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Protein

Ragulator complex protein LAMTOR4

Gene

LAMTOR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated.1 Publication

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiQ0VGL1

Names & Taxonomyi

Protein namesi
Recommended name:
Ragulator complex protein LAMTOR4
Alternative name(s):
Late endosomal/lysosomal adaptor and MAPK and MTOR activator 4
Cleaved into the following chain:
Gene namesi
Name:LAMTOR4
Synonyms:C7orf59
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000188186.10
HGNCiHGNC:33772 LAMTOR4
neXtProtiNX_Q0VGL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000188186
PharmGKBiPA162380687

Polymorphism and mutation databases

BioMutaiLAMTOR4
DMDMi121940512

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003258411 – 99Ragulator complex protein LAMTOR4Add BLAST99
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004244982 – 99Ragulator complex protein LAMTOR4, N-terminally processedAdd BLAST98

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylthreonine; in Ragulator complex protein LAMTOR4, N-terminally processedCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ0VGL1
MaxQBiQ0VGL1
PaxDbiQ0VGL1
PeptideAtlasiQ0VGL1
PRIDEiQ0VGL1
ProteomicsDBi58845
TopDownProteomicsiQ0VGL1

PTM databases

iPTMnetiQ0VGL1
PhosphoSitePlusiQ0VGL1

Expressioni

Gene expression databases

BgeeiENSG00000188186 Expressed in 199 organ(s), highest expression level in skin of abdomen
CleanExiHS_C7orf59
ExpressionAtlasiQ0VGL1 baseline and differential
GenevisibleiQ0VGL1 HS

Organism-specific databases

HPAiHPA020998

Interactioni

Subunit structurei

Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906).3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi133178, 16 interactors
DIPiDIP-61481N
IntActiQ0VGL1, 17 interactors
STRINGi9606.ENSP00000343118

Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ0VGL1
SMRiQ0VGL1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMTOR4 family.Curated

Phylogenomic databases

eggNOGiENOG410IZEZ Eukaryota
ENOG4112495 LUCA
GeneTreeiENSGT00390000016053
HOGENOMiHOG000047533
HOVERGENiHBG107668
InParanoidiQ0VGL1
KOiK20399
OMAiDESFMPN
PhylomeDBiQ0VGL1
TreeFamiTF324352

Family and domain databases

InterProiView protein in InterPro
IPR034601 LAMTOR4
PANTHERiPTHR33967 PTHR33967, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

Q0VGL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSALTQGLE RIPDQLGYLV LSEGAVLASS GDLENDEQAA SAISELVSTA
60 70 80 90
CGFRLHRGMN VPFKRLSVVF GEHTLLVTVS GQRVFVVKRQ NRGREPIDV
Length:99
Mass (Da):10,741
Last modified:September 5, 2006 - v1
Checksum:i0FB3D6613F295DEB
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JXA7C9JXA7_HUMAN
Ragulator complex protein LAMTOR4
LAMTOR4
137Annotation score:
A0A087WV46A0A087WV46_HUMAN
Ragulator complex protein LAMTOR4
LAMTOR4
82Annotation score:
A0A087WT92A0A087WT92_HUMAN
Ragulator complex protein LAMTOR4
LAMTOR4
72Annotation score:
A0A087WVU0A0A087WVU0_HUMAN
Ragulator complex protein LAMTOR4
LAMTOR4
41Annotation score:
A0A087WXQ3A0A087WXQ3_HUMAN
Ragulator complex protein LAMTOR4
LAMTOR4
19Annotation score:
A0A087WWR0A0A087WWR0_HUMAN
Ragulator complex protein LAMTOR4
LAMTOR4
20Annotation score:
A0A087WVK8A0A087WVK8_HUMAN
Ragulator complex protein LAMTOR4
LAMTOR4
24Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471091 Genomic DNA Translation: EAW76585.1
BC063401 mRNA Translation: AAH63401.1
BC105609 mRNA Translation: AAI05610.1
BC130553 mRNA Translation: AAI30554.1
BC130559 mRNA Translation: AAI30560.1
CCDSiCCDS34702.1
RefSeqiNP_001008396.1, NM_001008395.3
XP_016867687.1, XM_017012198.1
UniGeneiHs.406520

