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Entry version 152 (12 Aug 2020)
Sequence version 2 (01 Dec 2000)
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Protein

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Gene

hmg1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Acetyl-CoA acetyltransferase (erg10)
  2. Hydroxymethylglutaryl-CoA synthase (hcs1)
  3. 3-hydroxy-3-methylglutaryl-coenzyme A reductase (hmg1)
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei712Charge relay systemBy similarity1
Active sitei846Charge relay systemBy similarity1
Active sitei922Charge relay systemBy similarity1
Active sitei1018Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandNADP

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-191273, Cholesterol biosynthesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00058;UER00103

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC:1.1.1.34)
Short name:
HMG-CoA reductase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hmg1
Synonyms:its12
ORF Names:SPCC162.09c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:SPCC162.09c

Schizosaccharomyces pombe database

More...
PomBasei
SPCC162.09c, hmg1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 8CytoplasmicBy similarity8
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 203LumenalBy similarityAdd BLAST174
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 232CytoplasmicBy similarity8
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Topological domaini254 – 258LumenalBy similarity5
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Topological domaini280 – 320CytoplasmicBy similarityAdd BLAST41
Transmembranei321 – 341HelicalSequence analysisAdd BLAST21
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 417CytoplasmicSequence analysisAdd BLAST55
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21
Topological domaini439 – 526LumenalSequence analysisAdd BLAST88
Transmembranei527 – 547HelicalSequence analysisAdd BLAST21
Topological domaini548 – 1053CytoplasmicSequence analysisAdd BLAST506

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1163121

DrugCentral

More...
DrugCentrali
Q10283

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001144551 – 10533-hydroxy-3-methylglutaryl-coenzyme A reductaseAdd BLAST1053

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi518N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1024Phosphoserine1 Publication1
Modified residuei1028Phosphothreonine1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q10283

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10283

PRoteomics IDEntifications database

More...
PRIDEi
Q10283

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q10283

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
275573, 10 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPCC162.09c.1

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q10283

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini204 – 365SSDPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni548 – 615LinkerAdd BLAST68
Regioni616 – 1053CatalyticAdd BLAST438

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HMG-CoA reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2480, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001734_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10283

KEGG Orthology (KO)

More...
KOi
K00021

Identification of Orthologs from Complete Genome Data

More...
OMAi
NCITIMK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q10283

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00643, HMG-CoA_reductase_classI, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3270.10, 1 hit
3.30.70.420, 1 hit
3.90.770.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002202, HMG_CoA_Rdtase
IPR023074, HMG_CoA_Rdtase_cat_sf
IPR023076, HMG_CoA_Rdtase_CS
IPR004554, HMG_CoA_Rdtase_eu_arc
IPR023282, HMG_CoA_Rdtase_N
IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf
IPR000731, SSD

The PANTHER Classification System

More...
PANTHERi
PTHR10572, PTHR10572, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00368, HMG-CoA_red, 1 hit
PF12349, Sterol-sensing, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00071, HMGCOARDTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55035, SSF55035, 1 hit
SSF56542, SSF56542, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00533, HMG_CoA_R_NADP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00066, HMG_COA_REDUCTASE_1, 1 hit
PS00318, HMG_COA_REDUCTASE_2, 1 hit
PS50065, HMG_COA_REDUCTASE_4, 1 hit
PS50156, SSD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q10283-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIYKLAARYP IQVIAIVGIL VSMAYFSFLE ALTQEDFPVL IRALKRFGIL
60 70 80 90 100
DGFPNTRLPN EMILKLSSVQ GEDASVWEQI PAAELGGEGF VDFDITQWYY
110 120 130 140 150
PANAKVDVAQ LVEPYRNDCI FHDASGACHF FFKEVGNWTV SSIALPSNLA
160 170 180 190 200
NPPIDYFLDS SSTVIQRILP AIREHGISWS WLLQLIARTW MNTLKIASQA
210 220 230 240 250
SKTELLIVGT AYACMLISIV SLYLKMRRLG SKFWLFFSVL LSTLFSVQFA
260 270 280 290 300
MTLVRASGVR ISLVSLIESL PFLINVVALD KAAELTRQVI TRCSVSDSHS
310 320 330 340 350
PMHEDIAKAC RNAAPPILRH FSFGIVVLAI FSYCNFGIKQ FFLFAAVMIY
360 370 380 390 400
DLLLLFSFFV AILTLKLEMR RYNAKDDVRK VLIEEGLSES TARHVADGND
410 420 430 440 450
SSATTSAGSR YFKVRYGTKI ILFIFIAFNL FELCSIPFKH YAATSAAAAR
460 470 480 490 500
LIPLVRSQYP DFKSQRLLDD GVFDDVLSAI SSMSNIESPS VRLLPAVFYG
510 520 530 540 550
AELSSTSFLS TIHSFINNWS HYISASFLSK WIVCALSLSI AVNVFLLNAA
560 570 580 590 600
RLNSIKEEPE KKVVEKVVEV VKYIPSSNSS SIDDIQKDEI AQESVVRSLE
610 620 630 640 650
ECITLYNNGQ ISTLNDEEVV QLTLAKKIPL YALERVLKDV TRAVVIRRTV
660 670 680 690 700
VSRSSRTKTL ESSNCPVYHY DYSRVLNACC ENVIGYMPLP LGVAGPLIID
710 720 730 740 750
GKPFYIPMAT TEGALVASTM RGCKAINAGG GAVTVLTRDQ MSRGPCVAFP
760 770 780 790 800
NLTRAGRAKI WLDSPEGQEV MKKAFNSTSR FARLQHIKTA LAGTRLFIRF
810 820 830 840 850
CTSTGDAMGM NMISKGVEHA LVVMSNDAGF DDMQVISVSG NYCTDKKPAA
860 870 880 890 900
INWIDGRGKS VIAEAIIPGD AVKSVLKTTV EDLVKLNVDK NLIGSAMAGS
910 920 930 940 950
VGGFNAHAAN IVTAVYLATG QDPAQNVESS NCITLMDNVD GNLQLSVSMP
960 970 980 990 1000
SIEVGTIGGG TVLEPQGAML DLLGVRGAHM TSPGDNSRQL ARVVAAAVMA
1010 1020 1030 1040 1050
GELSLCSALA SGHLVKSHIG LNRSALNTPA MDSSAKKPAT DALKSVNSRV

