bindingi2690Copper 14; via tele nitrogenCombined sources1
Metal bindingi2717Copper 14; via tele nitrogenCombined sources1
Metal bindingi2962Copper 15; via tele nitrogenCombined sources1
Metal bindingi2981Copper 15; via tele nitrogenCombined sources1
Metal bindingi2990Copper 15; via tele nitrogenCombined sources1
Metal bindingi3091Copper 16; via tele nitrogenCombined sources1
Metal bindingi3095Copper 16; via tele nitrogenCombined sources1
Metal bindingi3122Copper 16; via tele nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOxygen transport, Transport
LigandCopper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemocyanin 1Imported
Alternative name(s):
Keyhole limpet hemocyanin A1 Publication
Short name:
KLH-A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLH11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMegathura crenulata (Giant keyhole limpet)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri55429 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Spiralia › Lophotrochozoa › Mollusca › Gastropoda › Vetigastropoda › Lepetellida › Fissurelloidea › Fissurellidae › Megathura

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Potent immunogen used classically as a carrier protein for haptens and more recently in human vaccines and for immunotherapy of bladder cancer.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000020430417 – 3414Hemocyanin 1Add BLAST3398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi64 ↔ 73Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki74 ↔ 762'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi185 ↔ 252Combined sources
Cross-linki287 ↔ 2902'-(S-cysteinyl)-histidine (Cys-His)1 Publication
Disulfide bondi339 ↔ 351Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi403N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi484 ↔ 495Combined sources
Cross-linki496 ↔ 4982'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Glycosylationi545N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi608 ↔ 674Combined sources
Disulfide bondi898 ↔ 909Combined sources
Cross-linki910 ↔ 9122'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi1021 ↔ 1088Combined sources
Disulfide bondi1178 ↔ 1184Combined sources
Disulfide bondi1315 ↔ 1324Combined sources
Cross-linki1325 ↔ 13272'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi1430 ↔ 1497Combined sources
Disulfide bondi1585 ↔ 1595Combined sources
Glycosylationi1648N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1727 ↔ 1738Combined sources
Cross-linki1739 ↔ 17412'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi1853 ↔ 1920Combined sources
Disulfide bondi2009 ↔ 2015Combined sources
Disulfide bondi2144 ↔ 2154Combined sources
Glycosylationi2145N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Cross-linki2155 ↔ 21572'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi2266 ↔ 2333Combined sources
Disulfide bondi2420 ↔ 2426Combined sources
Disulfide bondi2564 ↔ 2574Combined sources
Glycosylationi2571N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Cross-linki2575 ↔ 25772'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi2676 ↔ 2743Combined sources
Disulfide bondi2830 ↔ 2836Combined sources
Disulfide bondi2968 ↔ 2978Combined sources
Cross-linki2979 ↔ 29812'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi3081 ↔ 3148Combined sources
Glycosylationi3278N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3367 ↔ 3400Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably N-glycosylated (Probable). Asn-1280 and Asn-2484 are buried deeply in the protein which make them inaccessible for sugar attachment (Probable). Asn-3278 N-glycan is likely to represent a diantennate carbohydrate tree (Probable). The didecamer is almost evenly tagged by a total of 120 sugar trees (Probable).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Thioether bond

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		211, 15 N-Linked glycans

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Hemolymph.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homo-didecamer, with two decamers assembled face-to-face at their open ends. This didecamer form a stable 25 nM cylinder wall.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q10583

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati628 – 669WD 1Sequence analysisAdd BLAST42
Repeati1041 – 1082WD 2Sequence analysisAdd BLAST42
Repeati1450 – 1491WD 3Sequence analysisAdd BLAST42
Repeati1873 – 1914WD 4Sequence analysisAdd BLAST42
Repeati2163 – 2199WD 5Sequence analysisAdd BLAST37
Repeati2696 – 2737WD 6Sequence analysisAdd BLAST42
Repeati3101 – 3142WD 7Sequence analysisAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 437Functional unit a (wall)1 PublicationAdd BLAST421
Regioni438 – 851Functional unit b (wall)1 PublicationAdd BLAST414
Regioni852 – 1271Functional unit c (wall)1 PublicationAdd BLAST420
Regioni1272 – 1680Functional unit d (wall)1 PublicationAdd BLAST409
Regioni1681 – 2097Functional unit e (wall)1 PublicationAdd BLAST417
Regioni2098 – 2517Functional unit f (wall)1 PublicationAdd BLAST420
Regioni2518 – 2921Functional unit g (internal arc)1 PublicationAdd BLAST404
Regioni2922 – 3414Functional unit h (internal slab)1 PublicationAdd BLAST493

