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UniProtKB - Q10185 (ABC2_SCHPO)
Protein
ATP-binding cassette transporter abc2
Gene
abc2
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Functioni
Involved in vacuolar sequestration of glutathione S-conjugates. Together with abc4, required for accumulation of a red pigment (ade pigment) in the vacuole of a mutant affected in the adenine biosynthetic pathway.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 631 – 638 | ATP 1PROSITE-ProRule annotation | 8 | |
Nucleotide bindingi | 1273 – 1280 | ATP 2PROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ABC-type peptide transporter activity Source: GO_Central
- ABC-type phytochelatin transporter activity Source: PomBase
- ATPase-coupled transmembrane transporter activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- cellular detoxification of cadmium ion Source: PomBase
- glutathione transmembrane import into vacuole Source: PomBase
- phytochelatin 2 import into vacuole Source: PomBase
- transmembrane transport Source: GO_Central
Keywordsi
Molecular function | Translocase |
Biological process | Detoxification, Transport |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-SPO-189483, Heme degradation R-SPO-196741, Cobalamin (Cbl, vitamin B12) transport and metabolism R-SPO-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX) R-SPO-382556, ABC-family proteins mediated transport R-SPO-9707564, Cytoprotection by HMOX1 |
Protein family/group databases
TCDBi | 3.A.1.208.16, the atp-binding cassette (abc) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: ATP-binding cassette transporter abc2 (EC:7.-.-.-)Short name: ABC transporter abc2 Alternative name(s): ATP-energized glutathione S-conjugate pump abc2 Glutathione S-conjugate-transporting ATPase abc2 |
Gene namesi | Name:abc2 ORF Names:SPAC3F10.11c |
Organismi | Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
Taxonomic identifieri | 284812 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Taphrinomycotina › Schizosaccharomycetes › Schizosaccharomycetales › Schizosaccharomycetaceae › Schizosaccharomyces › |
Proteomesi |
|
Organism-specific databases
PomBasei | SPAC3F10.11c, abc2 |
VEuPathDBi | FungiDB:SPAC3F10.11c |
Subcellular locationi
Vacuole
- Vacuole membrane Curated; Multi-pass membrane protein PROSITE-ProRule annotation
Golgi apparatus
- Golgi apparatus Source: PomBase
Vacuole
- fungal-type vacuole Source: PomBase
- fungal-type vacuole membrane Source: PomBase
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 25 | VacuolarBy similarityAdd BLAST | 25 | |
Transmembranei | 26 – 46 | Helical; Name=1PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 47 – 65 | CytoplasmicBy similarityAdd BLAST | 19 | |
Transmembranei | 66 – 85 | Helical; Name=2PROSITE-ProRule annotationAdd BLAST | 20 | |
Topological domaini | 86 – 90 | VacuolarBy similarity | 5 | |
Transmembranei | 91 – 104 | Helical; Name=3PROSITE-ProRule annotationAdd BLAST | 14 | |
Topological domaini | 105 – 116 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 117 – 137 | Helical; Name=4PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 138 – 154 | VacuolarBy similarityAdd BLAST | 17 | |
Transmembranei | 155 – 175 | Helical; Name=5PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 176 – 259 | CytoplasmicBy similarityAdd BLAST | 84 | |
Transmembranei | 260 – 280 | Helical; Name=6PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 281 – 310 | VacuolarBy similarityAdd BLAST | 30 | |
Transmembranei | 311 – 331 | Helical; Name=7PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 332 – 387 | CytoplasmicBy similarityAdd BLAST | 56 | |
Transmembranei | 388 – 408 | Helical; Name=8PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 409 – 411 | VacuolarBy similarity | 3 | |
Transmembranei | 412 – 432 | Helical; Name=9PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 433 – 495 | CytoplasmicBy similarityAdd BLAST | 63 | |
Transmembranei | 496 – 516 | Helical; Name=10PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 517 – 539 | VacuolarBy similarityAdd BLAST | 23 | |
