We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q0VZ70 (CHSAD_CHOCO)
Protein
Chondramide synthase cmdD
Gene
cmdD
Organism
Chondromyces crocatus
Status
Functioni
Involved in the synthesis of chondramides. Activates R-beta-tyrosine and probably phenylalanine.
2 PublicationsMiscellaneous
Chondramides are secondary metabolites with antifungal and cytotoxic activity. They are non-ribosomally produced depsipeptides consisting of a polyketide chain and 3 amino acids (alanine, N-methyltryptophan and beta-tyrosine or alpha-methoxy-beta-tyrosine).
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 2 phosphopantetheines covalently.By similarity
Kineticsi
- KM=1.2 mM for R-beta-tyrosine1 Publication
GO - Molecular functioni
- ligase activity Source: UniProtKB-KW
- methyltransferase activity Source: InterPro
- phosphopantetheine binding Source: InterPro
- transferase activity, transferring phosphorus-containing groups Source: InterPro
GO - Biological processi
- amino acid adenylylation by nonribosomal peptide synthase Source: UniProtKB
- phosphorylation Source: InterPro
- toxin biosynthetic process Source: UniProtKB
Keywordsi
Molecular function | Ligase, Multifunctional enzyme |
Names & Taxonomyi
Protein namesi | Recommended name: Chondramide synthase cmdD1 PublicationIncluding the following 2 domains: ATP-dependent phenylalanine adenylase Short name: PheA Alternative name(s): Phenylalanine activase ATP-dependent tyrosine adenylase Short name: TrpA Alternative name(s): Tyrosine activase |
Gene namesi | Name:cmdDImported |
Organismi | Chondromyces crocatus |
Taxonomic identifieri | 52 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Deltaproteobacteria › Myxococcales › Sorangiineae › Polyangiaceae › Chondromyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000407279 | 1 – 3912 | Chondramide synthase cmdDAdd BLAST | 3912 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1446 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotationBy similarity | 1 | |
Modified residuei | 3024 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotationBy similarity | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PRIDEi | Q0VZ70 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1411 – 1485 | Carrier 1PROSITE-ProRule annotationAdd BLAST | 75 | |
Domaini | 2989 – 3064 | Carrier 2PROSITE-ProRule annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1995 – 2030 | DisorderedSequence analysisAdd BLAST | 36 |
Domaini
Two module-bearing peptide synthase. Each module incorporates one amino acid into the peptide product and can be further subdivided into domains responsible for substrate adenylation, condensation and epimerization (Probable).Curated2 Publications
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Sequence analysis
Keywords - Domaini
RepeatFamily and domain databases
Gene3Di | 1.10.1200.10, 2 hits 3.30.300.30, 3 hits 3.30.559.10, 3 hits 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR029058, AB_hydrolase IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR000253, FHA_dom IPR013216, Methyltransf_11 IPR010060, NRPS_synth IPR008279, PEP-util_enz_mobile_dom IPR036637, Phosphohistidine_dom_sf IPR020806, PKS_PP-bd IPR020802, PKS_thioesterase IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site IPR029063, SAM-dependent_MTases IPR001031, Thioesterase |
Pfami | View protein in Pfam PF00501, AMP-binding, 2 hits PF13193, AMP-binding_C, 1 hit PF00668, Condensation, 3 hits PF08241, Methyltransf_11, 1 hit PF00391, PEP-utilizers, 1 hit PF00550, PP-binding, 2 hits PF00975, Thioesterase, 1 hit |
SMARTi | View protein in SMART SM00823, PKS_PP, 2 hits SM00824, PKS_TE, 1 hit |
SUPFAMi | SSF47336, SSF47336, 2 hits SSF52009, SSF52009, 1 hit SSF53335, SSF53335, 1 hit SSF53474, SSF53474, 1 hit |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 2 hits TIGR01720, NRPS-para261, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 2 hits PS50075, CARRIER, 2 hits PS00012, PHOSPHOPANTETHEINE, 2 hits |
i Sequence
Sequence statusi: Complete.