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein is composed of 8 globular functional units (a->h), forming a 'pearl chain'. Each unit is separated from the next by a linker. Since the lengths but not the exact positions are known, lengths are indicated here in free text. Linker lengths in amino acids are: 20 (a->b), 13 (b->c), 19 (c->d), 16 (d->e), 14 (e->f), 17 (f->g), and 17 (g->h).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tyrosinase family. Hemocyanin subfamily.Curated

Keywords - Domaini

Repeat, Signal, WD repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1280.10, 8 hits
2.60.310.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028999, Haemocyanin_beta-sandwich
IPR036848, Haemocyanin_C_sf
IPR002227, Tyrosinase_Cu-bd
IPR008922, Unchr_di-copper_centre

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14830, Haemocyan_bet_s, 8 hits
PF00264, Tyrosinase, 9 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00092, TYROSINASE

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48056, SSF48056, 8 hits
SSF81277, SSF81277, 8 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00497, TYROSINASE_1, 7 hits
PS00498, TYROSINASE_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q10583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSVRLLIVV LALANAENLV RKSVEHLTQE ETLDLQAALR ELQMDSSSIG 
        60         70         80         90        100
FQKIAAAHGA PASCVHKDTS IACCIHGMPT FPHWHRAYVV HMERALQTKR 
       110        120        130        140        150
RTSGLPYWDW TEPITQLPSL AADPVYIDSQ GGKAHTNYWY RGNIDFLDKK 
       160        170        180        190        200
TNRAVDDRLF EKVKPGQHTH LMESVLDALE QDEFCKFEIQ FELAHNAIHY 
       210        220        230        240        250
LVGGKHDYSM ANLEYTAYDP IFFLHHSNVD RIFAIWQRLQ ELRNKDPKAM 
       260        270        280        290        300
DCAQELLHQK MEPFSWEDND IPLTNEHSTP ADLFDYCELH YDYDTLNLNG 
       310        320        330        340        350
MTPEELKTYL DERSSRARAF ASFRLKGFGG SANVFVYVCI PDDNDRNDDH 
       360        370        380        390        400
CEKAGDFFVL GGPSEMKWQF YRPYLFDLSD TVHKMGMKLD GHYTVKAELF 
       410        420        430        440        450
SVNGTALPDD LLPHPVVVHH PEKGFTDPPV KHHQSANLLV RKNINDLTRE 
       460        470        480        490        500
EVLNLREAFH KFQEDRSVDG YQATAEYHGL PARCPRPDAK DRYACCVHGM 
       510        520        530        540        550
PIFPHWHRLF VTQVEDALVG RGATIGIPYW DWTEPMTHIP GLAGNKTYVD 
       560        570        580        590        600
SHGASHTNPF HSSVIAFEEN APHTKRQIDQ RLFKPATFGH HTDLFNQILY 
       610        620        630        640        650
AFEQEDYCDF EVQFEITHNT IHAWTGGSEH FSMSSLHYTA FDPLFYFHHS 
       660        670        680        690        700
NVDRLWAVWQ ALQMRRHKPY RAHCAISLEH MHLKPFAFSS PLNNNEKTHA 
       710        720        730        740        750
NAMPNKIYDY ENVLHYTYED LTFGGISLEN IEKMIHENQQ EDRIYAGFLL 
       760        770        780        790        800
AGIRTSANVD IFIKTTDSVQ HKAGTFAVLG GSKEMKWGFD RVFKFDITHV 
       810        820        830        840        850
LKDLDLTADG DFEVTVDITE VDGTKLASSL IPHASVIREH ARVKFDKVPR 
       860        870        880        890        900
SRLIRKNVDR LSPEEMNELR KALALLKEDK SAGGFQQLGA FHGEPKWCPS 
       910        920        930        940        950
PEASKKFACC VHGMSVFPHW HRLLTVQSEN ALRRHGYDGA LPYWDWTSPL 
       960        970        980        990       1000
NHLPELADHE KYVDPEDGVE KHNPWFDGHI DTVDKTTTRS VQNKLFEQPE 
      1010       1020       1030       1040       1050
FGHYTSIAKQ VLLALEQDNF CDFEIQYEIA HNYIHALVGG AQPYGMASLR 
