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Entry version 60 (23 Feb 2022)
Sequence version 2 (17 Jun 2020)
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Protein

Hemocyanin 1

Gene

KLH1

Organism
Megathura crenulata (Giant keyhole limpet)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hemocyanins are copper-containing oxygen carriers occurring freely dissolved in the hemolymph of many mollusks and arthropods.

1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi17Divalent metal cation; structural1 Publication1
Metal bindingi58Copper 1; via tele nitrogenCombined sources1
Metal bindingi76Copper 1; via tele nitrogenCombined sources1
Metal bindingi85Copper 1; via tele nitrogenCombined sources1
Metal bindingi195Copper 2; via tele nitrogenCombined sources1
Metal bindingi199Copper 2; via tele nitrogenCombined sources1
Metal bindingi226Copper 2; via tele nitrogenCombined sources1
Metal bindingi478Copper 3; via tele nitrogenCombined sources1
Metal bindingi498Copper 3; via tele nitrogenCombined sources1
Metal bindingi507Copper 3; via tele nitrogenCombined sources1
Metal bindingi618Copper 4; via tele nitrogenCombined sources1
Metal bindingi622Copper 4; via tele nitrogenCombined sources1
Metal bindingi649Copper 4; via tele nitrogenCombined sources1
Metal bindingi737Divalent metal cation; structural1 Publication1
Metal bindingi892Copper 5; via tele nitrogenCombined sources1
Metal bindingi912Copper 5; via tele nitrogenCombined sources1
Metal bindingi921Copper 5; via tele nitrogenCombined sources1
Metal bindingi1031Copper 6; via tele nitrogenCombined sources1
Metal bindingi1035Copper 6; via tele nitrogenCombined sources1
Metal bindingi1062Copper 6; via tele nitrogenCombined sources1
Metal bindingi1309Copper 7; via tele nitrogenCombined sources1
Metal bindingi1327Copper 7; via tele nitrogenCombined sources1
Metal bindingi1336Copper 7; via tele nitrogenCombined sources1
Metal bindingi1440Copper 8; via tele nitrogenCombined sources1
Metal bindingi1444Copper 8; via tele nitrogenCombined sources1
Metal bindingi1471Copper 8; via tele nitrogenCombined sources1
Metal bindingi1721Copper 9; via tele nitrogenCombined sources1
Metal bindingi1741Copper 9; via tele nitrogenCombined sources1
Metal bindingi1750Copper 9; via tele nitrogenCombined sources1
Metal bindingi1863Copper 10; via tele nitrogenCombined sources1
Metal bindingi1867Copper 10; via tele nitrogenCombined sources1
Metal bindingi1894Copper 10; via tele nitrogenCombined sources1
Metal bindingi2138Copper 11; via tele nitrogenCombined sources1
Metal bindingi2157Copper 11; via tele nitrogenCombined sources1
Metal bindingi2166Copper 11; via tele nitrogenCombined sources1
Metal bindingi2276Copper 12; via tele nitrogenCombined sources1
Metal bindingi2280Copper 12; via tele nitrogenCombined sources1
Metal bindingi2307Copper 12; via tele nitrogenCombined sources1
Metal bindingi2424Divalent metal cation; structural1 Publication1
Metal bindingi2558Copper 13; via tele nitrogenCombined sources1
Metal bindingi2577Copper 13; via tele nitrogenCombined sources1
Metal bindingi2586Copper 13; via tele nitrogenCombined sources1
Metal bindingi2686Copper 14; via tele nitrogenCombined sources1
Metal bindingi2690Copper 14; via tele nitrogenCombined sources1
Metal bindingi2717Copper 14; via tele nitrogenCombined sources1
Metal bindingi2962Copper 15; via tele nitrogenCombined sources1
Metal bindingi2981Copper 15; via tele nitrogenCombined sources1
Metal bindingi2990Copper 15; via tele nitrogenCombined sources1
Metal bindingi3091Copper 16; via tele nitrogenCombined sources1
Metal bindingi3095Copper 16; via tele nitrogenCombined sources1
Metal bindingi3122Copper 16; via tele nitrogenCombined sources1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOxygen transport, Transport
LigandCopper, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hemocyanin 1Imported
Alternative name(s):
Keyhole limpet hemocyanin A1 Publication
Short name:
KLH-A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KLH11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMegathura crenulata (Giant keyhole limpet)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri55429 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaSpiraliaLophotrochozoaMolluscaGastropodaVetigastropodaLepetellidaFissurelloideaFissurellidaeMegathura

