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Entry version 124 (12 Aug 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Protein SWAP

Gene

swp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

It is a regulator of pre-mRNA splicing (and, possibly, of other RNA processing events). It may regulate its own expression at the level of RNA processing.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein SWAP
Alternative name(s):
Suppressor of white apricot protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:swp-1
Synonyms:swap
ORF Names:B0336.9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
B0336.9a ; CE31143 ; WBGene00006359 ; swp-1
B0336.9b ; CE30068 ; WBGene00006359 ; swp-1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000723411 – 749Protein SWAPAdd BLAST749

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q10580

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10580

PeptideAtlas

More...
PeptideAtlasi
Q10580

PRoteomics IDEntifications database

More...
PRIDEi
Q10580

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006359, Expressed in germ line (C elegans) and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q10580, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-26070N

Protein interaction database and analysis system

More...
IntActi
Q10580, 1 interactor

Molecular INTeraction database

More...
MINTi
Q10580

STRING: functional protein association networks

More...
STRINGi
6239.B0336.9d

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q10580

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati166 – 209SURP motif 1Add BLAST44
Repeati391 – 431SURP motif 2Add BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni8 – 124Dry CEEERYLAdd BLAST117

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi688 – 749Arg/Lys/Ser-rich (highly basic)Add BLAST62

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1847, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10580

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.790, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000061, Surp
IPR040397, SWAP
IPR035967, SWAP/Surp_sf
IPR019147, SWAP_N_domain

The PANTHER Classification System

More...
PANTHERi
PTHR13161, PTHR13161, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09750, DRY_EERY, 1 hit
PF01805, Surp, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01141, DRY_EERY, 1 hit
SM00648, SWAP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109905, SSF109905, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50128, SURP, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform a (identifier: Q10580-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPCNCFKSNV HVQEYKDLLV FGYASTIFPN DYQSEHIAEE RHTVPCLGDP
60 70 80 90 100
ENRVDRYDCR LLLPSIDVAI KRNGSPSEQC PTEAMEEDMC EEERYLDMYK
110 120 130 140 150
DIQREQEKEE EEKRRNDQRN AIGFDYGTGK VKARESDSED EPFEPPEGIK
160 170 180 190 200
FPVGLELPSN MKLHHIIEKT ASFIVANGTQ MEIVIKAKQR NNAEQFGFLE
210 220 230 240 250
FDHRLNPFYK YLQKLIREKK YIPDLNKRPK KLTKTSRAST SKPAISSSLA
260 270 280 290 300
AIAAAHGSDS EDSDSDYELH PSLLSGGAKR PVTPEKPGAI GPRKKPVEPE
310 320 330 340 350
KPPDFTLKPV GDISQRNDVY AALFKNLAHV TRQAAGVEEV KMNVEEAKKE
360 370 380 390 400
KENDHLDDPE YREWYENFYG RPCPWIGPRP MIPATPDLEP ILNSYAEHVA
410 420 430 440 450
QRGLEAEASL AAREDLQLHF MEPKSPYYSY YHHKVRMHQW RMYQPIEQNL
460 470 480 490 500
SPLVLNSPAP PSAVSSPGPS SLMSLNLSTP EPPLNRRQRR RLLDSSRLDE
510 520 530 540 550
SITEPGVIDP ITMLQIPKSV STPANLDILK TPISFSLRND EPRDESSFRF
560 570 580 590 600
DPDLDETAGP SDTTANFSDI SGLFPPPTPP VIPPSTQMQV DRKEKARIFM
610 620 630 640 650
EKLLQEKKAK KLQEEEERSK LEEETRKKAE KISESLSERK NTGRSDRREE
660 670 680 690 700
APKGARSLDE IINNRINSLL SESGFEPVEE MKRTDEDRER KRHRKRSRSR
710 720 730 740
RRSRSCSPRD RSREHKKSRK SGRHHRSRSR SSSRDRHRRN RSRSRDRRR
Length:749
Mass (Da):86,310
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F2627E37CD1C590
GO
Isoform b (identifier: Q10580-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
     514-515: Missing.

