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Protein

Probable clathrin heavy chain

Gene

chc1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-SPO-8866427 VLDLR internalisation and degradation
R-SPO-8964038 LDL clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Probable clathrin heavy chain
Gene namesi
Name:chc1
ORF Names:SPAC26A3.05
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC26A3.05
PomBaseiSPAC26A3.05 chc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002057841 – 1666Probable clathrin heavy chainAdd BLAST1666

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei392Phosphothreonine1 Publication1
Modified residuei393Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ10161
PaxDbiQ10161
PRIDEiQ10161

PTM databases

iPTMnetiQ10161

Interactioni

Subunit structurei

Clathrin triskelions, composed of 3 heavy chains and 3 light chains, are the basic subunits of the clathrin coat.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278555, 3 interactors
STRINGi4896.SPAC26A3.05.1

Structurei

3D structure databases

ProteinModelPortaliQ10161
SMRiQ10161
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati534 – 680CHCR 1Add BLAST147
Repeati683 – 825CHCR 2Add BLAST143
Repeati830 – 969CHCR 3Add BLAST140
Repeati975 – 1120CHCR 4Add BLAST146
Repeati1124 – 1265CHCR 5Add BLAST142
Repeati1270 – 1415CHCR 6Add BLAST146
Repeati1418 – 1561CHCR 7Add BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 67WD40-like repeat 1Add BLAST44
Regioni68 – 107WD40-like repeat 2Add BLAST40
Regioni108 – 148WD40-like repeat 3Add BLAST41
Regioni149 – 194WD40-like repeat 4Add BLAST46
Regioni195 – 255WD40-like repeat 5Add BLAST61
Regioni256 – 299WD40-like repeat 6Add BLAST44
Regioni300 – 328WD40-like repeat 7Add BLAST29

Domaini

The C-terminal third of the heavy chains forms the hub of the triskelion. This region contains the trimerization domain and the light-chain binding domain involved in the assembly of the clathrin lattice.
The N-terminal seven-bladed beta-propeller is formed by WD40-like repeats, and projects inward from the polyhedral outer clathrin coat. It constitutes a major protein-protein interaction node (By similarity).By similarity

Sequence similaritiesi

Belongs to the clathrin heavy chain family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000188877
InParanoidiQ10161
KOiK04646
OMAiVQQCTAF
OrthoDBiEOG092C02CU
PhylomeDBiQ10161

Family and domain databases

Gene3Di1.25.40.10, 5 hits
2.130.10.110, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR000547 Clathrin_H-chain/VPS_repeat
IPR015348 Clathrin_H-chain_linker_core
IPR016025 Clathrin_H-chain_N
IPR022365 Clathrin_H-chain_propeller_rpt
IPR016341 Clathrin_heavy_chain
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00637 Clathrin, 7 hits
PF09268 Clathrin-link, 1 hit
PF01394 Clathrin_propel, 1 hit
PIRSFiPIRSF002290 Clathrin_H_chain, 1 hit
SMARTiView protein in SMART
SM00299 CLH, 7 hits
SUPFAMiSSF48371 SSF48371, 6 hits
SSF50989 SSF50989, 1 hit
PROSITEiView protein in PROSITE
PS50236 CHCR, 7 hits

Sequencei

Sequence statusi: Complete.

