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Protein

Pentatricopeptide repeat-containing protein At4g18520, chloroplastic

Gene

PCMP-A2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for proper chloroplast development (Ref. 7, PubMed:24144791). Involved in the regulation of plastid gene expression probably through regulation of plastid-encoded polymerase (PEP) dependent chloroplast transcription (PubMed:24144791). Required for RNA editing of several chloroplastic transcripts, especially accD transcripts (PubMed:24144791, PubMed:26123918). Required for processing of the chloroplastic rpoA pre-mRNA (Ref. 6, Ref. 7). Required for the monocistronic rpoA transcript processing from the rpl23-rpl2-rps19-rpl22-rps3-rpl16-rpl14-rps8-rpl36-rps11-rpoA polycistron. Binds the intergenic sequence of rps11-rpoA for rpoA monocistronic RNA cleavage (Ref. 7).4 Publications

GO - Molecular functioni

GO - Biological processi

  • chloroplast RNA modification Source: TAIR
  • mRNA processing Source: UniProtKB-KW
  • RNA splicing Source: TAIR

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Pentatricopeptide repeat-containing protein At4g18520, chloroplastic
Alternative name(s):
Protein PIGMENT-DEFICIENT MUTANT 11 Publication
Protein SEEDLING LETHAL 11 Publication
Gene namesi
Name:PCMP-A2
Synonyms:PDM11 Publication, SEL11 Publication
Ordered Locus Names:At4g18520
ORF Names:F28J12.180
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G18520
TAIRilocus:2124603 AT4G18520

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

Pathology & Biotechi

Disruption phenotypei

Albino lethal phenotype with severe chloroplast development defects.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19ChloroplastSequence analysisAdd BLAST19
ChainiPRO_000036343620 – 617Pentatricopeptide repeat-containing protein At4g18520, chloroplasticAdd BLAST598

Proteomic databases

PaxDbiQ0WNP3
PRIDEiQ0WNP3

Expressioni

Tissue specificityi

Expressed specifically in aerial greening tissues, such as cotyledons, rosette leaves, cauline leaves, stems, sepals, stamens, carpels and siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ0WNP3 baseline and differential
GenevisibleiQ0WNP3 AT

Interactioni

Subunit structurei

Interacts with MORF8/RIP1, MORF2/RIP2 and MORF9/RIP9.1 Publication

Protein-protein interaction databases

BioGridi12877, 3 interactors
STRINGi3702.AT4G18520.1

Structurei

3D structure databases

ProteinModelPortaliQ0WNP3
SMRiQ0WNP3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati116 – 146PPR 1Add BLAST31
Repeati147 – 181PPR 2Add BLAST35
Repeati183 – 217PPR 3Add BLAST35
Repeati222 – 247PPR 4Add BLAST26
Repeati248 – 282PPR 5Add BLAST35
Repeati283 – 317PPR 6Add BLAST35
Repeati318 – 348PPR 7Add BLAST31
Repeati349 – 383PPR 8Add BLAST35
Repeati384 – 418PPR 9Add BLAST35
Repeati419 – 449PPR 10Add BLAST31
Repeati450 – 484PPR 11Add BLAST35
Repeati485 – 519PPR 12Add BLAST35
Repeati520 – 550PPR 13Add BLAST31
Repeati551 – 585PPR 14Add BLAST35

Sequence similaritiesi

Belongs to the PPR family. PCMP-A subfamily.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG4197 Eukaryota
ENOG410Z7Z7 LUCA
HOGENOMiHOG000077484
InParanoidiQ0WNP3
OMAiKLMYRMQ
OrthoDBiEOG093604HD
PhylomeDBiQ0WNP3

