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Entry version 120 (02 Jun 2021)
Sequence version 2 (05 May 2009)
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Protein

Regulator of telomere elongation helicase 1

Gene

Rtel1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.

UniRule annotation4 Publications

Miscellaneous

Able to elongate M.spretus telomeres in crosses between M.musculus and M.spretus.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi145Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi163Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi172Iron-sulfur (4Fe-4S)UniRule annotation1
Metal bindingi207Iron-sulfur (4Fe-4S)UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi42 – 49ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase
Biological processDNA damage, DNA repair
Ligand4Fe-4S, ATP-binding, Iron, Iron-sulfur, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-171319, Telomere Extension By Telomerase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Regulator of telomere elongation helicase 1UniRule annotation (EC:3.6.4.12UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rtel1
Synonyms:Kiaa1088, Rtel
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2139369, Rtel1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Death between days 10 and 11.5 of gestation with defects in the nervous system, heart, vasculature and extraembryonic tissues. Effects are due to severe genome instability and stochastic telomere loss in embryonic stem cells which display many chromosome breaks and fusions upon differentiation in vitro.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi48K → R: Abolishes G4-DNA unwinding activity. 1 Publication1
Mutagenesisi1160Q → A: Abolishes interaction with PCNA. 1 Publication1
Mutagenesisi1163I → A: Abolishes interaction with PCNA. 1 Publication1
Mutagenesisi1166F → A: Abolishes interaction with PCNA. 1 Publication1
Mutagenesisi1167F → A: Abolishes interaction with PCNA. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003706101 – 1203Regulator of telomere elongation helicase 1Add BLAST1203

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q0VGM9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q0VGM9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0VGM9

PRoteomics IDEntifications database

More...
PRIDEi
Q0VGM9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
260945 [Q0VGM9-1]
260946 [Q0VGM9-2]
260947 [Q0VGM9-3]
260948 [Q0VGM9-4]
260949 [Q0VGM9-5]
260950 [Q0VGM9-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0VGM9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0VGM9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in spleen, thymus, Peyer patches, kidney, and intestine. Not expressed in brain, heart, lung, skeletal muscles, skin and white fat. In the adult gonad, it is highly expressed in the testis, mainly in the spermatogonia and meiotic spermatocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely expressed in 8.5 dpc and 9.5 dpc embryos with a more restricted expression pattern at 13.5 dpc-15.5 dpc. In general, expression in embryos coincides with areas of actively proliferating cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000038685, Expressed in undifferentiated genital tubercle and 261 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0VGM9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0VGM9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TERF1.

Interacts (via PIP-box) with PCNA; the interaction is direct and essential for suppressing telomere fragility.

Interacts with MMS19; the interaction mediates the association of RTEL1 with the cytosolic iron-sulfur protein assembly (CIA) complex.

UniRule annotation1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000053120

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q0VGM9, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 296Helicase ATP-bindingUniRule annotationAdd BLAST290

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni998 – 1020DisorderedSequence analysisAdd BLAST23
Regioni1120 – 1203DisorderedSequence analysisAdd BLAST84

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi151 – 167Nuclear localization signalUniRule annotationAdd BLAST17
Motifi250 – 253DEAH box4
Motifi871 – 877Nuclear localization signalUniRule annotation7
Motifi1160 – 1167PIP-box8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1002 – 1020Polar residuesSequence analysisAdd BLAST19
Compositional biasi1125 – 1140Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1154 – 1168Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PIP-box (PCNA interacting peptide) motif mediates the interaction with PCNA and localization to replication foci.UniRule annotation1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the helicase family. RAD3/XPD subfamily.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1132, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182970

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006515_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0VGM9