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the use of a specific protein in the biotechnological industry.<p><a href='/help/biotechnological_use' target='_top'>More...</a></p>Biotechnological usei

Potent immunogen used classically as a carrier protein for haptens and more recently in human vaccines and for immunotherapy of bladder cancer.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000020430417 – 3414Hemocyanin 1Add BLAST3398

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi64 ↔ 73Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki74 ↔ 762'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi185 ↔ 252Combined sources
Cross-linki287 ↔ 2902'-(S-cysteinyl)-histidine (Cys-His)1 Publication
Disulfide bondi339 ↔ 351Combined sources
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi403N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi484 ↔ 495Combined sources
Cross-linki496 ↔ 4982'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Glycosylationi545N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi608 ↔ 674Combined sources
Disulfide bondi898 ↔ 909Combined sources
Cross-linki910 ↔ 9122'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi1021 ↔ 1088Combined sources
Disulfide bondi1178 ↔ 1184Combined sources
Disulfide bondi1315 ↔ 1324Combined sources
Cross-linki1325 ↔ 13272'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi1430 ↔ 1497Combined sources
Disulfide bondi1585 ↔ 1595Combined sources
Glycosylationi1648N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1727 ↔ 1738Combined sources
Cross-linki1739 ↔ 17412'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi1853 ↔ 1920Combined sources
Disulfide bondi2009 ↔ 2015Combined sources
Disulfide bondi2144 ↔ 2154Combined sources
Glycosylationi2145N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Cross-linki2155 ↔ 21572'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi2266 ↔ 2333Combined sources
Disulfide bondi2420 ↔ 2426Combined sources
Disulfide bondi2564 ↔ 2574Combined sources
Glycosylationi2571N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Cross-linki2575 ↔ 25772'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi2676 ↔ 2743Combined sources
Disulfide bondi2830 ↔ 2836Combined sources
Disulfide bondi2968 ↔ 2978Combined sources
Cross-linki2979 ↔ 29812'-(S-cysteinyl)-histidine (Cys-His)By similarity1 Publication
Disulfide bondi3081 ↔ 3148Combined sources
Glycosylationi3278N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3367 ↔ 3400Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Probably N-glycosylated (Probable). Asn-1280 and Asn-2484 are buried deeply in the protein which make them inaccessible for sugar attachment (Probable). Asn-3278 N-glycan is likely to represent a diantennate carbohydrate tree (Probable). The didecamer is almost evenly tagged by a total of 120 sugar trees (Probable).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Thioether bond

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
211, 15 N-Linked glycans

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Hemolymph.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homo-didecamer, with two decamers assembled face-to-face at their open ends. This didecamer form a stable 25 nM cylinder wall.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q10583

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati628 – 669WD 1Sequence analysisAdd BLAST42
Repeati1041 – 1082WD 2Sequence analysisAdd BLAST42
Repeati1450 – 1491WD 3Sequence analysisAdd BLAST42
Repeati1873 – 1914WD 4Sequence analysisAdd BLAST42
Repeati2163 – 2199WD 5Sequence analysisAdd BLAST37
Repeati2696 – 2737WD 6Sequence analysisAdd BLAST42
Repeati3101 – 3142WD 7Sequence analysisAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 437Functional unit a (wall)1 PublicationAdd BLAST421
Regioni438 – 851Functional unit b (wall)1 PublicationAdd BLAST414
Regioni852 – 1271Functional unit c (wall)1 PublicationAdd BLAST420
Regioni1272 – 1680Functional unit d (wall)1 PublicationAdd BLAST409
Regioni1681 – 2097Functional unit e (wall)1 PublicationAdd BLAST417
Regioni2098 – 2517Functional unit f (wall)1 PublicationAdd BLAST420
Regioni2518 – 2921Functional unit g (internal arc)1 PublicationAdd BLAST404
Regioni2922 – 3414Functional unit h (internal slab)1 PublicationAdd BLAST493

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein is composed of 8 globular functional units (a->h), forming a 'pearl chain'. Each unit is separated from the next by a linker. Since the lengths but not the exact positions are known, lengths are indicated here in free text. Linker lengths in amino acids are: 20 (a->b), 13 (b->c), 19 (c->d), 16 (d->e), 14 (e->f), 17 (f->g), and 17 (g->h).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tyrosinase family. Hemocyanin subfamily.Curated

