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Entry version 141 (16 Oct 2019)
Sequence version 3 (21 Mar 2012)
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Protein

U2 snRNP component prp10

Gene

prp10

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contacts pre-mRNA on both sides of the branch site early in spliceosome assembly.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-72163 mRNA Splicing - Major Pathway
R-SPO-72165 mRNA Splicing - Minor Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
U2 snRNP component prp10
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prp10
Synonyms:sap155
ORF Names:SPAC27F1.09c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:SPAC27F1.09c

Schizosaccharomyces pombe database

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PomBasei
SPAC27F1.09c prp10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001743261 – 1205U2 snRNP component prp10Add BLAST1205

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10178

PRoteomics IDEntifications database

More...
PRIDEi
Q10178

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q10178

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome composed of the U2, U5 and U6 snRNAs and at least brr2, cdc5, cwf2/prp3, cwf3/syf1, cwf4/syf3, cwf5/ecm2, spp42/cwf6, cwf7/spf27, cwf8, cwf9, cwf10, cwf11, cwf12, prp45/cwf13, cwf14, cwf15, cwf16, cwf17, cwf18, cwf19, cwf20, cwf21, cwf22, cwf23, cwf24, cwf25, cwf26, cyp7/cwf27, cwf28, cwf29/ist3, lea1, msl1, prp5/cwf1, prp10, prp12/sap130, prp17, prp22, sap61, sap62, sap114, sap145, slu7, smb1, smd1, smd3, smf1, smg1 and syf2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
278116, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q10178, 4 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC27F1.09c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q10178

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati393 – 429HEAT 1Add BLAST37
Repeati431 – 473HEAT 2Add BLAST43
Repeati475 – 505HEAT 3Add BLAST31
Repeati506 – 540HEAT 4Add BLAST35
Repeati541 – 578HEAT 5Add BLAST38
Repeati582 – 619HEAT 6Add BLAST38
Repeati665 – 702HEAT 7Add BLAST38
Repeati745 – 782HEAT 8Add BLAST38
Repeati828 – 865HEAT 9Add BLAST38
Repeati912 – 949HEAT 10Add BLAST38
Repeati954 – 991HEAT 11Add BLAST38
Repeati993 – 1024HEAT 12Add BLAST32
Repeati1025 – 1061HEAT 13Add BLAST37
Repeati1065 – 1102HEAT 14Add BLAST38
Repeati1107 – 1142HEAT 15Add BLAST36
Repeati1143 – 1179HEAT 16Add BLAST37

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SF3B1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000166737

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10178

KEGG Orthology (KO)

More...
KOi
K12828

Identification of Orthologs from Complete Genome Data

More...
OMAi
RSRWDAT

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015016 SF3b_su1
IPR038737 SF3b_su1-like

