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Entry version 72 (16 Oct 2019)
Sequence version 1 (05 Sep 2006)
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Protein
Submitted name:

Myt1l protein

Gene

Myt1l

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myt1l proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myt1lImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1100511 Myt1l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q0VGN2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q0VGN2 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini620 – 871MYT1InterPro annotationAdd BLAST252

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 22DisorderedSequence analysisAdd BLAST22
Regioni56 – 178DisorderedSequence analysisAdd BLAST123
Regioni221 – 248DisorderedSequence analysisAdd BLAST28
Regioni343 – 422DisorderedSequence analysisAdd BLAST80
Regioni450 – 509DisorderedSequence analysisAdd BLAST60
Regioni684 – 708DisorderedSequence analysisAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1057 – 1126Sequence analysisAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 17PolyampholyteSequence analysisAdd BLAST17
Compositional biasi90 – 172AcidicSequence analysisAdd BLAST83
Compositional biasi343 – 359PolarSequence analysisAdd BLAST17
Compositional biasi400 – 422PolyampholyteSequence analysisAdd BLAST23
Compositional biasi450 – 506PolyampholyteSequence analysisAdd BLAST57

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3803 Eukaryota
ENOG410ZPWS LUCA

KEGG Orthology (KO)

More...
KOi
K23193

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2H2C
IPR036060 Znf_C2H2C_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08474 MYT1, 1 hit
PF01530 zf-C2HC, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103637 SSF103637, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51802 ZF_CCHHC, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q0VGN2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVDSEEKRH RTRSKGVRVP VEPAIQELFS CPTPGCDGSG HVSGKYARHR
60 70 80 90 100
SVYGCPLAKK RKTQDKQPQE PAPKRKPFAV KADSSSVDEC YESDGTEDMD
110 120 130 140 150
DKEEDDDEEF SEDNDEQGDD DDEDEVDRED EEEIEEEDDE EDDDDEDGDD
160 170 180 190 200
VEEEEEDDDE EEEEEEEEEE NEDHQMSCTR IMQDTDKDDN NNDEYDNYDE
210 220 230 240 250
LVAKSLLNLG KIAEDAAYRA RTESEMNSNT SNSLEDDSDK NENLGRKSEL
260 270 280 290 300
SLDLDSDVVR ETVDSLKLLA QGHGVVLSEN ISDRSYAEGM SQQDSRNMNY
310 320 330 340 350
VMLGKPMNNG LMEKMVEESD EEVCLSSLEC LRNQCFDLAR KLSETNPQDR
360 370 380 390 400
SQPPNMSVRQ HVRQEDDFPG RTPDRSYSDM MNLMRLEEQL SPRSRTFSSC
410 420 430 440 450
AKEDGCHERD DDTTSVNSDR SEEVFDMTKG NLTLLEKAIA LETERAKAMR
460 470 480 490 500
EKMAMDAGRR DNLRSYEDQS PRQLAGEDRK SKSSDSHVKK PYYDPSRTEK
510 520 530 540 550
RESKCPTPGC DGTGHVTGLY PHHRSLSGCP HKDRVPPEIL AMHENVLKCP
560 570 580 590 600
TPGCTGRGHV NSNRNSHRSL SGCPIAAAEK LAKAQEKHQS CDVSKSNQAS
610 620 630 640 650
DRVLRPMCFV KQLEIPQYGY RNNVPTTTPR SNLAKELEKY SKTSFEYNSY
660 670 680 690 700
DNHTYGKRAI APKVQTRDIS PKGYDDAKRY CKNASPSSST TSSYAPSSSS
710 720 730 740 750
NLSCGGGSSA SSTCSKSSFD YTHDMEAAHM AAIAILNLST RCREMPQNLS
760 770 780 790 800
TKPQDLCTAR NPDMEVDENG TLDLSMNKQR PRDSCCPVLT PLEPMSPQQQ
810 820 830 840 850
AVMSSRCFQL SEGDCWDLPV DYTKMKPRRV DEDEPKEITP EDLDPFQEAL
860 870 880 890 900
EERRYPGEVT IPSPKPKYPQ CKESKKDLIT LSGCPLADKS IRSMLATSSQ
910 920 930 940 950
ELKCPTPGCD GSGHITGNYA SHRSLSGCPR AKKSGIRIAQ SKEDKEDQEP
960 970 980 990 1000
IRCPVPGCDG QGHITGKYAS HRSASGCPLA AKRQKDGYLN GSQFSWKSVK
1010 1020 1030 1040 1050
TEGMSCPTPG CDGSGHVSGS FLTHRSLSGC PRATSAMKKA KLSGEQMLTI
1060 1070 1080 1090 1100
KQRASNGIEN DEEIKQLDEE IKELNESNSQ MEADMIKLRT QITTMESNLK
1110 1120 1130 1140 1150
TIEEENKVIE QQNESLLHEL ANLSQSLIHS LANIQLPHMD PINEQNFDAY
1160 1170 1180
VTTLTEMYTN QDRYQSPENK ALLENIKQAV RGIQV
Length:1,185
Mass (Da):132,772
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C75AE6A2DC57854
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC094438 mRNA Translation: AAH94438.1

NCBI Reference Sequences

More...
RefSeqi
NP_001087244.1, NM_001093775.1
NP_001087245.1, NM_001093776.1
NP_001087247.1, NM_001093778.1
NP_032692.2, NM_008666.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
17933

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:17933

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094438 mRNA Translation: AAH94438.1
RefSeqiNP_001087244.1, NM_001093775.1
NP_001087245.1, NM_001093776.1
NP_001087247.1, NM_001093778.1
NP_032692.2, NM_008666.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ0VGN2

Genome annotation databases

GeneIDi17933
KEGGimmu:17933

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23040
MGIiMGI:1100511 Myt1l

Phylogenomic databases

eggNOGiKOG3803 Eukaryota
ENOG410ZPWS LUCA
KOiK23193

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Myt1l mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ0VGN2 MM

Family and domain databases

InterProiView protein in InterPro
IPR013681 Myelin_TF
IPR002515 Znf_C2H2C
IPR036060 Znf_C2H2C_sf
PfamiView protein in Pfam
PF08474 MYT1, 1 hit
PF01530 zf-C2HC, 6 hits
SUPFAMiSSF103637 SSF103637, 6 hits
PROSITEiView protein in PROSITE
PS51802 ZF_CCHHC, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ0VGN2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VGN2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: October 16, 2019
This is version 72 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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