Keywords - Domaini

Repeat, Signal, WD repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1280.10, 8 hits
2.60.310.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028999, Haemocyanin_beta-sandwich
IPR036848, Haemocyanin_C_sf
IPR002227, Tyrosinase_Cu-bd
IPR008922, Unchr_di-copper_centre

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14830, Haemocyan_bet_s, 8 hits
PF00264, Tyrosinase, 9 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00092, TYROSINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48056, SSF48056, 8 hits
SSF81277, SSF81277, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00497, TYROSINASE_1, 7 hits
PS00498, TYROSINASE_2, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q10583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSVRLLIVV LALANAENLV RKSVEHLTQE ETLDLQAALR ELQMDSSSIG
60 70 80 90 100
FQKIAAAHGA PASCVHKDTS IACCIHGMPT FPHWHRAYVV HMERALQTKR
110 120 130 140 150
RTSGLPYWDW TEPITQLPSL AADPVYIDSQ GGKAHTNYWY RGNIDFLDKK
160 170 180 190 200
TNRAVDDRLF EKVKPGQHTH LMESVLDALE QDEFCKFEIQ FELAHNAIHY
210 220 230 240 250
LVGGKHDYSM ANLEYTAYDP IFFLHHSNVD RIFAIWQRLQ ELRNKDPKAM
260 270 280 290 300
DCAQELLHQK MEPFSWEDND IPLTNEHSTP ADLFDYCELH YDYDTLNLNG
310 320 330 340 350
MTPEELKTYL DERSSRARAF ASFRLKGFGG SANVFVYVCI PDDNDRNDDH
360 370 380 390 400
CEKAGDFFVL GGPSEMKWQF YRPYLFDLSD TVHKMGMKLD GHYTVKAELF
410 420 430 440 450
SVNGTALPDD LLPHPVVVHH PEKGFTDPPV KHHQSANLLV RKNINDLTRE
460 470 480 490 500
EVLNLREAFH KFQEDRSVDG YQATAEYHGL PARCPRPDAK DRYACCVHGM
510 520 530 540 550
PIFPHWHRLF VTQVEDALVG RGATIGIPYW DWTEPMTHIP GLAGNKTYVD
560 570 580 590 600
SHGASHTNPF HSSVIAFEEN APHTKRQIDQ RLFKPATFGH HTDLFNQILY
610 620 630 640 650
AFEQEDYCDF EVQFEITHNT IHAWTGGSEH FSMSSLHYTA FDPLFYFHHS
660 670 680 690 700
NVDRLWAVWQ ALQMRRHKPY RAHCAISLEH MHLKPFAFSS PLNNNEKTHA
710 720 730 740 750
NAMPNKIYDY ENVLHYTYED LTFGGISLEN IEKMIHENQQ EDRIYAGFLL
760 770 780 790 800
AGIRTSANVD IFIKTTDSVQ HKAGTFAVLG GSKEMKWGFD RVFKFDITHV
810 820 830 840 850
LKDLDLTADG DFEVTVDITE VDGTKLASSL IPHASVIREH ARVKFDKVPR
860 870 880 890 900
SRLIRKNVDR LSPEEMNELR KALALLKEDK SAGGFQQLGA FHGEPKWCPS
910 920 930 940 950
PEASKKFACC VHGMSVFPHW HRLLTVQSEN ALRRHGYDGA LPYWDWTSPL
960 970 980 990 1000
NHLPELADHE KYVDPEDGVE KHNPWFDGHI DTVDKTTTRS VQNKLFEQPE
1010 1020 1030 1040 1050
FGHYTSIAKQ VLLALEQDNF CDFEIQYEIA HNYIHALVGG AQPYGMASLR
1060 1070 1080 1090 1100
YTAFDPLFYL HHSNTDRIWA IWQALQKYRG KPYNVANCAV TSMREPLQPF
1110 1120 1130 1140 1150
GLSANINTDH VTKEHSVPFN VFDYKTNFNY EYDTLEFNGL SISQLNKKLE
1160 1170 1180 1190 1200
AIKSQDRFFA GFLLSGFKKS SLVKFNICTD SSNCHPAGEF YLLGDENEMP
1210 1220 1230 1240 1250
WAYDRVFKYD ITEKLHDLKL HAEDHFYIDY EVFDLKPASL GKDLFKQPSV
1260 1270 1280 1290 1300
IHEPRIGHHE GEVYQAEVTS ANRIRKNIEN LSLGELESLR AAFLEIENDG
1310 1320 1330 1340 1350
TYESIAKFHG SPGLCQLNGN PISCCVHGMP TFPHWHRLYV VVVENALLKK
1360 1370 1380 1390 1400
GSSVAVPYWD WTKRIEHLPH LISDATYYNS RQHHYETNPF HHGKITHENE
1410 1420 1430 1440 1450
ITTRDPKDSL FHSDYFYEQV LYALEQDNFC DFEIQLEILH NALHSLLGGK
1460 1470 1480 1490 1500
GKYSMSNLDY AAFDPVFFLH HATTDRIWAI WQDLQRFRKR PYREANCAIQ
1510 1520 1530 1540 1550
LMHTPLQPFD KSDNNDEATK THATPHDGFE YQNSFGYAYD NLELNHYSIP
1560 1570 1580 1590 1600
QLDHMLQERK RHDRVFAGFL LHNIGTSADG HVFVCLPTGE HTKDCSHEAG
1610 1620 1630 1640 1650
MFSILGGQTE MSFVFDRLYK LDITKALKKN GVHLQGDFDL EIEITAVNGS
1660 1670 1680 1690 1700
