We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q0VGE8 (ZN816_HUMAN)
Protein
Zinc finger protein 816
Gene
ZNF816
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 227 – 251 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 257 – 279 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 621 – 643 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q0VGE8 |
SignaLinki | Q0VGE8 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 816 |
Gene namesi | Name:ZNF816 Synonyms:ZNF816A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26995, ZNF816 |
neXtProti | NX_Q0VGE8 |
VEuPathDBi | HostDB:ENSG00000180257 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 125893 |
OpenTargetsi | ENSG00000180257 |
PharmGKBi | PA165394953 |
Miscellaneous databases
Pharosi | Q0VGE8, Tdark |
Genetic variation databases
BioMutai | ZNF816 |
DMDMi | 290457609 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000294362 | 1 – 651 | Zinc finger protein 816Add BLAST | 651 |
Proteomic databases
jPOSTi | Q0VGE8 |
MassIVEi | Q0VGE8 |
MaxQBi | Q0VGE8 |
PaxDbi | Q0VGE8 |
PeptideAtlasi | Q0VGE8 |
PRIDEi | Q0VGE8 |
ProteomicsDBi | 58844 |
PTM databases
iPTMneti | Q0VGE8 |
PhosphoSitePlusi | Q0VGE8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000180257, Expressed in buccal mucosa cell and 138 other tissues |
ExpressionAtlasi | Q0VGE8, baseline and differential |
Genevisiblei | Q0VGE8, HS |
Organism-specific databases
HPAi | ENSG00000180257, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 125933, 14 interactors |
IntActi | Q0VGE8, 14 interactors |
STRINGi | 9606.ENSP00000350295 |
Miscellaneous databases
RNActi | Q0VGE8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 98 | KRABPROSITE-ProRule annotationAdd BLAST | 75 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 227 – 251 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 257 – 279 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 285 – 307 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 313 – 335 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 341 – 363 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 369 – 391 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 397 – 419 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 425 – 447 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 453 – 475 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 481 – 503 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 509 – 531 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 537 – 559 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 565 – 587 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 593 – 615 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 621 – 643 | C2H2-type 15PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154397 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q0VGE8 |
OMAi | SHEHSNT |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q0VGE8 |
TreeFami | TF341892 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q0VGE8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLREEATKKS KEKEPGMALP QGRLTFRDVA IEFSLEEWKC LNPAQRALYR
60 70 80 90 100
AVMLENYRNL EFVDSSLKSM MEFSSTRHSI TGEVIHTGTL QRHKSHHIGD
110 120 130 140 150
FCFPEMKKDI HHFEFQWQEV ERNGHEAPMT KIKKLTGSTD RSDHRHAGNK
160 170 180 190 200
PIKDQLGLSF HSHLPELHMF QTKGKISNQL DKSIGASSAS ESQRISCRLK
210 220 230 240 250
THISNKYGKN FLHSSFTQIQ EICMREKPCQ SNECGKAFNY SSLLRRHHIT
260 270 280 290 300
HSREREYKCD VCGKIFNQKQ YIVYHHRCHT GEKTYKCNEC GKTFTQMSSL
310 320 330 340 350
VCHRRLHTGE KPYKCNECGK TFSEKSSLRC HRRLHTGEKP YKCNECGKTF
360 370 380 390 400
GRNSALVIHK AIHTGEKPYK CNECGKTFSQ KSSLQCHHIL HTGEKPYKCE
410 420 430 440 450
ECDNVYIRRS HLERHRKIHT GEGSYKCKVC DKVFRSDSYL AEHQRVHTGE
460 470 480 490 500
KPYKCNKCGR SFSRKSSLQY HHTLHTGEKP YTCNECGKVF SRRENLARHH
510 520 530 540 550
RLHAGEKPYK CEECDKVFSR RSHLERHRRI HTGEKPYKCK VCDKAFRSDS
560 570 580 590 600
CLANHTRVHT GEKPYKCNKC AKVFNQKGIL AQHQRVHTGE KPYKCNECGK
610 620 630 640 650
VFNQKASLAK HQRVHTAEKP YKCNECGKAF TGQSTLIHHQ AIHGCRETLQ
M
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZX7 | M0QZX7_HUMAN | Zinc finger protein 816 | ZNF816 | 97 | Annotation score: | ||
F5GXJ3 | F5GXJ3_HUMAN | Zinc finger protein 816 | ZNF816 | 98 | Annotation score: | ||
