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Entry version 123 (23 Feb 2022)
Sequence version 1 (01 Oct 1996)
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Protein

Cleavage and polyadenylation specificity factor subunit 1

Gene

CPSF1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity).

May play a role in eye morphogenesis and the development of retinal ganglion cell projections to the midbrain (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • mRNA polyadenylation Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cleavage and polyadenylation specificity factor subunit 1
Alternative name(s):
Cleavage and polyadenylation specificity factor 160 kDa subunit
Short name:
CPSF 160 kDa subunit
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CPSF1
Synonyms:CPSF160
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBos taurus (Bovine)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9913 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaArtiodactylaRuminantiaPecoraBovidaeBovinaeBos
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000009136 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000743861 – 1444Cleavage and polyadenylation specificity factor subunit 1Add BLAST1444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei757PhosphoserineBy similarity1
Modified residuei767PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The N-terminus is blocked.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10569

PRoteomics IDEntifications database

More...
PRIDEi
Q10569

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSBTAG00000008355, Expressed in leukocyte and 97 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1.

Found in a complex with CPSF1, FIP1L1 and PAPOLA.

Interacts with FIP1L1, TENT2/GLD2 and SRRM1.

Interacts with TUT1; the interaction is direct and mediates the recruitment of the CPSF complex on the 3'UTR of selected pre-mRNAs (By similarity).

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q10569, 1 interactor

Molecular INTeraction database

More...
MINTi
Q10569

STRING: functional protein association networks

More...
STRINGi
9913.ENSBTAP00000011004

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q10569

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni406 – 439DisorderedSequence analysisAdd BLAST34
Regioni549 – 571DisorderedSequence analysisAdd BLAST23
Regioni716 – 778DisorderedSequence analysisAdd BLAST63
Regioni902 – 924DisorderedSequence analysisAdd BLAST23

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi894 – 909Nuclear localization signalSequence analysisAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi411 – 426Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi902 – 919Basic and acidic residuesSequence analysisAdd BLAST18

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CPSF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1896, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002414_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10569

Database of Orthologous Groups

More...
OrthoDBi
360328at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314322