Show »
Length:663
Mass (Da):76,514
Checksum:iB0EBFF4E9B96D7FD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8MPQ0Q8MPQ0_CAEEL
Protein SWAP
swp-1 B0336.9, CELE_B0336.9
751Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H2KY77H2KY77_CAEEL
DRY_EERY domain-containing protein
swp-1 B0336.9, CELE_B0336.9
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H2KY78H2KY78_CAEEL
DRY_EERY domain-containing protein
swp-1 B0336.9, CELE_B0336.9
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0044381 – 84Missing in isoform b. CuratedAdd BLAST84
Alternative sequenceiVSP_004439514 – 515Missing in isoform b. Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U06932 mRNA Translation: AAA64937.1
U06933 Genomic DNA Translation: AAA64938.1
FO080138 Genomic DNA Translation: CCD61525.1
FO080138 Genomic DNA Translation: CCD61526.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S53765, S50095

NCBI Reference Sequences

More...
RefSeqi
NP_001021120.1, NM_001025949.4
NP_741149.1, NM_171132.3 [Q10580-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
B0336.9a.1; B0336.9a.1; WBGene00006359 [Q10580-1]
B0336.9b.1; B0336.9b.1; WBGene00006359 [Q10580-2]
B0336.9b.2; B0336.9b.2; WBGene00006359 [Q10580-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
175795

UCSC genome browser

More...
UCSCi
B0336.9b.1, c. elegans [Q10580-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06932 mRNA Translation: AAA64937.1
U06933 Genomic DNA Translation: AAA64938.1
FO080138 Genomic DNA Translation: CCD61525.1
FO080138 Genomic DNA Translation: CCD61526.1
PIRiS53765, S50095
RefSeqiNP_001021120.1, NM_001025949.4
NP_741149.1, NM_171132.3 [Q10580-1]

3D structure databases

SMRiQ10580
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-26070N
IntActiQ10580, 1 interactor
MINTiQ10580
STRINGi6239.B0336.9d

Proteomic databases

EPDiQ10580
PaxDbiQ10580
PeptideAtlasiQ10580
PRIDEiQ10580

Genome annotation databases

EnsemblMetazoaiB0336.9a.1; B0336.9a.1; WBGene00006359 [Q10580-1]
B0336.9b.1; B0336.9b.1; WBGene00006359 [Q10580-2]
B0336.9b.2; B0336.9b.2; WBGene00006359 [Q10580-2]
GeneIDi175795
UCSCiB0336.9b.1, c. elegans [Q10580-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
175795
WormBaseiB0336.9a ; CE31143 ; WBGene00006359 ; swp-1
B0336.9b ; CE30068 ; WBGene00006359 ; swp-1

Phylogenomic databases

eggNOGiKOG1847, Eukaryota
InParanoidiQ10580

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10580

Gene expression databases

BgeeiWBGene00006359, Expressed in germ line (C elegans) and 5 other tissues
ExpressionAtlasiQ10580, baseline and differential

Family and domain databases

Gene3Di1.10.10.790, 2 hits
InterProiView protein in InterPro
IPR000061, Surp
IPR040397, SWAP
IPR035967, SWAP/Surp_sf
IPR019147, SWAP_N_domain
PANTHERiPTHR13161, PTHR13161, 1 hit
PfamiView protein in Pfam
PF09750, DRY_EERY, 1 hit
PF01805, Surp, 2 hits
SMARTiView protein in SMART
SM01141, DRY_EERY, 1 hit
SM00648, SWAP, 2 hits
SUPFAMiSSF109905, SSF109905, 2 hits
PROSITEiView protein in PROSITE
PS50128, SURP, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSWAP_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10580
Secondary accession number(s): Q17484, Q8WQH0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: August 12, 2020
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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