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Protein

AP-1 complex subunit beta-1

Gene

AP1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

GO - Molecular functioni

  • clathrin binding Source: InterPro
  • protein kinase binding Source: ParkinsonsUK-UCL
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295 MHC class II antigen presentation
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis

Protein family/group databases

TCDBi9.B.278.1.1 the organellar-targeting adaptor protein complex (o-apc) family

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit beta-1
Alternative name(s):
Adaptor protein complex AP-1 subunit beta-1
Adaptor-related protein complex 1 subunit beta-1
Beta-1-adaptin
Beta-adaptin 1
Clathrin assembly protein complex 1 beta large chain
Golgi adaptor HA1/AP1 adaptin beta subunit
Gene namesi
Name:AP1B1
Synonyms:ADTB1, BAM22, CLAPB2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100280.16
HGNCiHGNC:554 AP1B1
MIMi600157 gene
neXtProtiNX_Q10567

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi162
PharmGKBiPA24844

Polymorphism and mutation databases

BioMutaiAP1B1
DMDMi290457628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937381 – 949AP-1 complex subunit beta-1Add BLAST949

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318N6-acetyllysineCombined sources1
Modified residuei574Nitrated tyrosineBy similarity1

Keywords - PTMi

Acetylation, Nitration

Proteomic databases

EPDiQ10567
MaxQBiQ10567
PaxDbiQ10567
PeptideAtlasiQ10567
PRIDEiQ10567
ProteomicsDBi58857
58858 [Q10567-2]
58859 [Q10567-3]

PTM databases

iPTMnetiQ10567
PhosphoSitePlusiQ10567
SwissPalmiQ10567

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiENSG00000100280 Expressed in 228 organ(s), highest expression level in prostate gland
CleanExiHS_AP1B1
ExpressionAtlasiQ10567 baseline and differential
GenevisibleiQ10567 HS

Organism-specific databases

HPAiHPA065226
HPA068520

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).

Binary interactionsi

WithEntry#Exp.IntActNotes
Ap1m1P355855EBI-1171303,EBI-1040251From Mus musculus.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106671, 86 interactors
CORUMiQ10567
DIPiDIP-24207N
ELMiQ10567
IntActiQ10567, 62 interactors
MINTiQ10567
STRINGi9606.ENSP00000350199

Structurei

Secondary structure

1949
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ10567
SMRiQ10567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi576 – 725Pro-rich (stalk region)Add BLAST150

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1061 Eukaryota
COG5096 LUCA
HOGENOMiHOG000163270
HOVERGENiHBG050515
InParanoidiQ10567
KOiK12392
OrthoDBiEOG091G019U
PhylomeDBiQ10567
TreeFamiTF300318

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR026739 AP_beta
IPR016342 AP_complex_bsu_1_2_4
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR015151 B-adaptin_app_sub_C
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf
PANTHERiPTHR11134 PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PF09066 B2-adapt-app_C, 1 hit
PIRSFiPIRSF002291 AP_complex_beta, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SM00185 ARM, 2 hits
SM01020 B2-adapt-app_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q10567-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL
60 70 80 90 100
FPDVVNCMQT DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP
110 120 130 140 150
LIRALAVRTM GCIRVDKITE YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD
160 170 180 190 200
INAQLVEDQG FLDTLKDLIS DSNPMVVANA VAALSEIAES HPSSNLLDLN
210 220 230 240 250
PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI CERVTPRLSH
260 270 280 290 300
ANSAVVLSAV KVLMKFMEML SKDLDYYGTL LKKLAPPLVT LLSAEPELQY
310 320 330 340 350
VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN
360 370 380 390 400
IAQVLAELKE YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ
410 420 430 440 450
TKVNYVVQEA IVVIKDIFRK YPNKYESVIA TLCENLDSLD EPEARAAMIW
460 470 480 490 500
IVGEYAERID NADELLESFL EGFHDESTQV QLQLLTAIVK LFLKKPTETQ
510 520 530 540 550
ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV VLAEKPLISE
560 570 580 590 600
ETDLIEPTLL DELICYIGTL ASVYHKPPSA FVEGGRGVVH KSLPPRTASS
610 620 630 640 650
ESAESPETAP TGAPPGEQPD VIPAQGDLLG DLLNLDLGPP VSGPPLATSS
660 670 680 690 700
VQMGAVDLLG GGLDSLMGDE PEGIGGTNFV APPTAAVPAN LGAPIGSGLS
710 720 730 740 750
DLFDLTSGVG TLSGSYVAPK AVWLPAMKAK GLEISGTFTR QVGSISMDLQ
760 770 780 790 800
LTNKALQVMT DFAIQFNRNS FGLAPATPLQ VHAPLSPNQT VEISLPLSTV
810 820 830 840 850
GSVMKMEPLN NLQVAVKNNI DVFYFSTLYP LHILFVEDGK MDRQMFLATW
860 870 880 890 900
KDIPNENEAQ FQIRDCPLNA EAASSKLQSS NIFTVAKRNV EGQDMLYQSL
910 920 930 940
KLTNGIWVLA ELRIQPGNPS CTDLELSLKC RAPEVSQHVY QAYETILKN
Length:949
Mass (Da):104,637
Last modified:March 2, 2010 - v2
Checksum:iFE1BA762F9318585
GO
Isoform B (identifier: Q10567-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-673: Missing.