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHFKVHI

Database of Orthologous Groups

More...
OrthoDBi
186062at2759

TreeFam database of animal gene trees

More...
TreeFami
TF317291

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_03065, RTEL1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006555, ATP-dep_Helicase_C
IPR010614, DEAD_2
IPR014013, Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554, Helicase-like_DEXD_c2
IPR027417, P-loop_NTPase
IPR013020, Rad3/Chl1-like
IPR030845, RTEL1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06733, DEAD_2, 1 hit
PF13307, Helicase_C_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00488, DEXDc2, 1 hit
SM00491, HELICc2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00604, rad3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51193, HELICASE_ATP_BIND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q0VGM9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPRVVLNGVT VDFPFQPYPC QQEYMTKVLE CLQKKVNGIL ESPTGTGKTL
60 70 80 90 100
CLLCSTLAWQ QHLRDAVSSL KIAERVQGEL FASRTLSSWG SAAAASGDSI
110 120 130 140 150
ECYTDIPKII YASRTHSQLT QVIRELRNTA YRPKVCVLGS REQLCIHPEV
160 170 180 190 200
KKQESNHMQI SLCRKKVASR SCHFYNNVEA KFLEQDLATP ILDIEDLVKN
210 220 230 240 250
GSKQKMCPYY LSRNMKQQAD IIFMPYNYLL DAKSRKAHSI DLKGTVVIFD
260 270 280 290 300
EAHNVEKICE ESASFDLTPR DVASGLEIIN QVLEEQARVT QQGELQQEFI
310 320 330 340 350
VDTSSSGLNM ELEDIAKLKM ILLRLEEAID AVQLPGDDRG VTKPGSYIFE
360 370 380 390 400
LFAEAQITFQ TKGCILESLD QIIQHLAGRT GVFTNTAGLQ KLMDIIQIVF
410 420 430 440 450
SVDPPEGSPG SLVGLGISHS YKVHIHPETS HRRAAKRSDA WSTTASRKQG
460 470 480 490 500
KVLSYWCFSP SQSMRELVCQ GVRTLILTSG TLAPLSSFAL EMQIPFPVCL
510 520 530 540 550
ENPHIIDKNQ LWVGIVPRGP DGVQLSSAYD KRFSEECLSS LGKALSNIAR
560 570 580 590 600
VVPHGLLVFF PSYPVMEKSL EFWQVQGLAR KVEALKPLFV EPRNKGSFSE
610 620 630 640 650
VIDAYYQQVA SPASNGATFL AVCRGKASEG LDFSDMNGRG VIVTGLPYPP
660 670 680 690 700
RMDPRVVLKM QFLDEMRGRS GVGGQCLSGQ EWYQQQASRA VNQAIGRVIR
710 720 730 740 750
HRHDYGAIFL CDHRFAYADA RAQLPSWVRP YLKVYDNFGH VIRDVAQFFR
760 770 780 790 800
VAQKTMPLPV PQAVTSSVSE GEIALKDATL SSYSLSTRKA MSLDVHVPSL
810 820 830 840 850
RQKPIGLPAA GDSESSLCGE YEQQTFSAQQ RPMGLLAALE YNEQKAGASE
860 870 880 890 900
EQALGSSTPS LRCEKRLSTE QKGGRKKVRL VNHPEEPMAG TQAGRAKMFM
910 920 930 940 950
VAVKQALSQA NFDTFTQALQ HYKSSDDFEA LVASLTCLFA EDPKKHTLLK
960 970 980 990 1000
GFYQFVRPHH KQQFEDICFQ LTGQRCGYQP GKRELESKLT LSEGVDRQLD
1010 1020 1030 1040 1050
PGQHLNQGQP HLSAHPTSKG HTSHCTKVGC AVEKPGQPAV SDYLSDVHKA
1060 1070 1080 1090 1100
LGSASCNQLT AALRAYKQDD DLDKVVAVVA ALTTAKPEHL PLLQRFGMFV
1110 1120 1130 1140 1150
RRHHKPQFLQ TCADLMGLPT TGKDLELEGP RDESPTVPPE LTHEDLKPGP
1160 1170 1180 1190 1200
SMSKKPEKTQ SKISSFFRQR PDESVRSDDT TPKPMQLPPR LPHELMKPHR

