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Entry version 89 (16 Oct 2019)
Sequence version 2 (05 Apr 2011)
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Protein

Coiled-coil domain-containing protein 173

Gene

CCDC173

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 173
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC173
Synonyms:C2orf77
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25064 CCDC173

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q0VFZ6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000154479

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379577

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q0VFZ6

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC173

Domain mapping of disease mutations (DMDM)

More...
DMDMi
327478499

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003188461 – 552Coiled-coil domain-containing protein 173Add BLAST552

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q0VFZ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q0VFZ6

PeptideAtlas

More...
PeptideAtlasi
Q0VFZ6

PRoteomics IDEntifications database

More...
PRIDEi
Q0VFZ6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
58836

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q0VFZ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q0VFZ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000154479 Expressed in 101 organ(s), highest expression level in testis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0VFZ6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q0VFZ6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042995
HPA048454

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126216, 5 interactors

Protein interaction database and analysis system

More...
IntActi
Q0VFZ6, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000391504

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0VFZ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili53 – 143Sequence analysisAdd BLAST91
Coiled coili186 – 307Sequence analysisAdd BLAST122
Coiled coili348 – 409Sequence analysisAdd BLAST62
Coiled coili460 – 488Sequence analysisAdd BLAST29

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IERG Eukaryota
ENOG410ZE2M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111149

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006604

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q0VFZ6

Identification of Orthologs from Complete Genome Data

More...
OMAi
RQNLLYE

Database of Orthologous Groups

More...
OrthoDBi
994326at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0VFZ6

TreeFam database of animal gene trees

More...
TreeFami
TF328736

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039986 CCDC173

The PANTHER Classification System

More...
PANTHERi
PTHR28663 PTHR28663, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q0VFZ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTSSEMLVR FGRRCGRAKE STEIRNSEED QVLYLPLLPS KVDLQQVTII
60 70 80 90 100
PHDEWKRIQD SLDRLTREAA CLRAERKAKK EMHLRSQEVV KHWTNTYAGM
110 120 130 140 150
KEQKLEAKKK RDEEIEAERQ ILDLEEEIYK QGKRKKAIEN AKQYQFYQTE
160 170 180 190 200
RVKNFHSGLL LSRVMKERDA QIEFRKSKIK SDKKWEEQLK LNIEKAFKEE
210 220 230 240 250
QEKAEKRHRE RVALAKDHLK QIKEHEEEEE RRKKYEEKDA EEIKRQNALY
260 270 280 290 300
EIEMRKKLEK KREEMHESRR RFLEHMQDKH IIKAVEQQQQ EEEDEKMRKF
310 320 330 340 350
IKAKKRLIQM GKEKEAETHR LMEKRRERIH NFLSELLKEK LDNEDMIIAR
360 370 380 390 400
DIAEAEAEWE KREREKDEKN KAELKTIAEY RAIVMKNKEE EERQRKIEAK
410 420 430 440 450
EQLLAVMKAD QIFWEHEKEK KCKADKEHQE VQDAHIQQMA KNKFNAKQAK
460 470 480 490 500
QAELDYCRLT EALVAEKEKE FQDYAREVIE LESETTNKYI YPLVKAVQEG
510 520 530 540 550
PGGGRGPVFV DRGGLRPSYQ ANDVTGVQLP FYNSQGPKYN FQKSKRRLGF

TW
Length:552
Mass (Da):66,403
Last modified:April 5, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA727A02E40660938
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J9F8C9J9F8_HUMAN
Coiled-coil domain-containing prote...
CCDC173
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JQ25C9JQ25_HUMAN
Coiled-coil domain-containing prote...
CCDC173
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI17446 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC016772 Genomic DNA No translation available.
BC015980 mRNA Translation: AAH15980.1
BC117445 mRNA Translation: AAI17446.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46445.1

NCBI Reference Sequences

More...
RefSeqi
NP_001078916.1, NM_001085447.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000447353; ENSP00000391504; ENSG00000154479

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
129881

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:129881

UCSC genome browser

More...
UCSCi
uc002ufe.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC016772 Genomic DNA No translation available.
BC015980 mRNA Translation: AAH15980.1
BC117445 mRNA Translation: AAI17446.1 Different initiation.
CCDSiCCDS46445.1
RefSeqiNP_001078916.1, NM_001085447.1

3D structure databases

SMRiQ0VFZ6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi126216, 5 interactors
IntActiQ0VFZ6, 4 interactors
STRINGi9606.ENSP00000391504

PTM databases

iPTMnetiQ0VFZ6
PhosphoSitePlusiQ0VFZ6

Polymorphism and mutation databases

BioMutaiCCDC173
DMDMi327478499

Proteomic databases

MassIVEiQ0VFZ6
PaxDbiQ0VFZ6
PeptideAtlasiQ0VFZ6
PRIDEiQ0VFZ6
ProteomicsDBi58836

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
129881

Genome annotation databases

EnsembliENST00000447353; ENSP00000391504; ENSG00000154479
GeneIDi129881
KEGGihsa:129881
UCSCiuc002ufe.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
129881

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC173
HGNCiHGNC:25064 CCDC173
HPAiHPA042995
HPA048454
neXtProtiNX_Q0VFZ6
OpenTargetsiENSG00000154479
PharmGKBiPA162379577

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IERG Eukaryota
ENOG410ZE2M LUCA
GeneTreeiENSGT00730000111149
HOGENOMiHOG000006604
InParanoidiQ0VFZ6
OMAiRQNLLYE
OrthoDBi994326at2759
PhylomeDBiQ0VFZ6
TreeFamiTF328736

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CCDC173 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
129881
PharosiQ0VFZ6

Protein Ontology

More...
PROi
PR:Q0VFZ6

Gene expression databases

BgeeiENSG00000154479 Expressed in 101 organ(s), highest expression level in testis
ExpressionAtlasiQ0VFZ6 baseline and differential
GenevisibleiQ0VFZ6 HS

Family and domain databases

InterProiView protein in InterPro
IPR039986 CCDC173
PANTHERiPTHR28663 PTHR28663, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC173_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VFZ6
Secondary accession number(s): Q6PJF6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: April 5, 2011
Last modified: October 16, 2019
This is version 89 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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