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Protein

Heat shock protein 70 homolog lhs1

Gene

SPAC1F5.06

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Chaperone required for protein translocation and folding in the endoplasmic reticulum.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Hydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 70 homolog lhs1 (EC:3.6.1.3)
Gene namesi
ORF Names:SPAC1F5.06
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
Proteomesi
  • UP000002485 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:SPAC1F5.06
PomBaseiSPAC1F5.06

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001355722 – 848Heat shock protein 70 homolog lhs1Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi555N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi678N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi733N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi817N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ10061
PaxDbiQ10061
PRIDEiQ10061

PTM databases

SwissPalmiQ10061

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi278037, 1 interactor
STRINGi4896.SPAC1F5.06.1

Structurei

3D structure databases

ProteinModelPortaliQ10061
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi845 – 848Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ10061
KOiK09486
OMAiSITRQEF
OrthoDBiEOG092C0K07
PhylomeDBiQ10061

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q10061-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKRSVLTIIL FFSCQFWHAF ASSVLAIDYG TEWTKAALIK PGIPLEIVLT
60 70 80 90 100
KDTRRKEQSA VAFKGNERIF GVDASNLATR FPAHSIRNVK ELLDTAGLES
110 120 130 140 150
VLVQKYQSSY PAIQLVENEE TTSGISFVIS DEENYSLEEI IAMTMEHYIS
160 170 180 190 200
LAEEMAHEKI TDLVLTVPPH FNELQRSILL EAARILNKHV LALIDDNVAV
210 220 230 240 250
AIEYSLSRSF STDPTYNIIY DSGSGSTSAT VISFDTVEGS SLGKKQNITR
260 270 280 290 300
IRALASGFTL KLSGNEINRK LIGFMKNSFY QKHGIDLSHN HRALARLEKE
310 320 330 340 350
ALRVKHILSA NSEAIASIEE LADGIDFRLK ITRSVLESLC KDMEDAAVEP
360 370 380 390 400
INKALKKANL TFSEINSIIL FGGASRIPFI QSTLADYVSS DKISKNVNAD
410 420 430 440 450
EASVKGAAFY GASLTKSFRV KPLIVQDIIN YPYLLSLGTS EYIVALPDST
460 470 480 490 500
PYGMQHNVTI HNVSTIGKHP SFPLSNNGEL IGEFTLSNIT DVEKVCACSN
510 520 530 540 550
KNIQISFSSD RTKGILVPLS AIMTCEHGEL SSKHKLGDRV KSLFGSHDES
560 570 580 590 600
GLRNNESYPI GFTYKKYGEM SDNALRLASA KLERRLQIDK SKAAHDNALN
610 620 630 640 650
ELETLLYRAQ AMVDDDEFLE FANPEETKIL KNDSVESYDW LIEYGSQSPT
660 670 680 690 700
SEVTDRYKKL DDTLKSISFR FDQAKQFNTS LENFKNALER AESLLTNFDV
710 720 730 740 750
PDYPLNVYDE KDVKRVNSLR GTSYKKLGNQ YYNDTQWLKD NLDSHLSHTL
760 770 780 790 800
SEDPLIKVEE LEEKAKRLQE LTYEYLRRSL QQPKLKAKKG ASSSSTAESK
810 820 830 840
VEDETFTNDI EPTTALNSTS TQETEKSRAS VTQRPSSLQQ EIDDSDEL
Length:848
Mass (Da):94,898
Last modified:February 1, 1996 - v1
Checksum:iA1983FD4253F38F3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA92234.1
PIRiT38089
RefSeqiNP_592867.1, NM_001018267.2

Genome annotation databases

EnsemblFungiiSPAC1F5.06.1; SPAC1F5.06.1:pep; SPAC1F5.06
GeneIDi2541537
KEGGispo:SPAC1F5.06

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU329670 Genomic DNA Translation: CAA92234.1
PIRiT38089
RefSeqiNP_592867.1, NM_001018267.2

3D structure databases

ProteinModelPortaliQ10061
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi278037, 1 interactor
STRINGi4896.SPAC1F5.06.1

PTM databases

SwissPalmiQ10061

Proteomic databases

MaxQBiQ10061
PaxDbiQ10061
PRIDEiQ10061

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiSPAC1F5.06.1; SPAC1F5.06.1:pep; SPAC1F5.06
GeneIDi2541537
KEGGispo:SPAC1F5.06

Organism-specific databases

EuPathDBiFungiDB:SPAC1F5.06
PomBaseiSPAC1F5.06

Phylogenomic databases

InParanoidiQ10061
KOiK09486
OMAiSITRQEF
OrthoDBiEOG092C0K07
PhylomeDBiQ10061

Miscellaneous databases

PROiPR:Q10061

Family and domain databases

Gene3Di1.20.1270.10, 1 hit
InterProiView protein in InterPro
IPR018181 Heat_shock_70_CS
IPR029048 HSP70_C_sf
IPR013126 Hsp_70_fam
PANTHERiPTHR19375 PTHR19375, 1 hit
PfamiView protein in Pfam
PF00012 HSP70, 1 hit
PRINTSiPR00301 HEATSHOCK70
SUPFAMiSSF100934 SSF100934, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00329 HSP70_2, 1 hit
PS01036 HSP70_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLHS1_SCHPO
AccessioniPrimary (citable) accession number: Q10061
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
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Main funding by: National Institutes of Health

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