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Protein

Probable arginine kinase F46H5.3

Gene

F46H5.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine = ADP + N(omega)-phospho-L-arginine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei226ATPPROSITE-ProRule annotation1
Binding sitei266SubstrateBy similarity1
Binding sitei270ATPPROSITE-ProRule annotation1
Binding sitei312SubstrateBy similarity1
Binding sitei354SubstrateBy similarity1
Binding sitei364ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi162 – 166ATPPROSITE-ProRule annotation5
Nucleotide bindingi321 – 325ATPPROSITE-ProRule annotation5
Nucleotide bindingi349 – 354ATPPROSITE-ProRule annotation6

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-71288 Creatine metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine kinase F46H5.3 (EC:2.7.3.3)
Short name:
AK
Gene namesi
ORF Names:F46H5.3
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF46H5.3a ; CE37112 ; WBGene00018519
F46H5.3b ; CE33098 ; WBGene00018519

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002119881 – 396Probable arginine kinase F46H5.3Add BLAST396

Proteomic databases

EPDiQ10454
PaxDbiQ10454
PeptideAtlasiQ10454
PRIDEiQ10454

2D gel databases

World-2DPAGEi0020:Q10454

PTM databases

iPTMnetiQ10454

Expressioni

Gene expression databases

BgeeiWBGene00018519 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

BioGridi45911, 4 interactors
DIPiDIP-26821N
IntActiQ10454, 1 interactor
STRINGi6239.F46H5.3a.2

Structurei

3D structure databases

ProteinModelPortaliQ10454
SMRiQ10454
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 129Phosphagen kinase N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini159 – 396Phosphagen kinase C-terminalPROSITE-ProRule annotationAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni102 – 106Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the ATP:guanido phosphotransferase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3581 Eukaryota
COG3869 LUCA
GeneTreeiENSGT00550000074561
HOGENOMiHOG000232165
InParanoidiQ10454
KOiK00934
OMAiMYDGIAE
OrthoDBiEOG091G0HZ0
PhylomeDBiQ10454

Family and domain databases

Gene3Di1.10.135.10, 1 hit
InterProiView protein in InterPro
IPR000749 ATP-guanido_PTrfase
IPR022415 ATP-guanido_PTrfase_AS
IPR022414 ATP-guanido_PTrfase_cat
IPR022413 ATP-guanido_PTrfase_N
IPR036802 ATP-guanido_PTrfase_N_sf
IPR014746 Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11547 PTHR11547, 1 hit
PfamiView protein in Pfam
PF00217 ATP-gua_Ptrans, 1 hit
PF02807 ATP-gua_PtransN, 1 hit
SUPFAMiSSF48034 SSF48034, 1 hit
SSF55931 SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00112 PHOSPHAGEN_KINASE, 1 hit
PS51510 PHOSPHAGEN_KINASE_C, 1 hit
PS51509 PHOSPHAGEN_KINASE_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: Q10454-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLHRCSRVLS QFLGRGNSKM LREAYSTSLH CVQAQEGMSV SPDVIAKIEE
60 70 80 90 100
GYAKLQAAPE CHSLLKKYLT KEVVDQLKDK KTKLGANLLD VIQSGVANLD
110 120 130 140 150
SGVGVYAPDA EAYTLFKPLF DPLIQDYHNG FAPDAKQPNT DLGEGKTSAL
160 170 180 190 200
VDLDPEGKFI NSTRIRCGRS LQGYPFNPCL SEANYLEMES KVKAIFDNIT
210 220 230 240 250
DPELAGKYFP LDGMTKEIQD QLIKDHFLFK EGDRFLQAAN ACRYWPKGRG
260 270 280 290 300
IFHNNQKTFL IWCNEEDHLR IISMQEGGNV GQVLERLIKG VKTIEKQAPF
310 320 330 340 350
SRDDRLGWLT FCPSNLGTTV RASVHIRLPK ISAKPDFKSI CDGLKLQIRG
360 370 380 390
IHGEHSESEG GVYDISNKAR LGLTEFEAVK QMYDGIAHLI ALEKAA
Note: No experimental confirmation available.
Length:396
Mass (Da):44,168
Last modified:February 1, 2005 - v2
Checksum:i0DF10283D3FEA45B
GO
Isoform b (identifier: Q10454-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-37: Missing.