Show »
Length:942
Mass (Da):103,921
Checksum:i2DB97E5FBB283A38
GO
Isoform C (identifier: Q10567-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-673: Missing.
     923-925: Missing.

Show »
Length:939
Mass (Da):103,564
Checksum:iD8817293C15BD8E4
GO
Isoform 4 (identifier: Q10567-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     667-673: Missing.
     722-741: Missing.
     923-925: Missing.

Note: No experimental confirmation available.
Show »
Length:919
Mass (Da):101,348
Checksum:iAC046601DF0170D3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J1E7C9J1E7_HUMAN
AP-1 complex subunit beta-1
AP1B1
578Annotation score:
H7C034H7C034_HUMAN
AP-1 complex subunit beta-1
AP1B1
173Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062816777T → A4 PublicationsCorresponds to variant dbSNP:rs2857465Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_000163667 – 673Missing in isoform B, isoform C and isoform 4. 3 Publications7
Alternative sequenceiVSP_044928722 – 741Missing in isoform 4. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_038753923 – 925Missing in isoform C and isoform 4. 2 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13939 mRNA Translation: AAC98702.1
CT841508 mRNA Translation: CAJ86438.1
AC000041 Genomic DNA No translation available.
AC002059 Genomic DNA No translation available.
BC046242 mRNA Translation: AAH46242.1
U36268
, U36250, U36251, U36252, U36253, U36254, U36255, U36256, U36257, U36258, U36259, U36260, U36261, U36262, U36263, U36264, U36265, U36266, U36267, AF379038, AF379039 Genomic DNA Translation: AAC50684.2
L48038 Genomic DNA No translation available.
CCDSiCCDS13855.1 [Q10567-1]
CCDS13856.2 [Q10567-3]
CCDS54515.1 [Q10567-4]
PIRiI54360
RefSeqiNP_001118.3, NM_001127.3
NP_001159491.1, NM_001166019.1
NP_663782.2, NM_145730.2
UniGeneiHs.368794

Genome annotation databases

EnsembliENST00000317368; ENSP00000319361; ENSG00000100280
ENST00000357586; ENSP00000350199; ENSG00000100280
ENST00000402502; ENSP00000386071; ENSG00000100280
ENST00000405198; ENSP00000384194; ENSG00000100280
ENST00000415447; ENSP00000387612; ENSG00000100280
ENST00000432560; ENSP00000400065; ENSG00000100280
GeneIDi162
KEGGihsa:162
UCSCiuc003afi.4 human [Q10567-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13939 mRNA Translation: AAC98702.1
CT841508 mRNA Translation: CAJ86438.1
AC000041 Genomic DNA No translation available.
AC002059 Genomic DNA No translation available.
BC046242 mRNA Translation: AAH46242.1
U36268
, U36250, U36251, U36252, U36253, U36254, U36255, U36256, U36257, U36258, U36259, U36260, U36261, U36262, U36263, U36264, U36265, U36266, U36267, AF379038, AF379039 Genomic DNA Translation: AAC50684.2
L48038 Genomic DNA No translation available.
CCDSiCCDS13855.1 [Q10567-1]
CCDS13856.2 [Q10567-3]
CCDS54515.1 [Q10567-4]
PIRiI54360
RefSeqiNP_001118.3, NM_001127.3
NP_001159491.1, NM_001166019.1
NP_663782.2, NM_145730.2
UniGeneiHs.368794

