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Protein

Probable L-tyrosine/L-aspartate decarboxylase

Gene

mfnA

Organism
Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.UniRule annotation

Catalytic activityi

L-tyrosine = tyramine + CO2.UniRule annotation
L-aspartate = beta-alanine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: methanofuran biosynthesis

This protein is involved in the pathway methanofuran biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway methanofuran biosynthesis and in Cofactor biosynthesis.

Pathwayi: coenzyme A biosynthesis

This protein is involved in the pathway coenzyme A biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMARV351160:G1GJJ-1471-MONOMER
UniPathwayiUPA00080
UPA00241

Names & Taxonomyi

Protein namesi
Recommended name:
Probable L-tyrosine/L-aspartate decarboxylaseUniRule annotation (EC:4.1.1.11UniRule annotation, EC:4.1.1.25UniRule annotation)
Short name:
TDC/ADCUniRule annotation
Gene namesi
Name:mfnAUniRule annotation
Ordered Locus Names:UNCMA_14340
ORF Names:RCIX1543
OrganismiMethanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)
Taxonomic identifieri351160 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanocellalesMethanocellaceaeMethanocella
Proteomesi
  • UP000000663 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002931911 – 375Probable L-tyrosine/L-aspartate decarboxylaseAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei226N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

PRIDEiQ0W498

Interactioni

Protein-protein interaction databases

STRINGi351160.RCIX1543

Structurei

3D structure databases

ProteinModelPortaliQ0W498
SMRiQ0W498
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family. MfnA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00027 Archaea
COG0076 LUCA
HOGENOMiHOG000246269
KOiK18933
OMAiDPHKMGL
OrthoDBiPOG093Z06IK

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01610 MfnA_decarbox, 1 hit
InterProiView protein in InterPro
IPR020931 MfnA
IPR002129 PyrdxlP-dep_de-COase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00282 Pyridoxal_deC, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR03812 tyr_de_CO2_Arch, 1 hit

Sequencei

Sequence statusi: Complete.

Q0W498-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRERGLGEEE IFAELCEARS RDVPYGRVLS SMCTNPHPIA VKAHQEFVNT
60 70 80 90 100
NLGDPKLFPG TADIEHRCIG LIGDLLHLPA ATGYISTGGT ESNIQALRTA
110 120 130 140 150
IQMKHTDRRR ANIVVPESAH YSFEKASQML GIAIRRAPLD DLLRADPSEM
160 170 180 190 200
AALIDKNTIA LVAVAGTTEF GQIDPIEEIG RLAQEHDLYL HVDAAFGGFV
210 220 230 240 250
IPFMDRPAKF DFEIPGVQSI TIDPHKMGLS TIPSGGLLYR SESLMKVLEI
260 270 280 290 300
NAQYLTSMVQ TSLAGTRSGA SAASAYAVLQ YLGRAGYREI VATCMENTRI
310 320 330 340 350
LREQLEDMGM EPIIEPVLNI VTARAKDPVG LRKKLAEKNW YVSTTVHPCA
360 370
LRMVVMPHVT ADVIEAFTAD LKKVI
Length:375
Mass (Da):41,138
Last modified:September 5, 2006 - v1
Checksum:iE8990460A4847961
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM114193 Genomic DNA Translation: CAJ36795.1
RefSeqiWP_012035762.1, NC_009464.1

Genome annotation databases

EnsemblBacteriaiCAJ36795; CAJ36795; RCIX1543
GeneIDi5142888
KEGGirci:RCIX1543
PATRICifig|351160.9.peg.1479

Similar proteinsi

Entry informationi

Entry nameiMFNA_METAR
AccessioniPrimary (citable) accession number: Q0W498
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: September 5, 2006
Last modified: March 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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