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UniProtKB - Q10286 (ITR1_SCHPO)
Protein
Myo-inositol transporter 1
Gene
itr1
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Transporter for myo-inositol.
1 PublicationCatalytic activityi
GO - Molecular functioni
- myo-inositol:proton symporter activity Source: GO_Central
GO - Biological processi
- myo-inositol import across plasma membrane Source: PomBase
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-SPO-429593, Inositol transporters |
Names & Taxonomyi
Protein namesi | Recommended name: Myo-inositol transporter 1 |
Gene namesi | Name:itr1 ORF Names:SPAC4F8.15, SPAC7D4.01 |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC4F8.15, itr1 |
VEuPathDBi | FungiDB:SPAC4F8.15 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Vacuole
- Vacuole membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Golgi apparatus
- Golgi apparatus Source: PomBase
- Golgi membrane Source: UniProtKB-SubCell
Vacuole
- fungal-type vacuole membrane Source: PomBase
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 86 | CytoplasmicSequence analysisAdd BLAST | 86 | |
Transmembranei | 87 – 107 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 129 | LumenalSequence analysisAdd BLAST | 22 | |
Transmembranei | 130 – 150 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 151 – 156 | CytoplasmicSequence analysis | 6 | |
Transmembranei | 157 – 177 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 186 | LumenalSequence analysis | 9 | |
Transmembranei | 187 – 207 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 208 – 215 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 216 – 236 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 237 – 246 | LumenalSequence analysis | 10 | |
Transmembranei | 247 – 267 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 268 – 349 | CytoplasmicSequence analysisAdd BLAST | 82 | |
Transmembranei | 350 – 370 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 371 – 376 | LumenalSequence analysis | 6 | |
Transmembranei | 377 – 397 | Helical; Name=8Sequence analysisAdd BLAST | 21 | |
Topological domaini | 398 – 400 | CytoplasmicSequence analysis | 3 | |
Transmembranei | 401 – 421 | Helical; Name=9Sequence analysisAdd BLAST | 21 | |
Topological domaini | 422 – 441 | LumenalSequence analysisAdd BLAST | 20 | |
Transmembranei | 442 – 462 | Helical; Name=10Sequence analysisAdd BLAST | 21 | |
Topological domaini | 463 – 486 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 487 – 507 | Helical; Name=11Sequence analysisAdd BLAST | 21 | |
Topological domaini | 508 – 510 | LumenalSequence analysis | 3 | |
Transmembranei | 511 – 531 | Helical; Name=12Sequence analysisAdd BLAST | 21 | |
Topological domaini | 532 – 575 | CytoplasmicSequence analysisAdd BLAST | 44 |
Keywords - Cellular componenti
Golgi apparatus, Membrane, VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050453 | 1 – 575 | Myo-inositol transporter 1Add BLAST | 575 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 432 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | Q10286 |
PaxDbi | Q10286 |
PTM databases
iPTMneti | Q10286 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 279577, 4 interactors |
STRINGi | 4896.SPAC4F8.15.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | Q10286 |
OMAi | CVAPLYI |
PhylomeDBi | Q10286 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits |
i Sequence
Sequence statusi: Complete.
Q10286-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSISSKDFQN VTSAGFADDT FAADTFAADK KSPFESSVFE NKTQVLPVDS
60 70 80 90 100
VSRLSNGARS RSNSNISLSE PHALNDTVED QPVSKWVWVL AFAAGIGGLL
110 120 130 140 150
FGYDTGVISG ALVVIGTSLG GHELTNGGKE FITSATSLGA LLGGIIAGAL
160 170 180 190 200
ADFFGRKPVI AIASIIIIVG SIVQVTAHHL WHMIVGRFVI GWGVGIASLI
210 220 230 240 250
IPLYLSEIAP SKIRGRLVII YVLLITAGQV IAYGIDTAFE HVHNGWRWMV
260 270 280 290 300
GLAMVPAAFQ LFILIWLPES PRLLVKKERS QEAYNTLARI YPTAHPYEIK
310 320 330 340 350
TKLYLIQEGV RDPFSGSRWQ KIVKTFKELY FNPSNFRALI LACGLQAMQQ
360 370 380 390 400
LSGFNSLMYF SSTIFEVVGF NNPTATGLII AATNFVFTIV AFGVIDFFGR
410 420 430 440 450
RILLLLTVWG MIAALIVCAV AFHFLPKDEN GNYTSGQSNA WAIVVLISMI
460 470 480 490 500
VYVASYASGL GNLPWQQSEL FPMSVRGLGT GMSTAVNWAG NLGIGASFLT
510 520 530 540 550
LMSEITPTGT FALYGGLCFL GWLGALFCYP DLTDYTIEEI GELLKHGFGV
560 570
RESMRHLKRV RQERAWSRED KEQNN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98622 Genomic DNA Translation: CAA67211.1 CU329670 Genomic DNA Translation: CAB16718.1 AB027770 Genomic DNA Translation: BAA87074.1 |
PIRi | T43400 |
RefSeqi | NP_593858.2, NM_001019287.2 |
Genome annotation databases
EnsemblFungii | SPAC4F8.15.1; SPAC4F8.15.1:pep; SPAC4F8.15 |
GeneIDi | 2543145 |
KEGGi | spo:SPAC4F8.15 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98622 Genomic DNA Translation: CAA67211.1 CU329670 Genomic DNA Translation: CAB16718.1 AB027770 Genomic DNA Translation: BAA87074.1 |
PIRi | T43400 |
RefSeqi | NP_593858.2, NM_001019287.2 |
3D structure databases
SMRi | Q10286 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 279577, 4 interactors |
STRINGi | 4896.SPAC4F8.15.1 |
PTM databases
iPTMneti | Q10286 |
Proteomic databases
MaxQBi | Q10286 |
PaxDbi | Q10286 |
Genome annotation databases
EnsemblFungii | SPAC4F8.15.1; SPAC4F8.15.1:pep; SPAC4F8.15 |
GeneIDi | 2543145 |
KEGGi | spo:SPAC4F8.15 |
Organism-specific databases
PomBasei | SPAC4F8.15, itr1 |
VEuPathDBi | FungiDB:SPAC4F8.15 |
Phylogenomic databases
eggNOGi | KOG0254, Eukaryota |
HOGENOMi | CLU_001265_30_5_1 |
InParanoidi | Q10286 |
OMAi | CVAPLYI |
PhylomeDBi | Q10286 |
Enzyme and pathway databases
Reactomei | R-SPO-429593, Inositol transporters |
Miscellaneous databases
PROi | PR:Q10286 |
Family and domain databases
Gene3Di | 1.20.1250.20, 1 hit |
InterProi | View protein in InterPro IPR020846, MFS_dom IPR005828, MFS_sugar_transport-like IPR036259, MFS_trans_sf IPR003663, Sugar/inositol_transpt IPR005829, Sugar_transporter_CS |
Pfami | View protein in Pfam PF00083, Sugar_tr, 1 hit |
PRINTSi | PR00171, SUGRTRNSPORT |
SUPFAMi | SSF103473, SSF103473, 1 hit |
TIGRFAMsi | TIGR00879, SP, 1 hit |
PROSITEi | View protein in PROSITE PS50850, MFS, 1 hit PS00216, SUGAR_TRANSPORT_1, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ITR1_SCHPO | |
Accessioni | Q10286Primary (citable) accession number: Q10286 Secondary accession number(s): Q9UU75 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families