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Protein

Type IV inositol polyphosphate 5-phosphatase 7

Gene

IP5P7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has phosphatase activity toward PtdIns(4,5)P2 and at a lower extent toward PtdIns(3,4,5)P3 but not toward Ins(1,4,5)P3 (PubMed:19473324, PubMed:21677096, PubMed:23658066). Acts redundantly with CVP2 for maintaining vascular continuity (PubMed:19363154, PubMed:25813544). Regulates phosphoinositide-dependent VAN3 localization (PubMed:19473324). Functions in salt stress response by regulating reactive oxygen species (ROS) production and stress-responsive genes expression (PubMed:21677096).5 Publications

Miscellaneous

Cvp1 and cvp2 double mutant displays high PtdIns(4,5)P2 levels.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.3 Publications
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate.3 Publications

GO - Molecular functioni

GO - Biological processi

  • cellular response to salt stress Source: UniProtKB
  • leaf vascular tissue pattern formation Source: TAIR
  • phosphatidylinositol dephosphorylation Source: UniProtKB
  • regulation of reactive oxygen species metabolic process Source: UniProtKB

Keywordsi

Molecular functionHydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Type IV inositol polyphosphate 5-phosphatase 71 Publication (EC:3.1.3.363 Publications, EC:3.1.3.863 Publications)
Short name:
At5PTase71 Publication
Alternative name(s):
Protein CVP2 LIKE 11 Publication
Short name:
Protein CVL11 Publication
Gene namesi
Name:IP5P7Curated
Synonyms:CVL11 Publication, IPP4Imported
Ordered Locus Names:At2g32010Imported
ORF Names:F22D22.24Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G32010
TAIRilocus:2045502 AT2G32010

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype (PubMed:19473324). Increased salt sensitivity with reduced production of reactive oxygen species (ROS) (PubMed:21677096).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004332571 – 594Type IV inositol polyphosphate 5-phosphatase 7Add BLAST594

Proteomic databases

PaxDbiQ0WQ41
PRIDEiQ0WQ41

Expressioni

Tissue specificityi

Broadly expressed in emerging organs. Mostly localized in procambium of growing organs. Restricted to vascular differentiating cells of young organs.1 Publication

Developmental stagei

Expressed in developing veins of late torpedo, walking stick and bent cotyledon stage embryos.1 Publication

Gene expression databases

ExpressionAtlasiQ0WQ41 baseline and differential
GenevisibleiQ0WQ41 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G32010.1

Structurei

3D structure databases

ProteinModelPortaliQ0WQ41
SMRiQ0WQ41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni435 – 450Catalytic 1By similarityAdd BLAST16
Regioni515 – 530Catalytic 2By similarityAdd BLAST16

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
HOGENOMiHOG000241161
InParanoidiQ0WQ41
OMAiYYSRASD
OrthoDBiEOG0936064A
PhylomeDBiQ0WQ41

Family and domain databases

Gene3Di3.60.10.10, 2 hits
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 2 hits

Sequencei

Sequence statusi: Complete.

Q0WQ41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDDKTKKSK LSWSKKMVRK WFNIKSKTEK FQADVSLPQG VEVEHRNSFS
60 70 80 90 100
EREPCTIKKS KTEKLNKNWE QQARQRKMNY ENPRIIDVQN HSIFVATWNV
110 120 130 140 150
AGRSPPEDLN LDEWLHSSAP ADIYVLGFQE IVPLNAGNVL GAEDNGPAKK
160 170 180 190 200
WHSLIRKTLN NLPGASSACH TPSPIPVPIA EIDADFSGSS RQKNETFFNR
210 220 230 240 250
RSFQTPSVWS MEENDPSISQ PRLDRRFSVC DRVFFSHRPS DFDPSFRCGH
260 270 280 290 300
RPSDYSRRPS DYSRPSDYYS RPSNYSRPSD VSRWGSSDDD NGPGDSPSTF
310 320 330 340 350
LNSPGSFLGS AANENGYRTP WNSSQYCLVA SKQMVGIFLT IWVKSELREH
360 370 380 390 400
VKNMKVSCVG RGLMGYLGNK GSISISMLLH QTSFCFVCTH LTSGQKEGDE
410 420 430 440 450
LRRNSDVMEI LKKTRFPRVQ SSADEKSPEN ILQHDRVIWL GDLNYRIALS
460 470 480 490 500
YRSAKALVEM QNWRALLEND QLRIEQKRGH VFKGWNEGKI YFPPTYKYSN
510 520 530 540 550
NSDRYAGGDL HPKEKRRTPA WCDRILWHGE GLHQLSYVRG ESRFSDHRPV
560 570 580 590
YGIFSAEVES NHKRSKRTNS HSTARVEAEE LLPYARGYTE LTFF
Length:594
Mass (Da):68,245
Last modified:September 5, 2006 - v1
Checksum:iB9BBC2A961CCECAF
GO

