Zinc finger protein GLI2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 16396903
• DNA binding Source: MGIInferred from direct assayⁱ
  • 15614767
  • 16880529
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • 16880529
• promoter-specific chromatin binding Source: UniProtKBInferred from direct assayⁱ
  • 25808752
• proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • 16880529
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • 16880529
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 16611981
• transcription factor binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 25808752
• transcription regulatory region DNA binding Source: MGIInferred from direct assayⁱ
  • 19124651
• zinc ion binding Source: MGI

GO - Biological processⁱ

• anatomical structure development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 11485934
• anatomical structure formation involved in morphogenesis Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 9731531
• anterior/posterior pattern specification Source: MGIInferred from genetic interactionⁱ
  • 22841643
• axon guidance Source: MGIInferred from mutant phenotypeⁱ
  • 10409510
• branching morphogenesis of an epithelial tube Source: MGIInferred from mutant phenotypeⁱ
  • 9731531
• cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 9636069
  • 9655799
• cell proliferation Source: MGIInferred from genetic interactionⁱ
  • 19056373
• cellular response to organic cyclic compound Source: MGIInferred from direct assayⁱ
  • 19103752
• cellular response to virus Source: MGI
• cerebellar cortex morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 16571625
• chondrocyte differentiation Source: MGIInferred from genetic interactionⁱ
  • 23333501
• cochlea morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 17395647
• developmental growth Source: MGIInferred from mutant phenotypeⁱ
  • 16571630
• dorsal/ventral neural tube patterning Source: MGIInferred from direct assayⁱ
  • 9247260
• dorsal/ventral pattern formation Source: MGIInferred from genetic interactionⁱ
  • 16342201
• embryonic digestive tract development Source: MGIInferred from mutant phenotypeⁱ
  • 10693670
• embryonic digit morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 19056373
• epidermal cell differentiation Source: MGI
• floor plate formation Source: MGIInferred from mutant phenotypeⁱ
  • 9636069
  • 9655799
• head development Source: MGIInferred from mutant phenotypeⁱ
  • 19056373
• heart development Source: MGIInferred from genetic interactionⁱ
  • 11172440
• hindbrain development Source: MGIInferred from mutant phenotypeⁱ
  • 15496441
  • 8575294
• hindgut morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 11485934
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • 19056373
• kidney development Source: MGIInferred from genetic interactionⁱ
  • 11172440
• lung development Source: MGIInferred from mutant phenotypeⁱ
  • 9731531
• mammary gland development Source: MGIInferred from mutant phenotypeⁱ
  • 11783999
• mammary gland duct morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 11783999
• morphogenesis of an epithelium Source: MGIInferred from mutant phenotypeⁱ
  • 16707121
• negative regulation of apoptotic process Source: MGIInferred from direct assayⁱ
  • 19056373
• negative regulation of chondrocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 17328886
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from genetic interactionⁱ
  • 16611981
• neural tube development Source: MGIInferred from mutant phenotypeⁱ
  • 19056373
• neuron development Source: MGIInferred from mutant phenotypeⁱ
  • 16267219
• notochord regression Source: MGIInferred from genetic interactionⁱ
  • 10725236
• odontogenesis of dentin-containing tooth Source: MGIInferred from mutant phenotypeⁱ
  • 9655803
• osteoblast development Source: MGIInferred from direct assayⁱ
  • 16880529
• osteoblast differentiation Source: MGIInferred from genetic interactionⁱ
  • 22771375
• pattern specification process Source: MGIInferred from mutant phenotypeⁱ
  • 8575294
• pituitary gland development Source: MGIInferred from genetic interactionⁱ
  • 10725236
• positive regulation of cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 15496441
  • 9731531
• positive regulation of DNA replication Source: MGI
• positive regulation of neuron differentiation Source: MGIInferred from genetic interactionⁱ
  • 16950124
• positive regulation of transcription, DNA-templated Source: CACAOInferred from direct assayⁱ
  • 16254602
• positive regulation of transcription by RNA polymerase II Source: NTNU_SBInferred from direct assayⁱ
  • 16880529
• prostatic bud formation Source: MGIInferred from mutant phenotypeⁱ
  • 16707121
• proximal/distal pattern formation Source: MGIInferred from genetic interactionⁱ
  • 16342201
• regulation of smoothened signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • 19056373
• skeletal system development Source: MGIInferred from mutant phenotypeⁱ
  • 9006072
• smoothened signaling pathway Source: MGIInferred from mutant phenotypeⁱ
  • 19124651
• smoothened signaling pathway involved in dorsal/ventral neural tube patterning Source: MGIInferred from genetic interactionⁱ
  • 17395647
  • 20159594
• smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 16571625
• smoothened signaling pathway involved in spinal cord motor neuron cell fate specification Source: MGIInferred from genetic interactionⁱ
  • 15215207
• smoothened signaling pathway involved in ventral spinal cord interneuron specification Source: MGIInferred from genetic interactionⁱ
  • 15215207
• spinal cord dorsal/ventral patterning Source: MGIInferred from mutant phenotypeⁱ
  • 11748151
  • 16364285
• spinal cord motor neuron differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 21552265
• spinal cord ventral commissure morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 10409510
• tube development Source: MGIInferred from genetic interactionⁱ
  • 9731531
• ventral midline development Source: MGIInferred from mutant phenotypeⁱ
  • 10725236
• ventral spinal cord development Source: MGIInferred from mutant phenotypeⁱ
  • 11748151

