UniProtKB - Q0VGT2 (GLI2_MOUSE)
Zinc finger protein GLI2
Gli2
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 417 – 444 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 455 – 477 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 483 – 507 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 513 – 538 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 544 – 569 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 26 |
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- promoter-specific chromatin binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- transcription factor binding Source: UniProtKB
- transcription regulatory region sequence-specific DNA binding Source: MGI
- zinc ion binding Source: MGI
GO - Biological processi
- anatomical structure development Source: MGI
- anatomical structure formation involved in morphogenesis Source: MGI
- anterior/posterior pattern specification Source: MGI
- axon guidance Source: MGI
- branching morphogenesis of an epithelial tube Source: MGI
- cell differentiation Source: MGI
- cellular response to organic cyclic compound Source: MGI
- cellular response to virus Source: MGI
- cerebellar cortex morphogenesis Source: MGI
- chondrocyte differentiation Source: MGI
- cochlea morphogenesis Source: MGI
- developmental growth Source: MGI
- dorsal/ventral neural tube patterning Source: MGI
- dorsal/ventral pattern formation Source: MGI
- embryonic digestive tract development Source: MGI
- embryonic digit morphogenesis Source: MGI
- epidermal cell differentiation Source: MGI
- floor plate formation Source: MGI
- hair follicle morphogenesis Source: MGI
- head development Source: MGI
- heart development Source: MGI
- hindbrain development Source: MGI
- hindgut morphogenesis Source: MGI
- in utero embryonic development Source: MGI
- kidney development Source: MGI
- lung development Source: MGI
- mammary gland development Source: MGI
- mammary gland duct morphogenesis Source: MGI
- morphogenesis of an epithelium Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of chondrocyte differentiation Source: MGI
- negative regulation of smoothened signaling pathway Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- neural tube development Source: MGI
- neuron development Source: MGI
- notochord regression Source: MGI
- odontogenesis of dentin-containing tooth Source: MGI
- osteoblast development Source: MGI
- osteoblast differentiation Source: MGI
- pattern specification process Source: MGI
- pituitary gland development Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of DNA replication Source: MGI
- positive regulation of neuron differentiation Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- prostatic bud formation Source: MGI
- proximal/distal pattern formation Source: MGI
- regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
- skeletal system development Source: MGI
- smoothened signaling pathway Source: MGI
- smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGI
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: MGI
- smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: MGI
- smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: MGI
- spinal cord dorsal/ventral patterning Source: MGI
- spinal cord motor neuron differentiation Source: MGI
- spinal cord ventral commissure morphogenesis Source: MGI
- tube development Source: MGI
- ventral midline development Source: MGI
- ventral spinal cord development Source: MGI
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding, Repressor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-5610787, Hedgehog 'off' state R-MMU-5632684, Hedgehog 'on' state |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein GLI2CuratedAlternative name(s): Tax helper proteinBy similarity |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95728, Gli2 |
Subcellular locationi
Cytoskeleton
- axoneme Source: CACAO
Cytosol
- cytosol Source: Reactome
Nucleus
- nuclear speck Source: MGI
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Other locations
- ciliary tip Source: MGI
- cilium Source: UniProtKB
- cytoplasm Source: MGI
- membrane Source: MGI
- motile cilium Source: MGI
Keywords - Cellular componenti
Cell projection, Cilium, Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000406215 | 1 – 1544 | Zinc finger protein GLI2Add BLAST | 1544 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 145 | PhosphoserineBy similarity | 1 | |
Modified residuei | 230 | PhosphoserineBy similarity | 1 | |
Modified residuei | 232 | PhosphoserineBy similarity | 1 | |
Modified residuei | 238 | PhosphoserineBy similarity | 1 | |
Modified residuei | 385 | Phosphoserine; by DYRK2By similarity | 1 | |
Modified residuei | 707 | PhosphoserineCombined sources | 1 | |
Modified residuei | 708 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 740 | N6-acetyllysine; by EP300By similarity | 1 | |
Modified residuei | 997 | Phosphoserine; by DYRK2By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
PaxDbi | Q0VGT2 |
PeptideAtlasi | Q0VGT2 |
PRIDEi | Q0VGT2 |
PTM databases
iPTMneti | Q0VGT2 |
PhosphoSitePlusi | Q0VGT2 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000048402, Expressed in limb bud and 330 other tissues |
Genevisiblei | Q0VGT2, MM |
Interactioni
Subunit structurei
Interacts with ZIC1 and ZIC2 (PubMed:11238441).
Interacts with STK36 (PubMed:10806483).
Interacts with SUFU; this inhibits transcriptional activation mediated by GLI2 (PubMed:10806483, PubMed:23034632).
Interacts (via C-terminal internal region) with FOXC1 (via N-terminus); this interaction is direct and increases GLI2 DNA-binding and transcriptional activity through a smoothened (SMO)-independent Hedgehog (Hh) signaling pathway (PubMed:26565916, PubMed:25808752).
By similarity5 PublicationsBinary interactionsi
Hide detailsQ0VGT2
With | #Exp. | IntAct |
---|---|---|
Spop [Q6ZWS8] | 2 | EBI-9344284,EBI-7128920 |
SUFU [Q9UMX1] from Homo sapiens. | 3 | EBI-9344284,EBI-740595 |
GO - Molecular functioni
- transcription factor binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 199943, 47 interactors |
ComplexPortali | CPX-149, GLI2-SUFU complex |
CORUMi | Q0VGT2 |
DIPi | DIP-60772N |
ELMi | Q0VGT2 |
IntActi | Q0VGT2, 2 interactors |
STRINGi | 10090.ENSMUSP00000054837 |
Miscellaneous databases
RNActi | Q0VGT2, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 789 – 854 | Ser-richAdd BLAST | 66 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 417 – 444 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 28 | |
Zinc fingeri | 455 – 477 | C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 483 – 507 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 513 – 538 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 26 | |
Zinc fingeri | 544 – 569 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 26 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159213 |
HOGENOMi | CLU_003666_2_0_1 |
InParanoidi | Q0VGT2 |
OMAi | GAQDHSM |
OrthoDBi | 56870at2759 |
TreeFami | TF350216 |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
METSAPAPAL EKKEAKSGLL EDSSFPDPGK KACPLAVAAA VAAHGVPQQL
60 70 80 90 100
LPAFHAPLPI DMRHQEGRYH YDPHSVHSVH GPPTLSGSPV ISDISLIRLS
110 120 130 140 150
PHPAGPGESP FSAHHPYVNP HMEHYLRSVH SSPTLSMISA ARGLSPADVA
160 170 180 190 200
HEHLKERGLF SLAAPGTNPS DYYHQMTLMA SHPTPYGDLL MQSGGAASAP
210 220 230 240 250
HLHDYLNPVD ASRFSSPRVT PRLSRKRALS ISPLSDASLD LQRMIRTSPN
260 270 280 290 300
SLVAYINNSR SSSAASGSYG HLSAGALSPA FTFPHPINPV AYQQILSQQR
310 320 330 340 350
GLGSAFGHTP PLIQPSPTFL AQQPMTLTSI STMPTQLSSS SSNCLNDANQ
360 370 380 390 400
NKQNSESAVS STVNPITIHK RSKVKTEAEG LRPASPLGLT QEQLADLKED
410 420 430 440 450
LDRDDCKQEA EVVIYETNCH WADCTKEYDT QEQLVHHINN EHIHGEKKEF
460 470 480 490 500
VCRWQACTRE QKPFKAQYML VVHMRRHTGE KPHKCTFEGC SKAYSRLENL
510 520 530 540 550
KTHLRSHTGE KPYVCEHEGC NKAFSNASDR AKHQNRTHSN EKPYICKIPG
560 570 580 590 600
CTKRYTDPSS LRKHVKTVHG PDAHVTKKQR NDVHVRAPLL KENGDNEASA
610 620 630 640 650
EPGGRGPEES VEASSTSHTV EDCLHIKAIK TESSGLCQSS PGAQSSCSSE
660 670 680 690 700
PSPLGSAPNN DSGMEMPGTG PGSLGDLTAL ADTCPGADTS ALAAPSTGGL
710 720 730 740 750
QLRKHMSTVH RFEQLKREKL KSLKDSCSWA GPAPHTRNTK LPPLPVNGSV
760 770 780 790 800
LENFNNTGGG GPAGLLPSQR LPELTEVTML SQLQERRDSS TSTMSSAYTV
810 820 830 840 850
SRRSSGISPY FSSRRSSEAS PLGGLRPHNA SSADSYDPIS TDASRRSSEA
860 870 880 890 900
SQCSGGGPGL LNLTPAQQYN LRAKYAAATG GPPPTPLPGL DRVSLRTRLA
910 920 930 940 950
LLDAPERALP GACPHPLGPR RGSDGPTYSH GHGHGYAGAA PAFPHEGPNS
960 970 980 990 1000
STRRASDPVR RPDPLILPRV QRFHSTHNMN PGSLPPCADR RGLHVQSHPS
1010 1020 1030 1040 1050
VDSNLTRNAY SPRPPSINEN VVMEAVAAGV DGPGLECDLG LVEDELVLPD
1060 1070 1080 1090 1100
DVVQYIKAHT GGTLDDGIRQ GYPTEGTGFP ENSKLPSPGL QGHRRLAAAD
1110 1120 1130 1140 1150
SNMGPSAPGL GGCQLSYSPS SNLNKSNMPV QWNEVSSGTV DALPTQVKPP
1160 1170 1180 1190 1200
PFPHSNLAVV QQKPAFGQYP GYNPQSVQSS SGGLDSTQPH LQLRGAPSAS
1210 1220 1230 1240 1250
RGSYTQQPRQ PAAGSQCLGM SAAMSPQASY SQAHPQLSPN IVSGSLNQFS
1260 1270 1280 1290 1300
PSCSNMAAKP SHLGLPQQME VVPNATIMNG HQREHGVPNS SLAAVSQPHP
1310 1320 1330 1340 1350
VLSYPQQDSY QQGSNLLSSH QPGFMESQQN AGFGLMQPRP PLEPNTASRH
1360 1370 1380 1390 1400
RGVRSGQQQL YARTTGQAMV TSANQETAEA MPKGPAGTMV SLAPQPSQDT