I3L0H5 | I3L0H5_HUMAN | Zinc finger protein 816 | ZNF816 | 114 | Annotation score: | ||
M0QY99 | M0QY99_HUMAN | Zinc finger protein 816 | ZNF816 | 76 | Annotation score: | ||
M0R0G1 | M0R0G1_HUMAN | Zinc finger protein 816 | ZNF816 | 58 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 184 | I → IS in AAI05741 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033165 | 80 | I → N1 PublicationCorresponds to variant dbSNP:rs12459008Ensembl. | 1 | |
Natural variantiVAR_033166 | 162 | S → L1 PublicationCorresponds to variant dbSNP:rs11084210Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291990 mRNA Translation: BAF84679.1 AC010487 Genomic DNA No translation available. AC010328 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72106.1 BC105739 mRNA Translation: AAI05740.1 BC105740 mRNA Translation: AAI05741.1 BC105930 mRNA Translation: AAI05931.1 AL713804 mRNA Translation: CAH56373.1 |
CCDSi | CCDS33096.1 |
RefSeqi | NP_001026835.1, NM_001031665.2 NP_001189385.1, NM_001202456.1 NP_001189386.1, NM_001202457.1 |
Genome annotation databases
Ensembli | ENST00000357666; ENSP00000350295; ENSG00000180257 ENST00000444460; ENSP00000403266; ENSG00000180257 |
GeneIDi | 125893 |
KEGGi | hsa:125893 |
MANE-Selecti | ENST00000444460.7; ENSP00000403266.2; NM_001202457.3; NP_001189386.1 |
UCSCi | uc002qal.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK291990 mRNA Translation: BAF84679.1 AC010487 Genomic DNA No translation available. AC010328 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72106.1 BC105739 mRNA Translation: AAI05740.1 BC105740 mRNA Translation: AAI05741.1 BC105930 mRNA Translation: AAI05931.1 AL713804 mRNA Translation: CAH56373.1 |
CCDSi | CCDS33096.1 |
RefSeqi | NP_001026835.1, NM_001031665.2 NP_001189385.1, NM_001202456.1 NP_001189386.1, NM_001202457.1 |
3D structure databases
SMRi | Q0VGE8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 125933, 14 interactors |
IntActi | Q0VGE8, 14 interactors |
STRINGi | 9606.ENSP00000350295 |
PTM databases
iPTMneti | Q0VGE8 |
PhosphoSitePlusi | Q0VGE8 |
Genetic variation databases
BioMutai | ZNF816 |
DMDMi | 290457609 |
Proteomic databases
jPOSTi | Q0VGE8 |
MassIVEi | Q0VGE8 |
MaxQBi | Q0VGE8 |
PaxDbi | Q0VGE8 |
PeptideAtlasi | Q0VGE8 |
PRIDEi | Q0VGE8 |
ProteomicsDBi | 58844 |
Protocols and materials databases
Antibodypediai | 46251, 57 antibodies from 13 providers |
DNASUi | 125893 |
Genome annotation databases
Ensembli | ENST00000357666; ENSP00000350295; ENSG00000180257 ENST00000444460; ENSP00000403266; ENSG00000180257 |
GeneIDi | 125893 |
KEGGi | hsa:125893 |
MANE-Selecti | ENST00000444460.7; ENSP00000403266.2; NM_001202457.3; NP_001189386.1 |
UCSCi | uc002qal.3, human |
Organism-specific databases
CTDi | 125893 |
DisGeNETi | 125893 |
GeneCardsi | ZNF816 |
HGNCi | HGNC:26995, ZNF816 |
HPAi | ENSG00000180257, Low tissue specificity |
neXtProti | NX_Q0VGE8 |
OpenTargetsi | ENSG00000180257 |
PharmGKBi | PA165394953 |
VEuPathDBi | HostDB:ENSG00000180257 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154397 |
HOGENOMi | CLU_002678_44_5_1 |
InParanoidi | Q0VGE8 |
OMAi | SHEHSNT |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q0VGE8 |
TreeFami | TF341892 |
Enzyme and pathway databases
PathwayCommonsi | Q0VGE8 |
SignaLinki | Q0VGE8 |
Miscellaneous databases
BioGRID-ORCSi | 125893, 4 hits in 1020 CRISPR screens |
GenomeRNAii | 125893 |
Pharosi | Q0VGE8, Tdark |
PROi | PR:Q0VGE8 |
RNActi | Q0VGE8, protein |
Gene expression databases
Bgeei | ENSG00000180257, Expressed in buccal mucosa cell and 138 other tissues |
ExpressionAtlasi | Q0VGE8, baseline and differential |
Genevisiblei | Q0VGE8, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 14 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 15 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 8 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 15 hits PS50157, ZINC_FINGER_C2H2_2, 15 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN816_HUMAN | |
Accessioni | Q0VGE8Primary (citable) accession number: Q0VGE8 Secondary accession number(s): A8K7H5, Q3KR39, Q659B3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 10, 2007 |
Last sequence update: | March 2, 2010 | |
Last modified: | February 23, 2022 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families