itr1

Protein namesⁱ	Recommended name: Myo-inositol transporter 1
Gene namesⁱ	Name:itr1 ORF Names:SPAC4F8.15, SPAC7D4.01
Organismⁱ	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifierⁱ	284812 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › Schizosaccharomyces pombe
Proteomesⁱ	UP000002485 Componentⁱ: Chromosome I

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC4F8.15
PomBaseⁱ	SPAC4F8.15 itr1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 86	CytoplasmicSequence analysisAdd BLAST	86
Transmembraneⁱ	87 – 107	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	108 – 129	LumenalSequence analysisAdd BLAST	22
Transmembraneⁱ	130 – 150	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	151 – 156	CytoplasmicSequence analysis	6
Transmembraneⁱ	157 – 177	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	178 – 186	LumenalSequence analysis	9
Transmembraneⁱ	187 – 207	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	208 – 215	CytoplasmicSequence analysis	8
Transmembraneⁱ	216 – 236	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	237 – 246	LumenalSequence analysis	10
Transmembraneⁱ	247 – 267	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	268 – 349	CytoplasmicSequence analysisAdd BLAST	82
Transmembraneⁱ	350 – 370	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	371 – 376	LumenalSequence analysis	6
Transmembraneⁱ	377 – 397	Helical; Name=8Sequence analysisAdd BLAST	21
Topological domainⁱ	398 – 400	CytoplasmicSequence analysis	3
Transmembraneⁱ	401 – 421	Helical; Name=9Sequence analysisAdd BLAST	21
Topological domainⁱ	422 – 441	LumenalSequence analysisAdd BLAST	20
Transmembraneⁱ	442 – 462	Helical; Name=10Sequence analysisAdd BLAST	21
Topological domainⁱ	463 – 486	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	487 – 507	Helical; Name=11Sequence analysisAdd BLAST	21
Topological domainⁱ	508 – 510	LumenalSequence analysis	3
Transmembraneⁱ	511 – 531	Helical; Name=12Sequence analysisAdd BLAST	21
Topological domainⁱ	532 – 575	CytoplasmicSequence analysisAdd BLAST	44

Keywords - Cellular componentⁱ

Golgi apparatus, Membrane, Vacuole

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000050453	1 – 575	Myo-inositol transporter 1Add BLAST		575

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	432	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q10286
PaxDbⁱ	Q10286
PRIDEⁱ	Q10286

PTM databases

iPTMnetⁱ	Q10286

iPTMnetⁱ

Q10286

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	279577, 4 interactors
STRINGⁱ	4896.SPAC4F8.15.1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q10286
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMⁱ	HOG000202868
InParanoidⁱ	Q10286
KEGG Orthology (KO) More...KOⁱ	K08150
OMAⁱ	TSSMNWG
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C305R
PhylomeDBⁱ	Q10286

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q10286-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSISSKDFQN VTSAGFADDT FAADTFAADK KSPFESSVFE NKTQVLPVDS 
        60         70         80         90        100
VSRLSNGARS RSNSNISLSE PHALNDTVED QPVSKWVWVL AFAAGIGGLL 
       110        120        130        140        150
FGYDTGVISG ALVVIGTSLG GHELTNGGKE FITSATSLGA LLGGIIAGAL 
       160        170        180        190        200
ADFFGRKPVI AIASIIIIVG SIVQVTAHHL WHMIVGRFVI GWGVGIASLI 
       210        220        230        240        250
IPLYLSEIAP SKIRGRLVII YVLLITAGQV IAYGIDTAFE HVHNGWRWMV 
       260        270        280        290        300
GLAMVPAAFQ LFILIWLPES PRLLVKKERS QEAYNTLARI YPTAHPYEIK 
       310        320        330        340        350
TKLYLIQEGV RDPFSGSRWQ KIVKTFKELY FNPSNFRALI LACGLQAMQQ 
       360        370        380        390        400
LSGFNSLMYF SSTIFEVVGF NNPTATGLII AATNFVFTIV AFGVIDFFGR 
       410        420        430        440        450
RILLLLTVWG MIAALIVCAV AFHFLPKDEN GNYTSGQSNA WAIVVLISMI 
       460        470        480        490        500
VYVASYASGL GNLPWQQSEL FPMSVRGLGT GMSTAVNWAG NLGIGASFLT 
       510        520        530        540        550
LMSEITPTGT FALYGGLCFL GWLGALFCYP DLTDYTIEEI GELLKHGFGV 
       560        570 
RESMRHLKRV RQERAWSRED KEQNN

