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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

SPAC3F10.09

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathwayi: L-histidine biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (his1)
  2. Histidine biosynthesis bifunctional protein his7 (his7)
  3. Histidine biosynthesis bifunctional protein his7 (his7)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (SPAC3F10.09)
  5. Imidazole glycerol phosphate synthase hisHF (his4)
  6. Imidazoleglycerol-phosphate dehydratase (his5)
  7. Histidinol-phosphate aminotransferase (his3)
  8. Probable histidinol-phosphatase (SPCC1672.01)
  9. Histidinol dehydrogenase (his2)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • histidine biosynthetic process Source: PomBase
  • tryptophan biosynthetic process Source: GO_Central

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00009

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
5-proFAR isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
ORF Names:SPAC3F10.09
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC3F10.09
PomBaseiSPAC3F10.09

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001419611 – 2641-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseAdd BLAST264

Proteomic databases

MaxQBiQ10184
PaxDbiQ10184
PRIDEiQ10184

Interactioni

Protein-protein interaction databases

BioGridi279535, 13 interactors
STRINGi4896.SPAC3F10.09.1

Structurei

3D structure databases

ProteinModelPortaliQ10184
SMRiQ10184
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.Curated

Phylogenomic databases

HOGENOMiHOG000172261
InParanoidiQ10184
KOiK01814
OMAiMTKFRPC
OrthoDBiEOG092C43NB
PhylomeDBiQ10184

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006062 His_biosynth
IPR011858 HisA_euk
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00977 His_biosynth, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02129 hisA_euk, 1 hit

Sequencei

Sequence statusi: Complete.

Q10184-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKSQHTLFR PCIDIHQGQV KQIVGGTLGN DADVKTNYVS LKPSSYYAEL
60 70 80 90 100
YKLNHLEGAH VIMLGPNCEE AAKTALHTWP GALQIGGGIN ISNAQNWLQE
110 120 130 140 150
GASKVIVTSW LFPDAQFDLD RLKAISSKIG KDRLVVDVSC RRKDNRWFAA
160 170 180 190 200
INKWQVMTAF ELNEENLDLL SQYCSEFLIH AADVEGLCKG IDEDLVIKLG
210 220 230 240 250
EWVKIPTTYA GGGRSIEDLD LVDKLSKGKV DLTIGSALDI FGGVLEFTRV
260
VAWNRRFTPL PLQD
Length:264
Mass (Da):29,346
Last modified:October 1, 1996 - v1
Checksum:i8C97F79938BDEB60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93307.1
PIRiT38710
RefSeqiNP_593941.1, NM_001019369.2

Genome annotation databases

EnsemblFungiiSPAC3F10.09.1; SPAC3F10.09.1:pep; SPAC3F10.09
GeneIDi2543103
KEGGispo:SPAC3F10.09

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93307.1
PIRiT38710
RefSeqiNP_593941.1, NM_001019369.2

3D structure databases

ProteinModelPortaliQ10184
SMRiQ10184
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi279535, 13 interactors
STRINGi4896.SPAC3F10.09.1

Proteomic databases

MaxQBiQ10184
PaxDbiQ10184
PRIDEiQ10184

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC3F10.09.1; SPAC3F10.09.1:pep; SPAC3F10.09
GeneIDi2543103
KEGGispo:SPAC3F10.09

Organism-specific databases

EuPathDBiFungiDB:SPAC3F10.09
PomBaseiSPAC3F10.09

Phylogenomic databases

HOGENOMiHOG000172261
InParanoidiQ10184
KOiK01814
OMAiMTKFRPC
OrthoDBiEOG092C43NB
PhylomeDBiQ10184

Enzyme and pathway databases

UniPathwayi
UPA00031;UER00009

Miscellaneous databases

PROiPR:Q10184

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR006062 His_biosynth
IPR011858 HisA_euk
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00977 His_biosynth, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02129 hisA_euk, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHIS4_SCHPO
AccessioniPrimary (citable) accession number: Q10184
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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