Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 108 (11 Dec 2019)
Sequence version 2 (29 Apr 2008)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Ubiquitin carboxyl-terminal hydrolase 17-like protein 24

Gene

USP17L24

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.1 Publication

Caution

The RS447 megasatellite DNA is a highly polymorphic conserved tandem repetitive sequence which contains a copy of the USP17 gene. It is present with an interindividual variation in copy number, ranging from 20 to 103, and can be found in the genome both on chromosome 4 and chromosome 8. The high similarity between the UPS17-like genes makes impossible to clearly assign data to one of the genes of the family. Oligonucleotides designed in RNAi experiments are for instance not specific of a given UPS17-like gene.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei89Nucleophile1
Active sitei334Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processApoptosis, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5689880 Ub-specific processing proteases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 24 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 17
Ubiquitin thioesterase 17
Ubiquitin-specific-processing protease 17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:USP17L24
Synonyms:USP17, USP17H, USP17I, USP17J, USP17K, USP17L, USP17M
AND
AND
AND
AND
AND
AND
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000228856.3
HostDB:ENSG00000229579.4
HostDB:ENSG00000230430.4
HostDB:ENSG00000231051.3
HostDB:ENSG00000231637.3
HostDB:ENSG00000232264.4
HostDB:ENSG00000235780.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:44453 USP17L24
HGNC:44452 USP17L25
HGNC:44454 USP17L26
HGNC:44455 USP17L27
HGNC:44456 USP17L28
HGNC:44457 USP17L29
HGNC:44458 USP17L30

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
607011 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q0WX57

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi89C → S: Abolishes enzymatic activity. Loss of the pro-apoptotic function. 2 Publications1

Organism-specific databases

DisGeNET

More...
DisGeNETi
728369
728373
728379
728393
728400
728405
728419

Open Targets

More...
OpenTargetsi
ENSG00000228856

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q0WX57 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
USP17L25

Domain mapping of disease mutations (DMDM)

More...
DMDMi
187663978

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003316431 – 530Ubiquitin carboxyl-terminal hydrolase 17-like protein 24Add BLAST530

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q0WX57

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0WX57

PeptideAtlas

More...
PeptideAtlasi
Q0WX57

PRoteomics IDEntifications database

More...
PRIDEi
Q0WX57

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58846

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0WX57

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0WX57

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, liver and skeletal muscle.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000229579 Expressed in 1 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0WX57 baseline

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA045642

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q0WX57, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000427366

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q0WX57 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0WX57

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini80 – 375USPAdd BLAST296

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C19 family. USP17 subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1865 Eukaryota
ENOG410XQ92 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161948

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0WX57

KEGG Orthology (KO)

More...
KOi
K11845

Identification of Orthologs from Complete Genome Data

More...
OMAi
CKLCAME

Database of Orthologous Groups

More...
OrthoDBi
561804at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0WX57

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006861 HABP4_PAIRBP1-bd
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF00443 UCH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q0WX57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDDSLYLRG EWQFNHFSKL TSSRPDAAFA EIQRTSLPEK SPLSCETRVD
60 70 80 90 100
LCDDLAPVAR QLAPREKLPL SSRRPAAVGA GLQNMGNTCY VNASLQCLTY
110 120 130 140 150
TPPLANYMLS REHSQTCHRH KGCMLCTMQA HITRALHNPG HVIQPSQALA
160 170 180 190 200
AGFHRGKQED AHEFLMFTVD AMKKACLPGH KQVDHHSKDT TLIHQIFGGY
210 220 230 240 250
WRSQIKCLHC HGISDTFDPY LDIALDIQAA QSVQQALEQL VKPEELNGEN
260 270 280 290 300
AYHCGVCLQR APASKTLTLH TSAKVLILVL KRFSDVTGNK IAKNVQYPEC
310 320 330 340 350
LDMQPYMSQP NTGPLVYVLY AVLVHAGWSC HNGHYFSYVK AQEGQWYKMD
360 370 380 390 400
DAEVTASSIT SVLSQQAYVL FYIQKSEWER HSESVSRGRE PRALGAEDTD
410 420 430 440 450
RRATQGELKR DHPCLQAPEL DEHLVERATQ ESTLDHWKFL QEQNKTKPEF
460 470 480 490 500
NVRKVEGTLP PDVLVIHQSK YKCGMKNHHP EQQSSLLNLS SSTPTHQESM
510 520 530
NTGTLASLRG RARRSKGKNK HSKRALLVCQ
Length:530
Mass (Da):59,711
Last modified:April 29, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B0DC65280B2A098
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087X1Q3A0A087X1Q3_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP17L25 USP17L24, USP17L26
558Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti9R → G in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti9R → G in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti9R → G in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti23S → P in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti262P → S in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti310P → Q in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti310P → Q in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti360T → I in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti361S → P in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti364S → T in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti392R → S in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti398D → A in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti430Q → H in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti492S → T in AAO38845 (PubMed:17109758).Curated1
Sequence conflicti492S → T in AAQ11741 (PubMed:17109758).Curated1
Sequence conflicti492S → T in AAQ11742 (PubMed:17109758).Curated1
Sequence conflicti511R → G in AAQ11742 (PubMed:17109758).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF544011 mRNA Translation: AAQ11741.1
AF544012 mRNA Translation: AAQ11742.1
AY188990 mRNA Translation: AAO38845.1
AC116655 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS59464.1