Q10161-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQQLPIRFS EVLQLASVGI QPSSFGFANV TLESDKYVCV RDNPNGVNQV
60 70 80 90 100
VIVDLEDPSN VLRRPISADS VILHPKKKII ALKAQRQLQV FDLEAKAKIN
110 120 130 140 150
SYVMNQDVVY WTWISDSVIG MVTDTSVFHW TVSGSDPVKM FDRHSSLNGT
160 170 180 190 200
QIISYKSNYN EEWFTLIGIS SRDNRIAGNL QLYSKKRKVS QPLESHASAF
210 220 230 240 250
AVIQPEGVDH EVQVLALASR LPTGSKLSIV EVDRNPNNPA FATKTVDLFF
260 270 280 290 300
PPEAVNDFPI AIEIGSTYNV AYVVTKYGFI HVYDLETAKC IYMNRVSGES
310 320 330 340 350
IFVTTAHKSV NGLMAINRKG QVLSVSINPE TIIPYILSNL NDPGLAVRMA
360 370 380 390 400
SHANLPGADN LYMQQFQQLM AQGNYSEAAK VAASSPRGIL RTSQVIDQFK
410 420 430 440 450
LIQAAPGQIA PILQYFGTLL DKGPLNEHET IELARPVLAQ NRIQLLEKWY
460 470 480 490 500
GENKLACTEA LGDLVKPYNT PFALKIYETA NVPNKVVMCL SELGDFGKLA
510 520 530 540 550
TYTSQQNITP DYVSLLQNLV RVNPDQAAEF ATQMFNSNPS INLEKIVDIF
560 570 580 590 600
MSQNLVQQAT AFLLDALKDD NPEHSHLQTR LLEINLINAP QVADAILGNQ
610 620 630 640 650
MFTHFDRAVI ASLCERAGLV QRALELYDKP ADIKRVIVHS NLLNPEWLMN
660 670 680 690 700
YFSRFSPDEV YDYLREMLRS NLRQNLQIVV QIATRYSDLV GAQRIIEMFE
710 720 730 740 750
KFKTFEGLYY YLGSIVNITE DPEVVYKYIQ AACLMNQFTE VERICRDNNV
760 770 780 790 800
YNPEKVKNLL KEAKLADQLP LILVCDRYDF VNDLVFYLFR NNMFQFIEIY
810 820 830 840 850
VQRINPSKTP QVVGALLDID CDEELVQNLL MSVVGQVPVD ELVEEVERRN
860 870 880 890 900
RLKLLLPYLE SLLQSGSQDR AIYDALAKIY IDSNNNPEVF LKENNFYDTL
910 920 930 940 950
TVGKYCEKRD PYLAFIAYEK GGNDTEIINL CNENSMFKQL ARYLLKRSDS
960 970 980 990 1000
NLWSEVLQDS AYRRPLLDQV IATAVPESSD PEAVSIVVKA LMEVDLPSQL
1010 1020 1030 1040 1050
IELLEKIVLQ PSSFSENANL QNLLFLTAIK ADKSRVMEYI DKLDKYDVDE
1060 1070 1080 1090 1100
IAEIAIENGL YEEAFRIYKI HNKHEQAMKV LVEDIVSLDR AQDYAETVEQ
1110 1120 1130 1140 1150
PEVWSRLAKA QLDGIRIPDA IESYLKADDP SNYSEVIELA SRAGKYEELI
1160 1170 1180 1190 1200
KYLLMARSKM HEPDVDSALL IAYAKTNQLT EMETFLIGSN VADVKAVGDE
1210 1220 1230 1240 1250
CFESKNYEAA KLMYSSISNW SMLATTLVYL GEYQGAVDCA RKANSIKVWK
1260 1270 1280 1290 1300
QVGTACIDKR EFRLAQICGL NLIVHAEELP GLIRLYEERG YFEEVISLME
1310 1320 1330 1340 1350
AGLGLERAHM AFYTELAILY AKYKPERMME HLKLFWGRLN MAKVIRACDQ
1360 1370 1380 1390 1400
MHLWNEAVFL YVHDQSYDNA AAVMMEQPEA FDHQSFKDII VHVANLELYY
1410 1420 1430 1440 1450
RALNFYLEQH PMLLTDLLAA LTPRIDHPRV IRIFEKSENT PLILNFMVAI
1460 1470 1480 1490 1500
QHLNIQAVNH AYNDLLIEME DYQSLQDSIE NYDHFDAIAL ARRLEKHSLL
1510 1520 1530 1540 1550
EFRRIAAYIY RKNKRWTQSI ELSKQDRFYK DAIITARDSD QTTIAEDLMK
1560 1570 1580 1590 1600
YFVEIGNYEC FAAILYTCYH LLRNDLVMEI SWRKGLQDYA YPYFINFQCE
1610 1620 1630 1640 1650
MFSKVLNLEK DLKDRQAVKS EEESASTIGA GILGNTLMLT QGPMANNNDQ
1660
FDSFQQASPM PRLGNF
Length:1,666
Mass (Da):190,018
Last modified:October 1, 1996 - v1
Checksum:i16A6E84FEA2A7EA9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA93228.1
PIRiT38393
RefSeqiNP_594148.1, NM_001019572.2

Genome annotation databases

EnsemblFungiiSPAC26A3.05.1; SPAC26A3.05.1:pep; SPAC26A3.05
GeneIDi2542078
KEGGispo:SPAC26A3.05

Similar proteinsi

Entry informationi

Entry nameiCLH_SCHPO
AccessioniPrimary (citable) accession number: Q10161
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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