Sequence cautioni

The sequence AAD15403 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAC81920 differs from that shown. Reason: Frameshift at position 588.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti568T → I in CAC81920 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006223 Genomic DNA Translation: AAD15403.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08621.1
CP002685 Genomic DNA Translation: AEC08622.1
CP002685 Genomic DNA Translation: ANM62725.1
CP002685 Genomic DNA Translation: ANM62726.1
AK228865 mRNA Translation: BAF00758.1
AJ277885 mRNA Translation: CAC81920.1 Frameshift.
PIRiH84727
RefSeqiNP_001189654.1, NM_001202725.1
NP_001324864.1, NM_001336367.1
NP_001324865.1, NM_001336366.1
NP_180761.2, NM_128761.4
UniGeneiAt.13598

Genome annotation databases

EnsemblPlantsiAT2G32010.1; AT2G32010.1; AT2G32010
AT2G32010.2; AT2G32010.2; AT2G32010
AT2G32010.3; AT2G32010.3; AT2G32010
AT2G32010.4; AT2G32010.4; AT2G32010
GeneIDi817761
GrameneiAT2G32010.1; AT2G32010.1; AT2G32010
AT2G32010.2; AT2G32010.2; AT2G32010
AT2G32010.3; AT2G32010.3; AT2G32010
AT2G32010.4; AT2G32010.4; AT2G32010
KEGGiath:AT2G32010

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006223 Genomic DNA Translation: AAD15403.1 Sequence problems.
CP002685 Genomic DNA Translation: AEC08621.1
CP002685 Genomic DNA Translation: AEC08622.1
CP002685 Genomic DNA Translation: ANM62725.1
CP002685 Genomic DNA Translation: ANM62726.1
AK228865 mRNA Translation: BAF00758.1
AJ277885 mRNA Translation: CAC81920.1 Frameshift.
PIRiH84727
RefSeqiNP_001189654.1, NM_001202725.1
NP_001324864.1, NM_001336367.1
NP_001324865.1, NM_001336366.1
NP_180761.2, NM_128761.4
UniGeneiAt.13598

3D structure databases

ProteinModelPortaliQ0WQ41
SMRiQ0WQ41
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G32010.1

Proteomic databases

PaxDbiQ0WQ41
PRIDEiQ0WQ41

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G32010.1; AT2G32010.1; AT2G32010
AT2G32010.2; AT2G32010.2; AT2G32010
AT2G32010.3; AT2G32010.3; AT2G32010
AT2G32010.4; AT2G32010.4; AT2G32010
GeneIDi817761
GrameneiAT2G32010.1; AT2G32010.1; AT2G32010
AT2G32010.2; AT2G32010.2; AT2G32010
AT2G32010.3; AT2G32010.3; AT2G32010
AT2G32010.4; AT2G32010.4; AT2G32010
KEGGiath:AT2G32010

Organism-specific databases

AraportiAT2G32010
TAIRilocus:2045502 AT2G32010

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
HOGENOMiHOG000241161
InParanoidiQ0WQ41
OMAiYYSRASD
OrthoDBiEOG0936064A
PhylomeDBiQ0WQ41

Miscellaneous databases

PROiPR:Q0WQ41

Gene expression databases

ExpressionAtlasiQ0WQ41 baseline and differential
GenevisibleiQ0WQ41 AT

Family and domain databases

Gene3Di3.60.10.10, 2 hits
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000300 IPPc
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SUPFAMiSSF56219 SSF56219, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIP5P7_ARATH
AccessioniPrimary (citable) accession number: Q0WQ41
Secondary accession number(s): Q712G2, Q9SKZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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