Q0VZ70-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLREGQGTVA HAPPRPLPHA DVLPVSQAQR RLWFLCQLDG ASVAYNMPFV
60 70 80 90 100
TALDGHLDAR ALQRALDEII RRHESLRTTF RLQAEGPVQV IHPPAPLDLP
110 120 130 140 150
LHDLRSLDEP ARAAEIQRRI DRAAHQPFDI ERGPLLRAQL LRQSETRHVL
160 170 180 190 200
CLVIHHIVAD GWSIGVFVRE FEALYGAFSA SRPSPLTEPP LQYADFSRWQ
210 220 230 240 250
EERFPPSAVE RHLTYWKQKL SDVQPLQLPA DHPRPAVESF RGDHTIFRLD
260 270 280 290 300
RGLTRGLHEL AQCEGVTLFI TLLSAFNVLL GRYSGQDDLA IASGTANRKH
310 320 330 340 350
AELEGLIGFF VNTVVIRTDL SGNPTFRTVL SRVLASVMEA TEHEDLPFER
360 370 380 390 400
VVEELKPERT ASHNPLAQVA LTLQSFASNR LTLPGLTTSP CDFRFRTSKL
410 420 430 440 450
DLMLLVTEVD GELEVVVEYN TDLFEDATIA RMSAHLRTVM AAMVADPGAR
460 470 480 490 500
IGDISLLTTE ERHRLLVDWN DTALACPEAE GVHHAFEQNA ARQPDAIAVV
510 520 530 540 550
FDGDPISRIT YGALNERANQ LAHHLIQQGV GPDVVVGIHV ERSITMIVAL
560 570 580 590 600
LAVLKAGGAY LPLDPTYPQQ RLAFILADAG AQVILTQEKW FDDLPPHTAR
610 620 630 640 650
VLDLDAIAPQ LDANATSNPP LRATADHLAY IIYTSGSTGN PKGVLIPRRD
660 670 680 690 700
TWSVARALAE TYALTPESRV LQFASLNFDG SVVEITMTLF SGAALHVAPQ
710 720 730 740 750
EKLLPGAPLN AFLQRHAITH VQLAPSLLAR LPPEGLEHVR TIMVAGEASS
760 770 780 790 800
VGTVRGWLPG RRILNGYGPT ETTVGAAMIA FTEADDAYLA KLDALPIGRP
810 820 830 840 850
FYNKRVYLLD ARLQPVPVGV PGEIYVASPG LARGYINRPA ATAEKFLPNP
860 870 880 890 900
FSETPGERIY RTGDLARYLP DGNLVFLGRV DNQVKLRGLR IELEEIESAL
910 920 930 940 950
KSHPHVGDAA VIVHEAPADQ ATSERDGKRL VAYVVPRRGW EPEGAQSDHI
960 970 980 990 1000
ASWQTLHEQL LDESQAPEDW SFNITGWKSS YTGEALPAAE MRLWVESTVE
1010 1020 1030 1040 1050
RILAHGPKDV LEIGTGTGLL LARIAPRVRA YLATDFSLEA IRYLETCKAR
1060 1070 1080 1090 1100
APELSNVTLL QRMADDFTGF SAGQFDTIVL NSVVQYFPTL DYLSAVIEGA
1110 1120 1130 1140 1150
LRVLKPGGTL FLGDIRNLAL LDAFHASVQT AKASGTLSRD ELRYRVQQGV
1160 1170 1180 1190 1200
MNENELVIDP RFFTALSRKF PQITHVEVTP KRGLHRNELT LFRYDVALQV
1210 1220 1230 1240 1250
GGTPKGAPTI TWFDWREEGL TSDSLPPWLS DTLATSPDAG VGLRRVPNAR
1260 1270 1280 1290 1300
LQPDLAILSW LATRAEASLD AWRARQHDVP EGCAPEALWA LETTWPGRVH
1310 1320 1330 1340 1350
LSWAAGHPDG SFDLVVTPPQ AERRAPWSPA VDLTDEQLSA YVNHPLQAKV
1360 1370 1380 1390 1400
VRETLGQELR RYLQDKLPAY MVPTVLIPLP ALPLTSNGKL DRRALPAPDI
1410 1420 1430 1440 1450
ERRSRASTYV APRNAREETL VAIWSKVLGV DPIGVEDNFF ELGGDSILSI
1460 1470 1480 1490 1500
QIVGQAKQAG FSLTSRQMFE HQTIAALAEV ASASKSIQAE QGLVEGSIPL
1510 1520 1530 1540 1550
TPIQRWFFET HQETPDHFNQ AILLKVSADV SASRLEQAFH HLFTHHDALR
1560 1570 1580 1590 1600
MRFSRTADGF EQVNLGPIEG VTVDVIDLAH LPAAEQTRAL TEAATSLQQR
1610 1620 1630 1640 1650
LSITSGPLSR IALIHLGAEQ PARLLWILHH LVVDGVSWRI LLDDLVTVLR
1660 1670 1680 1690 1700
QLEAGQPARF PPKTTSFKEW SERLHATAQQ EQANTASSRA ERDAWRSVPV
1710 1720 1730 1740 1750