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4HMYX-ray7.00B1-584[»]
4P6ZX-ray3.00B1-584[»]
6CM9electron microscopy3.73B1-584[»]
6CRIelectron microscopy6.80B/I/J14-583[»]
6D83electron microscopy4.27B1-584[»]
6D84electron microscopy6.72B/F1-584[»]
6DFFelectron microscopy3.90B1-584[»]
ProteinModelPortaliQ10567
SMRiQ10567
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106671, 86 interactors
CORUMiQ10567
DIPiDIP-24207N
ELMiQ10567
IntActiQ10567, 62 interactors
MINTiQ10567
STRINGi9606.ENSP00000350199

Protein family/group databases

TCDBi9.B.278.1.1 the organellar-targeting adaptor protein complex (o-apc) family

PTM databases

iPTMnetiQ10567
PhosphoSitePlusiQ10567
SwissPalmiQ10567

Polymorphism and mutation databases

BioMutaiAP1B1
DMDMi290457628

Proteomic databases

EPDiQ10567
MaxQBiQ10567
PaxDbiQ10567
PeptideAtlasiQ10567
PRIDEiQ10567
ProteomicsDBi58857
58858 [Q10567-2]
58859 [Q10567-3]

Protocols and materials databases

DNASUi162
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317368; ENSP00000319361; ENSG00000100280
ENST00000357586; ENSP00000350199; ENSG00000100280
ENST00000402502; ENSP00000386071; ENSG00000100280
ENST00000405198; ENSP00000384194; ENSG00000100280
ENST00000415447; ENSP00000387612; ENSG00000100280
ENST00000432560; ENSP00000400065; ENSG00000100280
GeneIDi162
KEGGihsa:162
UCSCiuc003afi.4 human [Q10567-1]

Organism-specific databases

CTDi162
DisGeNETi162
EuPathDBiHostDB:ENSG00000100280.16
GeneCardsiAP1B1
HGNCiHGNC:554 AP1B1
HPAiHPA065226
HPA068520
MIMi600157 gene
neXtProtiNX_Q10567
PharmGKBiPA24844
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1061 Eukaryota
COG5096 LUCA
HOGENOMiHOG000163270
HOVERGENiHBG050515
InParanoidiQ10567
KOiK12392
OrthoDBiEOG091G019U
PhylomeDBiQ10567
TreeFamiTF300318

Enzyme and pathway databases

ReactomeiR-HSA-164940 Nef mediated downregulation of MHC class I complex cell surface expression
R-HSA-2132295 MHC class II antigen presentation
R-HSA-432720 Lysosome Vesicle Biogenesis
R-HSA-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

ChiTaRSiAP1B1 human
GeneWikiiAP1B1
GenomeRNAii162
PROiPR:Q10567
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100280 Expressed in 228 organ(s), highest expression level in prostate gland
CleanExiHS_AP1B1
ExpressionAtlasiQ10567 baseline and differential
GenevisibleiQ10567 HS

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.60.40.1150, 1 hit
3.30.310.10, 1 hit
InterProiView protein in InterPro
IPR026739 AP_beta
IPR016342 AP_complex_bsu_1_2_4
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR015151 B-adaptin_app_sub_C
IPR002553 Clathrin/coatomer_adapt-like_N
IPR008152 Clathrin_a/b/g-adaptin_app_Ig
IPR013041 Clathrin_app_Ig-like_sf
IPR013037 Clathrin_b-adaptin_app_Ig-like
IPR009028 Coatomer/calthrin_app_sub_C
IPR012295 TBP_dom_sf
PANTHERiPTHR11134 PTHR11134, 1 hit
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF02883 Alpha_adaptinC2, 1 hit
PF09066 B2-adapt-app_C, 1 hit
PIRSFiPIRSF002291 AP_complex_beta, 1 hit
SMARTiView protein in SMART
SM00809 Alpha_adaptinC2, 1 hit
SM00185 ARM, 2 hits
SM01020 B2-adapt-app_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF49348 SSF49348, 1 hit
SSF55711 SSF55711, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAP1B1_HUMAN
AccessioniPrimary (citable) accession number: Q10567
Secondary accession number(s): C9JRD1
, F8WDL0, P78436, Q20WL3, Q86X54
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 2, 2010
Last modified: October 10, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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