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Entry version 92 (31 Jul 2019)
Sequence version 1 (05 Sep 2006)
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Protein

MMS19 nucleotide excision repair protein homolog

Gene

MMS19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May select specific target apoproteins to which a Fe-S cluster produced by the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) pathway is transferred.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MMS19 nucleotide excision repair protein homologCurated
Alternative name(s):
MET18 homolog1 Publication
MMS19-like proteinCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MMS19Curated
Synonyms:MET181 Publication
Ordered Locus Names:At5g48120Imported
ORF Names:MDN11.21Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT5G48120

The Arabidopsis Information Resource

More...
TAIRi
locus:2162697 AT5G48120

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004335161 – 1134MMS19 nucleotide excision repair protein homologAdd BLAST1134

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0WVF8

PRoteomics IDEntifications database

More...
PRIDEi
Q0WVF8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0WVF8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0WVF8 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex composed of AE7, CIA1, MMS19 and NAR1.

Interacts with AE7.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT5G48120.1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati959 – 998HEAT 1Sequence analysisAdd BLAST40
Repeati1002 – 1047HEAT 2Sequence analysisAdd BLAST46
Repeati1050 – 1089HEAT 3Sequence analysisAdd BLAST40
Repeati1092 – 1130HEAT 4Sequence analysisAdd BLAST39

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MET18/MMS19 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1967 Eukaryota
ENOG410XNMZ LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000084458

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0WVF8

KEGG Orthology (KO)

More...
KOi
K15075

Identification of Orthologs from Complete Genome Data

More...
OMAi
FEIFACY

Database of Orthologous Groups

More...
OrthoDBi
944339at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0WVF8

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039920 MET18/MMS19
IPR024687 MMS19_C
IPR029240 MMS19_N

The PANTHER Classification System

More...
PANTHERi
PTHR12891 PTHR12891, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12460 MMS19_C, 1 hit
PF14500 MMS19_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q0WVF8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMVEPNQLVQ HLETFVDTNR SSSQQDDSLK AIASSLENDS LSITQLVREM
60 70 80 90 100
EMYLTTTDNL VRARGILLLA EILDCLKAKP LNDTIVHTLV GFFSEKLADW
110 120 130 140 150
RAMCGALVGC LALLKRKDVA GVVTDIDVQA MAKSMIQNVQ VQALALHERK
160 170 180 190 200
LAFELLECLL QQHSEAILTM GDLLVYAMCE AIDGEKDPQC LMIVFHLVEL
210 220 230 240 250
LAPLFPSPSG PLASDASDLF EVIGCYFPLH FTHTKDDEAN IRREDLSRGL
260 270 280 290 300
LLAISSTPFF EPYAIPLLLE KLSSSLPVAK VDSLKCLKDC ALKYGVDRMK
310 320 330 340 350
KHYGALWSAL KDTFYSSTGT HLSFAIESLT SPGFEMNEIH RDAVSLLQRL
360 370 380 390 400
VKQDISFLGF VVDDTRINTV FDTIYRYPQY KEMPDPSKLE VLVISQILSV
410 420 430 440 450
SAKASVQSCN IIFEAIFFRL MNTLGIVEKT STGDVVQNGN STVSTRLYHG
460 470 480 490 500
GLHLCIELLA ASKDLILGFE ECSPTSGCAN SGCSMVKSFS VPLIQVFTSA
510 520 530 540 550
VCRSNDDSVV DVYLGVKGLL TMGMFRGGSS PVSRTEFENI LVTLTSIITA
560 570 580 590 600
KSGKTVVWEL ALKALVCIGS FIDRYHESDK AMSYMSIVVD NLVSLACSSH
610 620 630 640 650
CGLPYQMILE ATSEVCSTGP KYVEKMVQGL EEAFCSSLSD FYVNGNFESI
660 670 680 690 700
DNCSQLLKCL TNKLLPRVAE IDGLEQLLVH FAISMWKQIE FCGVFSCDFN
710 720 730 740 750
GREFVEAAMT TMRQVVGIAL VDSQNSIIQK AYSVVSSCTL PAMESIPLTF
760 770 780 790 800
VALEGLQRDL SSRDELILSL FASVIIAASP SASIPDAKSL IHLLLVTLLK
810 820 830 840 850
GYIPAAQALG SMVNKLGSGS GGTNTSRDCS LEEACAIIFH ADFASGKKIS
860 870 880 890 900
SNGSAKIIVG SETTMSKICL GYCGSLDLQT RAITGLAWIG KGLLMRGNER
910 920 930 940 950
VNEIALVLVE CLKSNNCSGH ALHPSAMKHA ADAFSIIMSD SEVCLNRKFH
960 970 980 990 1000
AVIRPLYKQR CFSTIVPILE SLIMNSQTSL SRTMLHVALA HVISNVPVTV
1010 1020 1030 1040 1050
ILDNTKKLQP LILEGLSVLS LDSVEKETLF SLLLVLSGTL TDTKGQQSAS
1060 1070 1080 1090 1100
DNAHIIIECL IKLTSYPHLM VVRETSIQCL VALLELPHRR IYPFRREVLQ
1110 1120 1130
AIEKSLDDPK RKVREEAIRC RQAWASITSG SNIF
Length:1,134
Mass (Da):124,255
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0FBB9559E03FD15F
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB11076 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB017064, AB023039 Genomic DNA Translation: BAB11076.1 Sequence problems.
CP002688 Genomic DNA Translation: AED95621.1
CP002688 Genomic DNA Translation: ANM69256.1
CP002688 Genomic DNA Translation: ANM69257.1
AK226792 mRNA Translation: BAE98890.1