PALPLDHPQG TNRKASAAQV QVALSVADTH ALLHDAPRAY GTQVNDLLLT
1760 1770 1780 1790 1800
ALALAFNAWT GDATLALDLE GHGREEDLVG ADLSRTVGWF TTMHPVALRL
1810 1820 1830 1840 1850
PGRELSLALR AVKEQLRAQP GRGIAYGLFR YASGEGSLAS WPAPQVNFNY
1860 1870 1880 1890 1900
LGQLDAMTDT APLLGFAPEE IGPSDGPTGD RTHLFQVNGM VKDGSLQFTW
1910 1920 1930 1940 1950
TYSRELHRPE TVQKLAHDFA ETARRLTQHC LAHESHPTPG DFPAVTLSQN
1960 1970 1980 1990 2000
QLDVVLDALG ADRDNVAAIY PLTSLQEGLL FHSLSAVPAP VPALADEDDE
2010 2020 2030 2040 2050
EDDELDEEFD AEVDEEDEDE EEEEDDDGEN VYVTQLVFRI QGPLDAEKFR
2060 2070 2080 2090 2100
TAWQETVQRH PLLRSRFVWE GCERPLQVVL RSADLRWEED ELEEDSWSSP
2110 2120 2130 2140 2150
LRVHARREQQ AGMLLDEAPL FRLNLLRAED TEHHLIWTSH HILLDGWSGP
2160 2170 2180 2190 2200
LILKDVFASY DAQLLGESRT AADPPPYEAY VAWLKRQDGT ASERFWRENL
2210 2220 2230 2240 2250
RGFSAPTPLV VDNEEPTGKQ KHLHHRCKLS AETSQALKAL AESFRVTLST
2260 2270 2280 2290 2300
VYQAAWALLL HRYSGMSDVL FGVTVSGREA DVPGIEEMVG LFIRTVPLRL
2310 2320 2330 2340 2350
HVDESQTLGA WLKEVQARQI EQREHQYVSL VDIQRWSDVP GGTQLFDSMF
2360 2370 2380 2390 2400
VFENYPLDSA LLEQSGLRLT VSTMASPTHY PLVIAVVPGR TVETLFDHDT
2410 2420 2430 2440 2450
SRLSKHTVER LAAHWVELLT GMARRPDARI HTLPHLTSAE REKLLVTWNA
2460 2470 2480 2490 2500
RPYVDEQRKY RGEEEPFGEE LAAESTFLDL FQHHVAQTPD ALALVGPSLQ
2510 2520 2530 2540 2550
STDERPVSRT YRALSARVHL LARHLRGLGV GPEVTVGVCL DRSIELVIGM
2560 2570 2580 2590 2600
LAIFEAGGVY LPLDPSQPLE RLAYLVSDAR PEVVLTQQRW NDRLPEQATR
2610 2620 2630 2640 2650
RVALDTAWAE IEAQPEVSHQ HRTAGDNLAY VLYTSGSTGT PKGVQVTVDN
2660 2670 2680 2690 2700
LSRLTPALIT AFDVTPRSRV LQYSSLSFDG SISEVAMALG AGAALHLAPA
2710 2720 2730 2740 2750
HELVPGPPLQ KLLATRAITH VTLLPAALRW LSPRGLPALD VLIVTGEACP
2760 2770 2780 2790 2800
ASLVRTWASG RRFVNAYGPT EITVAATAME CPVTMFQETE QPPPIGCPLQ
2810 2820 2830 2840 2850
STEIYILDAH LRPVPVGVPG DLYIGGAKLT RGYIHRPALT AERYIPHPFS
2860 2870 2880 2890 2900
DRPGARLYVT GDIARYQLDG TIDFLGRRDN QVKVRGYRIE LGEVEAALND
2910 2920 2930 2940 2950
HPGVREAVVV AQKDGAGDNR LVAYWAAKST PPTTTEALRD ALSKRLAAYM
2960 2970 2980 2990 3000
IPSVFVRMDA LPLNATGKID RQGLPPVDDT MLDREQFVAP RTATEETLTA
3010 3020 3030 3040 3050
IWSSTLGVAR VGIRDDFFKL GGHSLLALNI TTQIQKRFGH VITVDSIFRA
3060 3070 3080 3090 3100
PTIAVLARVI DEALAPTGAR RALSLVVPLR ERGTKVPLFF AAGMGMHAHY
3110 3120 3130 3140 3150
LRPLAEHLGE DQPFYALQSP AQGGEITDMA TLVDTLIGAI QQIQPSGPYH
3160 3170 3180 3190 3200
LGGHSAGARI AFAVALELQR RGAEVPLVSI VDMRPPGRGA TSDESAEWTQ
3210 3220 3230 3240 3250
IGGLIGYVTM IKQAIGEGVL FVTPEELRKL DEAAAWQRTL DAFIAARWMP
3260 3270 3280 3290 3300
KDADVEQLQH LCAMNQNVVR VVRDHVPTDT HQGKLLVFSA AFAMRNGRQV
3310 3320 3330 3340 3350
STEGWQAFCA NPVTTHEVPG DHMTMLREPD VRGLAIKLRR EIDELALERT
3360 3370 3380 3390 3400
DEAPGLPTPP EFPVVWEHPE DARMLWVHDV THCREQMTPL DFCLRQQAMV
