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UniProtKB - Q0ZLH3 (PJVK_HUMAN)

Entry version 114 (07 Apr 2021)
Sequence version 1 (22 Aug 2006)
Previous versions | rss
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Protein

Pejvakin

Gene

PJVK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage. Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss. PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress. In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation.By similarity

Miscellaneous

'Pejvakin' means 'echo' in Persian.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processHearing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q0ZLH3

Protein family/group databases

Transport Classification Database

More...TCDBi		1.C.123.1.7, the pore-forming gasdermin (gasdermin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pejvakin1 Publication
Alternative name(s):
Autosomal recessive deafness type 59 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PJVK1 PublicationImported
Synonyms:DFNB59
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29502, PJVK

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610219, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q0ZLH3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000204311.12

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Membrane, Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Deafness, autosomal recessive, 59 (DFNB59)7 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of sensorineural hearing impairment with absent or severely abnormal auditory brainstem response but normal otoacoustic emissions (auditory neuropathy or auditory dys-synchrony). Auditory neuropathies result from a lesion in the area including the inner hair cells, connections between the inner hair cells and the cochlear branch of the auditory nerve, the auditory nerve itself and auditory pathways of the brainstem.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02738754T → I in DFNB59; causes hypervulnerability to sound. 2 PublicationsCorresponds to variant dbSNP:rs118203988EnsemblClinVar.1
Natural variantiVAR_083912167 – 352Missing in DFNB59. 1 PublicationAdd BLAST186
Natural variantiVAR_027388183R → W in DFNB59. 2 PublicationsCorresponds to variant dbSNP:rs111706634EnsemblClinVar.1
Natural variantiVAR_083913244L → R in DFNB59; unknown pathological significance. 1 Publication1
Natural variantiVAR_068891343C → S in DFNB59. 1 PublicationCorresponds to variant dbSNP:rs569088856Ensembl.1

Keywords - Diseasei

Deafness, Disease variant, Non-syndromic deafness

Organism-specific databases

DisGeNET

More...DisGeNETi		494513

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		PJVK

MalaCards human disease database

More...MalaCardsi		PJVK
MIMi610220, phenotype

Open Targets

More...OpenTargetsi		ENSG00000204311

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134927047

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q0ZLH3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PJVK

Domain mapping of disease mutations (DMDM)

More...DMDMi		114152117

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002490421 – 352PejvakinAdd BLAST352

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q0ZLH3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q0ZLH3

PeptideAtlas

More...PeptideAtlasi		Q0ZLH3

PRoteomics IDEntifications database

More...PRIDEi		Q0ZLH3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		58852

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q0ZLH3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q0ZLH3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204311, Expressed in sperm and 146 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q0ZLH3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q0ZLH3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204311, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAP1LC3B; interaction is direct.

Interacts with IQGAP1.

Interacts with ROCK2.

Interacts with TRIOBP.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		138969, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000386647

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q0ZLH3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the gasdermin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QWBQ, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000183140

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_068267_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q0ZLH3

Identification of Orthologs from Complete Genome Data

More...OMAi		FQIDDGR

Database of Orthologous Groups

More...OrthoDBi		1397132at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q0ZLH3

TreeFam database of animal gene trees

More...TreeFami		TF352821

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007677, Gasdermin
IPR040460, Gasdermin_pore

The PANTHER Classification System

More...PANTHERi		PTHR16399, PTHR16399, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04598, Gasdermin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q0ZLH3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFAAATKSFV KQVGDGGRLV PVPSLSEADK YQPLSLVVKK KRCFLFPRYK 
        60         70         80         90        100
FTSTPFTLKD ILLGDREISA GISSYQLLNY EDESDVSLYG RRGNHIVNDV 
       110        120        130        140        150
GINVAGSDSI AVKASFGIVT KHEVEVSTLL KEITTRKINF DHSLIRQSRS 
       160        170        180        190        200
SRKAVLCVVM ESIRTTRQCS LSVHAGIRGE AMRFHFMDEQ NPKGRDKAIV 
       210        220        230        240        250
FPAHTTIAFS VFELFIYLDG AFDLCVTSVS KGGFEREETA TFALLYRLRN 
       260        270        280        290        300
ILFERNRRVM DVISRSQLYL DDLFSDYYDK PLSMTDISLK EGTHIRVNLL 
       310        320        330        340        350
NHNIPKGPCI LCGMGNFKRE TVYGCFQCSV DGQKYVRLHA VPCFDIWHKR 

