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Protein

Putative choline kinase

Gene

SPAC13G7.12c

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphocholine from choline.
Proteins known to be involved in this subpathway in this organism are:
  1. Putative choline kinase (SPAC13G7.12c)
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphocholine from choline, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-SPO-1483191 Synthesis of PC
R-SPO-1483213 Synthesis of PE
UniPathwayiUPA00753; UER00737

Names & Taxonomyi

Protein namesi
Recommended name:
Putative choline kinase (EC:2.7.1.32)
Gene namesi
ORF Names:SPAC13G7.12c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC13G7.12c
PomBaseiSPAC13G7.12c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002062251 – 456Putative choline kinaseAdd BLAST456

Proteomic databases

MaxQBiQ10276
PaxDbiQ10276
PRIDEiQ10276

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi279285, 34 interactors
STRINGi4896.SPAC13G7.12c.1

Structurei

3D structure databases

ProteinModelPortaliQ10276
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

InParanoidiQ10276
KOiK00866
OMAiRAYLWCK
OrthoDBiEOG092C0QOM
PhylomeDBiQ10276

Family and domain databases

InterProiView protein in InterPro
IPR007521 Choline_kin_N
IPR011009 Kinase-like_dom_sf
PfamiView protein in Pfam
PF04428 Choline_kin_N, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits

Sequencei

Sequence statusi: Complete.

Q10276-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNFASEVDK NNAFDSAHPS RKCKGSLDCN DPDPIFRHKV LVIIHKLAIS
60 70 80 90 100
SWNRIPLTLC NKLHIKRISG ALTNAVYYVA PPEGYHAPKL LLRIYGPHVE
110 120 130 140 150
LFINRQVELE NLKRLARHNI GPYLIGEFSN GRFEQYMEST TLTCKTIRDP
160 170 180 190 200
KLSIYVGRRL CELHNFILLH PHEVLEMPAA WKNCLVWLPK AKAKILGRKH
210 220 230 240 250
SLAITSEFMK TLEEDFNAYY NWFVEWSRDK KDWFGLKMVF SHNDTQYGNL
260 270 280 290 300
LKIKAKKRSI PLSQKHRTLV PVDFEYAGPN LCAFDLANYF AEWMADYHHP
310 320 330 340 350
THNYLMDRSR YPDFNARKLV YHAYVEQSAV INDLLEIEDA SLLKTDISDE
360 370 380 390 400
LKNTFEKQIM NLEESVRAIS PAANIGWALW GILQCLEEDD EWEDLSVSSQ
410 420 430 440 450
VADRPEKQLV EGSTVPPIGT SSFDYIGYSS EKFDLFYEGC AALGLNGRNR

STFSYA
Length:456
Mass (Da):52,536
Last modified:October 1, 1996 - v1
Checksum:i08284FF1FC5FA089
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93600.1
PIRiS67441
RefSeqiNP_593714.1, NM_001019145.2

Genome annotation databases

EnsemblFungiiSPAC13G7.12c.1; SPAC13G7.12c.1:pep; SPAC13G7.12c
GeneIDi2542839
KEGGispo:SPAC13G7.12c

Similar proteinsi

Entry informationi

Entry nameiKICH_SCHPO
AccessioniPrimary (citable) accession number: Q10276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

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