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• transcription factor binding Source: UniProtKBInferred from physical interactionⁱ
  • 25808752

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
METSAPAPAL EKKEAKSGLL EDSSFPDPGK KACPLAVAAA VAAHGVPQQL 
        60         70         80         90        100
LPAFHAPLPI DMRHQEGRYH YDPHSVHSVH GPPTLSGSPV ISDISLIRLS 
       110        120        130        140        150
PHPAGPGESP FSAHHPYVNP HMEHYLRSVH SSPTLSMISA ARGLSPADVA 
       160        170        180        190        200
HEHLKERGLF SLAAPGTNPS DYYHQMTLMA SHPTPYGDLL MQSGGAASAP 
       210        220        230        240        250
HLHDYLNPVD ASRFSSPRVT PRLSRKRALS ISPLSDASLD LQRMIRTSPN 
       260        270        280        290        300
SLVAYINNSR SSSAASGSYG HLSAGALSPA FTFPHPINPV AYQQILSQQR 
       310        320        330        340        350
GLGSAFGHTP PLIQPSPTFL AQQPMTLTSI STMPTQLSSS SSNCLNDANQ 
       360        370        380        390        400
NKQNSESAVS STVNPITIHK RSKVKTEAEG LRPASPLGLT QEQLADLKED 
       410        420        430        440        450
LDRDDCKQEA EVVIYETNCH WADCTKEYDT QEQLVHHINN EHIHGEKKEF 
       460        470        480        490        500
VCRWQACTRE QKPFKAQYML VVHMRRHTGE KPHKCTFEGC SKAYSRLENL 
       510        520        530        540        550
KTHLRSHTGE KPYVCEHEGC NKAFSNASDR AKHQNRTHSN EKPYICKIPG 
       560        570        580        590        600
CTKRYTDPSS LRKHVKTVHG PDAHVTKKQR NDVHVRAPLL KENGDNEASA 
       610        620        630        640        650
EPGGRGPEES VEASSTSHTV EDCLHIKAIK TESSGLCQSS PGAQSSCSSE 
       660        670        680        690        700
PSPLGSAPNN DSGMEMPGTG PGSLGDLTAL ADTCPGADTS ALAAPSTGGL 
       710        720        730        740        750
QLRKHMSTVH RFEQLKREKL KSLKDSCSWA GPAPHTRNTK LPPLPVNGSV 
       760        770        780        790        800
LENFNNTGGG GPAGLLPSQR LPELTEVTML SQLQERRDSS TSTMSSAYTV 
       810        820        830        840        850
SRRSSGISPY FSSRRSSEAS PLGGLRPHNA SSADSYDPIS TDASRRSSEA 
       860        870        880        890        900
SQCSGGGPGL LNLTPAQQYN LRAKYAAATG GPPPTPLPGL DRVSLRTRLA 
       910        920        930        940        950
LLDAPERALP GACPHPLGPR RGSDGPTYSH GHGHGYAGAA PAFPHEGPNS 
       960        970        980        990       1000
STRRASDPVR RPDPLILPRV QRFHSTHNMN PGSLPPCADR RGLHVQSHPS 
      1010       1020       1030       1040       1050
VDSNLTRNAY SPRPPSINEN VVMEAVAAGV DGPGLECDLG LVEDELVLPD 
      1060       1070       1080       1090       1100
DVVQYIKAHT GGTLDDGIRQ GYPTEGTGFP ENSKLPSPGL QGHRRLAAAD 
      1110       1120       1130       1140       1150
SNMGPSAPGL GGCQLSYSPS SNLNKSNMPV QWNEVSSGTV DALPTQVKPP 
      1160       1170       1180       1190       1200
PFPHSNLAVV QQKPAFGQYP GYNPQSVQSS SGGLDSTQPH LQLRGAPSAS 
      1210       1220       1230       1240       1250
RGSYTQQPRQ PAAGSQCLGM SAAMSPQASY SQAHPQLSPN IVSGSLNQFS 
      1260       1270       1280       1290       1300
PSCSNMAAKP SHLGLPQQME VVPNATIMNG HQREHGVPNS SLAAVSQPHP 
      1310       1320       1330       1340       1350
VLSYPQQDSY QQGSNLLSSH QPGFMESQQN AGFGLMQPRP PLEPNTASRH 
      1360       1370       1380       1390       1400
RGVRSGQQQL YARTTGQAMV TSANQETAEA MPKGPAGTMV SLAPQPSQDT 
      1410       1420       1430       1440       1450
GRAQDQNTLY YYGQIHMYEQ NGGCPAVQPQ PPQPQACSDS IQPEPLPSPG 
      1460       1470       1480       1490       1500
VNQVSSTVDS QLLEPPQIDF DAIMDDGDHS SLFSGALSPT LLHNLSQNSS 
      1510       1520       1530       1540 
RLTTPRNSLT LPSIPAGISN MAVGDMSSML TSLAEESKFL NMMT       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot