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Entry version 117 (16 Oct 2019)
Sequence version 2 (27 Mar 2002)
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Protein

Probable ubiquitin fusion degradation protein C12B10.01c

Gene

SPAC12B10.01c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Miscellaneous

A cysteine residue is required for ubiquitin-thioester formation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1614Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ubiquitin fusion degradation protein C12B10.01c
Alternative name(s):
HECT-type E3 ubiquitin transferase C12B10.01c (EC:2.3.2.26)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SPAC12B10.01c, SPAC31F12.02c, SPAC637.15c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC12B10.01c

Schizosaccharomyces pombe database

More...
PomBasei
SPAC12B10.01c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001949991 – 1647Probable ubiquitin fusion degradation protein C12B10.01cAdd BLAST1647

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q10435

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10435

PRoteomics IDEntifications database

More...
PRIDEi
Q10435

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q10435

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
278072, 51 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC12B10.01c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1294 – 1647HECTPROSITE-ProRule annotationAdd BLAST354

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1183 – 1257K-boxAdd BLAST75

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPL family. K-HECT subfamily.Curated

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10435

KEGG Orthology (KO)

More...
KOi
K10590

Identification of Orthologs from Complete Genome Data

More...
OMAi
HGFNMDS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q10435

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078 HECTc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00632 HECT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119 HECTc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50237 HECT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q10435-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVQAYTNTP NLPNLIHSES ITNSPVFIPN LRSKSDNKHR LNTSEELPFT
60 70 80 90 100
KKRRATKHFL KMEVSAKISE PPSSKSVEFG RHLNMRHDFS ELLEQPLTTS
110 120 130 140 150
KTRVFKSFNE KLKGKPQLVK SDKGVLPLNK QSDILNSYER VLSNASVDSA
160 170 180 190 200
LDKKAEVDII PFDKSVMEPK NITFNDKSGL TKFGNSNSYE TTYSDSSNYH
210 220 230 240 250
TSTDSSQYND QDDHVYDDTN DGTDDDINNN EYKDDESSSG SESYERDEDV
260 270 280 290 300
DEEEEEDDDE NNDEGDDEDE NENDELRSEN GSPNPSAAVI NEQENMNMSG
310 320 330 340 350
IEEYDETNLL NELGRIRRGN QFQSLASSIL SSGNLENSDD EDVSLGPQTY
360 370 380 390 400
RFNSSFHPFR SAFSAPGVQF GRLLEGIKDF SDPTVQMLSL QELSEAFAMS
410 420 430 440 450
TEDMLVGLFS TDSYIAAFSE ILSGRNYDFG EVSIQLMLSC TTCVSNMMEA
460 470 480 490 500
LPLCMAKIAY SPIVRILCER MFDMQYIDIA EQALGVLERL SKDFGICILE
510 520 530 540 550
HRGMLAALQY FDFFYTTVQR TAISLAANCC KFLDESNASA AEEIIPLLSN
560 570 580 590 600
ILQSSDTIVV SKAYSCLETI IESLKTSPNI IETIISEDLI TTIVNALTNS
610 620 630 640 650
TSQNKSMHLQ VQLLHIISSL CQSSSALILP FLNHNLPDVM YEMLCGIPPS
660 670 680 690 700
DTSHQADMIT MQSLYYCPIE LIENLLRAIT SLLPKNTSNL SDEFNTKLYR
710 720 730 740 750
LNSILLTVVM DIYFIVPLHD IRSLAVTTAL KMLCSIRENN LDGLVCSLPL
760 770 780 790 800
SSFIASILNS RKSDNFLKRD ALEMCLFLLE ALPNVYSSLF IREGVVQEVG
810 820 830 840 850
FLVRSTNADM KKIKLSISFS QNKSAARHEE LKNLSTLKSL AKEFLSNYKE
860 870 880 890 900
ENLENSTLVQ LKQLSKHLLS ETKQDESFSE LAKIFQEGSN ITSHELLHSG
910 920 930 940 950
LIHNLLLSLK KFGSSSLRTF LLAMNTCDER EVLEFGNGPL VSLIFCLQNL
960 970 980 990 1000
LSTVENFQLS TLPPDTENAV DHVFSRQFKL RLMALPGSRI RPPFRSLVVS
1010 1020 1030 1040 1050
INGLATIRTL DNYLHSRISV RNETGRRFSI LREAGSLRES MSGSSRNSSG
1060 1070 1080 1090 1100
DYTDSMSQDA PNHTTEPSER RDSSTSSHFE EHFVFSLMGK KVPRNKTIFR
1110 1120 1130 1140 1150
ILYEYIQLSD DHTLDDFWKT PVPIFYGEPD CIHNDMKGEL NYENETEGFS
1160 1170 1180 1190 1200
INIREILDLL SILYYGIRDV HTLFPDKHFR GNIENILTDF SNWKLSAKLN
1210 1220 1230 1240 1250
RQLEEQQLVV HGCLPSWCIS LTSAYPFLVP FETRYLLLQS TAFGLSRSVS
1260 1270 1280 1290 1300
FLLSRNPELS KNESSSILQF VSLHRQKIRI SRKKIFNYAL HLLATYAASE
1310 1320 1330 1340 1350
NILEIEYEDE VGSGLGPTLE FYTSVSKEFT LNSLDIWRND QPNSKFVYQA
1360 1370 1380 1390 1400
SGLFPSPIPL LGSSPENERK ISLFFALGQF VARSIYDSRI ISIQFNPLFF
1410 1420 1430 1440 1450
ARNIPLTISS VAKVDKGLAN SLRYLEKLIP GKNPTNAETD IKLEDLHLDF
1460 1470 1480 1490 1500
TLPGFPSIEL IPDGASTPVT TFNVSDYLNY VIDYTVGKGV QQQLEAFQNG
1510 1520 1530 1540 1550
FSSVFPYTSL QVLTEHELVT LFGTVDEDWS YATLMKSIVA DHGYTMESPT
1560 1570 1580 1590 1600
IQRLLTLMSQ MNFQEQRDFL QFITGSRKLP IGGFAGLNPP LTVVRRLNEP
1610 1620 1630 1640
PYVPDDYLPS VMTCVNYLKL PEYSSSEVLG SRLSKAILEG QGSFHLS
Length:1,647
Mass (Da):185,617
Last modified:March 27, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA2A005E7DFB0676B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA22594.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T37568
T38617

