UniProtKB - Q0ZME4 (VME1_CVHN5)
Protein
Membrane protein
Gene
M
Organism
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
Status
Functioni
Component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins.UniRule annotation
Miscellaneous
Isolate N5 belongs to genotype C. Genotype C probably arose from recombination between genotypes A and B.
GO - Molecular functioni
- structural constituent of virion Source: UniProtKB-UniRule
GO - Biological processi
- mitigation of host immune response by virus Source: UniProtKB-KW
Keywordsi
Biological process | Host-virus interaction, Viral immunoevasion |
Names & Taxonomyi
Protein namesi | Recommended name: Membrane proteinUniRule annotationShort name: M proteinUniRule annotation Alternative name(s): E1 glycoproteinUniRule annotation Matrix glycoproteinUniRule annotation Membrane glycoproteinUniRule annotation |
Gene namesi | Name:MUniRule annotation ORF Names:6 |
Organismi | Human coronavirus HKU1 (isolate N5) (HCoV-HKU1) |
Taxonomic identifieri | 443241 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Betacoronavirus › Embecovirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion membrane UniRule annotation; Multi-pass membrane protein UniRule annotation
- Host Golgi apparatus membrane UniRule annotation; Multi-pass membrane protein UniRule annotation Note: Largely embedded in the lipid bilayer.UniRule annotation
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | Virion surfaceUniRule annotationAdd BLAST | 20 | |
Transmembranei | 21 – 41 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 42 – 51 | IntravirionUniRule annotation | 10 | |
Transmembranei | 52 – 72 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 73 – 80 | Virion surfaceUniRule annotation | 8 | |
Transmembranei | 81 – 101 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 102 – 223 | IntravirionUniRule annotationAdd BLAST | 122 |
GO - Cellular componenti
- host cell Golgi membrane Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-UniRule
- viral envelope Source: UniProtKB-UniRule
- virion membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Viral matrix protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000297817 | 1 – 223 | Membrane proteinAdd BLAST | 223 |
Keywords - PTMi
GlycoproteinInteractioni
Subunit structurei
Homomultimer.
Interacts with envelope E protein in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex.
Forms a complex with HE and S proteins.
Interacts with nucleocapsid N protein. This interaction probably participates in RNA packaging into the virus.
UniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the betacoronaviruses M protein family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
HAMAPi | MF_04202, BETA_CORONA_M, 1 hit |
InterProi | View protein in InterPro IPR002574, M_CoV |
Pfami | View protein in Pfam PF01635, CoV_M, 1 hit |
PROSITEi | View protein in PROSITE PS51927, COV_M, 1 hit |
i Sequence
Sequence statusi: Complete.
Q0ZME4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNESIFPHWN SDQAITFLKE WNFSLGVILL LITIILQFGY TSRSMFVYLI
60 70 80 90 100
KMIILWLMWP LTIILTIFNC FYALNNVFLG LSILFTIISI VIWILYFVNS
110 120 130 140 150
IRLFIRTGSW WSFNPETNNL MCIDMKGKMY VRPVIEDYHT LTATVIRGHL
160 170 180 190 200
YIQGVKLGTG YTLADLPVYV TVAKVQVLCT YKRAFLDKLD VNSGFAVFVK
210 220
SKVGNYRLPS SKSSGMDTAL LRA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ339101 Genomic RNA Translation: ABC70722.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ339101 Genomic RNA Translation: ABC70722.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Family and domain databases
HAMAPi | MF_04202, BETA_CORONA_M, 1 hit |
InterProi | View protein in InterPro IPR002574, M_CoV |
Pfami | View protein in Pfam PF01635, CoV_M, 1 hit |
PROSITEi | View protein in PROSITE PS51927, COV_M, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VME1_CVHN5 | |
Accessioni | Q0ZME4Primary (citable) accession number: Q0ZME4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 21, 2007 |
Last sequence update: | July 24, 2007 | |
Last modified: | October 7, 2020 | |
This is version 60 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |