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Entry version 91 (29 Sep 2021)
Sequence version 1 (05 Sep 2006)
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Protein
Submitted name:

Disks large-associated protein 2

Gene

Dlgap2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Disks large-associated protein 2Imported
Submitted name:
Dlgap2 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dlgap2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443181, Dlgap2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000047495

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q0VF59

PRoteomics IDEntifications database

More...
PRIDEi
Q0VF59

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
344612

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q0VF59

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000047495, Expressed in frontal cortex and 97 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q0VF59, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q0VF59

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni246 – 312DisorderedSequence analysisAdd BLAST67
Regioni614 – 670DisorderedSequence analysisAdd BLAST57
Regioni724 – 757DisorderedSequence analysisAdd BLAST34
Regioni986 – 1026DisorderedSequence analysisAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi246 – 261Polar residuesSequence analysisAdd BLAST16
Compositional biasi295 – 312Polar residuesSequence analysisAdd BLAST18
Compositional biasi627 – 670Polar residuesSequence analysisAdd BLAST44
Compositional biasi742 – 757Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi1004 – 1026Basic and acidic residuesSequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SAPAP family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157913

Identification of Orthologs from Complete Genome Data

More...
OMAi
QMDHHRC

Database of Orthologous Groups

More...
OrthoDBi
197925at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q0VF59

TreeFam database of animal gene trees

More...
TreeFami
TF321382

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR030525, DLGAP2
IPR005026, SAPAP

The PANTHER Classification System

More...
PANTHERi
PTHR12353, PTHR12353, 1 hit
PTHR12353:SF3, PTHR12353:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03359, GKAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q0VF59-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALRKVLPG ILQKHCCILP DRNTESQCTL CGEPEEEEGG DLAQPGLSFP
60 70 80 90 100
GPAEEDIDQQ YSWSPTQHFN EERYSPAPRN MKGLTGSRNQ PQLCAGHTCG
110 120 130 140 150
LSPPDDCEHP HDHMHHGSDV RQPYLLSPAE SCPMDHHRCS PRSSVHSECM
160 170 180 190 200
MMPVMLGDHV SSSTFPRMHY SSHYDTRDDC AMSHTSTKVN RIPANLLDQF
210 220 230 240 250
EKQLPLHRDG FHTLQYQRAS AATEQRNESP GRIRHLVHSV QKLFTKSHSL
260 270 280 290 300
EGSSKSNING TKSDSRVDDH HQSHLSKHSK RSKSKERKPE SKHKSGMSSW
310 320 330 340 350
WSSDDNLDSD STYRTPSVAH RHHMDHIPHC YPEALQSPFG DLSLKTSKSN
360 370 380 390 400
NDVKCSACEG LALTPDTRYM KRSSWSTLTV SQAKEAYRKS SLNLDKPLVH
410 420 430 440 450
PEIKPSLRPC HYLQVPQDDW GAYPTGGKEE EIPCRRMRSG SYIKAMGDEE
460 470 480 490 500
SGESDSSPKT SPTVAIRPEP LLKPIIQRPL GDHQTQSYLQ AATEVPVGHS
510 520 530 540 550
LNPSINYNSP KFRSRNQSYM RAVSTLSQAS CVSQMSEAEV NGQFESVCES
560 570 580 590 600
VFSEVESQAM DALDLPGCFR TRSHSYLRAI QAGYSQDDEC IPVMTSSNMT
610 620 630 640 650
STIRSTAAVS YTNYKKTPPP VPPRTTSKPL ISVTAQSSTE STQDAYQDSR
660 670 680 690 700
AQRMSPWPQD SRGGLYNSMD SLDSNKAMNL ALETAAAQRH AADTQSSSTR
710 720 730 740 750
SIDKAVLASK AEELLKSRCS SIGVQDSEFP DHQPYPRSDV ETATDSDTES
760 770 780 790 800
RGLREYHSVG VQVEDEKRHG RFKRSNSVTA AVQADLELEG FPGHVSMEDK
810 820 830 840 850
GLQFGSSFQR HSEPSTPTQY GALRTVRTQG LFSYREDYRT QVDTSTLPPP
860 870 880 890 900
DPWLEPSLDT VETGRMSPCR RDGSWFLKLL HTETKRMEGW CKEMEREAEE
910 920 930 940 950
NDLLEDILGK IRSAVGSAQL LMSQKFQQFY WLCQQNMDPS AMPRPTSQDL
960 970 980 990 1000
AGYWDMLQLS VEDVSMKFDE LHQLKLNDWK IIESPERKEE RKIPPPIPKK
1010 1020 1030 1040 1050
PPKGKFPITR EKSLDLPDRQ RQEARRRLMA AKRAASFRQN SATERADSIE
1060
IYIPEAQTRL
Length:1,060
Mass (Da):119,272
Last modified:September 5, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD6198AE3AD1A3510
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BJ42DLGP2_MOUSE
Disks large-associated protein 2
Dlgap2 Dap2
1,059Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC118969 mRNA Translation: AAI18970.1

NCBI Reference Sequences

More...
RefSeqi
NP_001139437.1, NM_001145965.1
NP_766498.2, NM_172910.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000152652; ENSMUSP00000123078; ENSMUSG00000047495

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
244310

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:244310

UCSC genome browser

More...
UCSCi
uc012gac.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC118969 mRNA Translation: AAI18970.1
RefSeqiNP_001139437.1, NM_001145965.1
NP_766498.2, NM_172910.3

3D structure databases

SMRiQ0VF59
ModBaseiSearch...

PTM databases

SwissPalmiQ0VF59

Proteomic databases

PeptideAtlasiQ0VF59
PRIDEiQ0VF59
ProteomicsDBi344612

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
21955, 88 antibodies

The DNASU plasmid repository

More...
DNASUi
244310

Genome annotation databases

EnsembliENSMUST00000152652; ENSMUSP00000123078; ENSMUSG00000047495
GeneIDi244310
KEGGimmu:244310
UCSCiuc012gac.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9228
MGIiMGI:2443181, Dlgap2
VEuPathDBiHostDB:ENSMUSG00000047495

Phylogenomic databases

GeneTreeiENSGT00940000157913
OMAiQMDHHRC
OrthoDBi197925at2759
PhylomeDBiQ0VF59
TreeFamiTF321382

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
244310, 0 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Dlgap2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000047495, Expressed in frontal cortex and 97 other tissues
ExpressionAtlasiQ0VF59, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR030525, DLGAP2
IPR005026, SAPAP
PANTHERiPTHR12353, PTHR12353, 1 hit
PTHR12353:SF3, PTHR12353:SF3, 1 hit
PfamiView protein in Pfam
PF03359, GKAP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ0VF59_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q0VF59
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 5, 2006
Last sequence update: September 5, 2006
Last modified: September 29, 2021
This is version 91 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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