HLDSHVIHSP TILFEAGTDS AHTDDGHTEP VMIRKDITQL DKRQQLSLVK
1710 1720 1730 1740 1750
ALESMKADHS SDGFQAIASF HALPPLCPSP AASKRFACCV HGMATFPQWH
1760 1770 1780 1790 1800
RLYTVQFQDS LRKHGAVVGL PYWDWTLPRS ELPELLTVST IHDPETGRDI
1810 1820 1830 1840 1850
PNPFIGSKIE FEGENVHTKR DINRDRLFQG STKTHHNWFI EQALLALEQT
1860 1870 1880 1890 1900
NYCDFEVQFE IMHNGVHTWV GGKEPYGIGH LHYASYDPLF YIHHSQTDRI
1910 1920 1930 1940 1950
WAIWQSLQRF RGLSGSEANC AVNLMKTPLK PFSFGAPYNL NDHTHDFSKP
1960 1970 1980 1990 2000
EDTFDYQKFG YIYDTLEFAG WSIRGIDHIV RNRQEHSRVF AGFLLEGFGT
2010 2020 2030 2040 2050
SATVDFQVCR TAGDCEDAGY FTVLGGEKEM PWAFDRLYKY DITETLDKMN
2060 2070 2080 2090 2100
LRHDEIFQIE VTITSYDGTV LDSGLIPTPS IIYDPAHHDI SSHHLSLNKV
2110 2120 2130 2140 2150
RHDLSTLSER DIGSLKYALS SLQADTSADG FAAIASFHGL PAKCNDSHNN
2160 2170 2180 2190 2200
EVACCIHGMP TFPHWHRLYT LQFEQALRRH GSSVAVPYWD WTKPIHNIPH
2210 2220 2230 2240 2250
LFTDKEYYDV WRNKVMPNPF ARGYVPSHDT YTVRDVQEGL FHLTSTGEHS
2260 2270 2280 2290 2300
ALLNQALLAL EQHDYCDFAV QFEVMHNTIH YLVGGPQVYS LSSLHYASYD
2310 2320 2330 2340 2350
PIFFIHHSFV DKVWAVWQAL QEKRGLPSDR ADCAVSLMTQ NMRPFHYEIN
2360 2370 2380 2390 2400
HNQFTKKHAV PNDVFKYELL GYRYDNLEIG GMNLHEIEKE IKDKQHHVRV
2410 2420 2430 2440 2450
FAGFLLHGIR TSADVQFQIC KTSEDCHHGG QIFVLGGTKE MAWAYNRLFK
2460 2470 2480 2490 2500
YDITHALHDA HITPEDVFHP SEPFFIKVSV TAVNGTVLPA SILHAPTIIY
2510 2520 2530 2540 2550
EPGLDHHEDH HSSSMAGHGV RKEINTLTTA EVDNLKDAMR AVMADHGPNG
2560 2570 2580 2590 2600
YQAIAAFHGN PPMCPMPDGK NYSCCTHGMA TFPHWHRLYT KQMEDALTAH
2610 2620 2630 2640 2650
GARVGLPYWD GTTAFTALPT FVTDEEDNPF HHGHIDYLGV DTTRSPRDKL
2660 2670 2680 2690 2700
FNDPERGSES FFYRQVLLAL EQTDFCQFEV QFEITHNAIH SWTGGLTPYG
2710 2720 2730 2740 2750
MSTLEYTTYD PLFWLHHANT DRIWAIWQAL QEYRGLPYDH ANCEIQAMKR
2760 2770 2780 2790 2800
PLRPFSDPIN HNAFTHSNAK PTDVFEYSRF NFQYDNLRFH GMTIKKLEHE
2810 2820 2830 2840 2850
LEKQKEEDRT FAAFLLHGIK KSADVSFDVC NHDGECHFAG TFAILGGEHE
2860 2870 2880 2890 2900
MPWSFDRLFR YDITQVLKQM HLEYDSDFTF HMRIIDTSGK QLPSDLIKMP
2910 2920 2930 2940 2950
TVEHSPGGKH HEKHHEDHHE DILVRKNIHS LSHHEAEELR DALYKLQNDE
2960 2970 2980 2990 3000
SHGGYEHIAG FHGYPNLCPE KGDEKYPCCV HGMSIFPHWH RLHTIQFERA
3010 3020 3030 3040 3050
LKKHGSHLGI PYWDWTQTIS SLPTFFADSG NNNPFFKYHI RSINQDTVRD
3060 3070 3080 3090 3100
VNEAIFQQTK FGEFSSIFYL ALQALEEDNY CDFEVQYEIL HNEVHALIGG
3110 3120 3130 3140 3150
AEKYSMSTLE YSAFDPYFMI HHASLDKIWI IWQELQKRRV KPAHAGSCAG
3160 3170 3180 3190 3200
DIMHVPLHPF NYESVNNDDF TRENSLPNAV VDSHRFNYKY DNLNLHGHNI
3210 3220 3230 3240 3250
EELEEVLRSL RLKSRVFAGF VLSGIRTTAV VKVYIKSGTD SDDEYAGSFV
3260 3270 3280 3290 3300
ILGGAKEMPW AYERLYRFDI TETVHNLNLT DDHVKFRFDL KKYDHTELDA
3310 3320 3330 3340 3350
SVLPAPIIVR RPNNAVFDII EIPIGKDVNL PPKVVVKRGT KIMFMSVDEA
3360 3370 3380 3390 3400
VTTPMLNLGS YTAMFKCKVP PFSFHAFELG KMYSVESGDY FMTASTTELC
3410
NDNNLRIHVH VDDE
Length:3,414
Mass (Da):392,246
Last modified:June 17, 2020 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1DE70B29A343AD01
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAG28307 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAG28309 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti17E → G AA sequence (PubMed:8829804).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ698341 Genomic DNA Translation: CAG28309.2 Sequence problems.
AJ698339 mRNA Translation: CAG28307.2 Sequence problems.