Transmembranei | 540 – 560 | Helical; Name=11PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 561 – 910 | CytoplasmicBy similarityAdd BLAST | 350 | |
Transmembranei | 911 – 931 | Helical; Name=12PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 932 – 968 | VacuolarBy similarityAdd BLAST | 37 | |
Transmembranei | 969 – 990 | Helical; Name=13PROSITE-ProRule annotationAdd BLAST | 22 | |
Topological domaini | 991 – 1033 | CytoplasmicBy similarityAdd BLAST | 43 | |
Transmembranei | 1034 – 1054 | Helical; Name=14PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1055 | VacuolarBy similarity | 1 | |
Transmembranei | 1056 – 1076 | Helical; Name=15PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1077 – 1147 | CytoplasmicBy similarityAdd BLAST | 71 | |
Transmembranei | 1148 – 1168 | Helical; Name=16PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1169 – 1172 | VacuolarBy similarity | 4 | |
Transmembranei | 1173 – 1193 | Helical; Name=17PROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 1194 – 1478 | CytoplasmicBy similarityAdd BLAST | 285 |
Keywords - Cellular componenti
Membrane, VacuolePathology & Biotechi
Disruption phenotypei
Cells lacking both abc2 and abc4 show sensitivity to cycloheximide (CHX) and 4-nitroquinoline oxide (4-NQO), and decreased accumulation of monochlorobimane-glutathione (MCIB-GS).1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000093468 | 1 – 1478 | ATP-binding cassette transporter abc2Add BLAST | 1478 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 86 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 139 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 839 | Phosphoserine1 Publication | 1 | |
Modified residuei | 843 | Phosphoserine1 Publication | 1 | |
Modified residuei | 863 | Phosphoserine1 Publication | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | Q10185 |
PaxDbi | Q10185 |
PTM databases
iPTMneti | Q10185 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 279622, 21 interactors |
STRINGi | 4896.SPAC3F10.11c.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 268 – 557 | ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST | 290 | |
Domaini | 593 – 821 | ABC transporter 1PROSITE-ProRule annotationAdd BLAST | 229 | |
Domaini | 918 – 1202 | ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST | 285 | |
Domaini | 1239 – 1473 | ABC transporter 2PROSITE-ProRule annotationAdd BLAST | 235 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 828 – 867 | DisorderedSequence analysisAdd BLAST | 40 |
Sequence similaritiesi
Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]Curated
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0054, Eukaryota |
HOGENOMi | CLU_000604_27_3_1 |
InParanoidi | Q10185 |
OMAi | ICMATPV |
PhylomeDBi | Q10185 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q10185-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLEQDLDPF VGGNWMNSAY KGFTFLSATW LAPNIYLLIS GCLQYFYEVR
60 70 80 90 100
KRSHYFHFRR FWTIWLKSLV IMVLLFTHIY DCYKTNESVW NVLSIITYFL
110 120 130 140 150
ALFLHVVEQP TLRIPMASLL MFWLFKFLAS ALVLLLRPNY TMFPMLNVVP
160 170 180 190 200
SITFFCSLVC LLAEIYVPPA NRVWYPDDAA ELEETGLRPS RFTYANIFSR
210 220 230 240 250
ISFGWLSPLM KFGYRNYLTE SDAWSLPPAE RSSNLTIVFE KNWISHAKKK
260 270 280 290 300
KSSLYMWGVL FLNHWKLTVV IIVLKLVQDV VAFIQPNLIR KIVIFVSSYS
310 320 330 340 350
SEHPQPPQVG FSLAIAMFLT NVVQTALLQQ YFQLGMVLGM RWRSELITAI
360 370 380 390 400
YRKSLRLSSA ARQSRSVGDI VNYMSVDTQK VCDLTMFLFV IVSGPFQIVL
410 420 430 440 450
ALTNLYHLVG YGALSGAFVT FLLFPCNVVI ASIFKRFQNR QMKNKDARSQ
460 470 480 490 500
FMTEIINNIR SIKLYAWENI FLQKLLQLRN TRELRMLKKI GIVNTIGNFT
510 520 530 540 550
WLFAPILVSA ATFGTFIVLY GKTRVLSVDI VFACLSLFNL LQFPLTMLPI
560 570 580 590 600
VVSSVLEASV AISRIYGFLT AGELDSNAVQ RYPANKEPSG VCLEIKKGTF
610 620 630 640 650
SWSGPGQNAA EPTLRDIDFV ARRGELCCIV GKVGMGKSSL LEACLGNMQK
660 670 680 690 700
HSGSVFRCGS IAYAAQQPWI LNATIQENIL FGLELDPEFY EKTIRACCLL
710 720 730 740 750
RDFEILADGD QTEVGEKGIS LSGGQKARIS LARAVYSRSD IYLLDDILSA
