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Protein

Manganese transporter pdt1

Gene

pdt1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transports manganese ions into the cell. Regulates cell morphogenesis through control of manganese homeostasis.1 Publication

GO - Molecular functioni

  • manganese ion transmembrane transporter activity Source: PomBase
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • cellular manganese ion homeostasis Source: PomBase
  • manganese ion transmembrane transport Source: PomBase

Keywordsi

Biological processTransport
LigandManganese, Metal-binding

Enzyme and pathway databases

ReactomeiR-SPO-1222556 ROS, RNS production in phagocytes
R-SPO-425410 Metal ion SLC transporters
R-SPO-6798695 Neutrophil degranulation
R-SPO-6803544 Ion influx/efflux at host-pathogen interface
R-SPO-917937 Iron uptake and transport

Protein family/group databases

TCDBi2.A.55.1.4 the metal ion (mn(2+)-iron) transporter (nramp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese transporter pdt1
Gene namesi
Name:pdt1
ORF Names:SPAC27F1.08
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC27F1.08
PomBaseiSPAC27F1.08 pdt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei104 – 124HelicalSequence analysisAdd BLAST21
Transmembranei152 – 172HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei325 – 345HelicalSequence analysisAdd BLAST21
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Transmembranei417 – 437HelicalSequence analysisAdd BLAST21
Transmembranei440 – 460HelicalSequence analysisAdd BLAST21
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126081 – 521Manganese transporter pdt1Add BLAST521

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42Phosphoserine1 Publication1
Modified residuei43Phosphothreonine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10177
PaxDbiQ10177
PRIDEiQ10177

PTM databases

iPTMnetiQ10177
SwissPalmiQ10177

Interactioni

Protein-protein interaction databases

BioGridi278751, 37 interactors
STRINGi4896.SPAC27F1.08.1

Family & Domainsi

Sequence similaritiesi

Belongs to the NRAMP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000152204
InParanoidiQ10177
KOiK12346
OMAiIMPHTIY
OrthoDBiEOG092C1BTT
PhylomeDBiQ10177

Family and domain databases

HAMAPiMF_00221 NRAMP, 1 hit
InterProiView protein in InterPro
IPR001046 NRAMP_fam
PANTHERiPTHR11706 PTHR11706, 1 hit
PfamiView protein in Pfam
PF01566 Nramp, 1 hit
PRINTSiPR00447 NATRESASSCMP
TIGRFAMsiTIGR01197 nramp, 1 hit

Sequencei

Sequence statusi: Complete.

Q10177-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSQSYYMND LDDLRSLESS TLNKKDTAIN ELNPEQNDTR RSTDLLLEDK
60 70 80 90 100
YGIQTGFSKY WKKCTYGIRE YCKFIGPGFL IAVAYIDPGN YSTDLDAGSR
110 120 130 140 150
FQYKLLFIVF LSNLFAVYLQ SLCIRLGSVT GMDLARNCRE HYNRYICWSF
160 170 180 190 200
YVLAEIAIIA TDIAEVIGTA VALKILMHIP LVAGVVITIL DVLLVLIAWR
210 220 230 240 250
PEGSMLSVRI FETAVALLVL VVAISFAVVL GRVHIGGAGT VFKGFLPSST
260 270 280 290 300
VFSREGLYSS IGILGATVMP HSLFLGSGLV QTRLRDLDVR RGNYTPVGDC
310 320 330 340 350
SDYRPTHETI KHSLTYSIVE VALSLFTFAL FTNSSILIVA GAVFYNTSGA
360 370 380 390 400
DTSDLFSIYD LLKEYVSISC GRLFAVALLF SGMSAGYVCT IAGQIVSEGY
410 420 430 440 450
INWNLRPWLR RVITRAIAII PCLVVSAAVG QSGLNQVLNA SQVCLSILLP
460 470 480 490 500
FLTFPLVMFT CSRKVMRVVS DSTNEETGQL IRETHDYSLG WTMTIVTWAI
510 520
WLFLTALNLL LIVWLGMGVS F
Length:521
Mass (Da):57,641
Last modified:October 1, 1996 - v1
Checksum:iF14271E85FD7805A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93297.1
PIRiT38466
RefSeqiNP_594537.1, NM_001019966.2

Genome annotation databases

EnsemblFungiiSPAC27F1.08.1; SPAC27F1.08.1:pep; SPAC27F1.08
GeneIDi2542283
KEGGispo:SPAC27F1.08

Similar proteinsi

Entry informationi

Entry nameiPDT1_SCHPO
AccessioniPrimary (citable) accession number: Q10177
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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