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Protein

Type IV inositol polyphosphate 5-phosphatase 7

Gene

IP5P7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has phosphatase activity toward PtdIns(4,5)P2 and at a lower extent toward PtdIns(3,4,5)P3 but not toward Ins(1,4,5)P3 (PubMed:19473324, PubMed:21677096, PubMed:23658066). Acts redundantly with CVP2 for maintaining vascular continuity (PubMed:19363154, PubMed:25813544). Regulates phosphoinositide-dependent VAN3 localization (PubMed:19473324). Functions in salt stress response by regulating reactive oxygen species (ROS) production and stress-responsive genes expression (PubMed:21677096).5 Publications

Miscellaneous

Cvp1 and cvp2 double mutant displays high PtdIns(4,5)P2 levels.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cellular response to salt stress Source: UniProtKB
  • leaf vascular tissue pattern formation Source: TAIR
  • phosphatidylinositol dephosphorylation Source: UniProtKB
  • regulation of reactive oxygen species metabolic process Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type IV inositol polyphosphate 5-phosphatase 71 Publication (EC:3.1.3.363 Publications, EC:3.1.3.863 Publications)
Short name:
At5PTase71 Publication
Alternative name(s):
Protein CVP2 LIKE 11 Publication
Short name:
Protein CVL11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IP5P7Curated
Synonyms:CVL11 Publication, IPP4Imported
Ordered Locus Names:At2g32010Imported
ORF Names:F22D22.24Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G32010

The Arabidopsis Information Resource

More...
TAIRi
locus:2045502 AT2G32010

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype (PubMed:19473324). Increased salt sensitivity with reduced production of reactive oxygen species (ROS) (PubMed:21677096).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004332571 – 594Type IV inositol polyphosphate 5-phosphatase 7Add BLAST594

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0WQ41

PRoteomics IDEntifications database

More...
PRIDEi
Q0WQ41

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Broadly expressed in emerging organs. Mostly localized in procambium of growing organs. Restricted to vascular differentiating cells of young organs.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in developing veins of late torpedo, walking stick and bent cotyledon stage embryos.1 Publication

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0WQ41 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0WQ41 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT2G32010.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q0WQ41

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0WQ41

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni435 – 450Catalytic 1By similarityAdd BLAST16
Regioni515 – 530Catalytic 2By similarityAdd BLAST16

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0565 Eukaryota
COG5411 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000241161

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0WQ41

Identification of Orthologs from Complete Genome Data

More...
OMAi
VFWAEVE

Database of Orthologous Groups

More...
OrthoDBi
EOG0936064A

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0WQ41

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03372 Exo_endo_phos, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00128 IPPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219 SSF56219, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q0WQ41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDDKTKKSK LSWSKKMVRK WFNIKSKTEK FQADVSLPQG VEVEHRNSFS
60 70 80 90 100
EREPCTIKKS KTEKLNKNWE QQARQRKMNY ENPRIIDVQN HSIFVATWNV
110 120 130 140 150
AGRSPPEDLN LDEWLHSSAP ADIYVLGFQE IVPLNAGNVL GAEDNGPAKK
160 170 180 190 200
WHSLIRKTLN NLPGASSACH TPSPIPVPIA EIDADFSGSS RQKNETFFNR
210 220 230 240 250
RSFQTPSVWS MEENDPSISQ PRLDRRFSVC DRVFFSHRPS DFDPSFRCGH
260 270 280 290 300
RPSDYSRRPS DYSRPSDYYS RPSNYSRPSD VSRWGSSDDD NGPGDSPSTF
310 320 330 340 350
LNSPGSFLGS AANENGYRTP WNSSQYCLVA SKQMVGIFLT IWVKSELREH
360 370 380 390 400
VKNMKVSCVG RGLMGYLGNK GSISISMLLH QTSFCFVCTH LTSGQKEGDE
410 420 430 440 450
LRRNSDVMEI LKKTRFPRVQ SSADEKSPEN ILQHDRVIWL GDLNYRIALS
460 470 480 490 500
YRSAKALVEM QNWRALLEND QLRIEQKRGH VFKGWNEGKI YFPPTYKYSN
510 520 530 540 550
NSDRYAGGDL HPKEKRRTPA WCDRILWHGE GLHQLSYVRG ESRFSDHRPV
560 570 580 590
YGIFSAEVES NHKRSKRTNS HSTARVEAEE LLPYARGYTE LTFF
Length:594
Mass (Da):68,245
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB9BBC2A961CCECAF
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD15403 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAC81920 differs from that shown. Reason: Frameshift at position 588.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti568T → I in CAC81920 (Ref. 4) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC006223 Genomic DNA Translation: AAD15403.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08621.1
CP002685 Genomic DNA Translation: AEC08622.1
CP002685 Genomic DNA Translation: ANM62725.1
CP002685 Genomic DNA Translation: ANM62726.1
AK228865 mRNA Translation: BAF00758.1
AJ277885 mRNA Translation: CAC81920.1 Frameshift.

