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Entry version 111 (12 Aug 2020)
Sequence version 2 (29 Aug 2001)
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Protein

Pentatricopeptide repeat-containing protein 5, mitochondrial

Gene

ppr5

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mitochondrial RNA-binding protein that acts as a general negative regulator of mitochondrial translation.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processProtein biosynthesis, Translation regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pentatricopeptide repeat-containing protein 5, mitochondrial
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ppr5
ORF Names:SPAC1093.01, SPAC12B10.18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC1093.01

Schizosaccharomyces pombe database

More...
PomBasei
SPAC1093.01, ppr5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Seems to stimulate mitochondrial biogenesis and especially mitochondrial protein synthesis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000116844? – 1261Pentatricopeptide repeat-containing protein 5, mitochondrial

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q10451

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10451

PRoteomics IDEntifications database

More...
PRIDEi
Q10451

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
279362, 46 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC1093.01.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati365 – 404PPR 1Add BLAST40
Repeati405 – 442PPR 2Add BLAST38
Repeati443 – 479PPR 3Add BLAST37
Repeati480 – 514PPR 4Add BLAST35
Repeati550 – 584PPR 5Add BLAST35
Repeati806 – 849PPR 6Add BLAST44
Repeati852 – 886PPR 7Add BLAST35
Repeati887 – 924PPR 8Add BLAST38
Repeati925 – 959PPR 9Add BLAST35
Repeati960 – 995PPR 10Add BLAST36
Repeati996 – 1031PPR 11Add BLAST36
Repeati1032 – 1068PPR 12Add BLAST37
Repeati1109 – 1143PPR 13Add BLAST35
Repeati1144 – 1179PPR 14Add BLAST36
Repeati1180 – 1214PPR 15Add BLAST35

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4197, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002863_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10451

Identification of Orthologs from Complete Genome Data

More...
OMAi
STYENMV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q10451

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002885, Pentatricopeptide_repeat
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01535, PPR, 2 hits
PF13041, PPR_2, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00756, PPR, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51375, PPR, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q10451-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVYTKAWFLQ NIARQTLGKN VAVHRPPLKL GNMTNWIQQQ QAQTNLSLSN
60 70 80 90 100
TKAPGSLDER LFLTEDDIIF HDRSIQLGYF DPSLSERKQS PPGKSLHRFV
110 120 130 140 150
DNLNPNSSHF SASLLPASLS SLCDSTCGDV DDEQQFNSLA TSPLSTETQS
160 170 180 190 200
EVSDPLLDTL TPNSLESSFA SISLNSFTSA NEFIQFLKRL ASSKLSIHTF
210 220 230 240 250
DLYKLVRNSP ELLTLEAYNI VLQCMSTDDY FLSSSKNIQK IIKVYVDMLN
260 270 280 290 300
SFISPNVTTF ETVIFALCRR AKFVHQKIES LSKRTIYAHP SIAKEIQPEL
310 320 330 340 350
LDLQSEMPLQ TAVFMFTSSL INHDLIYSPQ FYAILIESVS LYGTQSQLDS
360 370 380 390 400
LLECVPLGTI EANGHPDLLP ALIRALGRAK RLNSCFQLLE RYNLSDPTSD
410 420 430 440 450
TSMTNVRSWE GLMEAYFDTD HHVEASALMK SFFRKADSNQ VIPSSILDCF
460 470 480 490 500
LRRLAQLGHY KESAEWLGMA IEKISTYKAS PSTLSSILEA ACLNNNDKFA
510 520 530 540 550
IAFVRKYTLS RFSDCHAVLL RYLDLLARSG NVDLLHLHAY PVICSVSSHT
560 570 580 590 600
NFTFSNVYKA FIENGKIDVA LRLLRKHIDP KVSLGNNTAP SSNSVALQLS
610 620 630 640 650
ILNGFWEVLT EELQKDVHVL LSLVSTLENQ VNFPQVDFTT PLLRHITGYL
660 670 680 690 700
VSRRLEPELI SPRVFGFLLE YAAFNVVQTE GTFTSKVILT DLLKCYSNGT
710 720 730 740 750
YKASFKNVHV VLRSFTYLKE DEMLVASVRD DIVSEAVVGF STDNNGQKIL
760 770 780 790 800
ADISQVCYCL DDLECIDQSI NSLVSKMLTS ASPEQVDVNI LFFQFGKLIE
810 820 830 840 850
TNKFLHPEVY PTLISVLSKN KRFDAVQRVF EHSKHLYRKI STKSLEKANW
860 870 880 890 900
FMALILDAMI LSSSFARQFK SSNLFCDNMK MLGYIPRAST FAHLINNSTR
910 920 930 940 950
RGDTDDATTA LNIFEETKRH NVKPSVFLYN AVLSKLGRAR RTTECWKLFQ
960 970 980 990 1000
EMKESGLLPT SVTYGTVINA ACRIGDESLA EKLFAEMENQ PNYQPRVAPY
1010 1020 1030 1040 1050
NTMIQFEVQT MFNREKALFY YNRLCATDIE PSSHTYKLLM DAYGTLKPVN
1060 1070 1080 1090 1100
VGSVKAVLEL MERTDVPILS MHYAAYIHIL GNVVSDVQAA TSCYMNALAK
1110 1120 1130 1140 1150
HDAGEIQLDA NLFQSQIESL IANDRIVEGI QIVSDMKRYN VSLNAYIVNA
1160 1170 1180 1190 1200
LIKGFTKVGM ISKARYYFDL LECEGMSGKE PSTYENMVRA YLSVNDGRKA
1210 1220 1230 1240 1250
MEIVEQLKRK RYPLPVVNRI SSLVNSHMGQ KPKRRSLNTS HSSLASLGNA
1260
STQHSINSSI N
Length:1,261
Mass (Da):141,950
Last modified:August 29, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCE50E79822981F2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA94707.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T50065

NCBI Reference Sequences

More...
RefSeqi
NP_594649.2, NM_001020077.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC1093.01.1; SPAC1093.01.1:pep; SPAC1093.01

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542921

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC1093.01

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA94707.1
PIRiT50065
RefSeqiNP_594649.2, NM_001020077.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi279362, 46 interactors
STRINGi4896.SPAC1093.01.1

Proteomic databases

MaxQBiQ10451
PaxDbiQ10451
PRIDEiQ10451

Genome annotation databases

EnsemblFungiiSPAC1093.01.1; SPAC1093.01.1:pep; SPAC1093.01
GeneIDi2542921
KEGGispo:SPAC1093.01

Organism-specific databases

EuPathDBiFungiDB:SPAC1093.01
PomBaseiSPAC1093.01, ppr5

Phylogenomic databases

eggNOGiKOG4197, Eukaryota
HOGENOMiCLU_002863_0_0_1
InParanoidiQ10451
OMAiSTYENMV
PhylomeDBiQ10451

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10451

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002885, Pentatricopeptide_repeat
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF01535, PPR, 2 hits
PF13041, PPR_2, 1 hit
TIGRFAMsiTIGR00756, PPR, 3 hits
PROSITEiView protein in PROSITE
PS51375, PPR, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPR5_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10451
Secondary accession number(s): Q9UTQ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: August 29, 2001
Last modified: August 12, 2020
This is version 111 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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