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Protein

Histone acetyltransferase mst2

Gene

mst2

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the mst2 complex which is a highly specific H3 lysine 14 (H3K14) acetyltransferase that functions together with gcn5 to regulate global levels of H3K14 acetylation (H3K14ac), critical for DNA damage checkpoint activation. Negatively regulates telomere silencing. Telomere silencing is increased due to histone hypoacetylation and/or an increase in the ratio of methylated histones to acetylated histones. Telomeric histone acetylation contributes to normal meiotic progression.2 Publications

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei243Acetyl-CoABy similarity1
Active sitei274Proton donor/acceptorBy similarity1
Binding sitei278Acetyl-CoABy similarity1
Binding sitei287Acetyl-CoABy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 156C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

GO - Molecular functioni

  • histone acetyltransferase activity (H3-K14 specific) Source: PomBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Transferase
Biological processDNA damage
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase mst2 (EC:2.3.1.48By similarity)
Gene namesi
Name:mst2
ORF Names:SPAC17G8.13c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC17G8.13c
PomBaseiSPAC17G8.13c mst2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515651 – 407Histone acetyltransferase mst2Add BLAST407

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei198N6-acetyllysine; by autocatalysisBy similarity1

Post-translational modificationi

Autoacetylation at Lys-198 is required for proper function.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ10325
PaxDbiQ10325
PRIDEiQ10325

Interactioni

Subunit structurei

Component of the mst2 complex composed of at least eaf6, mst2, nto1, pdp3, ptf1, ptf2 and tfg3.1 Publication

Protein-protein interaction databases

BioGridi278645, 104 interactors
STRINGi4896.SPAC17G8.13c.1

Structurei

3D structure databases

ProteinModelPortaliQ10325
SMRiQ10325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 372MYST-type HATPROSITE-ProRule annotationAdd BLAST275

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni241 – 243Acetyl-CoA bindingBy similarity3
Regioni248 – 254Acetyl-CoA bindingBy similarity7

Sequence similaritiesi

Belongs to the MYST (SAS/MOZ) family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri131 – 156C2HC MYST-typePROSITE-ProRule annotationAdd BLAST26

Keywords - Domaini

Zinc-finger

Phylogenomic databases

InParanoidiQ10325
KOiK11378
OrthoDBiEOG092C043Q
PhylomeDBiQ10325

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q10325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPATILKSTA SSKTLLIIKF DTNSSRYPFY KKHLLELNSE STFLGLLTKG
60 70 80 90 100
QADTSITRLN QDDVRLFEKA KTVADRTKDV AYSFSDPILS TQLRTPPPQP
110 120 130 140 150
TSIRYLYFGT YRIKPWYTSP YPEEYSCAKN LYICESCLKY MNSDHVLQRH
160 170 180 190 200
KMKCSWSYPP GDEIYRDKNI SIFEVDGQRQ PIYCQNLCLL AKMFLHSKML
210 220 230 240 250
YYDVEPFLFY VLTEFDGQEC KVIGYFSKEK RSASDYNVSC ILTLPIYQRR
260 270 280 290 300
GYGVFLIDFS YLLTQVEGKL GSPEKPLSDL GLVTYRSYWK MRVAKALLEI
310 320 330 340 350
TTPISINAIA KSTSMVCDDV ISTLESLSVF KYDPLKKKYV LQLKRDELEN
360 370 380 390 400
VYKAWNIKHP QRVNPKLLRW TPYLGEEQIS NLLLKENILI PLPQKRLLDN

SHHLDSV
Length:407
Mass (Da):47,275
Last modified:October 1, 1996 - v1
Checksum:i27B70EB7AB947102
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93696.1
PIRiT37865
RefSeqiNP_593736.1, NM_001019167.2

Genome annotation databases

EnsemblFungiiSPAC17G8.13c.1; SPAC17G8.13c.1:pep; SPAC17G8.13c
GeneIDi2542170
KEGGispo:SPAC17G8.13c

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93696.1
PIRiT37865
RefSeqiNP_593736.1, NM_001019167.2

3D structure databases

ProteinModelPortaliQ10325
SMRiQ10325
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278645, 104 interactors
STRINGi4896.SPAC17G8.13c.1

Proteomic databases

MaxQBiQ10325
PaxDbiQ10325
PRIDEiQ10325

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC17G8.13c.1; SPAC17G8.13c.1:pep; SPAC17G8.13c
GeneIDi2542170
KEGGispo:SPAC17G8.13c

Organism-specific databases

EuPathDBiFungiDB:SPAC17G8.13c
PomBaseiSPAC17G8.13c mst2

Phylogenomic databases

InParanoidiQ10325
KOiK11378
OrthoDBiEOG092C043Q
PhylomeDBiQ10325

Miscellaneous databases

PROiPR:Q10325

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR002717 HAT_MYST-type
IPR036388 WH-like_DNA-bd_sf
PfamiView protein in Pfam
PF01853 MOZ_SAS, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS51726 MYST_HAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMST2_SCHPO
AccessioniPrimary (citable) accession number: Q10325
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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Main funding by: National Institutes of Health

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