NCBI Reference Sequences

More...
RefSeqi
NP_001229255.1, NM_001242326.1
NP_001229256.1, NM_001242327.1
NP_001229257.1, NM_001242328.1
NP_001229259.1, NM_001242330.1
NP_001229260.1, NM_001242331.1
NP_001229261.1, NM_001242332.1
NP_001243796.1, NM_001256867.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000504104; ENSP00000422887; ENSG00000228856
ENST00000504481; ENSP00000425375; ENSG00000232264
ENST00000504543; ENSP00000423777; ENSG00000231051
ENST00000509271; ENSP00000422097; ENSG00000230430
ENST00000509660; ENSP00000427366; ENSG00000229579
ENST00000511681; ENSP00000422969; ENSG00000231637
ENST00000515574; ENSP00000423211; ENSG00000235780

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
728369
728373
728379
728393
728400
728405
728419

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:728369
hsa:728373
hsa:728379
hsa:728393
hsa:728400
hsa:728405
hsa:728419

UCSC genome browser

More...
UCSCi
uc021xll.1 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF544011 mRNA Translation: AAQ11741.1
AF544012 mRNA Translation: AAQ11742.1
AY188990 mRNA Translation: AAO38845.1
AC116655 Genomic DNA No translation available.
CCDSiCCDS59464.1
RefSeqiNP_001229255.1, NM_001242326.1
NP_001229256.1, NM_001242327.1
NP_001229257.1, NM_001242328.1
NP_001229259.1, NM_001242330.1
NP_001229260.1, NM_001242331.1
NP_001229261.1, NM_001242332.1
NP_001243796.1, NM_001256867.1

3D structure databases

SMRiQ0WX57
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ0WX57, 6 interactors
STRINGi9606.ENSP00000427366

PTM databases

iPTMnetiQ0WX57
PhosphoSitePlusiQ0WX57

Polymorphism and mutation databases

BioMutaiUSP17L25
DMDMi187663978

Proteomic databases

jPOSTiQ0WX57
PaxDbiQ0WX57
PeptideAtlasiQ0WX57
PRIDEiQ0WX57
ProteomicsDBi58846

Genome annotation databases

EnsembliENST00000504104; ENSP00000422887; ENSG00000228856
ENST00000504481; ENSP00000425375; ENSG00000232264
ENST00000504543; ENSP00000423777; ENSG00000231051
ENST00000509271; ENSP00000422097; ENSG00000230430
ENST00000509660; ENSP00000427366; ENSG00000229579
ENST00000511681; ENSP00000422969; ENSG00000231637
ENST00000515574; ENSP00000423211; ENSG00000235780
GeneIDi728369
728373
728379
728393
728400
728405
728419
KEGGihsa:728369
hsa:728373
hsa:728379
hsa:728393
hsa:728400
hsa:728405
hsa:728419
UCSCiuc021xll.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
728369
728373
728379
728393
728400
728405
728419
DisGeNETi728369
728373
728379
728393
728400
728405
728419
EuPathDBiHostDB:ENSG00000228856.3
HostDB:ENSG00000229579.4
HostDB:ENSG00000230430.4
HostDB:ENSG00000231051.3
HostDB:ENSG00000231637.3
HostDB:ENSG00000232264.4
HostDB:ENSG00000235780.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
USP17L24
USP17L25
USP17L26
USP17L27
USP17L28
USP17L29
USP17L30
HGNCiHGNC:44453 USP17L24
HGNC:44452 USP17L25
HGNC:44454 USP17L26
HGNC:44455 USP17L27
HGNC:44456 USP17L28
HGNC:44457 USP17L29
HGNC:44458 USP17L30
HPAiHPA045642
MIMi607011 gene
neXtProtiNX_Q0WX57
OpenTargetsiENSG00000228856

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1865 Eukaryota
ENOG410XQ92 LUCA
GeneTreeiENSGT00940000161948
InParanoidiQ0WX57
KOiK11845
OMAiCKLCAME
OrthoDBi561804at2759
PhylomeDBiQ0WX57

Enzyme and pathway databases

ReactomeiR-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

PharosiQ0WX57 Tbio

Protein Ontology

More...
PROi
PR:Q0WX57
RNActiQ0WX57 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000229579 Expressed in 1 organ(s), highest expression level in blood
ExpressionAtlasiQ0WX57 baseline

Family and domain databases

InterProiView protein in InterPro
IPR006861 HABP4_PAIRBP1-bd
IPR038765 Papain-like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF00443 UCH, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiU17LO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0WX57
Secondary accession number(s): A8MRA9, Q0WX56, Q3BEM1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: December 11, 2019
This is version 108 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Peptidase families
    Classification of peptidase families and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again