MK
Length:352
Mass (Da):39,913
Last modified:August 22, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7DEBA07E73A3C92E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8Y7D2A0A2R8Y7D2_HUMAN
Pejvakin
PJVK
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0PK15A0PK15_HUMAN
DFNB59 protein
PJVK DFNB59, hCG_2043344
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3A9H7C3A9_HUMAN
Pejvakin
PJVK
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1C3H7C1C3_HUMAN
Pejvakin
PJVK
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y564A0A2R8Y564_HUMAN
Pejvakin
PJVK
300Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YD96A0A2R8YD96_HUMAN
Pejvakin
PJVK
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02738754T → I in DFNB59; causes hypervulnerability to sound. 2 PublicationsCorresponds to variant dbSNP:rs118203988EnsemblClinVar.1
Natural variantiVAR_083912167 – 352Missing in DFNB59. 1 PublicationAdd BLAST186
Natural variantiVAR_027388183R → W in DFNB59. 2 PublicationsCorresponds to variant dbSNP:rs111706634EnsemblClinVar.1
Natural variantiVAR_083913244L → R in DFNB59; unknown pathological significance. 1 Publication1
Natural variantiVAR_053103265R → C. Corresponds to variant dbSNP:rs17304212EnsemblClinVar.1
Natural variantiVAR_083914299L → R1 Publication1
Natural variantiVAR_068891343C → S in DFNB59. 1 PublicationCorresponds to variant dbSNP:rs569088856Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ365827 mRNA Translation: ABC94894.1
BC127902 mRNA Translation: AAI27903.1
BC146938 mRNA Translation: AAI46939.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42787.1

NCBI Reference Sequences

More...RefSeqi		NP_001036167.1, NM_001042702.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000375129; ENSP00000364271; ENSG00000204311
ENST00000644580; ENSP00000495855; ENSG00000204311

Database of genes from NCBI RefSeq genomes

More...GeneIDi		494513

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:494513

UCSC genome browser

More...UCSCi		uc002umi.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ365827 mRNA Translation: ABC94894.1
BC127902 mRNA Translation: AAI27903.1
BC146938 mRNA Translation: AAI46939.1
CCDSiCCDS42787.1
RefSeqiNP_001036167.1, NM_001042702.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi138969, 1 interactor
STRINGi9606.ENSP00000386647

Protein family/group databases

TCDBi1.C.123.1.7, the pore-forming gasdermin (gasdermin) family

PTM databases

iPTMnetiQ0ZLH3
PhosphoSitePlusiQ0ZLH3

Genetic variation databases

BioMutaiPJVK
DMDMi114152117

Proteomic databases

EPDiQ0ZLH3
PaxDbiQ0ZLH3
PeptideAtlasiQ0ZLH3
PRIDEiQ0ZLH3
ProteomicsDBi58852

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		33935, 62 antibodies

Genome annotation databases

EnsembliENST00000375129; ENSP00000364271; ENSG00000204311
ENST00000644580; ENSP00000495855; ENSG00000204311
GeneIDi494513
KEGGihsa:494513
UCSCiuc002umi.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		494513
DisGeNETi494513

GeneCards: human genes, protein and diseases

More...GeneCardsi		PJVK
GeneReviewsiPJVK
HGNCiHGNC:29502, PJVK
HPAiENSG00000204311, Tissue enriched (testis)
MalaCardsiPJVK
MIMi610219, gene
610220, phenotype
neXtProtiNX_Q0ZLH3
OpenTargetsiENSG00000204311
Orphaneti90636, Autosomal recessive non-syndromic sensorineural deafness type DFNB
PharmGKBiPA134927047
VEuPathDBiHostDB:ENSG00000204311.12

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QWBQ, Eukaryota
GeneTreeiENSGT00950000183140
HOGENOMiCLU_068267_0_0_1
InParanoidiQ0ZLH3
OMAiFQIDDGR
OrthoDBi1397132at2759
PhylomeDBiQ0ZLH3
TreeFamiTF352821

Enzyme and pathway databases

PathwayCommonsiQ0ZLH3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		494513, 1 hit in 979 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DFNB59, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		494513
PharosiQ0ZLH3, Tbio

Protein Ontology

More...PROi		PR:Q0ZLH3
RNActiQ0ZLH3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204311, Expressed in sperm and 146 other tissues
ExpressionAtlasiQ0ZLH3, baseline and differential
GenevisibleiQ0ZLH3, HS

Family and domain databases

InterProiView protein in InterPro
IPR007677, Gasdermin
IPR040460, Gasdermin_pore
PANTHERiPTHR16399, PTHR16399, 1 hit
PfamiView protein in Pfam
PF04598, Gasdermin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPJVK_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0ZLH3
Secondary accession number(s): A0PK14, B9EJE2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: August 22, 2006
Last modified: April 7, 2021
This is version 114 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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