PGR
Length:1,053
Mass (Da):114,877
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i33E5C2365222D238
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti751N → D in AAB39277 (PubMed:8896278).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L76979 Genomic DNA Translation: AAB39277.1
CU329672 Genomic DNA Translation: CAA19589.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S72194

NCBI Reference Sequences

More...
RefSeqi
NP_588235.1, NM_001023225.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPCC162.09c.1; SPCC162.09c.1:pep; SPCC162.09c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2538999

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPCC162.09c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76979 Genomic DNA Translation: AAB39277.1
CU329672 Genomic DNA Translation: CAA19589.1
PIRiS72194
RefSeqiNP_588235.1, NM_001023225.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi275573, 10 interactors
STRINGi4896.SPCC162.09c.1

Chemistry databases

BindingDBiQ10283
ChEMBLiCHEMBL1163121
DrugCentraliQ10283

PTM databases

iPTMnetiQ10283

Proteomic databases

MaxQBiQ10283
PaxDbiQ10283
PRIDEiQ10283

Genome annotation databases

EnsemblFungiiSPCC162.09c.1; SPCC162.09c.1:pep; SPCC162.09c
GeneIDi2538999
KEGGispo:SPCC162.09c

Organism-specific databases

EuPathDBiFungiDB:SPCC162.09c
PomBaseiSPCC162.09c, hmg1

Phylogenomic databases

eggNOGiKOG2480, Eukaryota
HOGENOMiCLU_001734_0_0_1
InParanoidiQ10283
KOiK00021
OMAiNCITIMK
PhylomeDBiQ10283

Enzyme and pathway databases

UniPathwayiUPA00058;UER00103
ReactomeiR-SPO-191273, Cholesterol biosynthesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10283

Family and domain databases

CDDicd00643, HMG-CoA_reductase_classI, 1 hit
Gene3Di1.10.3270.10, 1 hit
3.30.70.420, 1 hit
3.90.770.10, 1 hit
InterProiView protein in InterPro
IPR002202, HMG_CoA_Rdtase
IPR023074, HMG_CoA_Rdtase_cat_sf
IPR023076, HMG_CoA_Rdtase_CS
IPR004554, HMG_CoA_Rdtase_eu_arc
IPR023282, HMG_CoA_Rdtase_N
IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf
IPR000731, SSD
PANTHERiPTHR10572, PTHR10572, 1 hit
PfamiView protein in Pfam
PF00368, HMG-CoA_red, 1 hit
PF12349, Sterol-sensing, 1 hit
PRINTSiPR00071, HMGCOARDTASE
SUPFAMiSSF55035, SSF55035, 1 hit
SSF56542, SSF56542, 1 hit
TIGRFAMsiTIGR00533, HMG_CoA_R_NADP, 1 hit
PROSITEiView protein in PROSITE
PS00066, HMG_COA_REDUCTASE_1, 1 hit
PS00318, HMG_COA_REDUCTASE_2, 1 hit
PS50065, HMG_COA_REDUCTASE_4, 1 hit
PS50156, SSD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMDH_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10283
Secondary accession number(s): O74425
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 1, 2000
Last modified: August 12, 2020
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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