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Entry version 69 (02 Jun 2021)
Sequence version 2 (10 Aug 2010)
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Protein

Probable ubiquitin-like-specific protease 2A

Gene

ULP2A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins.

By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei400By similarity1
Active sitei430By similarity1
Active sitei485By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.B67, 399

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable ubiquitin-like-specific protease 2A (EC:3.4.22.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ULP2A
Ordered Locus Names:At4g33620
ORF Names:T16L1.110
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G33620

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003959731 – 774Probable ubiquitin-like-specific protease 2AAdd BLAST774

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0WKV8

PRoteomics IDEntifications database

More...
PRIDEi
Q0WKV8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
245269

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0WKV8, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT4G33620.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0WKV8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni118 – 141DisorderedSequence analysisAdd BLAST24
Regioni548 – 568DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi118 – 134Polar residuesSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0779, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_353883_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0WKV8

Identification of Orthologs from Complete Genome Data

More...
OMAi
WCLEVET

Database of Orthologous Groups

More...
OrthoDBi
179156at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR003653, Peptidase_C48_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02902, Peptidase_C48, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50600, ULP_PROTEASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q0WKV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLRSVQSRS KRKPIDVFDY SDEDDRVEEE SKKLLRKFDS PVTKKHHCAI
60 70 80 90 100
DKYEFLRCFA KDTQSESKVL QHIVIDVEVP VKEEPSRCEL SGDGNSDLID
110 120 130 140 150
VISNGSHRRI GIDSLTSSSL SENDEVSTGE ATNPASDPHE VDPENAQVLI
160 170 180 190 200
IPDVIIYGDI YCTNSKLTFS RNCMNVESSS VNATKGTFSC QWTIEDIIKI
210 220 230 240 250
ESQWCLEVET AFVNVLLKSR KPEGVDIAKD ISGIDLLKFS VYDPKWSKEV
260 270 280 290 300
ETIRSLDSRY KNIWFDTITE SEEIAFSGHD LGTSLTNLAD SFEDLVYPQG
310 320 330 340 350
EPDAVVVRKQ DIELLKPRRF INDTIIDFYI KYLKNRISPK ERGRFHFFNC
360 370 380 390 400
FFFRKLANLD KGTPSTCGGR EAYQRVQKWT KNVDLFEKDY IFIPINCSFH
410 420 430 440 450
WSLVIICHPG ELVPSHVENP QRVPCILHLD SIKGSHKGGL INIFPSYLRE
460 470 480 490 500
EWKARHENTT NDSSRAPNMQ SISLELPQQE NSFDCGLFLL HYLDLFVAQA
510 520 530 540 550
PAKFNPSLIS RSANFLTRNW FPAKEASLKR RNILELLYNL HKGHDPSILP
560 570 580 590 600
ANSKSEPPHC GVSNRNDQET ESENVIECCN WIKPFDGSSS TVTDISQTKT
610 620 630 640 650
CSPDLILSKE VSYSGGYDPP SSKLRKVFMS PIVEEVQESC EKKDHLEMDI
660 670 680 690 700
QKSTGHEIET LRKEGCMLYI EDSDDEEAVS VEYVSDSQDS YEVEMKVEDD
710 720 730 740 750
DDDELIVTGE SSGIHGSREI KSDSASIERV NKSRDSTAAS CYNDFLLVLS
760 770
DDERSSDDKE NILISSNVMA KPKT
Length:774
Mass (Da):87,796
Last modified:August 10, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i47B0300090271186
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAF02249 differs from that shown. Intron retention.Curated
The sequence CAA20575 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB80079 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL031394 Genomic DNA Translation: CAA20575.1 Sequence problems.
AL161583 Genomic DNA Translation: CAB80079.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE86254.2
AK230453 mRNA Translation: BAF02249.1 Sequence problems.

Protein sequence database of the Protein Information Resource

More...
PIRi
T04979

NCBI Reference Sequences

More...
RefSeqi
NP_001320126.1, NM_001342223.1

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G33620.1; AT4G33620.1; AT4G33620

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
829502

Gramene; a comparative resource for plants

More...
Gramenei
AT4G33620.1; AT4G33620.1; AT4G33620

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G33620

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031394 Genomic DNA Translation: CAA20575.1 Sequence problems.
AL161583 Genomic DNA Translation: CAB80079.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE86254.2
AK230453 mRNA Translation: BAF02249.1 Sequence problems.
PIRiT04979
RefSeqiNP_001320126.1, NM_001342223.1

3D structure databases

SMRiQ0WKV8
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G33620.1

Proteomic databases

PaxDbiQ0WKV8
PRIDEiQ0WKV8
ProteomicsDBi245269

Genome annotation databases

EnsemblPlantsiAT4G33620.1; AT4G33620.1; AT4G33620
GeneIDi829502
GrameneiAT4G33620.1; AT4G33620.1; AT4G33620
KEGGiath:AT4G33620

Organism-specific databases

AraportiAT4G33620

Phylogenomic databases

eggNOGiKOG0779, Eukaryota
HOGENOMiCLU_353883_0_0_1
InParanoidiQ0WKV8
OMAiWCLEVET
OrthoDBi179156at2759

Enzyme and pathway databases

BRENDAi3.4.22.B67, 399

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q0WKV8

Gene expression databases

ExpressionAtlasiQ0WKV8, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR003653, Peptidase_C48_C
PfamiView protein in Pfam
PF02902, Peptidase_C48, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600, ULP_PROTEASE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiULP2A_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0WKV8
Secondary accession number(s): F4JJ09, O81879
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: August 10, 2010
Last modified: June 2, 2021
This is version 69 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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