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Entry version 156 (29 Sep 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Chromo domain-containing protein 1

Gene

chp1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the kinetochore which plays a role in stabilizing microtubules and so allowing accurate chromosome segregation. Has a role in the RNA interference (RNAi) pathway which is important for heterochromatin formation and accurate chromosome segregation. A member of the RNA-induced transcriptional silencing (RITS) complex which is involved in the biosynthesis of dsRNA from primer siRNAs provided by the RNA-directed RNA polymerase (RDRC) complex.

4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Chromosome partition, RNA-mediated gene silencing

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SPO-73772, RNA Polymerase I Promoter Escape
R-SPO-983231, Factors involved in megakaryocyte development and platelet production

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chromo domain-containing protein 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chp11 Publication
ORF Names:SPAC18G6.02cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC18G6.02c, chp1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC18G6.02c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000802381 – 960Chromo domain-containing protein 1Add BLAST960

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q10103

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q10103

PRoteomics IDEntifications database

More...
PRIDEi
Q10103

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q10103

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Ago1, chp1 and tas3 interact to form the core of the RNA-induced transcriptional silencing (RITS) complex. The RITS complex interacts with the RDRC complex via interaction between ago1 and hrr1. Clr4 has a role in mediating this interaction (PubMed:14704433).

Interacts with dri1 (PubMed:33693625).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
278711, 120 interactors

Database of interacting proteins

More...
DIPi
DIP-29301N

Protein interaction database and analysis system

More...
IntActi
Q10103, 5 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC18G6.02c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1960
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q10103

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q10103

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q10103

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 74ChromoPROSITE-ProRule annotationAdd BLAST53

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1911, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_307797_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q10103

Identification of Orthologs from Complete Genome Data

More...
OMAi
WYDNTWE

Family and domain databases

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...
IDEALi
IID50149

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR023779, Chromodomain_CS
IPR035979, RBD_domain_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00385, Chromo, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00298, CHROMO, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54160, SSF54160, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00598, CHROMO_1, 1 hit
PS50013, CHROMO_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q10103-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSVKPLPDI DSNEGETDAD VYEVEDILAD RVNKNGINEY YIKWAGYDWY
60 70 80 90 100
DNTWEPEQNL FGAEKVLKKW KKRKKLIAKG LLEPFDAEDN EAKKMKREKE
110 120 130 140 150
ILRQQRQKRK SELTQLSQKV KEKFKKMRKK PARRIVTIAN DEEEEDDQTM
160 170 180 190 200
DEDAFERKSM QGELKERNLT DKTSTLSTSF GETSPDVNPF YLSEWPTVTD
210 220 230 240 250
SILLSKSLSS DAIPLKNGEI KSTMLMPSDS DNSVPGIQNS NNLENTGAFV
260 270 280 290 300
ENANSPQSNT PLSTFRHSSP LSLSPVITSD NDVANSLFFS NSTPLPSSLK
310 320 330 340 350
IKKEAPKLET HTILVSDNSG SLTKQDILSY FAFIKGNIEV FFLKSPKKDK
360 370 380 390 400
VCNMAYIQFD SIEQAKLAYD KGHPSWHVTL VKGKISTDME ECKVSKSILK
410 420 430 440 450
TTPSKKANAR SVSFTQTTTD TLSESEKFAS NVDLDENFDF NVNVTNEDAK
460 470 480 490 500
QLKKSVIGSS WTTVNNDWNS VSKSDQTFEN DGASKVVPAG NITLNSDNSL
510 520 530 540 550
HHSISESEDL SSASTLSDYF RFVLRVGKSL YYAGELSFDI SKLKAETEHQ
560 570 580 590 600
QLLRSLVSCK QVDVLRFVTS QYLEVFGTCL TKVLSGSLCI RSDVDMTHFK
610 620 630 640 650
NILNRGNGAG IVLGSNYTLL LFTEDNNALM NLYDCQGQSN SPFWMVIFEP
660 670 680 690 700
LESILVEWSA KNLRPKKPYH KSQSYLSYLL QLGHIDLHKI GAFQATQILI
710 720 730 740 750
VSKQPSPEAE ELEDTFREAA IPTFRGLEIP ESLFLSQNVF VFLNVSLEDD
760 770 780 790 800
FDQLQFLTLA KRKSCKFFLF GLSLPLKSPN DSHVGTDFKK NNEPLDKLTY
810 820 830 840 850
SQYLRPMFPK GGVVSVTLSA LIKTPRLLEL ISPFLEIKKD SWILILPPSI
860 870 880 890 900
VDMVKSYFVT NNPDKSLLEI QNLLNTLQRY LTNPALKNVT LYQDWDIVID
910 920 930 940 950
DSADVSLAST LQLYQKKNYD KYRRFVLIHE LKNELTPVNG LDIVDYDEFK
960
ETFMRAIGLK
Length:960
Mass (Da):108,726
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE92C16BBD0D5957C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA92382.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T37916

NCBI Reference Sequences

More...
RefSeqi
NP_593666.1, NM_001019098.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC18G6.02c.1; SPAC18G6.02c.1:pep; SPAC18G6.02c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2542239

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC18G6.02c

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA92382.1
PIRiT37916
RefSeqiNP_593666.1, NM_001019098.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2RSNNMR-A1-75[»]
3G7LX-ray2.20A15-75[»]
3TIXX-ray2.90B/D504-960[»]
BMRBiQ10103
SMRiQ10103
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi278711, 120 interactors
DIPiDIP-29301N
IntActiQ10103, 5 interactors
STRINGi4896.SPAC18G6.02c.1

PTM databases

iPTMnetiQ10103

Proteomic databases

MaxQBiQ10103
PaxDbiQ10103
PRIDEiQ10103

Genome annotation databases

EnsemblFungiiSPAC18G6.02c.1; SPAC18G6.02c.1:pep; SPAC18G6.02c
GeneIDi2542239
KEGGispo:SPAC18G6.02c

Organism-specific databases

PomBaseiSPAC18G6.02c, chp1
VEuPathDBiFungiDB:SPAC18G6.02c

Phylogenomic databases

eggNOGiKOG1911, Eukaryota
HOGENOMiCLU_307797_0_0_1
InParanoidiQ10103
OMAiWYDNTWE

Enzyme and pathway databases

ReactomeiR-SPO-73772, RNA Polymerase I Promoter Escape
R-SPO-983231, Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

EvolutionaryTraceiQ10103

Protein Ontology

More...
PROi
PR:Q10103

Family and domain databases

IDEALiIID50149
InterProiView protein in InterPro
IPR016197, Chromo-like_dom_sf
IPR000953, Chromo/chromo_shadow_dom
IPR023780, Chromo_domain
IPR023779, Chromodomain_CS
IPR035979, RBD_domain_sf
PfamiView protein in Pfam
PF00385, Chromo, 1 hit
SMARTiView protein in SMART
SM00298, CHROMO, 1 hit
SUPFAMiSSF54160, SSF54160, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS00598, CHROMO_1, 1 hit
PS50013, CHROMO_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHP1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q10103
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 29, 2021
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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