SKQ
Length:1,203
Mass (Da):133,767
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i670573FEF1E2D1B1
GO
Isoform 2 (identifier: Q0VGM9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1019-1019: K → KAHFSKP

Show »
Length:1,209
Mass (Da):134,435
Checksum:iC32760C3E6338652
GO
Isoform 3 (identifier: Q0VGM9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     981-1019: GKRELESKLTLSEGVDRQLDPGQHLNQGQPHLSAHPTSK → AHFSKP

Show »
Length:1,170
Mass (Da):130,163
Checksum:iE7F3C92BE6DB121D
GO
Isoform 4 (identifier: Q0VGM9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1021-1095: Missing.

Show »
Length:1,128
Mass (Da):125,832
Checksum:i54033FCBB9727478
GO
Isoform 5 (identifier: Q0VGM9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     981-1019: Missing.

Show »
Length:1,164
Mass (Da):129,495
Checksum:i934A4C88FEB9BCA3
GO
Isoform 6 (identifier: Q0VGM9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     451-527: KVLSYWCFSP...RGPDGVQLSS → TNLHCRKLYL...HYYYYFVFSR
     528-1203: Missing.

Show »
Length:527
Mass (Da):59,317
Checksum:iC258999E8C8B6E81
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YLW7Z4YLW7_MOUSE
Regulator of telomere elongation he...
Rtel1
992Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AU08A2AU08_MOUSE
Regulator of telomere elongation he...
Rtel1
162Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6RDU0F6RDU0_MOUSE
Regulator of telomere elongation he...
Rtel1
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6X1P9F6X1P9_MOUSE
Regulator of telomere elongation he...
Rtel1
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UWJ0F6UWJ0_MOUSE
Regulator of telomere elongation he...
Rtel1
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GX41V9GX41_MOUSE
Regulator of telomere elongation he...
Rtel1
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32375 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAM26418 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti180A → T in AAI05579 (PubMed:19468303).Curated1
Sequence conflicti381G → R in AAR27234 (PubMed:15210109).Curated1
Sequence conflicti381G → R in AAR27235 (PubMed:15210109).Curated1
Sequence conflicti381G → R in AAR27236 (PubMed:15210109).Curated1
Sequence conflicti381G → R in AAR27237 (PubMed:15210109).Curated1
Sequence conflicti381G → R in AAR27238 (PubMed:15210109).Curated1
Sequence conflicti383F → S in AAI05579 (PubMed:19468303).Curated1
Sequence conflicti402V → A in AAI05579 (PubMed:19468303).Curated1
Sequence conflicti416G → S in AAR27234 (PubMed:15210109).Curated1
Sequence conflicti416G → S in AAR27235 (PubMed:15210109).Curated1
Sequence conflicti416G → S in AAR27236 (PubMed:15210109).Curated1
Sequence conflicti416G → S in AAR27237 (PubMed:15210109).Curated1
Sequence conflicti416G → S in AAR27238 (PubMed:15210109).Curated1
Sequence conflicti619F → L in AAI05579 (PubMed:19468303).Curated1
Sequence conflicti633F → S in AAI05579 (PubMed:19468303).Curated1
Sequence conflicti796H → R in AAI05579 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036945451 – 527KVLSY…VQLSS → TNLHCRKLYLAQPLHNNNIT SGVMPTESQRQEALLSTQRH LLGQWQNPGSARPPLPDLGY IIINHYRHYYYYFVFSR in isoform 6. 1 PublicationAdd BLAST77
Alternative sequenceiVSP_036946528 – 1203Missing in isoform 6. 1 PublicationAdd BLAST676
Alternative sequenceiVSP_036947981 – 1019GKREL…HPTSK → AHFSKP in isoform 3. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_036948981 – 1019Missing in isoform 5. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_0369491019K → KAHFSKP in isoform 2. 2 Publications1
Alternative sequenceiVSP_0369501021 – 1095Missing in isoform 4. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY481619 mRNA Translation: AAR27234.1
AY481620 mRNA Translation: AAR27235.1
AY481621 mRNA Translation: AAR27236.1
AY481622 mRNA Translation: AAR27237.1
AY481623 mRNA Translation: AAR27238.1
AK173097 mRNA Translation: BAD32375.1 Different initiation.
AK145145 mRNA Translation: BAE26258.1
AL928965 Genomic DNA Translation: CAM26413.1
AL928965 Genomic DNA Translation: CAM26414.1
AL928965 Genomic DNA Translation: CAM26415.1
AL928965 Genomic DNA Translation: CAM26416.1
AL928965 Genomic DNA Translation: CAM26417.1
AL928965 Genomic DNA Translation: CAM26418.1 Sequence problems.
BC105578 mRNA Translation: AAI05579.1
BC144977 mRNA Translation: AAI44978.1
BC144978 mRNA Translation: AAI44979.1
BC145658 mRNA Translation: AAI45659.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17208.1 [Q0VGM9-2]
CCDS50849.1 [Q0VGM9-1]
CCDS50850.1 [Q0VGM9-4]
CCDS50851.1 [Q0VGM9-3]
CCDS50852.1 [Q0VGM9-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001001882.3, NM_001001882.3 [Q0VGM9-2]
NP_001160137.1, NM_001166665.1 [Q0VGM9-1]
NP_001160138.1, NM_001166666.1 [Q0VGM9-3]
NP_001160139.1, NM_001166667.1 [Q0VGM9-5]
NP_001160140.1, NM_001166668.1 [Q0VGM9-4]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000048608; ENSMUSP00000043563; ENSMUSG00000038685 [Q0VGM9-4]
ENSMUST00000054622; ENSMUSP00000053120; ENSMUSG00000038685 [Q0VGM9-2]
ENSMUST00000098971; ENSMUSP00000096571; ENSMUSG00000038685 [Q0VGM9-3]
ENSMUST00000108814; ENSMUSP00000104442; ENSMUSG00000038685 [Q0VGM9-1]
ENSMUST00000108815; ENSMUSP00000104443; ENSMUSG00000038685 [Q0VGM9-5]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
269400