NCBI Reference Sequences

More...
RefSeqi
NP_001318759.1, NM_001344759.1
NP_001330951.1, NM_001344760.1
NP_199623.2, NM_124186.5

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT5G48120.1; AT5G48120.1; AT5G48120
AT5G48120.2; AT5G48120.2; AT5G48120
AT5G48120.3; AT5G48120.3; AT5G48120

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
834864

Gramene; a comparative resource for plants

More...
Gramenei
AT5G48120.1; AT5G48120.1; AT5G48120
AT5G48120.2; AT5G48120.2; AT5G48120
AT5G48120.3; AT5G48120.3; AT5G48120

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT5G48120

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB017064, AB023039 Genomic DNA Translation: BAB11076.1 Sequence problems.
CP002688 Genomic DNA Translation: AED95621.1
CP002688 Genomic DNA Translation: ANM69256.1
CP002688 Genomic DNA Translation: ANM69257.1
AK226792 mRNA Translation: BAE98890.1
RefSeqiNP_001318759.1, NM_001344759.1
NP_001330951.1, NM_001344760.1
NP_199623.2, NM_124186.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT5G48120.1

Proteomic databases

PaxDbiQ0WVF8
PRIDEiQ0WVF8

Genome annotation databases

EnsemblPlantsiAT5G48120.1; AT5G48120.1; AT5G48120
AT5G48120.2; AT5G48120.2; AT5G48120
AT5G48120.3; AT5G48120.3; AT5G48120
GeneIDi834864
GrameneiAT5G48120.1; AT5G48120.1; AT5G48120
AT5G48120.2; AT5G48120.2; AT5G48120
AT5G48120.3; AT5G48120.3; AT5G48120
KEGGiath:AT5G48120

Organism-specific databases

AraportiAT5G48120
TAIRilocus:2162697 AT5G48120

Phylogenomic databases

eggNOGiKOG1967 Eukaryota
ENOG410XNMZ LUCA
HOGENOMiHOG000084458
InParanoidiQ0WVF8
KOiK15075
OMAiFEIFACY
OrthoDBi944339at2759
PhylomeDBiQ0WVF8

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q0WVF8

Gene expression databases

ExpressionAtlasiQ0WVF8 baseline and differential
GenevisibleiQ0WVF8 AT

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR039920 MET18/MMS19
IPR024687 MMS19_C
IPR029240 MMS19_N
PANTHERiPTHR12891 PTHR12891, 1 hit
PfamiView protein in Pfam
PF12460 MMS19_C, 1 hit
PF14500 MMS19_N, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMMS19_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0WVF8
Secondary accession number(s): Q9FI26
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2015
Last sequence update: September 5, 2006
Last modified: July 31, 2019
This is version 92 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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