The PANTHER Classification System

More...
PANTHERi
PTHR12097 PTHR12097, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08920 SF3b1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q10178-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSTGTYPYKM FKMDVTNLNK VEDVEIERLR AERELLRRQK EAAKNSSTNG
60 70 80 90 100
SVNIEGTQDS NDLQYNAHLF KSSNPKEEYD SAIDVRNDIS QDEDDYKRTN
110 120 130 140 150
DVNDSYRLVR QYEAPKELLN EYADESYDPM QERQSKKQIQ DRESDYQKQR
160 170 180 190 200
YDRQLTPTRV DAFQPDGTQS NGRSYAEVMR QVELEKEERR VHMELNQRRR
210 220 230 240 250
EGTLKEVEEE ESISDKKREL ELNNTEISQK PKRSRWDQAP PSVTQVSTTK
260 270 280 290 300
RRSRWDKAPE NFTISEHVIE NGISEDLINK EVNVVEEKLR PPVRLLTEEE
310 320 330 340 350
LNELLPSEGY AILEPPPGYL ESIHPELLQK GTTLDTYHVP QEQELPLEKE
360 370 380 390 400
LPAALPTEIP GVGDLAFFKQ EDVKYFGKLL KVEDEAKLTI AELRERKILR
410 420 430 440 450
LLLKVKNGTP PMRKSALRQL TDQARDFGAA ALFNQILPLL MERTLEDQER
460 470 480 490 500
HLLVKVIDRI LYKLDDLVRP FTHKILVVIE PLLIDEDYYA RAEGREIISN
510 520 530 540 550
LAKASGLAHM IATMRPDIDH VDEYVRNTTA RAFSVVASAL GVPALLPFLK
560 570 580 590 600
AVCRSKKSWQ ARHTGVRIIQ QIALLLGCSI LPHLKNLVDC IGHGLEDEQQ
610 620 630 640 650
KVRIMTALSL SALAEAATPY GIEAFDSVLK PLWSGVQRHR GKSLAAFLKA
660 670 680 690 700
TGFIIPLMEP EYASHFTRRI MKILLREFNS PDEEMKKIVL KVVSQCASTD
710 720 730 740 750
GVTPEYLRTD VLPEFFHCFW SRRMASDRRS YKQVVETTVV LAQQVGSRQI
760 770 780 790 800
VERVVNNFKD ESEPYRKMTA ETVDKVIGSL GVSEIDERLE ELLLDGVLFA
810 820 830 840 850
FQEQSVEEKV ILTCFSTVVN ALGTRCKPYL PQIVSTILYR LNNKSANVRE
860 870 880 890 900
QAADLVSSIT IVLKACGEEA LMRKLGVVLY EYLGEEYPEV LGSILGAIKA
910 920 930 940 950
IVSVVGMSSM QPPIRDLLPR LTPILRNRHE KVQENTIDLV GKIADRGSEY
960 970 980 990 1000
VSAREWMRIC FELIDMLKAH KKSIRRAAVN TFGYISKAIG PQDVLATLLN
1010 1020 1030 1040 1050
NLKVQERQNR VCTTVAIAIV AETCMPFTVV PALMADYRTP EMNVQNGVLK
1060 1070 1080 1090 1100
SLAFMFEYIG EQARDYVYAI TPLLADALMD RDAVHRQTAA SVIKHLSLGC
1110 1120 1130 1140 1150
VGLGVEDAMI HLLNILWPNI LEESPHVINA VREGIDGIRN CIGVGPIMAY
1160 1170 1180 1190 1200
LVQGLFHPSR KVRNTYWTSY NSAYVQSADA MVPYYPHVDD DQFNNYDMKT

LHICI
Length:1,205
Mass (Da):137,183
Last modified:March 21, 2012 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE72C08FEACC8ADF
GO
Isoform B (identifier: Q10178-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-20: Missing.

Show »
Length:1,188
Mass (Da):135,151
Checksum:iF927BA0565CCF983
GO
Isoform E (identifier: Q10178-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     4-20: Missing.
     55-76: Missing.

Show »
Length:1,166
Mass (Da):132,675
Checksum:iCEF7FA6B226F61CD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0426184 – 20Missing in isoform B and isoform E. CuratedAdd BLAST17
Alternative sequenceiVSP_04261955 – 76Missing in isoform E. CuratedAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93298.3
AB027815 Genomic DNA Translation: BAA87119.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T38467

NCBI Reference Sequences

More...
RefSeqi
NP_594538.2, NM_001019967.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2541619

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC27F1.09c

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93298.3
AB027815 Genomic DNA Translation: BAA87119.1
PIRiT38467
RefSeqiNP_594538.2, NM_001019967.2

3D structure databases

SMRiQ10178
ModBaseiSearch...

Protein-protein interaction databases

BioGridi278116, 30 interactors
IntActiQ10178, 4 interactors
STRINGi4896.SPAC27F1.09c.1

PTM databases

iPTMnetiQ10178

Proteomic databases

PaxDbiQ10178
PRIDEiQ10178

Genome annotation databases

GeneIDi2541619
KEGGispo:SPAC27F1.09c

Organism-specific databases

EuPathDBiFungiDB:SPAC27F1.09c
PomBaseiSPAC27F1.09c prp10

Phylogenomic databases

HOGENOMiHOG000166737
InParanoidiQ10178
KOiK12828
OMAiRSRWDAT

Enzyme and pathway databases

ReactomeiR-SPO-72163 mRNA Splicing - Major Pathway
R-SPO-72165 mRNA Splicing - Minor Pathway

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q10178

Family and domain databases

Gene3Di1.25.10.10, 3 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR015016 SF3b_su1
IPR038737 SF3b_su1-like
PANTHERiPTHR12097 PTHR12097, 1 hit
PfamiView protein in Pfam
PF08920 SF3b1, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSF3B1_SCHPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10178
Secondary accession number(s): Q9USE7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: March 21, 2012
Last modified: October 16, 2019
This is version 141 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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