Protein sequence database of the Protein Information Resource

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PIRi
H84727

NCBI Reference Sequences

More...
RefSeqi
NP_001189654.1, NM_001202725.1
NP_001324864.1, NM_001336367.1
NP_001324865.1, NM_001336366.1
NP_180761.2, NM_128761.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
At.13598

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G32010.1; AT2G32010.1; AT2G32010
AT2G32010.2; AT2G32010.2; AT2G32010
AT2G32010.3; AT2G32010.3; AT2G32010
AT2G32010.4; AT2G32010.4; AT2G32010

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
817761

Gramene; a comparative resource for plants

More...
Gramenei
AT2G32010.1; AT2G32010.1; AT2G32010
AT2G32010.2; AT2G32010.2; AT2G32010
AT2G32010.3; AT2G32010.3; AT2G32010
AT2G32010.4; AT2G32010.4; AT2G32010

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G32010

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006223 Genomic DNA Translation: AAD15403.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08621.1
CP002685 Genomic DNA Translation: AEC08622.1
CP002685 Genomic DNA Translation: ANM62725.1
CP002685 Genomic DNA Translation: ANM62726.1
AK228865 mRNA Translation: BAF00758.1
AJ277885 mRNA Translation: CAC81920.1 Frameshift.
PIRiH84727
RefSeqiNP_001189654.1, NM_001202725.1
NP_001324864.1, NM_001336367.1
NP_001324865.1, NM_001336366.1
NP_180761.2, NM_128761.4
UniGeneiAt.13598

3D structure databases

ProteinModelPortaliQ0WQ41
SMRiQ0WQ41
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G32010.1

Proteomic databases

PaxDbiQ0WQ41
PRIDEiQ0WQ41

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G32010.1; AT2G32010.1; AT2G32010
AT2G32010.2; AT2G32010.2; AT2G32010
AT2G32010.3; AT2G32010.3; AT2G32010
AT2G32010.4; AT2G32010.4; AT2G32010
GeneIDi817761
GrameneiAT2G32010.1; AT2G32010.1; AT2G32010
AT2G32010.2; AT2G32010.2; AT2G32010
AT2G32010.3; AT2G32010.3; AT2G32010
AT2G32010.4; AT2G32010.4; AT2G32010
KEGGiath:AT2G32010

Organism-specific databases

AraportiAT2G32010
TAIRilocus:2045502 AT2G32010

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
HOGENOMiHOG000241161
InParanoidiQ0WQ41
OMAiVFWAEVE
OrthoDBiEOG0936064A
PhylomeDBiQ0WQ41

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q0WQ41

Gene expression databases

ExpressionAtlasiQ0WQ41 baseline and differential
GenevisibleiQ0WQ41 AT

Family and domain databases

Gene3Di3.60.10.10, 2 hits
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIP5P7_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0WQ41
Secondary accession number(s): Q712G2, Q9SKZ8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: September 5, 2006
Last modified: December 5, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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