NCBI Reference Sequences

More...
RefSeqi
NP_594633.2, NM_001020061.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC12B10.01c.1; SPAC12B10.01c.1:pep; SPAC12B10.01c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541575

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC12B10.01c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA22594.1
PIRiT37568
T38617
RefSeqiNP_594633.2, NM_001020061.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi278072, 51 interactors
STRINGi4896.SPAC12B10.01c.1

PTM databases

iPTMnetiQ10435

Proteomic databases

MaxQBiQ10435
PaxDbiQ10435
PRIDEiQ10435

Genome annotation databases

EnsemblFungiiSPAC12B10.01c.1; SPAC12B10.01c.1:pep; SPAC12B10.01c
GeneIDi2541575
KEGGispo:SPAC12B10.01c

Organism-specific databases

EuPathDBiFungiDB:SPAC12B10.01c
PomBaseiSPAC12B10.01c

Phylogenomic databases

InParanoidiQ10435
KOiK10590
OMAiHGFNMDS
PhylomeDBiQ10435

Enzyme and pathway databases

ReactomeiR-SPO-983168 Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10435

Family and domain databases

CDDicd00078 HECTc, 1 hit
Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
PfamiView protein in Pfam
PF00632 HECT, 1 hit
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50237 HECT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYDE1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10435
Secondary accession number(s): O14101
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 27, 2002
Last modified: October 16, 2019
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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