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:269400

UCSC genome browser

More...
UCSCi
uc008olu.2, mouse [Q0VGM9-6]
uc008olv.2, mouse [Q0VGM9-2]
uc008olw.2, mouse [Q0VGM9-1]
uc008olx.2, mouse [Q0VGM9-3]
uc012cmk.1, mouse [Q0VGM9-5]
uc012cml.1, mouse [Q0VGM9-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY481619 mRNA Translation: AAR27234.1
AY481620 mRNA Translation: AAR27235.1
AY481621 mRNA Translation: AAR27236.1
AY481622 mRNA Translation: AAR27237.1
AY481623 mRNA Translation: AAR27238.1
AK173097 mRNA Translation: BAD32375.1 Different initiation.
AK145145 mRNA Translation: BAE26258.1
AL928965 Genomic DNA Translation: CAM26413.1
AL928965 Genomic DNA Translation: CAM26414.1
AL928965 Genomic DNA Translation: CAM26415.1
AL928965 Genomic DNA Translation: CAM26416.1
AL928965 Genomic DNA Translation: CAM26417.1
AL928965 Genomic DNA Translation: CAM26418.1 Sequence problems.
BC105578 mRNA Translation: AAI05579.1
BC144977 mRNA Translation: AAI44978.1
BC144978 mRNA Translation: AAI44979.1
BC145658 mRNA Translation: AAI45659.1
CCDSiCCDS17208.1 [Q0VGM9-2]
CCDS50849.1 [Q0VGM9-1]
CCDS50850.1 [Q0VGM9-4]
CCDS50851.1 [Q0VGM9-3]
CCDS50852.1 [Q0VGM9-5]
RefSeqiNP_001001882.3, NM_001001882.3 [Q0VGM9-2]
NP_001160137.1, NM_001166665.1 [Q0VGM9-1]
NP_001160138.1, NM_001166666.1 [Q0VGM9-3]
NP_001160139.1, NM_001166667.1 [Q0VGM9-5]
NP_001160140.1, NM_001166668.1 [Q0VGM9-4]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053120

