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Protein

Probable multifunctional protein ADE2

Gene

pacs-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Probable multifunctional protein ADE2 (pacs-1)
  2. Adenylosuccinate lyase (adsl-1)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route).
Proteins known to be involved in this subpathway in this organism are:
  1. Probable multifunctional protein ADE2 (pacs-1)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Ligase, Lyase, Multifunctional enzyme
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-73817 Purine ribonucleoside monophosphate biosynthesis
UniPathwayiUPA00074; UER00130
UPA00074; UER00131

Names & Taxonomyi

Protein namesi
Recommended name:
Probable multifunctional protein ADE2
Including the following 2 domains:
Phosphoribosylaminoimidazole-succinocarboxamide synthase (EC:6.3.2.6)
Alternative name(s):
SAICAR synthetase
Phosphoribosylaminoimidazole carboxylase (EC:4.1.1.21)
Alternative name(s):
AIR carboxylase
Short name:
AIRC
Gene namesi
Name:pacs-1Imported
ORF Names:B0286.3Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiB0286.3 ; CE03863 ; WBGene00015116 ; pacs-1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000750341 – 423Probable multifunctional protein ADE2Add BLAST423

Proteomic databases

EPDiQ10457
PaxDbiQ10457
PeptideAtlasiQ10457
PRIDEiQ10457

Expressioni

Gene expression databases

BgeeiWBGene00015116

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-311886,EBI-311886

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi39128, 2 interactors
DIPiDIP-24510N
IntActiQ10457, 20 interactors
STRINGi6239.B0286.3

Structurei

3D structure databases

ProteinModelPortaliQ10457
SMRiQ10457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 263SAICAR synthetaseAdd BLAST263
Regioni264 – 423AIR carboxylaseAdd BLAST160

Sequence similaritiesi

In the N-terminal section; belongs to the SAICAR synthetase family.Curated
In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily.Curated

Phylogenomic databases

eggNOGiKOG2835 Eukaryota
COG0041 LUCA
COG0152 LUCA
GeneTreeiENSGT00390000010172
HOGENOMiHOG000082628
InParanoidiQ10457
KOiK01587
OMAiWSDEQII
OrthoDBiEOG091G08DN
PhylomeDBiQ10457

Family and domain databases

Gene3Di3.40.50.7700, 1 hit
HAMAPiMF_02045 PurE_classII, 1 hit
MF_00137 SAICAR_synth, 1 hit
InterProiView protein in InterPro
IPR033626 PurE_classII
IPR000031 PurE_dom
IPR035893 PurE_sf
IPR028923 SAICAR_synt/ADE2_N
IPR018236 SAICAR_synthetase_CS
PfamiView protein in Pfam
PF00731 AIRC, 1 hit
PF01259 SAICAR_synt, 1 hit
SMARTiView protein in SMART
SM01001 AIRC, 1 hit
SUPFAMiSSF52255 SSF52255, 1 hit
TIGRFAMsiTIGR01162 purE, 1 hit
PROSITEiView protein in PROSITE
PS01057 SAICAR_SYNTHETASE_1, 1 hit
PS01058 SAICAR_SYNTHETASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q10457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLAEIASR PENLELLAEG KTKQIFDIKG EKDYVLIRSK DSLTAFNAVR
60 70 80 90 100
KNELEGKSRI ASKTTSNVFE YLQLLGLPTH FEKSISETEF VARKCTMIPI
110 120 130 140 150
EWVARRVATG SFLKRNPGVK EGFRFNDLKL ETFFKDDAND DPQWTDEQIV
160 170 180 190 200
SNGLMIDHLK IGREEISLMK KMTKLVFRAL EKGWALSNSA LIDMKIEFGV
210 220 230 240 250
TVEGEILLAD VIDNDSWRVW PENDRRLQLD KQVYRDMKEV TEEGLALVLK
260 270 280 290 300
NYTKVMDITA TFSKHQQKCH VLVIMGSGSD GVFARKISDE AKKFGLETTL
310 320 330 340 350
KVSSAHKTTS DTLEVIADFE ESGVPTVVIA VAGRSNGLGP VIAGNSSLPV
360 370 380 390 400
INCPPPSEST SLDIWSSLRM PNGIGCTTVL DPSEAALAAA KILASHNHIV
410 420
FGKVLTAQLK NQINIYNANR KLE
Length:423
Mass (Da):46,978
Last modified:October 1, 1996 - v1
Checksum:i101CD65318C4804A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD61663.1
PIRiT15309
RefSeqiNP_494771.1, NM_062370.5
UniGeneiCel.16061

Genome annotation databases

EnsemblMetazoaiB0286.3; B0286.3; WBGene00015116
GeneIDi173772
KEGGicel:CELE_B0286.3
UCSCiB0286.3 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPUR6_CAEEL
AccessioniPrimary (citable) accession number: Q10457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: March 28, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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