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Entry version 141 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Putative dihydroxy-acid dehydratase, mitochondrial

Gene

SPAC17G8.06c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterCuratedNote: Binds 1 [4Fe-4S] cluster.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-isoleucine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-isoleucine from 2-oxobutanoate. This subpathway is part of the pathway L-isoleucine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-isoleucine from 2-oxobutanoate, the pathway L-isoleucine biosynthesis and in Amino-acid biosynthesis.

Pathwayi: L-valine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-valine from pyruvate. This subpathway is part of the pathway L-valine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-valine from pyruvate, the pathway L-valine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi157Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi232Iron-sulfur (4Fe-4S)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Branched-chain amino acid biosynthesis
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00047;UER00057
UPA00049;UER00061

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Putative dihydroxy-acid dehydratase, mitochondrial (EC:4.2.1.9)
Short name:
DAD
Alternative name(s):
2,3-dihydroxy acid hydrolyase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:SPAC17G8.06c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC17G8.06c

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC17G8.06c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – ?MitochondrionSequence analysis
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000015635? – 598Putative dihydroxy-acid dehydratase, mitochondrial

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q10318

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10318

PRoteomics IDEntifications database

More...
PRIDEi
Q10318

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278631, 3 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC17G8.06c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q10318

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IlvD/Edd family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2448, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_014271_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10318

Identification of Orthologs from Complete Genome Data

More...
OMAi
IPGHVHL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q10318

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.30.80, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00012, IlvD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042096, Dihydro-acid_dehy_C
IPR004404, DihydroxyA_deHydtase
IPR000581, DiOHA_6PGluconate_deHydtase
IPR020558, DiOHA_6PGluconate_deHydtase_CS
IPR037237, IlvD/EDD_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00920, ILVD_EDD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143975, SSF143975, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00110, ilvD, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00886, ILVD_EDD_1, 1 hit
PS00887, ILVD_EDD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q10318-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFCKLLRCQ NGIASKRAAL SLKGFKTSSI NLVEKKLNKY SETITGPKSQ
60 70 80 90 100
GASQAMLYAT GLNEEDMKKP QVGIASCWYE GNPCNMHLLD LGRRVKEGVK
110 120 130 140 150
KAGLTGFQFN TIGVSDGISM GTTGMRYSLQ SREIIADSIE TVMQGQWYDA
160 170 180 190 200
NVSIPGCDKN MPGCLIAMGR FNRPSIMVYG GSIRAGHSPC QNNAPIDIVS
210 220 230 240 250
AFQSYGEFIT GKIDEPTRHD IIRHACPGGG ACGGMYTANT MASCAEAMGM
260 270 280 290 300
TLPGSSSYLA GSPEKFAECE AAGSAIKRLL VDDIKPRDIM TRSAFENAMV
310 320 330 340 350
LTMTLGGSTN SVLHLIAIAK SVGITLTLDD FQAVSNRTPF IADMKPSGKY
360 370 380 390 400
VMEDLFAIGG IPSVLKYLHA EGLIDGSNIT VTGKTLAENL RGFKDLAEGQ
410 420 430 440 450
KIIRPLSNPI KTEGHLRVLR GSLAPEGSVA KITGKEGLNF TGKARVFDAE
460 470 480 490 500
NDFIAALERG EFKKGEKTVV IIRFEGPKGG PGMPEMLKPS SAIMGAGLGK
510 520 530 540 550
DVALLTDGRF SGGSHGFLIG HVDPEAQVGG PIALVQDGDV IEINAVKNTL
560 570 580 590
DLMVDEKEMA RRRSVWKAPP LKYQQGTLLK YARNVSTASK GAVTDSLE
Length:598
Mass (Da):63,927
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF9E5544F0B87393
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti196I → V in BAA13915 (PubMed:9501991).Curated1
Sequence conflicti205Y → F in BAA13915 (PubMed:9501991).Curated1
Sequence conflicti270E → A in BAA13915 (PubMed:9501991).Curated1
Sequence conflicti285K → E in BAA13915 (PubMed:9501991).Curated1
Sequence conflicti290M → L in BAA13915 (PubMed:9501991).Curated1
Sequence conflicti293S → F in BAA13915 (PubMed:9501991).Curated1
Sequence conflicti318I → T in BAA13915 (PubMed:9501991).Curated1
Sequence conflicti399G → D in BAA13915 (PubMed:9501991).Curated1
Sequence conflicti552L → V in BAA13915 (PubMed:9501991).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93689.1
D89254 mRNA Translation: BAA13915.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T37858
T43179

NCBI Reference Sequences

More...
RefSeqi
NP_593729.1, NM_001019160.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC17G8.06c.1; SPAC17G8.06c.1:pep; SPAC17G8.06c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542155

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC17G8.06c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93689.1
D89254 mRNA Translation: BAA13915.1
PIRiT37858
T43179
RefSeqiNP_593729.1, NM_001019160.2

3D structure databases

SMRiQ10318
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi278631, 3 interactors
STRINGi4896.SPAC17G8.06c.1

Proteomic databases

MaxQBiQ10318
PaxDbiQ10318
PRIDEiQ10318

Genome annotation databases

EnsemblFungiiSPAC17G8.06c.1; SPAC17G8.06c.1:pep; SPAC17G8.06c
GeneIDi2542155
KEGGispo:SPAC17G8.06c

Organism-specific databases

PomBaseiSPAC17G8.06c
VEuPathDBiFungiDB:SPAC17G8.06c

Phylogenomic databases

eggNOGiKOG2448, Eukaryota
HOGENOMiCLU_014271_4_2_1
InParanoidiQ10318
OMAiIPGHVHL
PhylomeDBiQ10318

Enzyme and pathway databases

UniPathwayiUPA00047;UER00057
UPA00049;UER00061

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10318

Family and domain databases

Gene3Di3.50.30.80, 1 hit
HAMAPiMF_00012, IlvD, 1 hit
InterProiView protein in InterPro
IPR042096, Dihydro-acid_dehy_C
IPR004404, DihydroxyA_deHydtase
IPR000581, DiOHA_6PGluconate_deHydtase
IPR020558, DiOHA_6PGluconate_deHydtase_CS
IPR037237, IlvD/EDD_N
PfamiView protein in Pfam
PF00920, ILVD_EDD, 1 hit
SUPFAMiSSF143975, SSF143975, 1 hit
TIGRFAMsiTIGR00110, ilvD, 1 hit
PROSITEiView protein in PROSITE
PS00886, ILVD_EDD_1, 1 hit
PS00887, ILVD_EDD_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiILV3_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10318
Secondary accession number(s): P78903
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 141 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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