PTM databases

iPTMnetiQ0VGM9
PhosphoSitePlusiQ0VGM9

Proteomic databases

jPOSTiQ0VGM9
MaxQBiQ0VGM9
PaxDbiQ0VGM9
PRIDEiQ0VGM9
ProteomicsDBi260945 [Q0VGM9-1]
260946 [Q0VGM9-2]
260947 [Q0VGM9-3]
260948 [Q0VGM9-4]
260949 [Q0VGM9-5]
260950 [Q0VGM9-6]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
269400

Genome annotation databases

EnsembliENSMUST00000048608; ENSMUSP00000043563; ENSMUSG00000038685 [Q0VGM9-4]
ENSMUST00000054622; ENSMUSP00000053120; ENSMUSG00000038685 [Q0VGM9-2]
ENSMUST00000098971; ENSMUSP00000096571; ENSMUSG00000038685 [Q0VGM9-3]
ENSMUST00000108814; ENSMUSP00000104442; ENSMUSG00000038685 [Q0VGM9-1]
ENSMUST00000108815; ENSMUSP00000104443; ENSMUSG00000038685 [Q0VGM9-5]
GeneIDi269400
KEGGimmu:269400
UCSCiuc008olu.2, mouse [Q0VGM9-6]
uc008olv.2, mouse [Q0VGM9-2]
uc008olw.2, mouse [Q0VGM9-1]
uc008olx.2, mouse [Q0VGM9-3]
uc012cmk.1, mouse [Q0VGM9-5]
uc012cml.1, mouse [Q0VGM9-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
51750
MGIiMGI:2139369, Rtel1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1132, Eukaryota
GeneTreeiENSGT00950000182970
HOGENOMiCLU_006515_4_0_1
InParanoidiQ0VGM9
OMAiAHFKVHI
OrthoDBi186062at2759
TreeFamiTF317291

Enzyme and pathway databases

ReactomeiR-MMU-171319, Telomere Extension By Telomerase

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
269400, 14 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rtel1, mouse

Protein Ontology

More...
PROi
PR:Q0VGM9
RNActiQ0VGM9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000038685, Expressed in undifferentiated genital tubercle and 261 other tissues
ExpressionAtlasiQ0VGM9, baseline and differential
GenevisibleiQ0VGM9, MM

Family and domain databases

HAMAPiMF_03065, RTEL1, 1 hit
InterProiView protein in InterPro
IPR006555, ATP-dep_Helicase_C
IPR010614, DEAD_2
IPR014013, Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554, Helicase-like_DEXD_c2
IPR027417, P-loop_NTPase
IPR013020, Rad3/Chl1-like
IPR030845, RTEL1
PfamiView protein in Pfam
PF06733, DEAD_2, 1 hit
PF13307, Helicase_C_2, 1 hit
SMARTiView protein in SMART
SM00488, DEXDc2, 1 hit
SM00491, HELICc2, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
TIGRFAMsiTIGR00604, rad3, 1 hit
PROSITEiView protein in PROSITE
PS51193, HELICASE_ATP_BIND_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRTEL1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VGM9
Secondary accession number(s): A2AU09
, A2AU10, A2AU11, A2AU12, A2AU13, A2AU14, Q3UM40, Q5F0J8, Q69ZS1, Q6H1L0, Q6H1L1, Q6H1L2, Q6H1L3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 5, 2009
Last modified: June 2, 2021
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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