Genome annotation databases

EnsembliENST00000341942; ENSP00000343118; ENSG00000188186
GeneIDi389541
KEGGihsa:389541
UCSCiuc003utq.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471091 Genomic DNA Translation: EAW76585.1
BC063401 mRNA Translation: AAH63401.1
BC105609 mRNA Translation: AAI05610.1
BC130553 mRNA Translation: AAI30554.1
BC130559 mRNA Translation: AAI30560.1
CCDSiCCDS34702.1
RefSeqiNP_001008396.1, NM_001008395.3
XP_016867687.1, XM_017012198.1
UniGeneiHs.406520

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5VOKX-ray2.89B/D/F/H1-99[»]
5X6UX-ray2.40D1-99[»]
5X6VX-ray2.02D1-99[»]
5Y38X-ray2.80B1-99[»]
5Y39X-ray2.65D/I1-99[»]
5Y3AX-ray2.90D/I1-99[»]
6B9XX-ray1.42D1-99[»]
6EHPX-ray2.30D1-99[»]
6EHRX-ray2.90D1-99[»]
ProteinModelPortaliQ0VGL1
SMRiQ0VGL1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133178, 16 interactors
DIPiDIP-61481N
IntActiQ0VGL1, 17 interactors
STRINGi9606.ENSP00000343118

PTM databases

iPTMnetiQ0VGL1
PhosphoSitePlusiQ0VGL1

Polymorphism and mutation databases

BioMutaiLAMTOR4
DMDMi121940512

Proteomic databases

EPDiQ0VGL1
MaxQBiQ0VGL1
PaxDbiQ0VGL1
PeptideAtlasiQ0VGL1
PRIDEiQ0VGL1
ProteomicsDBi58845
TopDownProteomicsiQ0VGL1

Protocols and materials databases

DNASUi389541
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341942; ENSP00000343118; ENSG00000188186
GeneIDi389541
KEGGihsa:389541
UCSCiuc003utq.3 human

Organism-specific databases

CTDi389541
EuPathDBiHostDB:ENSG00000188186.10
GeneCardsiLAMTOR4
H-InvDBiHIX0033651
HGNCiHGNC:33772 LAMTOR4
HPAiHPA020998
neXtProtiNX_Q0VGL1
OpenTargetsiENSG00000188186
PharmGKBiPA162380687
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZEZ Eukaryota
ENOG4112495 LUCA
GeneTreeiENSGT00390000016053
HOGENOMiHOG000047533
HOVERGENiHBG107668
InParanoidiQ0VGL1
KOiK20399
OMAiDESFMPN
PhylomeDBiQ0VGL1
TreeFamiTF324352

Enzyme and pathway databases

ReactomeiR-HSA-1632852 Macroautophagy
R-HSA-165159 mTOR signalling
R-HSA-166208 mTORC1-mediated signalling
R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK
R-HSA-5628897 TP53 Regulates Metabolic Genes
R-HSA-8943724 Regulation of PTEN gene transcription
SIGNORiQ0VGL1

Miscellaneous databases

ChiTaRSiLAMTOR4 human
GenomeRNAii389541
PROiPR:Q0VGL1

Gene expression databases

BgeeiENSG00000188186 Expressed in 199 organ(s), highest expression level in skin of abdomen
CleanExiHS_C7orf59
ExpressionAtlasiQ0VGL1 baseline and differential
GenevisibleiQ0VGL1 HS

Family and domain databases

InterProiView protein in InterPro
IPR034601 LAMTOR4
PANTHERiPTHR33967 PTHR33967, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLTOR4_HUMAN
AccessioniPrimary (citable) accession number: Q0VGL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: September 5, 2006
Last modified: September 12, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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