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Protein

Apoptosis-inducing factor 1

Gene

aif1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Putative FAD-dependent oxidoreductase involved in the resistance to cercosporin and other singlet oxygen-generating photosensitizers. Translocates from mitochondria to the nucleus under apoptotic conditions, where it degrades DNA and induces apoptosis (By similarity).By similarity

Miscellaneous

Present with 1560 molecules/cell in log phase SD medium.

Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi99Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1
Metal bindingi117Iron-sulfur (2Fe-2S)PROSITE-ProRule annotation1
Metal bindingi120Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processApoptosis
Ligand2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Apoptosis-inducing factor 1 (EC:1.-.-.-)
Gene namesi
Name:aif1
ORF Names:SPAC26F1.14c, SPAC29A4.01c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26F1.14c
PomBaseiSPAC26F1.14c aif1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001166251 – 611Apoptosis-inducing factor 1Add BLAST611

Proteomic databases

MaxQBiQ10499
PaxDbiQ10499
PRIDEiQ10499

PTM databases

SwissPalmiQ10499

Interactioni

Protein-protein interaction databases

STRINGi4896.SPAC26F1.14c.1

Structurei

3D structure databases

ProteinModelPortaliQ10499
SMRiQ10499
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini56 – 154RieskePROSITE-ProRule annotationAdd BLAST99

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi38 – 41Poly-Ser4

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000276711
InParanoidiQ10499
OMAiGAQLRYC
OrthoDBiEOG092C1TNC

Family and domain databases

Gene3Di2.102.10.10, 1 hit
3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR017941 Rieske_2Fe-2S
IPR036922 Rieske_2Fe-2S_sf
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF00355 Rieske, 1 hit
SUPFAMiSSF50022 SSF50022, 1 hit
SSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
PROSITEiView protein in PROSITE
PS51296 RIESKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q10499-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLRFFINQP RFIQFTFLRN KKDRILGLQL GKQPFRMSSS SGLKQQGLAQ
60 70 80 90 100
KKKFQLEFDP SSVSKNGTKT EAKVVGTEFG VLLVRARNTY FATAGKCSHY
110 120 130 140 150
GAPLAKGVVT SDGHIVCPWH GACFNAATGD VEDTPAIAAL RTFPVTEEGD
160 170 180 190 200
GSLWIEVEDK NDNGASVLQP EGCWRNKATE VYNKGSVETE VTAPHVCIIG
210 220 230 240 250
GGKGASVAAE YLREKNFKGK ITIFTREDEV PYDRPKLSKS LLHDISKLAL
260 270 280 290 300
RSKEYYDDLD ISFHFNTDVT KIDLAEKKIY CGSDEKPTES YTKLILATGG
310 320 330 340 350
EPNKLPIPGL DSKNVYLLRS IADASKLAAV TTEAGDKKNI VIIGSSFIGL
360 370 380 390 400
ELAVVLKDHN VSVIGMESIP FEKVMGKEVG TALKALHEQN GIAFYLENSI
410 420 430 440 450
KEVKTSSNDS SKAEHIVLKD GQSIPADVVI LAAGVKPNLR YLGNAVSLEK
460 470 480 490 500
DGGVKVDEHC RVLGAEDVYA VGDIAHAPFA GLPSSGEKSH TRIEHWDVAG
510 520 530 540 550
NLGRVAADHI LFGNKAGYTT KSFTPYFWSA QGKQLRYCGN NAAEGFDDVV
560 570 580 590 600
IQGSLSDYKF ACFFTKGEKV VGVCSIMKDP VVSQCARLFI KDAMPSKSQL
610
KENFDVLSIP L
Length:611
Mass (Da):66,566
Last modified:May 16, 2012 - v3
Checksum:i3885A888830EDC76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAB55362.4
PIRiT38406
RefSeqiXP_001713117.2, XM_001713065.2

Genome annotation databases

EnsemblFungiiSPAC26F1.14c.1; SPAC26F1.14c.1:pep; SPAC26F1.14c
KEGGispo:SPAC26F1.14c

Similar proteinsi

Entry informationi

Entry nameiAIF1_SCHPO
AccessioniPrimary (citable) accession number: Q10499
Secondary accession number(s): O14004
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 16, 2012
Last modified: February 28, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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