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ698341 Genomic DNA Translation: CAG28309.2 Sequence problems.
AJ698339 mRNA Translation: CAG28307.2 Sequence problems.

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3L6WX-ray4.00A/B2922-3412[»]
3QJOX-ray4.00A/B2922-3412[»]
4BEDelectron microscopy9.00A/C17-1680[»]
B/D1681-3414[»]
SMRiQ10583
ModBaseiSearch...
PDBe-KBiSearch...

PTM databases

GlyConnecti211, 15 N-Linked glycans

Family and domain databases

Gene3Di1.10.1280.10, 8 hits
2.60.310.10, 8 hits
InterProiView protein in InterPro
IPR028999, Haemocyanin_beta-sandwich
IPR036848, Haemocyanin_C_sf
IPR002227, Tyrosinase_Cu-bd
IPR008922, Unchr_di-copper_centre
PfamiView protein in Pfam
PF14830, Haemocyan_bet_s, 8 hits
PF00264, Tyrosinase, 9 hits
PRINTSiPR00092, TYROSINASE
SUPFAMiSSF48056, SSF48056, 8 hits
SSF81277, SSF81277, 8 hits
PROSITEiView protein in PROSITE
PS00497, TYROSINASE_1, 7 hits
PS00498, TYROSINASE_2, 8 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCY1_MEGCR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10583
Secondary accession number(s): Q53IP9, Q6KC56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: June 17, 2020
Last modified: February 23, 2022
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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