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Entry version 148 (07 Oct 2020)
Sequence version 1 (01 Oct 1996)
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Protein

Serine/threonine-protein kinase sck2

Gene

sck2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein kinase that is part of growth control pathway which is at least partially redundant with the cAMP pathway.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei295ATPPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei392Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi272 – 280ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-1257604, PIP3 activates AKT signaling
R-SPO-1358803, Downregulation of ERBB2:ERBB3 signaling
R-SPO-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-SPO-165158, Activation of AKT2
R-SPO-165181, Inhibition of TSC complex formation by PKB
R-SPO-198323, AKT phosphorylates targets in the cytosol
R-SPO-198693, AKT phosphorylates targets in the nucleus
R-SPO-203615, eNOS activation
R-SPO-389357, CD28 dependent PI3K/Akt signaling
R-SPO-389513, CTLA4 inhibitory signaling
R-SPO-392451, G beta:gamma signalling through PI3Kgamma
R-SPO-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-SPO-5218920, VEGFR2 mediated vascular permeability
R-SPO-5628897, TP53 Regulates Metabolic Genes
R-SPO-6804757, Regulation of TP53 Degradation
R-SPO-6804758, Regulation of TP53 Activity through Acetylation
R-SPO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SPO-9009391, Extra-nuclear estrogen signaling
R-SPO-9031628, NGF-stimulated transcription

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Serine/threonine-protein kinase sck2 (EC:2.7.11.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sck2
ORF Names:SPAC22E12.14c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPAC22E12.14c

Schizosaccharomyces pombe database

More...
PomBasei
SPAC22E12.14c, sck2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000866401 – 646Serine/threonine-protein kinase sck2Add BLAST646

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q10364

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10364

PRoteomics IDEntifications database

More...
PRIDEi
Q10364

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q10364

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278357, 206 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC22E12.14c.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini266 – 527Protein kinasePROSITE-ProRule annotationAdd BLAST262
Domaini528 – 605AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST78

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0598, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_52_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10364

KEGG Orthology (KO)

More...
KOi
K08286

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEPSGYL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q10364

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR017892, Pkinase_C
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q10364-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMNKWAKNWF GLSKKSVSTN SAKGSLPRSP LASIQTNQPV EEGEGGSLPS
60 70 80 90 100
VSNLGPSSID HPMEEFASDQ STVGNRNSND ILPEVDHEPS GYLKLQIGSL
110 120 130 140 150
VLGGPHTDAA LAMECSRLNQ LFVVVQFGTT EFVSPPLKWE SPGRDIGTSS
160 170 180 190 200
RDSANVSRSS SMMSSHPIPT PAIQRTSSIP NPLTPSYVVF DVAKPVPIDV
210 220 230 240 250
NIYDHGNNNE FVGRTYIHPS YNYGQFEQFC NSVEVSPAYN RMVDLRLSLN
260 270 280 290 300
TVFQPLSQHS YGPDDFVPLK LIGKGTFGQV YLVRKKDTER VYAMKVLSKK
310 320 330 340 350
VIVRRKEVAH TVGERDILVQ TSAADSPFIV ALRFSFQTPK DLYLVTDYMA
360 370 380 390 400
GGELFWHLQK SVRFPEERAK FYIAELLLAL QALHKRGIVY RDLKPENILL
410 420 430 440 450
DVQGHIALCD FGLSKANLSV GTTTRTFCGT TDYLAPEVIL DEAGYDMMVD
460 470 480 490 500
FWSLGVLLYE MTCGWSPFYA DNTQQLYKNI VFGKVRFPRG LLSVEARDLI
510 520 530 540 550
KLLLNRNPKH RLGAHGDVEE VMKHPFFDGI DWKKLAAKEI SPPFKPIVEG
560 570 580 590 600
EIDVSNFDVE FTNKAIDRDF SSTDEMSTSA PLSSTVQNGF KGFTYIDASA
610 620 630 640
MDEAFGYHNS NDSASSISSQ DDYSKDNSDM DLNRANDEVF MGQIDP
Length:646
Mass (Da):71,899
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F37BF7F1D8C56FF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93901.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38171

NCBI Reference Sequences

More...
RefSeqi
NP_594840.1, NM_001020269.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC22E12.14c.1; SPAC22E12.14c.1:pep; SPAC22E12.14c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541867

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC22E12.14c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93901.1
PIRiT38171
RefSeqiNP_594840.1, NM_001020269.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi278357, 206 interactors
STRINGi4896.SPAC22E12.14c.1

PTM databases

iPTMnetiQ10364

Proteomic databases

MaxQBiQ10364
PaxDbiQ10364
PRIDEiQ10364

Genome annotation databases

EnsemblFungiiSPAC22E12.14c.1; SPAC22E12.14c.1:pep; SPAC22E12.14c
GeneIDi2541867
KEGGispo:SPAC22E12.14c

Organism-specific databases

EuPathDBiFungiDB:SPAC22E12.14c
PomBaseiSPAC22E12.14c, sck2

Phylogenomic databases

eggNOGiKOG0598, Eukaryota
HOGENOMiCLU_000288_52_3_1
InParanoidiQ10364
KOiK08286
OMAiHEPSGYL
PhylomeDBiQ10364

Enzyme and pathway databases

ReactomeiR-SPO-1257604, PIP3 activates AKT signaling
R-SPO-1358803, Downregulation of ERBB2:ERBB3 signaling
R-SPO-1474151, Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-SPO-165158, Activation of AKT2
R-SPO-165181, Inhibition of TSC complex formation by PKB
R-SPO-198323, AKT phosphorylates targets in the cytosol
R-SPO-198693, AKT phosphorylates targets in the nucleus
R-SPO-203615, eNOS activation
R-SPO-389357, CD28 dependent PI3K/Akt signaling
R-SPO-389513, CTLA4 inhibitory signaling
R-SPO-392451, G beta:gamma signalling through PI3Kgamma
R-SPO-450385, Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-SPO-5218920, VEGFR2 mediated vascular permeability
R-SPO-5628897, TP53 Regulates Metabolic Genes
R-SPO-6804757, Regulation of TP53 Degradation
R-SPO-6804758, Regulation of TP53 Activity through Acetylation
R-SPO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SPO-9009391, Extra-nuclear estrogen signaling
R-SPO-9031628, NGF-stimulated transcription

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10364

Family and domain databases

InterProiView protein in InterPro
IPR000961, AGC-kinase_C
IPR011009, Kinase-like_dom_sf
IPR017892, Pkinase_C
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069, Pkinase, 1 hit
PF00433, Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00133, S_TK_X, 1 hit
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285, AGC_KINASE_CTER, 1 hit
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCK2_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10364
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 7, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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