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR002885 Pentatricopeptide_repeat
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF01535 PPR, 7 hits
PF13041 PPR_2, 2 hits
TIGRFAMsiTIGR00756 PPR, 8 hits
PROSITEiView protein in PROSITE
PS51375 PPR, 13 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q0WNP3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFSLSLIQPR LRISEIPVTQ SYKSPTICYS SDSRTKREEQ RHVRLPGFRL
60 70 80 90 100
VSGKRASFDS GFSGFKGENV NQDDSSSFDS ERVDYALLAE WLQSSNGMRL
110 120 130 140 150
IKRIHAMALK CFDDQVIYFG NNLISSCVRL GDLVYARKVF DSMPEKNTVT
160 170 180 190 200
WTAMIDGYLK YGLEDEAFAL FEDYVKHGIR FTNERMFVCL LNLCSRRAEF
210 220 230 240 250
ELGRQVHGNM VKVGVGNLIV ESSLVYFYAQ CGELTSALRA FDMMEEKDVI
260 270 280 290 300
SWTAVISACS RKGHGIKAIG MFIGMLNHWF LPNEFTVCSI LKACSEEKAL
310 320 330 340 350
RFGRQVHSLV VKRMIKTDVF VGTSLMDMYA KCGEISDCRK VFDGMSNRNT
360 370 380 390 400
VTWTSIIAAH AREGFGEEAI SLFRIMKRRH LIANNLTVVS ILRACGSVGA
410 420 430 440 450
LLLGKELHAQ IIKNSIEKNV YIGSTLVWLY CKCGESRDAF NVLQQLPSRD
460 470 480 490 500
VVSWTAMISG CSSLGHESEA LDFLKEMIQE GVEPNPFTYS SALKACANSE
510 520 530 540 550
SLLIGRSIHS IAKKNHALSN VFVGSALIHM YAKCGFVSEA FRVFDSMPEK
560 570 580 590 600
NLVSWKAMIM GYARNGFCRE ALKLMYRMEA EGFEVDDYIF ATILSTCGDI
610
ELDEAVESSA TCYLETS
Length:617
Mass (Da):69,275
Last modified:September 5, 2006 - v1
Checksum:i0F279AA6FBA72D6A
GO

Sequence cautioni

The sequence CAA16732 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78854 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021710 Genomic DNA Translation: CAA16732.1 Sequence problems.
AL161548 Genomic DNA Translation: CAB78854.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84057.1
AK229394 mRNA Translation: BAF01256.1
PIRiT04548
RefSeqiNP_193587.4, NM_117966.5
UniGeneiAt.32894

Genome annotation databases

EnsemblPlantsiAT4G18520.1; AT4G18520.1; AT4G18520
GeneIDi827584
GrameneiAT4G18520.1; AT4G18520.1; AT4G18520
KEGGiath:AT4G18520

Similar proteinsi

Cross-referencesi

Web resourcesi

Arabidopsis PPR Protein Database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021710 Genomic DNA Translation: CAA16732.1 Sequence problems.
AL161548 Genomic DNA Translation: CAB78854.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84057.1
AK229394 mRNA Translation: BAF01256.1
PIRiT04548
RefSeqiNP_193587.4, NM_117966.5
UniGeneiAt.32894

3D structure databases

ProteinModelPortaliQ0WNP3
SMRiQ0WNP3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12877, 3 interactors
STRINGi3702.AT4G18520.1

Proteomic databases

PaxDbiQ0WNP3
PRIDEiQ0WNP3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G18520.1; AT4G18520.1; AT4G18520
GeneIDi827584
GrameneiAT4G18520.1; AT4G18520.1; AT4G18520
KEGGiath:AT4G18520

Organism-specific databases

AraportiAT4G18520
TAIRilocus:2124603 AT4G18520

Phylogenomic databases

eggNOGiKOG4197 Eukaryota
ENOG410Z7Z7 LUCA
HOGENOMiHOG000077484
InParanoidiQ0WNP3
OMAiKLMYRMQ
OrthoDBiEOG093604HD
PhylomeDBiQ0WNP3

Miscellaneous databases

PROiPR:Q0WNP3

Gene expression databases

ExpressionAtlasiQ0WNP3 baseline and differential
GenevisibleiQ0WNP3 AT

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR002885 Pentatricopeptide_repeat
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF01535 PPR, 7 hits
PF13041 PPR_2, 2 hits
TIGRFAMsiTIGR00756 PPR, 8 hits
PROSITEiView protein in PROSITE
PS51375 PPR, 13 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPP319_ARATH
AccessioniPrimary (citable) accession number: Q0WNP3
Secondary accession number(s): O49520
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 5, 2006
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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