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR018846, Cleavage/polyA-sp_fac_asu_N
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03178, CPSF_A, 1 hit
PF10433, MMS1_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q10569-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYAVYKQAHP PTGLEFSMYC NFFNNSERNL VVAGTSQLYV YRLNRDSEAP
60 70 80 90 100
TKNDRSTDGK AHREHREKLE LVASFSFFGN VMSMASVQLA GAKRDALLLS
110 120 130 140 150
FKDAKLSVVE YDPGTHDLKT LSLHYFEEPE LRDGFVQNVH TPRVRVDPDG
160 170 180 190 200
RCAAMLIYGT RLVVLPFRRE SLAEEHEGLV GEGQRSSFLP SYIIDVRALD
210 220 230 240 250
EKLLNIVDLQ FLHGYYEPTL LILFEPNQTW PGRVAVRQDT CSIVAISLNI
260 270 280 290 300
TQKVHPVIWS LTSLPFDCTQ ALAVPKPIGG VVIFAVNSLL YLNQSVPPYG
310 320 330 340 350
VALNSLTTGT TAFPLRTQEG VRITLDCAQA AFISYDKMVI SLKGGEIYVL
360 370 380 390 400
TLITDGMRSV RAFHFDKAAA SVLTTSMVTM EPGYLFLGSR LGNSLLLKYT
410 420 430 440 450
EKLQEPPAST AREAADKEEP PSKKKRVDAT TGWSGSKSVP QDEVDEIEVY
460 470 480 490 500
GSEAQSGTQL ATYSFEVCDS ILNIGPCANA AMGEPAFLSE EFQNSPEPDL
510 520 530 540 550
EIVVCSGYGK NGALSVLQKS IRPQVVTTFE LPGCYDMWTV IAPVRKEQEE
560 570 580 590 600
TLKGEGTEPE PGAPEAEDDG RRHGFLILSR EDSTMILQTG QEIMELDASG
610 620 630 640 650
FATQGPTVFA GNIGDNRYIV QVSPLGIRLL EGVNQLHFIP VDLGSPIVQC
660 670 680 690 700
AVADPYVVIM SAEGHVTMFL LKNDSYGGRH HRLALHKPPL HHQSKVITLC
710 720 730 740 750
VYRDVSGMFT TESRLGGVRD ELGGRGGPEA EGQGAETSPT VDDEEEMLYG
760 770 780 790 800
DSGSLFSPSK EEARRSSQPP ADRDPAPFRA EPTHWCLLVR ENGAMEIYQL
810 820 830 840 850
PDWRLVFLVK NFPVGQRVLV DSSFGQPTTQ GEARKEEATR QGELPLVKEV
860 870 880 890 900
LLVALGSRQR RPYLLVHVDQ ELLIYEAFPH DSQLGQGNLK VRFKKVPHNI
910 920 930 940 950
NFREKKPKPS KKKAEGGSTE EGTGPRGRVA RFRYFEDIYG YSGVFICGPS
960 970 980 990 1000
PHWLLVTGRG ALRLHPMGID GPIDSFAPFH NINCPRGFLY FNRQGELRIS
1010 1020 1030 1040 1050
VLPAYLSYDA PWPVRKIPLR CTAHYVAYHV ESKVYAVATS TSTPCTRVPR
1060 1070 1080 1090 1100
MTGEEKEFET IERDERYVHP QQEAFCIQLI SPVSWEAIPN ARIELEEWEH
1110 1120 1130 1140 1150
VTCMKTVSLR SEETVSGLKG YVAAGTCLMQ GEEVTCRGRI LIMDVIEVVP
1160 1170 1180 1190 1200
EPGQPLTKNK FKVLYEKEQK GPVTALCHCN GHLVSAIGQK IFLWSLRASE
1210 1220 1230 1240 1250
LTGMAFIDTQ LYIHQMISVK NFILAADVMK SISLLRYQEE SKTLSLVSRD
1260 1270 1280 1290 1300
AKPLEVYSVD FMVDNAQLGF LVSDRDRNLM VYMYLPEAKE SFGGMRLLRR
1310 1320 1330 1340 1350
ADFHVGAHVN TFWRTPCRGA AEGPSKKSVV WENKHITWFA TLDGGIGLLL
1360 1370 1380 1390 1400
PMQEKTYRRL LMLQNALTTM LPHHAGLNPR AFRMLHVDRR VLQNAVRNVL
1410 1420 1430 1440
DGELLNRYLY LSTMERGELA KKIGTTPDII LDDLLETDRV TAHF
Length:1,444
Mass (Da):161,214
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i226B3A4F9812E0FA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X83097 mRNA Translation: CAA58152.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S57335

NCBI Reference Sequences

More...
RefSeqi
NP_777145.1, NM_174720.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
282703

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bta:282703

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83097 mRNA Translation: CAA58152.1
PIRiS57335
RefSeqiNP_777145.1, NM_174720.3

3D structure databases

SMRiQ10569
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ10569, 1 interactor
MINTiQ10569
STRINGi9913.ENSBTAP00000011004

Proteomic databases

PaxDbiQ10569
PRIDEiQ10569

Genome annotation databases

GeneIDi282703
KEGGibta:282703

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
29894

Phylogenomic databases

eggNOGiKOG1896, Eukaryota
HOGENOMiCLU_002414_0_0_1
InParanoidiQ10569
OrthoDBi360328at2759
TreeFamiTF314322

Gene expression databases

BgeeiENSBTAG00000008355, Expressed in leukocyte and 97 other tissues

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR004871, Cleavage/polyA-sp_fac_asu_C
IPR018846, Cleavage/polyA-sp_fac_asu_N
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF03178, CPSF_A, 1 hit
PF10433, MMS1_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCPSF1_BOVIN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10569
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 23, 2022
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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