Length:575

Mass (Da):62,758

Last modified:November 1, 1997 - v1

Checksum:ⁱ3B7C5EFF86C596AE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X98622 Genomic DNA Translation: CAA67211.1 CU329670 Genomic DNA Translation: CAB16718.1 AB027770 Genomic DNA Translation: BAA87074.1
PIRⁱ	T43400
NCBI Reference Sequences More...RefSeqⁱ	NP_593858.2, NM_001019287.2

Genome annotation databases

EnsemblFungiⁱ	SPAC4F8.15.1; SPAC4F8.15.1:pep; SPAC4F8.15
GeneIDⁱ	2543145
KEGGⁱ	spo:SPAC4F8.15

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q10286	Uncharacterized protein		Tortispora caseinolytica NRRL Y-17796		484	UniRef50_Q10286
Myo-inositol transporter Itr1		SCHJY		580
Myo-inositol transporter Itr1		SCHCR		568
Uncharacterized protein		Saitoella complicata NRRL Y-17804		554
Myo-inositol transporter Itr1		SCHOY		568

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X98622 Genomic DNA Translation: CAA67211.1 CU329670 Genomic DNA Translation: CAB16718.1 AB027770 Genomic DNA Translation: BAA87074.1
PIRⁱ	T43400
RefSeqⁱ	NP_593858.2, NM_001019287.2

3D structure databases

ProteinModelPortalⁱ	Q10286
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	279577, 4 interactors
STRINGⁱ	4896.SPAC4F8.15.1

PTM databases

iPTMnetⁱ	Q10286

iPTMnetⁱ

Q10286

Proteomic databases

MaxQBⁱ	Q10286
PaxDbⁱ	Q10286
PRIDEⁱ	Q10286

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	SPAC4F8.15.1; SPAC4F8.15.1:pep; SPAC4F8.15
GeneIDⁱ	2543145
KEGGⁱ	spo:SPAC4F8.15

Organism-specific databases

EuPathDBⁱ	FungiDB:SPAC4F8.15
PomBaseⁱ	SPAC4F8.15 itr1

Phylogenomic databases

HOGENOMⁱ	HOG000202868
InParanoidⁱ	Q10286
KOⁱ	K08150
OMAⁱ	TSSMNWG
OrthoDBⁱ	EOG092C305R
PhylomeDBⁱ	Q10286

Enzyme and pathway databases

Reactomeⁱ	R-SPO-429593 Inositol transporters

Reactomeⁱ

R-SPO-429593 Inositol transporters

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q10286

PROⁱ

PR:Q10286

Family and domain databases

CDDⁱ	cd06174 MFS, 1 hit
InterProⁱ	View protein in InterPro IPR020846 MFS_dom IPR005828 MFS_sugar_transport-like IPR036259 MFS_trans_sf IPR003663 Sugar/inositol_transpt IPR005829 Sugar_transporter_CS
Pfamⁱ	View protein in Pfam PF00083 Sugar_tr, 1 hit
PRINTSⁱ	PR00171 SUGRTRNSPORT
SUPFAMⁱ	SSF103473 SSF103473, 1 hit
TIGRFAMsⁱ	TIGR00879 SP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50850 MFS, 1 hit PS00216 SUGAR_TRANSPORT_1, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ITR1_SCHPO
Accessionⁱ	Q10286Primary (citable) accession number: Q10286 Secondary accession number(s): Q9UU75
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q10286 (ITR1_SCHPO)

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Myo-inositol transporter 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Vacuole

Golgi apparatus

Golgi apparatus

Plasma Membrane

Vacuole

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