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Entry version 113 (31 Jul 2019)
Sequence version 1 (05 Sep 2006)
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Protein
Submitted name:

Heterogeneous nuclear ribonucleoprotein A3

Gene

Hnrnpa3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRibonucleoproteinImported, RNA-bindingPROSITE-ProRule annotation, Viral nucleoproteinImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Heterogeneous nuclear ribonucleoprotein A3Imported
Submitted name:
Hnrpa3 proteinImported
Submitted name:
MCG1305, isoform CRA_dImported
Submitted name:
MCG48756Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hnrnpa3Imported
Synonyms:Hnrpa3Imported
ORF Names:mCG_1305Imported, mCG_48756Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1917171 Hnrnpa3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Virion

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Proteomic databases

    Consortium for Top Down Proteomics

    More...
    TopDownProteomicsi
    Q0VG47

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000059005 Expressed in 290 organ(s), highest expression level in olfactory bulb

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 96RRMInterPro annotationAdd BLAST84
    Domaini104 – 183RRMInterPro annotationAdd BLAST80

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni182 – 203DisorderedSequence analysisAdd BLAST22
    Regioni313 – 357DisorderedSequence analysisAdd BLAST45

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG0118 Eukaryota
    COG0724 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000234442

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    FFLKFGE

    Database of Orthologous Groups

    More...
    OrthoDBi
    1202220at2759

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd12763 RRM1_hnRNPA3, 1 hit
    cd12582 RRM2_hnRNPA3, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.70.330, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR034513 hnRNPA3_RRM1
    IPR034516 hnRNPA3_RRM2
    IPR012677 Nucleotide-bd_a/b_plait_sf
    IPR035979 RBD_domain_sf
    IPR000504 RRM_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00076 RRM_1, 2 hits

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00360 RRM, 2 hits

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF54928 SSF54928, 2 hits

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50102 RRM, 2 hits

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q0VG47-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEGHDPKEPE QLRKLFIGGL SFETTDDSLR EHFEKWGTLT DCVVMRDPQT
    60 70 80 90 100
    KRSRGFGFVT YSCVEEVDAA MCARPHKVDG RVVEPKRAVS REDSVKPGAH
    110 120 130 140 150
    LTVKKIFVGG IKEDTEEYNL RDYFEKYGKI ETIEVMEDRQ SGKKRGFAFV
    160 170 180 190 200
    TFDDHDTVDK IVVQKYHTIN GHNCEVKKAL SKQEMQSAGS QRGRGGGSGN
    210 220 230 240 250
    FMGRGGNFGG GGGNFGRGGN FGGRGGYGGG GGGSRGSYGG GDGGYNGFGG
    260 270 280 290 300
    DGGNYGGGPG YSSRGGYGGG GPGYGNQGGG YGGGGGGYDG YNEGGNFGGG
    310 320 330 340 350
    NYGGGGNYND FGNYSGQQQS NYGPMKGGSF GGRSSGSPYG GGYGSGGGSG

    GYGSRRF
    Length:357
    Mass (Da):37,086
    Last modified:September 5, 2006 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i222DBB3DF00D2D7A
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    BC116250 mRNA Translation: AAI16251.1
    BC116251 mRNA Translation: AAI16252.1
    BC157919 mRNA Translation: AAI57920.1
    BC158038 mRNA Translation: AAI58039.1
    CH466519 Genomic DNA Translation: EDL27190.1
    CH466519 Genomic DNA Translation: EDL27191.1
    CH466530 Genomic DNA Translation: EDL35262.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_444493.1, NM_053263.1
    XP_011237818.1, XM_011239516.2

    Genome annotation databases

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    229279

    UCSC genome browser

    More...
    UCSCi
    uc008kel.2 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    BC116250 mRNA Translation: AAI16251.1
    BC116251 mRNA Translation: AAI16252.1
    BC157919 mRNA Translation: AAI57920.1
    BC158038 mRNA Translation: AAI58039.1
    CH466519 Genomic DNA Translation: EDL27190.1
    CH466519 Genomic DNA Translation: EDL27191.1
    CH466530 Genomic DNA Translation: EDL35262.1
    RefSeqiNP_444493.1, NM_053263.1
    XP_011237818.1, XM_011239516.2

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Proteomic databases

    TopDownProteomicsiQ0VG47

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    GeneIDi229279
    UCSCiuc008kel.2 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    220988
    MGIiMGI:1917171 Hnrnpa3

    Phylogenomic databases

    eggNOGiKOG0118 Eukaryota
    COG0724 LUCA
    HOGENOMiHOG000234442
    OMAiFFLKFGE
    OrthoDBi1202220at2759

    Miscellaneous databases

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000059005 Expressed in 290 organ(s), highest expression level in olfactory bulb

    Family and domain databases

    CDDicd12763 RRM1_hnRNPA3, 1 hit
    cd12582 RRM2_hnRNPA3, 1 hit
    Gene3Di3.30.70.330, 2 hits
    InterProiView protein in InterPro
    IPR034513 hnRNPA3_RRM1
    IPR034516 hnRNPA3_RRM2
    IPR012677 Nucleotide-bd_a/b_plait_sf
    IPR035979 RBD_domain_sf
    IPR000504 RRM_dom
    PfamiView protein in Pfam
    PF00076 RRM_1, 2 hits
    SMARTiView protein in SMART
    SM00360 RRM, 2 hits
    SUPFAMiSSF54928 SSF54928, 2 hits
    PROSITEiView protein in PROSITE
    PS50102 RRM, 2 hits

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ0VG47_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VG47
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
    Last sequence update: September 5, 2006
    Last modified: July 31, 2019
    This is version 113 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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