760 770 780 790 800
VDQHVNRDLV RNLLGSKGLL RSRCVILSTN SLTVLKEASM IYMLRNGKII
810 820 830 840 850
ESGSFTQLSS SPDSQLFQLL SEFSKKDTAS STGADTPLSR SQSVITSSTD
860 870 880 890 900
VTSSASRSSD TVSNYPKATI KGTGRIRKRL TDEDNVKATG QAAEKMERGK
910 920 930 940 950
VKWKVYWTYF KACSLFLIFL YFLFIIGGIG MNVGTNVWLK HWSEVNTQLG
960 970 980 990 1000
YNPKPYFYLG IYTLFGLLSC ALISLSSLTI TVFCAIKSCR YLHDSMVKAV
1010 1020 1030 1040 1050
LRAPMSFFET TPTGRILNRF SSDVYRVDEV ISRVFMFFFR NLFQIVFVLA
1060 1070 1080 1090 1100
VICYSSPMFM ILIVPLFFLY RYNQVYYTQT SRELKRLDSV TRSPLYAHFQ
1110 1120 1130 1140 1150
ESLGGLSTIR AYDMEDTFIS ENDIRVDTNH RIWFLYFSSN RWQAIRVEAI
1160 1170 1180 1190 1200
GALVVFSSAF FGVLSAVRGN PNSGLVGLSL SYAVQITQSL TFVVRQSVDV
1210 1220 1230 1240 1250
ETNIVSVERM LEYIGLPSEA PSIIPDHRPP EGWPSHGAIK FDHYSVRYRE
1260 1270 1280 1290 1300
NLPLVLNDIS VNIKPQEKIG IVGRTGAGKS TLTLALFRLI EPTSGDIQLD
1310 1320 1330 1340 1350
DINITSIGLH DLRSRLAIIP QENQAFEGTI RENLDPNANA TDEEIWHALE
1360 1370 1380 1390 1400
AASLKQFIQT LDGGLYSRVT EGGANLSSGQ RQLMCLTRAL LTPTRVLLLD
1410 1420 1430 1440 1450
EATAAVDVET DAIVQRTIRE RFNDRTILTI AHRINTVMDS NRILVLDHGK
1460 1470
VVEFDSTKKL LENKASLFYS LAKESGLI
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1287 | F → L in BAA13892 (PubMed:9501991).Curated | 1 | |
Sequence conflicti | 1301 – 1303 | DIN → YIH in BAA13892 (PubMed:9501991).Curated | 3 | |
Sequence conflicti | 1311 | D → H in BAA13892 (PubMed:9501991).Curated | 1 | |
Sequence conflicti | 1467 | L → V in BAA13892 (PubMed:9501991).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAA93309.3 D89231 mRNA Translation: BAA13892.1 |
PIRi | T38712 |
RefSeqi | NP_593943.3, NM_001019371.3 |
Genome annotation databases
EnsemblFungii | SPAC3F10.11c.1; SPAC3F10.11c.1:pep; SPAC3F10.11c |
GeneIDi | 2543193 |
KEGGi | spo:SPAC3F10.11c |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU329670 Genomic DNA Translation: CAA93309.3 D89231 mRNA Translation: BAA13892.1 |
PIRi | T38712 |
RefSeqi | NP_593943.3, NM_001019371.3 |
3D structure databases
SMRi | Q10185 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 279622, 21 interactors |
STRINGi | 4896.SPAC3F10.11c.1 |
Protein family/group databases
TCDBi | 3.A.1.208.16, the atp-binding cassette (abc) superfamily |
PTM databases
iPTMneti | Q10185 |
Proteomic databases
MaxQBi | Q10185 |
PaxDbi | Q10185 |
Genome annotation databases
EnsemblFungii | SPAC3F10.11c.1; SPAC3F10.11c.1:pep; SPAC3F10.11c |
GeneIDi | 2543193 |
KEGGi | spo:SPAC3F10.11c |
Organism-specific databases
PomBasei | SPAC3F10.11c, abc2 |
VEuPathDBi | FungiDB:SPAC3F10.11c |
Phylogenomic databases
eggNOGi | KOG0054, Eukaryota |
HOGENOMi | CLU_000604_27_3_1 |
InParanoidi | Q10185 |
OMAi | ICMATPV |
PhylomeDBi | Q10185 |
Enzyme and pathway databases
Reactomei | R-SPO-189483, Heme degradation R-SPO-196741, Cobalamin (Cbl, vitamin B12) transport and metabolism R-SPO-2142691, Synthesis of Leukotrienes (LT) and Eoxins (EX) R-SPO-382556, ABC-family proteins mediated transport R-SPO-9707564, Cytoprotection by HMOX1 |
Miscellaneous databases
PROi | PR:Q10185 |
Family and domain databases
Gene3Di | 1.20.1560.10, 2 hits 3.40.50.300, 2 hits |
InterProi | View protein in InterPro IPR003593, AAA+_ATPase IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf IPR003439, ABC_transporter-like_ATP-bd IPR017871, ABC_transporter-like_CS IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF00664, ABC_membrane, 2 hits PF00005, ABC_tran, 2 hits |
SMARTi | View protein in SMART SM00382, AAA, 2 hits |
SUPFAMi | SSF52540, SSF52540, 2 hits SSF90123, SSF90123, 2 hits |
PROSITEi | View protein in PROSITE PS50929, ABC_TM1F, 2 hits PS00211, ABC_TRANSPORTER_1, 1 hit PS50893, ABC_TRANSPORTER_2, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ABC2_SCHPO | |
Accessioni | Q10185Primary (citable) accession number: Q10185 Secondary accession number(s): P78928 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Schizosaccharomyces pombe
Schizosaccharomyces pombe: entries and gene names - SIMILARITY comments
Index of protein domains and families