      1060       1070       1080       1090       1100
YTAFDPLFYL HHSNTDRIWA IWQALQKYRG KPYNVANCAV TSMREPLQPF 
      1110       1120       1130       1140       1150
GLSANINTDH VTKEHSVPFN VFDYKTNFNY EYDTLEFNGL SISQLNKKLE 
      1160       1170       1180       1190       1200
AIKSQDRFFA GFLLSGFKKS SLVKFNICTD SSNCHPAGEF YLLGDENEMP 
      1210       1220       1230       1240       1250
WAYDRVFKYD ITEKLHDLKL HAEDHFYIDY EVFDLKPASL GKDLFKQPSV 
      1260       1270       1280       1290       1300
IHEPRIGHHE GEVYQAEVTS ANRIRKNIEN LSLGELESLR AAFLEIENDG 
      1310       1320       1330       1340       1350
TYESIAKFHG SPGLCQLNGN PISCCVHGMP TFPHWHRLYV VVVENALLKK 
      1360       1370       1380       1390       1400
GSSVAVPYWD WTKRIEHLPH LISDATYYNS RQHHYETNPF HHGKITHENE 
      1410       1420       1430       1440       1450
ITTRDPKDSL FHSDYFYEQV LYALEQDNFC DFEIQLEILH NALHSLLGGK 
      1460       1470       1480       1490       1500
GKYSMSNLDY AAFDPVFFLH HATTDRIWAI WQDLQRFRKR PYREANCAIQ 
      1510       1520       1530       1540       1550
LMHTPLQPFD KSDNNDEATK THATPHDGFE YQNSFGYAYD NLELNHYSIP 
      1560       1570       1580       1590       1600
QLDHMLQERK RHDRVFAGFL LHNIGTSADG HVFVCLPTGE HTKDCSHEAG 
      1610       1620       1630       1640       1650
MFSILGGQTE MSFVFDRLYK LDITKALKKN GVHLQGDFDL EIEITAVNGS 
      1660       1670       1680       1690       1700
HLDSHVIHSP TILFEAGTDS AHTDDGHTEP VMIRKDITQL DKRQQLSLVK 
      1710       1720       1730       1740       1750
ALESMKADHS SDGFQAIASF HALPPLCPSP AASKRFACCV HGMATFPQWH 
      1760       1770       1780       1790       1800
RLYTVQFQDS LRKHGAVVGL PYWDWTLPRS ELPELLTVST IHDPETGRDI 
      1810       1820       1830       1840       1850
PNPFIGSKIE FEGENVHTKR DINRDRLFQG STKTHHNWFI EQALLALEQT 
      1860       1870       1880       1890       1900
NYCDFEVQFE IMHNGVHTWV GGKEPYGIGH LHYASYDPLF YIHHSQTDRI 
      1910       1920       1930       1940       1950
WAIWQSLQRF RGLSGSEANC AVNLMKTPLK PFSFGAPYNL NDHTHDFSKP 
      1960       1970       1980       1990       2000
EDTFDYQKFG YIYDTLEFAG WSIRGIDHIV RNRQEHSRVF AGFLLEGFGT 
      2010       2020       2030       2040       2050
SATVDFQVCR TAGDCEDAGY FTVLGGEKEM PWAFDRLYKY DITETLDKMN 
      2060       2070       2080       2090       2100
LRHDEIFQIE VTITSYDGTV LDSGLIPTPS IIYDPAHHDI SSHHLSLNKV 
      2110       2120       2130       2140       2150
RHDLSTLSER DIGSLKYALS SLQADTSADG FAAIASFHGL PAKCNDSHNN 
      2160       2170       2180       2190       2200
EVACCIHGMP TFPHWHRLYT LQFEQALRRH GSSVAVPYWD WTKPIHNIPH 
      2210       2220       2230       2240       2250
LFTDKEYYDV WRNKVMPNPF ARGYVPSHDT YTVRDVQEGL FHLTSTGEHS 
      2260       2270       2280       2290       2300
ALLNQALLAL EQHDYCDFAV QFEVMHNTIH YLVGGPQVYS LSSLHYASYD 
      2310       2320       2330       2340       2350
PIFFIHHSFV DKVWAVWQAL QEKRGLPSDR ADCAVSLMTQ NMRPFHYEIN 
      2360       2370       2380       2390       2400
HNQFTKKHAV PNDVFKYELL GYRYDNLEIG GMNLHEIEKE IKDKQHHVRV 
      2410       2420       2430       2440       2450
FAGFLLHGIR TSADVQFQIC KTSEDCHHGG QIFVLGGTKE MAWAYNRLFK 
      2460       2470       2480       2490       2500
YDITHALHDA HITPEDVFHP SEPFFIKVSV TAVNGTVLPA SILHAPTIIY 
      2510       2520       2530       2540       2550
EPGLDHHEDH HSSSMAGHGV RKEINTLTTA EVDNLKDAMR AVMADHGPNG 
      2560       2570       2580       2590       2600
YQAIAAFHGN PPMCPMPDGK NYSCCTHGMA TFPHWHRLYT KQMEDALTAH 
      2610       2620       2630       2640       2650