1410 1420 1430 1440 1450
GRAQDQNTLY YYGQIHMYEQ NGGCPAVQPQ PPQPQACSDS IQPEPLPSPG
1460 1470 1480 1490 1500
VNQVSSTVDS QLLEPPQIDF DAIMDDGDHS SLFSGALSPT LLHNLSQNSS
1510 1520 1530 1540
RLTTPRNSLT LPSIPAGISN MAVGDMSSML TSLAEESKFL NMMT
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA5AA27 | A5AA27_MOUSE | GLI-Kruppel family member | Gli2 | 447 | Annotation score: | ||
F6UUE3 | F6UUE3_MOUSE | Zinc finger protein GLI2 | Gli2 | 270 | Annotation score: | ||
A0A1B0GXK7 | A0A1B0GXK7_MOUSE | Zinc finger protein GLI2 | Gli2 | 244 | Annotation score: | ||
A5AA25 | A5AA25_MOUSE | GLI-Kruppel family member | Gli2 | 92 | Annotation score: | ||
A5A9W5 | A5A9W5_MOUSE | GLI-Kruppel family member | Gli2 | 85 | Annotation score: | ||
A5AA26 | A5AA26_MOUSE | GLI-Kruppel family member | Gli2 | 49 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 71 | Y → S in AAH85190 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC109271 Genomic DNA No translation available. AC122287 Genomic DNA No translation available. AC132589 Genomic DNA No translation available. BC085190 mRNA Translation: AAH85190.1 |
CCDSi | CCDS35692.1 |
RefSeqi | NP_001074594.1, NM_001081125.1 |
Genome annotation databases
Ensembli | ENSMUST00000062483; ENSMUSP00000054837; ENSMUSG00000048402 |
GeneIDi | 14633 |
KEGGi | mmu:14633 |
UCSCi | uc007cim.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC109271 Genomic DNA No translation available. AC122287 Genomic DNA No translation available. AC132589 Genomic DNA No translation available. BC085190 mRNA Translation: AAH85190.1 |
CCDSi | CCDS35692.1 |
RefSeqi | NP_001074594.1, NM_001081125.1 |
3D structure databases
SMRi | Q0VGT2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199943, 47 interactors |
ComplexPortali | CPX-149, GLI2-SUFU complex |
CORUMi | Q0VGT2 |
DIPi | DIP-60772N |
ELMi | Q0VGT2 |
IntActi | Q0VGT2, 2 interactors |
STRINGi | 10090.ENSMUSP00000054837 |
PTM databases
iPTMneti | Q0VGT2 |
PhosphoSitePlusi | Q0VGT2 |
Proteomic databases
PaxDbi | Q0VGT2 |
PeptideAtlasi | Q0VGT2 |
PRIDEi | Q0VGT2 |
Protocols and materials databases
Antibodypediai | 3768, 331 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000062483; ENSMUSP00000054837; ENSMUSG00000048402 |
GeneIDi | 14633 |
KEGGi | mmu:14633 |
UCSCi | uc007cim.1, mouse |
Organism-specific databases
CTDi | 2736 |
MGIi | MGI:95728, Gli2 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159213 |
HOGENOMi | CLU_003666_2_0_1 |
InParanoidi | Q0VGT2 |
OMAi | GAQDHSM |
OrthoDBi | 56870at2759 |
TreeFami | TF350216 |
Enzyme and pathway databases
Reactomei | R-MMU-5610787, Hedgehog 'off' state R-MMU-5632684, Hedgehog 'on' state |
Miscellaneous databases
BioGRID-ORCSi | 14633, 2 hits in 17 CRISPR screens |
ChiTaRSi | Gli2, mouse |
PROi | PR:Q0VGT2 |
RNActi | Q0VGT2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000048402, Expressed in limb bud and 330 other tissues |
Genevisiblei | Q0VGT2, MM |
Family and domain databases
InterProi | View protein in InterPro IPR043359, GLI-like IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
PANTHERi | PTHR45718, PTHR45718, 1 hit |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLI2_MOUSE | |
Accessioni | Q0VGT2Primary (citable) accession number: Q0VGT2 Secondary accession number(s): E9PYJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 5, 2011 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 133 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families