Note: No experimental confirmation available.
Show »
Length:359
Mass (Da):39,991
Checksum:i7EC508115BDF086F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0127501 – 37Missing in isoform b. CuratedAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081399 Genomic DNA Translation: CCD71355.1
FO081399 Genomic DNA Translation: CCD71356.1
PIRiT34272
RefSeqiNP_509217.2, NM_076816.2 [Q10454-1]
NP_872253.1, NM_182453.5 [Q10454-2]
UniGeneiCel.17036

Genome annotation databases

EnsemblMetazoaiF46H5.3a.1; F46H5.3a.1; WBGene00018519 [Q10454-1]
F46H5.3a.2; F46H5.3a.2; WBGene00018519 [Q10454-1]
F46H5.3a.3; F46H5.3a.3; WBGene00018519 [Q10454-1]
F46H5.3a.4; F46H5.3a.4; WBGene00018519 [Q10454-1]
GeneIDi180986
KEGGicel:CELE_F46H5.3
UCSCiF46H5.3b.2 c. elegans [Q10454-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081399 Genomic DNA Translation: CCD71355.1
FO081399 Genomic DNA Translation: CCD71356.1
PIRiT34272
RefSeqiNP_509217.2, NM_076816.2 [Q10454-1]
NP_872253.1, NM_182453.5 [Q10454-2]
UniGeneiCel.17036

3D structure databases

ProteinModelPortaliQ10454
SMRiQ10454
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45911, 4 interactors
DIPiDIP-26821N
IntActiQ10454, 1 interactor
STRINGi6239.F46H5.3a.2

PTM databases

iPTMnetiQ10454

2D gel databases

World-2DPAGEi0020:Q10454

Proteomic databases

EPDiQ10454
PaxDbiQ10454
PeptideAtlasiQ10454
PRIDEiQ10454

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF46H5.3a.1; F46H5.3a.1; WBGene00018519 [Q10454-1]
F46H5.3a.2; F46H5.3a.2; WBGene00018519 [Q10454-1]
F46H5.3a.3; F46H5.3a.3; WBGene00018519 [Q10454-1]
F46H5.3a.4; F46H5.3a.4; WBGene00018519 [Q10454-1]
GeneIDi180986
KEGGicel:CELE_F46H5.3
UCSCiF46H5.3b.2 c. elegans [Q10454-1]

Organism-specific databases

CTDi180986
WormBaseiF46H5.3a ; CE37112 ; WBGene00018519
F46H5.3b ; CE33098 ; WBGene00018519

Phylogenomic databases

eggNOGiKOG3581 Eukaryota
COG3869 LUCA
GeneTreeiENSGT00550000074561
HOGENOMiHOG000232165
InParanoidiQ10454
KOiK00934
OMAiMYDGIAE
OrthoDBiEOG091G0HZ0
PhylomeDBiQ10454

Enzyme and pathway databases

ReactomeiR-CEL-71288 Creatine metabolism

Miscellaneous databases

PROiPR:Q10454

Gene expression databases

BgeeiWBGene00018519 Expressed in 5 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.10.135.10, 1 hit
InterProiView protein in InterPro
IPR000749 ATP-guanido_PTrfase
IPR022415 ATP-guanido_PTrfase_AS
IPR022414 ATP-guanido_PTrfase_cat
IPR022413 ATP-guanido_PTrfase_N
IPR036802 ATP-guanido_PTrfase_N_sf
IPR014746 Gln_synth/guanido_kin_cat_dom
PANTHERiPTHR11547 PTHR11547, 1 hit
PfamiView protein in Pfam
PF00217 ATP-gua_Ptrans, 1 hit
PF02807 ATP-gua_PtransN, 1 hit
SUPFAMiSSF48034 SSF48034, 1 hit
SSF55931 SSF55931, 1 hit
PROSITEiView protein in PROSITE
PS00112 PHOSPHAGEN_KINASE, 1 hit
PS51510 PHOSPHAGEN_KINASE_C, 1 hit
PS51509 PHOSPHAGEN_KINASE_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKARG1_CAEEL
AccessioniPrimary (citable) accession number: Q10454
Secondary accession number(s): Q86NG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: February 1, 2005
Last modified: September 12, 2018
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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