GARVGLPYWD GTTAFTALPT FVTDEEDNPF HHGHIDYLGV DTTRSPRDKL 
      2660       2670       2680       2690       2700
FNDPERGSES FFYRQVLLAL EQTDFCQFEV QFEITHNAIH SWTGGLTPYG 
      2710       2720       2730       2740       2750
MSTLEYTTYD PLFWLHHANT DRIWAIWQAL QEYRGLPYDH ANCEIQAMKR 
      2760       2770       2780       2790       2800
PLRPFSDPIN HNAFTHSNAK PTDVFEYSRF NFQYDNLRFH GMTIKKLEHE 
      2810       2820       2830       2840       2850
LEKQKEEDRT FAAFLLHGIK KSADVSFDVC NHDGECHFAG TFAILGGEHE 
      2860       2870       2880       2890       2900
MPWSFDRLFR YDITQVLKQM HLEYDSDFTF HMRIIDTSGK QLPSDLIKMP 
      2910       2920       2930       2940       2950
TVEHSPGGKH HEKHHEDHHE DILVRKNIHS LSHHEAEELR DALYKLQNDE 
      2960       2970       2980       2990       3000
SHGGYEHIAG FHGYPNLCPE KGDEKYPCCV HGMSIFPHWH RLHTIQFERA 
      3010       3020       3030       3040       3050
LKKHGSHLGI PYWDWTQTIS SLPTFFADSG NNNPFFKYHI RSINQDTVRD 
      3060       3070       3080       3090       3100
VNEAIFQQTK FGEFSSIFYL ALQALEEDNY CDFEVQYEIL HNEVHALIGG 
      3110       3120       3130       3140       3150
AEKYSMSTLE YSAFDPYFMI HHASLDKIWI IWQELQKRRV KPAHAGSCAG 
      3160       3170       3180       3190       3200
DIMHVPLHPF NYESVNNDDF TRENSLPNAV VDSHRFNYKY DNLNLHGHNI 
      3210       3220       3230       3240       3250
EELEEVLRSL RLKSRVFAGF VLSGIRTTAV VKVYIKSGTD SDDEYAGSFV 
      3260       3270       3280       3290       3300
ILGGAKEMPW AYERLYRFDI TETVHNLNLT DDHVKFRFDL KKYDHTELDA 
      3310       3320       3330       3340       3350
SVLPAPIIVR RPNNAVFDII EIPIGKDVNL PPKVVVKRGT KIMFMSVDEA 
      3360       3370       3380       3390       3400
VTTPMLNLGS YTAMFKCKVP PFSFHAFELG KMYSVESGDY FMTASTTELC 
      3410 
NDNNLRIHVH VDDE
Length:3,414
Mass (Da):392,246
Last modified:June 17, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DE70B29A343AD01
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAG28307 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAG28309 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17E → G AA sequence (PubMed:8829804).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ698341 Genomic DNA Translation: CAG28309.2 Sequence problems.
AJ698339 mRNA Translation: CAG28307.2 Sequence problems.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ698341 Genomic DNA Translation: CAG28309.2 Sequence problems.
AJ698339 mRNA Translation: CAG28307.2 Sequence problems.

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L6WX-ray4.00A/B2922-3412[»]
3QJOX-ray4.00A/B2922-3412[»]
4BEDelectron microscopy9.00A/C17-1680[»]
B/D1681-3414[»]
SMRiQ10583
ModBaseiSearch...
PDBe-KBiSearch...

PTM databases

GlyConnecti211, 15 N-Linked glycans

Family and domain databases

Gene3Di1.10.1280.10, 8 hits
2.60.310.10, 8 hits
InterProiView protein in InterPro
IPR028999, Haemocyanin_beta-sandwich
IPR036848, Haemocyanin_C_sf
IPR002227, Tyrosinase_Cu-bd
IPR008922, Unchr_di-copper_centre
PfamiView protein in Pfam
PF14830, Haemocyan_bet_s, 8 hits
PF00264, Tyrosinase, 9 hits
PRINTSiPR00092, TYROSINASE
SUPFAMiSSF48056, SSF48056, 8 hits
SSF81277, SSF81277, 8 hits
PROSITEiView protein in PROSITE
PS00497, TYROSINASE_1, 7 hits
PS00498, TYROSINASE_2, 8 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCY1_MEGCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10583
Secondary accession number(s): Q53IP9, Q6KC56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 17, 2020
Last modified: February 23, 2022
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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