3410 3420 3430 3440 3450
EGSNLANLAY GVPFTGEIRL INTYVYQKII PTTASPTELA AAMKRAEASV
3460 3470 3480 3490 3500
AALLPDLGRW WTETLLPEIE AHLEALDPEN NYDFVHRHTL VEALAEAHRR
3510 3520 3530 3540 3550
TARLWEIHFR LLQPVMLAIS RFVDLCKDLS TDDDPIDPYA LLVGFPNKTT
3560 3570 3580 3590 3600
EGNRALWSLS RLALETPEVA SILTSNEASR VSWKLRSTRG GRAFVAQLDA
3610 3620 3630 3640 3650
YLATYGQRND STYLDAPTWE EDPTPVIRNL QAYMTQPERD LDAELNALSE
3660 3670 3680 3690 3700
QRTQRLDALR ARLRHYPRAV VDEFEQALTA AQTATVLSED HNYWIDYKIT
3710 3720 3730 3740 3750
HRLRHLCLYL GEQLKDWELL GDCEEIFYLS MDDVSRAAVE TKRGGPFSAN
3760 3770 3780 3790 3800
QRFYHLACAR KDEAKRFHGV QPPRFLGTPS PLPALHDALS LASARFTGVA
3810 3820 3830 3840 3850
PSPSNDEKEI VGLSGAKGKA RGKARVARNL ADVPTLEPGE ILVAMAMLPA
3860 3870 3880 3890 3900
WTPLFATVAA IVTDSGGMLS HAAVVAREYG IPAVVGTQVG TQRIRDGQLV
3910
EVDGERGVVT LL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM179409 Genomic DNA Translation: CAJ46692.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AM179409 Genomic DNA Translation: CAJ46692.1 |
3D structure databases
SMRi | Q0VZ70 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 52.CMC5_047510 |
Proteomic databases
PRIDEi | Q0VZ70 |
Family and domain databases
Gene3Di | 1.10.1200.10, 2 hits 3.30.300.30, 3 hits 3.30.559.10, 3 hits 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR010071, AA_adenyl_domain IPR029058, AB_hydrolase IPR036736, ACP-like_sf IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR000253, FHA_dom IPR013216, Methyltransf_11 IPR010060, NRPS_synth IPR008279, PEP-util_enz_mobile_dom IPR036637, Phosphohistidine_dom_sf IPR020806, PKS_PP-bd IPR020802, PKS_thioesterase IPR009081, PP-bd_ACP IPR006162, Ppantetheine_attach_site IPR029063, SAM-dependent_MTases IPR001031, Thioesterase |
Pfami | View protein in Pfam PF00501, AMP-binding, 2 hits PF13193, AMP-binding_C, 1 hit PF00668, Condensation, 3 hits PF08241, Methyltransf_11, 1 hit PF00391, PEP-utilizers, 1 hit PF00550, PP-binding, 2 hits PF00975, Thioesterase, 1 hit |
SMARTi | View protein in SMART SM00823, PKS_PP, 2 hits SM00824, PKS_TE, 1 hit |
SUPFAMi | SSF47336, SSF47336, 2 hits SSF52009, SSF52009, 1 hit SSF53335, SSF53335, 1 hit SSF53474, SSF53474, 1 hit |
TIGRFAMsi | TIGR01733, AA-adenyl-dom, 2 hits TIGR01720, NRPS-para261, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 2 hits PS50075, CARRIER, 2 hits PS00012, PHOSPHOPANTETHEINE, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CHSAD_CHOCO | |
Accessioni | Q0VZ70Primary (citable) accession number: Q0VZ70 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 5, 2011 |
Last sequence update: | September 5, 2006 | |
Last modified: | February 23, 2022 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |